primaquine has been researched along with Pregnancy in 35 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A targeted malaria elimination project, including mass drug administrations (MDA) of dihydroartemisinin/piperaquine plus a single low dose primaquine is underway in villages along the Thailand Myanmar border." | 3.83 | The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border. ( Elvina, E; Kajeechiwa, L; Kyawt, K; Min, JR; Nosten, F; Nosten, S; Oo, PT; Peapah, P; PoWah, W; Shee, PW; Thwin, MM; von Seidlein, L; Wiladphaingern, J; Yee, NL, 2016) |
| " Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy." | 3.77 | Prophylactic use of antimalarials during pregnancy. ( Bozzo, P; Einarson, A; Irvine, MH, 2011) |
| " vivax malaria attacks were treated with quinine or chloroquine plus primaquine." | 3.69 | Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. ( Camargo, LM; Cardoso, MA; Ferreira, MU; Szarfarc, SC, 1994) |
| " The malarial drugs primaquine and chloroquine are used as examples of mechanism 2." | 3.67 | Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides. ( Akintonwa, DA, 1984) |
| "FDA for the treatment of P." | 2.72 | Tafenoquine for ( Gautam, CS; Sharma, J; Singh, H; Singh, J, 2021) |
| "Metformin has well known anti-malarial properties." | 2.55 | Malaria and diabetes. ( Aggarwal, S; Dutta, D; Kalra, S; Khandelwal, D; Singla, R, 2017) |
| "We compare recurrence rates observed after primary P." | 1.56 | Quantifying and preventing Plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil. ( Corder, RM; Davenport, MP; de Lima, ACP; Docken, SS; Ferreira, MU; Khoury, DS, 2020) |
| "Independent of G6PD deficiency, the current pregnancy and lactation restrictions will exclude ~13% of females from radical cure treatment." | 1.48 | Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. ( Bancone, G; Chu, CS; Jittamala, P; Taylor, WRJ; Watson, J; White, NJ, 2018) |
| "1." | 1.43 | UK malaria treatment guidelines 2016. ( Beeching, NJ; Bell, DJ; Chiodini, PL; Lalloo, DG; Shingadia, D; Whitty, CJM, 2016) |
| "Despite the encouragement of early treatment, malaria was the major cause of death in children after the neonatal period in 1988." | 1.29 | Malaria treatment in Vanuatu: new national treatment guidelines. ( Reeve, PA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 8 (22.86) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, J | 1 |
| Gautam, CS | 1 |
| Singh, H | 1 |
| Singh, J | 1 |
| Brummaier, T | 1 |
| Gilder, ME | 1 |
| Gornsawun, G | 2 |
| Chu, CS | 4 |
| Bancone, G | 4 |
| Pimanpanarak, M | 1 |
| Chotivanich, K | 1 |
| Nosten, F | 4 |
| McGready, R | 1 |
| Corder, RM | 1 |
| de Lima, ACP | 1 |
| Khoury, DS | 1 |
| Docken, SS | 1 |
| Davenport, MP | 1 |
| Ferreira, MU | 2 |
| Spiegelenberg, JP | 1 |
| Bastiaens, GJH | 1 |
| Hassing, RJ | 1 |
| Kalra, S | 1 |
| Khandelwal, D | 1 |
| Singla, R | 1 |
| Aggarwal, S | 1 |
| Dutta, D | 1 |
| Devine, A | 1 |
| Parmiter, M | 1 |
| Price, RN | 1 |
| Lubell, Y | 1 |
| Yeung, S | 1 |
| Watson, J | 1 |
| Taylor, WRJ | 1 |
| Jittamala, P | 1 |
| White, NJ | 1 |
| Porn, P | 1 |
| Pal, S | 1 |
| Bansil, P | 1 |
| Domingo, GJ | 1 |
| Lalloo, DG | 1 |
| Shingadia, D | 1 |
| Bell, DJ | 1 |
| Beeching, NJ | 1 |
| Whitty, CJM | 1 |
| Chiodini, PL | 1 |
| Mwaiswelo, R | 1 |
| Ngasala, B | 1 |
| Jovel, I | 1 |
| Aydin-Schmidt, B | 1 |
| Gosling, R | 1 |
| Premji, Z | 1 |
| Mmbando, B | 1 |
| Björkman, A | 1 |
| Mårtensson, A | 1 |
| Kajeechiwa, L | 1 |
| Thwin, MM | 1 |
| Shee, PW | 1 |
| Yee, NL | 1 |
| Elvina, E | 1 |
| Peapah, P | 1 |
| Kyawt, K | 1 |
| Oo, PT | 1 |
| PoWah, W | 1 |
| Min, JR | 1 |
| Wiladphaingern, J | 1 |
| von Seidlein, L | 1 |
| Nosten, S | 1 |
| Freedman, DO | 1 |
| Irvine, MH | 1 |
| Einarson, A | 1 |
| Bozzo, P | 1 |
| Singh, N | 1 |
| Mishra, AK | 1 |
| Shukla, MM | 1 |
| Chand, SK | 1 |
| Bharti, PK | 1 |
| Coldren, RL | 1 |
| Jongsakul, K | 1 |
| Vayakornvichit, S | 1 |
| Noedl, H | 1 |
| Fukudas, MM | 1 |
| Lesko, CR | 1 |
| Arguin, PM | 1 |
| Newman, RD | 1 |
| Stürchler, D | 1 |
| Akintonwa, DA | 1 |
| Beveridge, E | 1 |
| Caldwell, IC | 1 |
| Latter, VS | 1 |
| Neal, RA | 1 |
| Udall, V | 1 |
| Waldron, MM | 1 |
| Schrier, SL | 1 |
| Reeve, PA | 1 |
| Cardoso, MA | 1 |
| Camargo, LM | 1 |
| Szarfarc, SC | 1 |
| Kager, PA | 1 |
| Zijlmans, CW | 1 |
| Boele van Hensbroek, M | 1 |
| Wetsteyn, JC | 1 |
| Barry, M | 1 |
| Heppner, DG | 1 |
| Gasser, RA | 1 |
| Kester, KE | 1 |
| Botella de Maglia, J | 1 |
| Espacio Casanovas, A | 1 |
| Brown, GV | 1 |
| Wong, HB | 1 |
| van der Ende, A | 1 |
| du Maine, A | 1 |
| Simmons, CF | 1 |
| Schwartz, AL | 1 |
| Strous, GJ | 1 |
| Shen, PL | 1 |
| Xu, JM | 1 |
| Qian, XM | 1 |
| Zhang, YP | 1 |
| Yu, YC | 1 |
| Ye, JF | 1 |
| Vesell, ES | 1 |
| Saint-Yves, IF | 1 |
| Herzog, P | 1 |
| Nir, I | 1 |
| Hamilton, PJ | 1 |
| Gebbie, DA | 1 |
| Hutt, MS | 1 |
| Lothe, F | 1 |
| Wilks, NE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Clinical Study to Assess the Safety and Feasibility of Controlled Blood-stage Plasmodium Vivax Human Malaria Infection Through Experimental Inoculation of Cryopreserved Infected Erythrocytes in Healthy Thai Adults[NCT05071079] | 16 participants (Anticipated) | Interventional | 2022-05-23 | Recruiting | |||
| Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094] | Phase 4 | 388 participants (Anticipated) | Interventional | 2023-06-26 | Recruiting | ||
| Efficacy and Safety of a Single Low-dose Primaquine Added to Standard Artemether-lumefantrine Treatment for the Clearance of Plasmodium Falciparum Gametocytes.[NCT02090036] | Phase 4 | 220 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for primaquine and Pregnancy
| Article | Year |
|---|---|
Tafenoquine for
Topics: Aminoquinolines; Antimalarials; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Primaqu | 2021 |
Malaria and diabetes.
Topics: Animals; Antimalarials; Diabetes Mellitus, Type 2; Female; Glucosephosphate Dehydrogenase Deficiency | 2017 |
Clinical practice. Malaria prevention in short-term travelers.
Topics: Adult; Animals; Antimalarials; Child; DEET; Drug Resistance; Endemic Diseases; Female; Humans; Malar | 2008 |
Malaria prophylaxis in travellers: the current position.
Topics: Africa; Amodiaquine; Antimalarials; Asia; Chloroquine; Culicidae; Drug Resistance; Female; Humans; I | 1984 |
[The treatment of malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malar | 1997 |
Chemoprophylaxis of malaria.
Topics: Adolescent; Adult; Africa; Anemia, Hemolytic; Asia; Australia; Child; Child, Preschool; Chloroquine; | 1986 |
Recent progress in pharmacogenetics.
Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; C | 1969 |
1 trial available for primaquine and Pregnancy
| Article | Year |
|---|---|
Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial.
Topics: Adolescent; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Pr | 2016 |
27 other studies available for primaquine and Pregnancy
| Article | Year |
|---|---|
Vivax malaria in pregnancy and lactation: a long way to health equity.
Topics: Adolescent; Aminoquinolines; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Femal | 2020 |
Quantifying and preventing Plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil.
Topics: Adolescent; Adult; Antimalarials; Brazil; Case-Control Studies; Child; Chloroquine; Female; Humans; | 2020 |
Treatment of relapsing Plasmodium vivax malaria during pregnancy.
Topics: Aminoquinolines; Antimalarials; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Primaqu | 2021 |
Using G6PD tests to enable the safe treatment of Plasmodium vivax infections with primaquine on the Thailand-Myanmar border: A cost-effectiveness analysis.
Topics: Adult; Antimalarials; Cost-Benefit Analysis; Diagnostic Tests, Routine; Female; Glucosephosphate Deh | 2017 |
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.
Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency | 2018 |
Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood.
Topics: Adult; Aminoquinolines; Antimalarials; Area Under Curve; Biosensing Techniques; Clinical Enzyme Test | 2018 |
UK malaria treatment guidelines 2016.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Breast Feeding; Child; Child, Preschool; Female; Hum | 2016 |
The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Artemisinins; Child; Child, Pres | 2016 |
Prophylactic use of antimalarials during pregnancy.
Topics: Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug Combinations; Female; Hum | 2011 |
Diagnostic and prognostic utility of an inexpensive rapid on site malaria diagnostic test (ParaHIT f) among ethnic tribal population in areas of high, low and no transmission in central India.
Topics: Adult; Antimalarials; Child; Chloroquine; Ethnicity; Female; Humans; India; Infant; Malaria, Falcipa | 2005 |
Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Plasmodium ovale; Pregnancy; Pr | 2007 |
Congenital malaria in the United States: a review of cases from 1966 to 2005.
Topics: Female; Humans; Infant, Newborn; Malaria; Malaria, Vivax; Population Surveillance; Pregnancy; Pregna | 2007 |
Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides.
Topics: Adult; Chemical Phenomena; Chemistry; Child; Chlorfenvinphos; Chloroquine; Cytochrome P-450 Enzyme S | 1984 |
The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).
Topics: Aminoquinolines; Animals; Chagas Disease; Culture Techniques; Female; Fetus; Furazolidone; Guinea Pi | 1980 |
Human erythrocyte G6PD deficiency: pathophysiology, prevalence, diagnosis, and management.
Topics: Black People; Blood Transfusion; Chloroquine; Female; Genetic Counseling; Glucosephosphate Dehydroge | 1980 |
Malaria treatment in Vanuatu: new national treatment guidelines.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; H | 1994 |
Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon.
Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Animals; Brazil; Child; Child | 1994 |
Primaquine prophylaxis against malaria.
Topics: Antimalarials; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Primaquine | 1999 |
Primaquine prophylaxis against malaria.
Topics: Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Falciparum; Malar | 1999 |
[Prevention of malaria].
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Female; Humans; Malaria; Malaria, Fa | 1999 |
Recommendations for the prevention of malaria among travelers.
Topics: Adult; Animals; Antimalarials; Breast Feeding; Centers for Disease Control and Prevention, U.S.; Chi | 1990 |
Erythrocytic glucose-6-phosphate dehydrogenase deficiency and its significance with special emphasis on malaria.
Topics: Child; Child, Preschool; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehy | 1986 |
Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron.
Topics: Cell Line; Choriocarcinoma; Endocytosis; Female; Humans; Iron; Kinetics; Monensin; Pregnancy; Primaq | 1987 |
[The embryotoxicity of primaquine octylamide in rats].
Topics: Animals; Antimalarials; Embryonic and Fetal Development; Female; Fetal Resorption; Fetus; Pregnancy; | 1985 |
The chemotherapy and prophylaxis of malaria.
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Fe | 1973 |
[Genes and drugs].
Topics: Bis-Trimethylammonium Compounds; Cytochrome Reductases; Female; Genes; Halothane; Humans; Isoniazid; | 1973 |
Anaemia in pregnancy associated with "big spleen disease".
Topics: Adolescent; Adult; Anemia, Hypochromic; Chloroquine; Female; Humans; Liver; Malaria; Pregnancy; Preg | 1966 |