primaquine has been researched along with Trypanosomiasis, African in 3 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eight other test compounds from the Cancer Chemotherapy National Service Center (CCNSC) were not toxic to cell growth, although two (4-biphenylcarboxylic acid and 1-[p-chlorobenzyl]-2-ethyl-5-methyl-indole-3-acetic acid) inhibited Crithidia alpha-glycerophosphate dehydrogenase below 1 mm." | 1.25 | Effects of some antitumor agents on growth and glycolytic enzymes of the flagellate Crithidia. ( Bacchi, CJ; Ciaccio, EI; Koren, LE, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shetty, RV | 1 |
| Blanton, CD | 1 |
| ROBERTSON, DH | 1 |
| Bacchi, CJ | 1 |
| Ciaccio, EI | 1 |
| Koren, LE | 1 |
3 other studies available for primaquine and Trypanosomiasis, African
| Article | Year |
|---|---|
Synthesis of 2-substituted primaquine analogues as potential antimalarials.
Topics: Animals; Antimalarials; Cricetinae; Haplorhini; Leishmaniasis, Visceral; Macaca mulatta; Malaria; Mi | 1978 |
The haemolytic effect of primaquine and nitrofurazone in cases of sleeping sickness with the haemolytic trait.
Topics: Animals; Antimalarials; Black People; Cell Death; Hemolysis; Humans; Nitrofurans; Nitrofurazone; Pri | 1961 |
Effects of some antitumor agents on growth and glycolytic enzymes of the flagellate Crithidia.
Topics: Acetates; Acids; Antineoplastic Agents; Antiprotozoal Agents; Arsenicals; Benzoxazoles; Eukaryota; G | 1969 |