primidone has been researched along with Abnormalities, Drug-Induced in 27 studies
Primidone: A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite.
primidone : A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy." | 7.66 | Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982) |
| "Fourteen epileptic women treated with primidone, either alone or in combination with other antiepileptic drugs, were studied prospectively during their pregnancy." | 3.66 | Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women. ( Beck-Mannagetta, G; Göpfert-Geyer, I; Helge, H; Jäger-Roman, E; Koch, S; Nau, H; Rating, D; Schmidt, D, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (96.30) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koch, S | 2 |
| Göpfert-Geyer, I | 2 |
| Jäger-Roman, E | 2 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 2 |
| Helge, H | 2 |
| Friis, ML | 1 |
| Mallow, DW | 1 |
| Herrick, MK | 1 |
| Gathman, G | 1 |
| Krauss, CM | 1 |
| Holmes, LB | 1 |
| VanLang, Q | 1 |
| Keith, DA | 1 |
| Burn, J | 1 |
| Baraitser, M | 1 |
| Nau, H | 1 |
| Beck-Mannagetta, G | 1 |
| Schmidt, D | 1 |
| Myhre, SA | 1 |
| Williams, R | 1 |
| Majewski, F | 1 |
| Raff, W | 1 |
| Fischer, P | 1 |
| Huenges, R | 1 |
| Petruch, F | 1 |
| Hanson, JW | 1 |
| Smith, DW | 1 |
| Conomy, JP | 1 |
| Livingston, S | 1 |
| Rudd, NL | 1 |
| Freedom, RM | 1 |
| Goodman, RM | 1 |
| Katznelson, MB | 1 |
| Hertz, M | 1 |
| Katznelson, D | 1 |
| Rotem, Y | 1 |
| Sullivan, FM | 1 |
| McElhatton, PR | 1 |
| Waziri, M | 1 |
| Ionasescu, V | 1 |
| Zellweger, H | 2 |
| Bishun, NP | 1 |
| Smith, NS | 1 |
| Williams, DC | 1 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Yerby, MS | 1 |
| Leavitt, A | 1 |
| Erickson, DM | 1 |
| McCormick, KB | 1 |
| Loewenson, RB | 1 |
| Sells, CJ | 1 |
| Benedetti, TJ | 1 |
| Cohen, A | 1 |
| Mundel, G | 1 |
| Lowe, CR | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Meyer, JG | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Elshove, J | 1 |
| van Eck, JH | 1 |
2 reviews available for primidone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
Anticonvulsants during pregnancy: a danger to the developing fetus?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome | 1974 |
1 trial available for primidone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
24 other studies available for primidone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Fetal exposure to anticonvulsant drugs. Detailed pathological study of a case.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Adult; Anticonvulsants; Brain; Cardiomegaly; Epilepsy; E | 1980 |
Four siblings with similar malformations after exposure to phenytoin and primidone.
Topics: Abnormalities, Drug-Induced; Child; Child Development; Child, Preschool; Embryonic and Fetal Develop | 1984 |
Primidone teratogenicity or Noonan syndrome?
Topics: Abnormalities, Drug-Induced; Diagnosis, Differential; Female; Humans; Infant, Newborn; Noonan Syndro | 1982 |
Teratogenic and pharmacokinetic studies of primidone during pregnancy and in the offspring of epileptic women.
Topics: Abnormalities, Drug-Induced; Child Development; Epilepsy; Female; Humans; Infant, Newborn; Kinetics; | 1982 |
Teratogenic effects associated with maternal primidone therapy.
Topics: Abnormalities, Drug-Induced; Child; Child Development; Child, Preschool; Craniofacial Dysostosis; Ep | 1981 |
[Teratogenicity of anticonvulsant drugs (author's transl)].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Brain Damage, Chronic; Child; Child, Pre | 1980 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
A possible primidone embryopathy.
Topics: Abnormalities, Drug-Induced; Aortic Coarctation; Face; Female; Heart Septal Defects, Ventricular; Hu | 1979 |
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epil | 1976 |
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Fema | 1977 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Chromosomes and anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cells, Cultured; Chromatids; Chromosome Aberrations; C | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
[The fetal primidone syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy; Female; Fetal Diseases; Fetal Growth | 1988 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |