Page last updated: 2024-11-03

primaquine and Pregnancy

primaquine has been researched along with Pregnancy in 35 studies

Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"A targeted malaria elimination project, including mass drug administrations (MDA) of dihydroartemisinin/piperaquine plus a single low dose primaquine is underway in villages along the Thailand Myanmar border."3.83The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border. ( Elvina, E; Kajeechiwa, L; Kyawt, K; Min, JR; Nosten, F; Nosten, S; Oo, PT; Peapah, P; PoWah, W; Shee, PW; Thwin, MM; von Seidlein, L; Wiladphaingern, J; Yee, NL, 2016)
" Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy."3.77Prophylactic use of antimalarials during pregnancy. ( Bozzo, P; Einarson, A; Irvine, MH, 2011)
" vivax malaria attacks were treated with quinine or chloroquine plus primaquine."3.69Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. ( Camargo, LM; Cardoso, MA; Ferreira, MU; Szarfarc, SC, 1994)
" The malarial drugs primaquine and chloroquine are used as examples of mechanism 2."3.67Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides. ( Akintonwa, DA, 1984)
"FDA for the treatment of P."2.72Tafenoquine for ( Gautam, CS; Sharma, J; Singh, H; Singh, J, 2021)
"Metformin has well known anti-malarial properties."2.55Malaria and diabetes. ( Aggarwal, S; Dutta, D; Kalra, S; Khandelwal, D; Singla, R, 2017)
"We compare recurrence rates observed after primary P."1.56Quantifying and preventing Plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil. ( Corder, RM; Davenport, MP; de Lima, ACP; Docken, SS; Ferreira, MU; Khoury, DS, 2020)
"Independent of G6PD deficiency, the current pregnancy and lactation restrictions will exclude ~13% of females from radical cure treatment."1.48Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. ( Bancone, G; Chu, CS; Jittamala, P; Taylor, WRJ; Watson, J; White, NJ, 2018)
"1."1.43UK malaria treatment guidelines 2016. ( Beeching, NJ; Bell, DJ; Chiodini, PL; Lalloo, DG; Shingadia, D; Whitty, CJM, 2016)
"Despite the encouragement of early treatment, malaria was the major cause of death in children after the neonatal period in 1988."1.29Malaria treatment in Vanuatu: new national treatment guidelines. ( Reeve, PA, 1994)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199012 (34.29)18.7374
1990's7 (20.00)18.2507
2000's4 (11.43)29.6817
2010's8 (22.86)24.3611
2020's4 (11.43)2.80

Authors

AuthorsStudies
Sharma, J1
Gautam, CS1
Singh, H1
Singh, J1
Brummaier, T1
Gilder, ME1
Gornsawun, G2
Chu, CS4
Bancone, G4
Pimanpanarak, M1
Chotivanich, K1
Nosten, F4
McGready, R1
Corder, RM1
de Lima, ACP1
Khoury, DS1
Docken, SS1
Davenport, MP1
Ferreira, MU2
Spiegelenberg, JP1
Bastiaens, GJH1
Hassing, RJ1
Kalra, S1
Khandelwal, D1
Singla, R1
Aggarwal, S1
Dutta, D1
Devine, A1
Parmiter, M1
Price, RN1
Lubell, Y1
Yeung, S1
Watson, J1
Taylor, WRJ1
Jittamala, P1
White, NJ1
Porn, P1
Pal, S1
Bansil, P1
Domingo, GJ1
Lalloo, DG1
Shingadia, D1
Bell, DJ1
Beeching, NJ1
Whitty, CJM1
Chiodini, PL1
Mwaiswelo, R1
Ngasala, B1
Jovel, I1
Aydin-Schmidt, B1
Gosling, R1
Premji, Z1
Mmbando, B1
Björkman, A1
Mårtensson, A1
Kajeechiwa, L1
Thwin, MM1
Shee, PW1
Yee, NL1
Elvina, E1
Peapah, P1
Kyawt, K1
Oo, PT1
PoWah, W1
Min, JR1
Wiladphaingern, J1
von Seidlein, L1
Nosten, S1
Freedman, DO1
Irvine, MH1
Einarson, A1
Bozzo, P1
Singh, N1
Mishra, AK1
Shukla, MM1
Chand, SK1
Bharti, PK1
Coldren, RL1
Jongsakul, K1
Vayakornvichit, S1
Noedl, H1
Fukudas, MM1
Lesko, CR1
Arguin, PM1
Newman, RD1
Stürchler, D1
Akintonwa, DA1
Beveridge, E1
Caldwell, IC1
Latter, VS1
Neal, RA1
Udall, V1
Waldron, MM1
Schrier, SL1
Reeve, PA1
Cardoso, MA1
Camargo, LM1
Szarfarc, SC1
Kager, PA1
Zijlmans, CW1
Boele van Hensbroek, M1
Wetsteyn, JC1
Barry, M1
Heppner, DG1
Gasser, RA1
Kester, KE1
Botella de Maglia, J1
Espacio Casanovas, A1
Brown, GV1
Wong, HB1
van der Ende, A1
du Maine, A1
Simmons, CF1
Schwartz, AL1
Strous, GJ1
Shen, PL1
Xu, JM1
Qian, XM1
Zhang, YP1
Yu, YC1
Ye, JF1
Vesell, ES1
Saint-Yves, IF1
Herzog, P1
Nir, I1
Hamilton, PJ1
Gebbie, DA1
Hutt, MS1
Lothe, F1
Wilks, NE1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Clinical Study to Assess the Safety and Feasibility of Controlled Blood-stage Plasmodium Vivax Human Malaria Infection Through Experimental Inoculation of Cryopreserved Infected Erythrocytes in Healthy Thai Adults[NCT05071079]16 participants (Anticipated)Interventional2022-05-23Recruiting
Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094]Phase 4388 participants (Anticipated)Interventional2023-06-26Recruiting
Efficacy and Safety of a Single Low-dose Primaquine Added to Standard Artemether-lumefantrine Treatment for the Clearance of Plasmodium Falciparum Gametocytes.[NCT02090036]Phase 4220 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for primaquine and Pregnancy

ArticleYear
Tafenoquine for
    The Indian journal of medical research, 2021, Volume: 154, Issue:6

    Topics: Aminoquinolines; Antimalarials; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Primaqu

2021
Malaria and diabetes.
    JPMA. The Journal of the Pakistan Medical Association, 2017, Volume: 67, Issue:5

    Topics: Animals; Antimalarials; Diabetes Mellitus, Type 2; Female; Glucosephosphate Dehydrogenase Deficiency

2017
Clinical practice. Malaria prevention in short-term travelers.
    The New England journal of medicine, 2008, Aug-07, Volume: 359, Issue:6

    Topics: Adult; Animals; Antimalarials; Child; DEET; Drug Resistance; Endemic Diseases; Female; Humans; Malar

2008
Malaria prophylaxis in travellers: the current position.
    Experientia, 1984, Dec-15, Volume: 40, Issue:12

    Topics: Africa; Amodiaquine; Antimalarials; Asia; Chloroquine; Culicidae; Drug Resistance; Female; Humans; I

1984
[The treatment of malaria].
    Nederlands tijdschrift voor geneeskunde, 1997, Sep-13, Volume: 141, Issue:37

    Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malar

1997
Chemoprophylaxis of malaria.
    The Medical journal of Australia, 1986, Jun-23, Volume: 144, Issue:13

    Topics: Adolescent; Adult; Africa; Anemia, Hemolytic; Asia; Australia; Child; Child, Preschool; Chloroquine;

1986
Recent progress in pharmacogenetics.
    Advances in pharmacology, 1969, Volume: 7

    Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; C

1969

Trials

1 trial available for primaquine and Pregnancy

ArticleYear
Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial.
    Malaria journal, 2016, Aug-26, Volume: 15, Issue:1

    Topics: Adolescent; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Pr

2016

Other Studies

27 other studies available for primaquine and Pregnancy

ArticleYear
Vivax malaria in pregnancy and lactation: a long way to health equity.
    Malaria journal, 2020, Jan-22, Volume: 19, Issue:1

    Topics: Adolescent; Aminoquinolines; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Femal

2020
Quantifying and preventing Plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Antimalarials; Brazil; Case-Control Studies; Child; Chloroquine; Female; Humans;

2020
Treatment of relapsing Plasmodium vivax malaria during pregnancy.
    Journal of travel medicine, 2021, Jul-07, Volume: 28, Issue:5

    Topics: Aminoquinolines; Antimalarials; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Primaqu

2021
Using G6PD tests to enable the safe treatment of Plasmodium vivax infections with primaquine on the Thailand-Myanmar border: A cost-effectiveness analysis.
    PLoS neglected tropical diseases, 2017, Volume: 11, Issue:5

    Topics: Adult; Antimalarials; Cost-Benefit Analysis; Diagnostic Tests, Routine; Female; Glucosephosphate Deh

2017
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency

2018
Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Adult; Aminoquinolines; Antimalarials; Area Under Curve; Biosensing Techniques; Clinical Enzyme Test

2018
UK malaria treatment guidelines 2016.
    The Journal of infection, 2016, Volume: 72, Issue:6

    Topics: Adult; Antimalarials; Artemisinins; Artesunate; Breast Feeding; Child; Child, Preschool; Female; Hum

2016
The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border.
    Malaria journal, 2016, 09-27, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Artemisinins; Child; Child, Pres

2016
Prophylactic use of antimalarials during pregnancy.
    Canadian family physician Medecin de famille canadien, 2011, Volume: 57, Issue:11

    Topics: Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug Combinations; Female; Hum

2011
Diagnostic and prognostic utility of an inexpensive rapid on site malaria diagnostic test (ParaHIT f) among ethnic tribal population in areas of high, low and no transmission in central India.
    BMC infectious diseases, 2005, Jun-21, Volume: 5

    Topics: Adult; Antimalarials; Child; Chloroquine; Ethnicity; Female; Humans; India; Infant; Malaria, Falcipa

2005
Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman.
    The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:5

    Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Plasmodium ovale; Pregnancy; Pr

2007
Congenital malaria in the United States: a review of cases from 1966 to 2005.
    Archives of pediatrics & adolescent medicine, 2007, Volume: 161, Issue:11

    Topics: Female; Humans; Infant, Newborn; Malaria; Malaria, Vivax; Population Surveillance; Pregnancy; Pregna

2007
Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides.
    Journal of theoretical biology, 1984, Jan-07, Volume: 106, Issue:1

    Topics: Adult; Chemical Phenomena; Chemistry; Child; Chlorfenvinphos; Chloroquine; Cytochrome P-450 Enzyme S

1984
The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980, Volume: 74, Issue:1

    Topics: Aminoquinolines; Animals; Chagas Disease; Culture Techniques; Female; Fetus; Furazolidone; Guinea Pi

1980
Human erythrocyte G6PD deficiency: pathophysiology, prevalence, diagnosis, and management.
    Comprehensive therapy, 1980, Volume: 6, Issue:7

    Topics: Black People; Blood Transfusion; Chloroquine; Female; Genetic Counseling; Glucosephosphate Dehydroge

1980
Malaria treatment in Vanuatu: new national treatment guidelines.
    Papua and New Guinea medical journal, 1994, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; H

1994
Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon.
    European journal of clinical nutrition, 1994, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Animals; Brazil; Child; Child

1994
Primaquine prophylaxis against malaria.
    Annals of internal medicine, 1999, Mar-16, Volume: 130, Issue:6

    Topics: Antimalarials; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Primaquine

1999
Primaquine prophylaxis against malaria.
    Annals of internal medicine, 1999, Mar-16, Volume: 130, Issue:6

    Topics: Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Falciparum; Malar

1999
[Prevention of malaria].
    Revista clinica espanola, 1999, Volume: 199, Issue:8

    Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Female; Humans; Malaria; Malaria, Fa

1999
Recommendations for the prevention of malaria among travelers.
    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 1990, Mar-09, Volume: 39, Issue:RR-3

    Topics: Adult; Animals; Antimalarials; Breast Feeding; Centers for Disease Control and Prevention, U.S.; Chi

1990
Erythrocytic glucose-6-phosphate dehydrogenase deficiency and its significance with special emphasis on malaria.
    The Journal of the Singapore Paediatric Society, 1986, Volume: 28, Issue:1-2

    Topics: Child; Child, Preschool; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehy

1986
Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron.
    The Journal of biological chemistry, 1987, Jun-25, Volume: 262, Issue:18

    Topics: Cell Line; Choriocarcinoma; Endocytosis; Female; Humans; Iron; Kinetics; Monensin; Pregnancy; Primaq

1987
[The embryotoxicity of primaquine octylamide in rats].
    Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1985, Volume: 3, Issue:3

    Topics: Animals; Antimalarials; Embryonic and Fetal Development; Female; Fetal Resorption; Fetus; Pregnancy;

1985
The chemotherapy and prophylaxis of malaria.
    The Medical journal of Australia, 1973, Dec-08, Volume: 2, Issue:23

    Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Fe

1973
[Genes and drugs].
    Harefuah, 1973, Volume: 85, Issue:6

    Topics: Bis-Trimethylammonium Compounds; Cytochrome Reductases; Female; Genes; Halothane; Humans; Isoniazid;

1973
Anaemia in pregnancy associated with "big spleen disease".
    British medical journal, 1966, Sep-03, Volume: 2, Issue:5513

    Topics: Adolescent; Adult; Anemia, Hypochromic; Chloroquine; Female; Humans; Liver; Malaria; Pregnancy; Preg

1966