primaquine has been researched along with Malaria in 622 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 days) high-dose (1 mg/kg twice daily) primaquine (PQ) for uncomplicated malaria because of any Plasmodium species in children randomized to early- or delayed treatment." | 9.69 | Ultra-short course, high-dose primaquine to prevent Plasmodium vivax infection following uncomplicated pediatric malaria: A randomized, open-label, non-inferiority trial of early versus delayed treatment. ( Batty, KT; Davis, TME; Kasian, B; Laman, M; Lorry, L; Manning, L; Moore, BR; Pomat, W; Robinson, LJ; Salman, S; Tesine, P; Woon, SA; Yadi, G; Yambo, P, 2023) |
| "Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria." | 9.69 | Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study. ( Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M, 2023) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 9.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention." | 9.08 | Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. ( Church, LW; Cryz, SJ; Fryauff, DJ; Hoffman, SL; Mouzin, E; Richards, AL; Subianto, B; Sutamihardja, MA; Widjaja, H, 1998) |
| "A clinical field trial was conducted to determine if mefloquine is effective in the treatment of malaria due to Plasmodium vivax." | 9.05 | A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria. ( Dixon, KE; Phintuyothin, P; Pitaktong, U, 1985) |
| "Glucose-6-phosphate dehydrogenase-normal adult volunteers infected with mosquito-bone Chesson strain vivax malaria were treated with chloroquine and primaquine during the initial attack." | 9.04 | Radical cure of Chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine. ( Clyde, DF; McCarthy, VC, 1977) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 8.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents." | 8.91 | Quinoline-based antimalarial hybrid compounds. ( D'hooghe, M; Vandekerckhove, S, 2015) |
| "Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its use." | 8.82 | Primaquine therapy for malaria. ( Baird, JK; Hoffman, SL, 2004) |
| "Primaquine prevents relapses of Plasmodium vivax malaria but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 8.31 | Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function. ( Anstey, NM; Douglas, NM; Ley, B; Piera, KA; Price, RN; Rumaseb, A, 2023) |
| "Primaquine and tafenoquine are the only licensed drugs that effectively kill the hypnozoite stage and are used to prevent Plasmodium vivax malaria relapse." | 8.12 | Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure. ( Boonyuen, U; Chamchoy, K; Krudsood, S; Patrapuvich, R; Sudsumrit, S; Thita, T, 2022) |
| "Primaquine and tafenoquine are the two 8-aminoquinoline (8-AQ) antimalarial drugs approved for malarial radical cure - the elimination of liver stage hypnozoites after infection with Plasmodium vivax." | 8.02 | Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure. ( Burke, PA; Chavas, TEJ; Flaherty, SM; Ho, DK; Huber, HE; Jackson, C; LeGuyader, CLM; Li, Q; Lin, H; Maktabi, M; Pottenger, A; Pybus, B; Rochford, R; Roy, D; Srinivasan, S; Stayton, PS; Strauch, P; Vlaskin, V; Wesche, D; Zhang, J, 2021) |
| "We reviewed the clinical efficacy of chloroquine for Plasmodium vivax malaria, the changing trend of parasite clearance time, and fever clearance time during 2000-2016 in South Korea." | 7.96 | Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016. ( Cho, SH; Kwak, YG; Lee, KS; Lee, SE; Park, SY; Park, Y; Park, YS; Shin, HI; Song, JE; Yeom, JS, 2020) |
| "Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA)." | 7.85 | Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing. ( Banda, CG; Chipasula-Teleka, A; Hayes, DJ; Terlouw, DJ, 2017) |
| "Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P." | 7.85 | Synthesis of primaquine glyco-conjugates as potential tissue schizontocidal antimalarial agents. ( Anand, N; Azad, CS; Bhardwaj, J; Dutta, GP; Puri, SK; Saxena, AK; Saxena, M; Siddiqui, AJ, 2017) |
| "Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission." | 7.85 | Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms. ( Aguiar, AC; Cunico, W; Drawanz, BB; Figueiredo, FJ; Katsuragawa, TH; Krettli, AU; Neuenfeldt, PD; Sinnis, P; Zavala, F, 2017) |
| "Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) are at risk for developing hemolytic anemia when given the antimalarial drug primaquine (PQ)." | 7.83 | Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs. ( Baresel, PC; Campo, B; Marcsisin, SR; Reichard, GA; Rochford, R; Sousa, J; Tekwani, BL; Vuong, CT; Walker, LA; Wickham, KS, 2016) |
| "Various polymer drug conjugates (13-16) such as primaquine and dihydroartemisinin conjugated 2-propoxy substituted polyphosphazenes (13), primaquine and dihydroartemisinin conjugated 4-acetamidophenoxy substituted polyphosphazenes (14), primaquine and dihydroartemisinin conjugated 4-formyl substituted polyphosphazenes (15) and primaquine and dihydroartemisinin conjugated 4-aminoethylbenzoate substituted polyphosphazenes (16) were synthesized using substituted polyphosphazenes as polymer and primaquine and dihydroartemisinin as combination antimalarial pharmacophores and formulated to nanoparticles to achieve novel controlled combined drug delivery approach for radical cure of malaria." | 7.81 | Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin. ( Bhardwaj, TR; Kumar, S; Murthy, RS; Sharma, R; Singh, RK, 2015) |
| "Primaquine phosphate has been used to prevent relapse as a radical cure after the acute-phase treatment of vivax and ovale malaria however." | 7.79 | [Clinical experience of primaquine use for treatment of vivax and ovale malaria in Japanese travelers]. ( Kanagawa, S; Kano, S; Kato, Y; Kobayashi, T; Mizuno, Y; Ohmagari, N; Takeshita, N; Ujiie, M; Yamauchi, Y, 2013) |
| "After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria." | 7.78 | Reinventing primaquine for endemic malaria. ( Baird, JK, 2012) |
| "Millions of people receive primaquine against sexual plasmodia responsible for malaria transmission." | 7.77 | Consideration of ethics in primaquine therapy against malaria transmission. ( Baird, JK; Surjadjaja, C, 2011) |
| "New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type, poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA) and poly[alpha,beta-(N-3-hydroxypropyl-DL-aspartamide)] (PHPA), were synthesized, characterized and screened for their antimalarial activity." | 7.75 | Macromolecular prodrugs. XII. Primaquine conjugates: synthesis and preliminary antimalarial evaluation. ( Kos, G; Rajić, Z; Singh, PP; Singh, S; Zorc, B, 2009) |
| "Primaquine (PQ) is one of the most widely used antimalarial and is the only available drug till date to combat relapsing form of malaria especially in case of Plasmodium vivax and Plasmodium ovale." | 7.74 | Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. ( Singh, KK; Vingkar, SK, 2008) |
| "The costs of mefloquine, chloroquine, doxycycline, primaquine, and atovaquone/proguanil are calculated for various durations of exposure to malaria." | 7.73 | Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis. ( Bryan, JP, 2006) |
| "To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where C-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized." | 7.72 | Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. ( Jain, M; Jain, R; Jena, GB; Kaul, CL; Ramarao, P; Sachdeva, S; Singh, PP; Singh, S; Tikoo, K; Vangapandu, S, 2004) |
| "Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro." | 7.71 | Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine. ( Biswas, S; Dua, VK; Puri, SK; Sharma, VP; Sinha, SN; Valecha, N, 2002) |
| "To investigate the activity of daphnetin(DPNT) against the exo-erythrocytic stage of rodent malaria." | 7.71 | [Effect of daphnetin on the exo-erythrocytic stage of rodent malaria]. ( Liu, YG; Ni, QZ; Ni, YC; Wang, QM; Xu, YQ, 2001) |
| "The aim of this preliminary study was to investigate the potential use of the transdermal route for primaquine administration in the treatment of malaria." | 7.69 | Preliminary evaluation of primaquine activity on rodent malaria model after transdermal administration. ( Couarraze, G; Deharo, E; Landau, I; Mayorga, P, 1997) |
| "In searching for efficient, safe and radically curative agent and causal prophylactics for malaria, seven 2-methyl-5-substituted phenoxy-6-methoxy-8-(1-methyl-4-aminobutylamino)-quinolines (II1-7) were synthesized and their antimalarial activities were compared with the corresponding 4-methyl substituted derivatives of primaquine." | 7.68 | [Synthesis of 2-methyl-5-substituted phenoxy-primaquine and antimalarials activity]. ( Deng, RX; Wang, J; Zhong, BH; Zhong, JX, 1990) |
| "The pharmacokinetics of mefloquine (M) were studied in 59 male Thai patients with falciparum malaria." | 7.68 | Pharmacokinetics of mefloquine in combination with sulfadoxine-pyrimethamine and primaquine in male Thai patients with falciparum malaria. ( Back, DJ; Breckenridge, AM; Bunnag, D; Karbwang, J, 1990) |
| "The antimalarial effect of intravenously administered primaquine (PQ) can be improved and its toxicity diminished by linking it to a macromolecular carrier protein." | 7.67 | Carrier-linked primaquine in the chemotherapy of malaria. ( Altszuler, R; Capuano, A; Hofsteenge, J; Moore, S, 1986) |
| "Five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against Plasmodium cynomolgi in Rhesus monkeys and for blood schizonticidal antimalarial activity against Plasmodium berghei in mice." | 7.67 | 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. ( Berrang, B; Carroll, FI; Linn, CP, 1985) |
| "Two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity." | 7.67 | Sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. ( Berrang, B; Carroll, FI; Linn, CP, 1985) |
| "One hundred and ten consecutive patients with falciparum malaria were treated with Fansidar and primaquine." | 7.67 | Clinical efficacy of sulfadoxine-pyrimethamine in the treatment of falciparum malaria in Sabah, Malaysia. ( Tan, HS; Tan, PE, 1984) |
| "When the terminal amino group in the side chain of primaquine was blocked with an ethoxyacetyl group shown in 2, or eliminated by oxidative deamination to carboxylic acid 3, the antimalarial effect was markedly reduced in a screening assay which measures tissue schizonticidal activity." | 7.67 | Antimalarial activity and inhibition of monoamine oxidases A and B by exo-erythrocytic antimalarials. Optical isomers of primaquine, N-acylated congeners, primaquine metabolites and 5-phenoxy-substituted analogues. ( Abell, CW; Bembenek, ME; Brossi, A; Landau, I; Millet, P, 1987) |
| "A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity." | 7.66 | Antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. A highly effective series of blood and tissue schizonticidal agents. ( Blumbergs, P; LaMontagne, MP; Strube, RE, 1982) |
| "A number of 5-phenylthio and 5-anilino derivatives of primaquine have been prepared which are less toxic but less active than primaquine itself in murine and monkey antimalarial screens." | 7.66 | Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine. ( Chen, EH; Nodiff, EA; Saggiomo, AJ; Tanabe, K; Verma, BL, 1978) |
| "Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens." | 7.65 | Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine. ( Chen, EH; Nodiff, EA; Saggiomo, AJ; Tanabe, K; Verma, BL, 1977) |
| "vivax malaria were eligible for study." | 6.78 | Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia. ( Baird, JK; Basri, H; Ekawati, LL; Elyazar, I; Farrar, J; Meilia, RA; Nurleila, S; Putri, FA; Setiabudy, R; Sudoyo, H; Sutanto, I; Taylor, WR; Tjahjono, B, 2013) |
| " Despite the dosage employed, the frequency and duration of use, and excretion primarily through the bowels as the active parent compound, primaquine appeared to have little or no significant effect against a variety of common intestinal parasites." | 6.69 | Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention. ( Basri, H; Fryauff, DJ; Jones, TR; Mouzin, E; Prodjodipuro, P; Subianto, B; Widjaja, H, 1998) |
| "Primaquine is the only treatment licensed for therapy against relapse caused by dormant liver stages occurring in some species, and against the sexual blood stages responsible for transmission to mosquitoes in all species." | 6.48 | Primaquine toxicity forestalls effective therapeutic management of the endemic malarias. ( Baird, JK, 2012) |
| " No severe adverse events associated with the MDA were identified in the pilot; there were severe adverse events in a separate, subsequent campaign." | 5.91 | Acceptability, Feasibility, Drug Safety, and Effectiveness of a Pilot Mass Drug Administration with a Single Round of Sulfadoxine-Pyrimethamine Plus Primaquine and Indoor Residual Spraying in Communities with Malaria Transmission in Haiti, 2018. ( Ashton, R; Battle, KE; Cameron, E; Chang, MA; Cohen, J; Dalexis, PE; Desir, L; Dismer, AM; Drakeley, C; Druetz, T; Eisele, TP; Fouché, B; Hamre, KES; Herman, C; Holmes, K; Impoinvil, D; Lafortune, W; Lemoine, JF; Mérilien, JB; Noland, GS; Pothin, E; Rogier, E; Stresman, G; Telfort, MA; van den Hoogen, L; Williamson, J; Young, AJ, 2023) |
| "Plasmodium vivax malaria is considered a major threat to malaria eradication." | 5.91 | Interventions for promoting patients' adherence to 14-day primaquine treatment in a highly malaria-endemic township in Myanmar: a qualitative study among key stakeholders. ( Aung, PL; Cui, L; Kyaw, MP; Lawpoolsri, S; Linn, NYY; Nguitragool, W; Ring, Z; Sattabongkot, J; Win, KM, 2023) |
| "Malaria is a major cause of death in low-income countries." | 5.72 | Effects of Host Genetic Polymorphisms on the Efficacy of the Radical Cure Malaria Drug Primaquine. ( Mohan, M; Nain, M; Sharma, A, 2022) |
| "Primaquine was effective in preventing P." | 5.72 | Relapse of Plasmodium vivax and Plasmodium ovale Malaria With and Without Primaquine Treatment in a Nonendemic Area. ( Björklund, D; Carlander, C; Färnert, A; Hellgren, U; Hervius Askling, H; Sondén, K; Stenström, C; Wångdahl, A; Wyss, K; Zhang, J, 2022) |
| "5 days) high-dose (1 mg/kg twice daily) primaquine (PQ) for uncomplicated malaria because of any Plasmodium species in children randomized to early- or delayed treatment." | 5.69 | Ultra-short course, high-dose primaquine to prevent Plasmodium vivax infection following uncomplicated pediatric malaria: A randomized, open-label, non-inferiority trial of early versus delayed treatment. ( Batty, KT; Davis, TME; Kasian, B; Laman, M; Lorry, L; Manning, L; Moore, BR; Pomat, W; Robinson, LJ; Salman, S; Tesine, P; Woon, SA; Yadi, G; Yambo, P, 2023) |
| "Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria." | 5.69 | Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study. ( Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M, 2023) |
| "Malaria is the most common parasitic disease around the world, especially in tropical and sub-tropical regions." | 5.62 | Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatment. ( Alencar, LMR; Alexis, F; da Silva de Barros, AO; Dos Santos Matos, AP; Dos Santos, CC; Franetich, JF; Iram, SH; Mazier, D; Paumgartten, FJR; Portilho, FL; Ricci-Junior, E; Santos-Oliveira, R, 2021) |
| "Malaria is a disease that requires new drugs not only to fight Plasmodium but also to reduce symptoms of infection such as fever and inflammation." | 5.56 | Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. ( Bastos, MM; Boechat, N; Carvalho, RCC; Coutinho, JP; Ferreira, MLG; Krettli, AU; Pinheiro, LCS; Rosas, EC; Sa, PM; Seito, LN, 2020) |
| " The medicine primaquine (PQ) is used in the treatment, although several side effects and low oral bioavailability are reported." | 5.56 | Interaction with Modified Cyclodextrin as a Way to Increase the Antimalarial Activity of Primaquine. ( de Carvalho, LB; de Fátima Abreu Venceslau, A; de Matos Alves Pinto, L; Jaime, C; Torres, LH, 2020) |
| " Patients with uncomplicated falciparum malaria, G6PD activity of ≥70% of the adjusted male median (AMM) and haemoglobin levels ≥8g/dl are recruited into the study and randomized to either receive standard schizonticidal treatment plus 7-day high dose primaquine (total dose 7mg/kg) or standard care in a 1:1 ratio." | 5.51 | Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA). ( Abate, DT; Alam, MS; Anose, RT; Baird, K; Christian, M; Degaga, TS; Hailu, A; Hossain, MS; Karahalios, A; Kibria, MG; Kidane, FG; Lee, G; Ley, B; Mnjala, H; Price, RN; Rajasekhar, M; Rumaseb, A; Simpson, JA; Sutanto, I; Tego, TT; Thriemer, K; Weston, S; Woyessa, A, 2022) |
| " Comparative pharmacokinetic (PK) and liver distribution studies of oral and intravenous PQ and TQ were also performed." | 5.40 | Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. ( Caridha, D; Hickman, M; Li, Q; Melendez, V; O'Neil, M; Pybus, B; Xie, L; Zeng, Q; Zhang, J, 2014) |
| "Primaquine phosphate has been used for preventing relapse of Plasmodium vivax and P." | 5.33 | Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I. ( Baird, JK; Hill, DR; Lewis, LS; Magill, AJ; Parise, ME; Ryan, ET, 2006) |
| " This result suggests that the transdermal route may be a very interesting approach for malaria prophylaxis and should encourage further studies in order to determine the absolute bioavailability of the drug as well as its dose-effect relationship." | 5.30 | Rodent malaria prophylaxis by transdermal delivery of primaquine. ( Coquelin, F; Couarraze, G; Mayorga, P; Miltgen, F, 1998) |
| " While most patients with tertian malaria were cured with the standard chloroquine and primaquine regimen, a higher dosage was required for one case acquired in Papua New Guinea." | 5.30 | Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance. ( Chang, HL; Chang, SC; Chen, YC; Fang, CT; Hsieh, WC; Hsueh, PR; Hung, CC, 1999) |
| "Primaquine was shown to be a safe and effective prophylactic drug against both P." | 5.30 | Primaquine as prophylaxis for malaria for nonimmune travelers: A comparison with mefloquine and doxycycline. ( Regev-Yochay, G; Schwartz, E, 1999) |
| "Primaquine was acylated with trifluoroacetic anhydride to give 6-methoxy-8-(4-trifluoroacetamido-1-methylbutyl) aminoquinoline (compound 2 in Table) and 5-trifluoro-acetyl-6-methoxy-8-(4-trifluoroacetamido-1-methylbutyl )- aminoquinoline (compound 6), bis (trifluoroacetyl) primaquine, which was subsequently hydrolyzed to yield 5-trifluoroacetyl-6-methoxy-8-(4-amino-1-methylbutyl)-aminoquinoline (compound 11), 5-trifluoroacetyprimaquine or trifluoroacetoprimaquine, coded M8506." | 5.28 | [Studies on the tissue schizonticide of malaria parasite: synthesis of 5-trieluoroacetyl-primaquine and its derivatives]. ( Chen, C; Fang, W; Zheng, XY, 1992) |
| "3 h, which declined monoexponentially with a half-life of 5." | 5.27 | Pharmacokinetics of primaquine in patients with P. vivax malaria. ( Bharucha, ED; Bhatia, SC; Desai, ND; Doshi, KJ; Gupta, KC; Revankar, SN; Saraph, YS; Satoskar, RS; Subrahmanyam, D; Vaidya, AB, 1986) |
| "Chloroquine combined with primaquine has been the standard radical curative regimen for Plasmodium vivax and Plasmodium ovale malaria for over half a century." | 5.19 | Pharmacokinetic interactions between primaquine and chloroquine. ( Ashley, EA; Charunwatthana, P; Day, NP; Hanboonkunupakarn, B; Hanpithakpong, W; Jittamala, P; Lawpoolsri, S; Lee, SJ; Pukrittayakamee, S; Tarning, J; White, NJ, 2014) |
| "Chloroquine plus primaqine is an inexpensive and highly effective treatment for uncomplicated knowlesi malaria infections in humans and there is no evidence of drug resistance." | 5.14 | Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. ( Cox-Singh, J; Daneshvar, C; Davis, TM; Divis, PC; Rafa'ee, MZ; Singh, B; Zakaria, SK, 2010) |
| " falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission." | 5.12 | Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. ( Alifrangis, M; Bousema, T; Drakeley, C; Enevold, A; Gosling, R; Mosha, F; Ndaro, A; Sauerwein, R; Shekalaghe, S; van Meegeren, M, 2007) |
| "A rapid single-step screening method for detection of glucose-6-phosphate dehydrogenase (G6 PD) deficiency was evaluated on Halmahera Island, Maluku Province, Indonesia, and in Shan and Mon States, Myanmar, in combination with a rapid diagnosis of malaria by an acridine orange staining method." | 5.09 | Field trials of a rapid test for G6PD deficiency in combination with a rapid diagnosis of malaria. ( Basuki, S; Dachlan, YP; Horie, T; Htay, HH; Ishii, A; Iwai, K; Kawamoto, F; Kojima, S; Lin, K; Marwoto, H; Matsuoka, H; Tantular, IS; Wongsrichanalai, C, 1999) |
| "To improve upon the efficacy of primaquine prophylaxis for malaria (94%, Plasmodium falciparum malaria; 85%, Plasmodium vivax malaria), we administered chloroquine (300 mg weekly) in combination with primaquine (30 mg daily) to nonimmune Colombian soldiers during 16 weeks of patrol in a region of endemicity and for a further 1 week in base camp." | 5.09 | Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers. ( Berman, J; Herrera, R; Padilla, J; Rodriquez, M; Sanchez, J; Soto, J; Toledo, J, 1999) |
| "Immune suppression and disturbances of normal leukocyte populations are side effects attributed to many antimalarial drugs and were concerns during a recent year-long placebo-controlled trial that compared daily primaquine (0." | 5.08 | Lymphocyte proliferative response and subset profiles during extended periods of chloroquine or primaquine prophylaxis. ( Baird, JK; Fryauff, DJ; Hadiputranto, H; Hoffman, SL; Larasati, RP; Mouzin, E; Pudjoprawoto, N; Ratiwayanto, S; Richards, AL; Richie, TL; Subianto, B; Sutamihardja, MA; Tjitra, E, 1996) |
| "Immune suppression, a potential side effect of long-term chemoprophylaxis, was evaluated as part of a randomized, placebo-controlled trial that compared daily primaquine against weekly chloroquine for malaria prevention." | 5.08 | Lymphocyte response to tetanus toxoid among Indonesian men immunized with tetanus-diphtheria during extended chloroquine or primaquine prophylaxis. ( Church, LW; Fryauff, DJ; Hadiputranto, H; Hoffman, SL; Mouzin, E; Ratiwayanto, S; Richards, AL; Richie, TL; Subianto, B; Sutamihardja, MA; Tjitra, E; Widjaja, H, 1997) |
| "Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention." | 5.08 | Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. ( Church, LW; Cryz, SJ; Fryauff, DJ; Hoffman, SL; Mouzin, E; Richards, AL; Subianto, B; Sutamihardja, MA; Widjaja, H, 1998) |
| "A clinical field trial was conducted to determine if mefloquine is effective in the treatment of malaria due to Plasmodium vivax." | 5.05 | A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria. ( Dixon, KE; Phintuyothin, P; Pitaktong, U, 1985) |
| "Glucose-6-phosphate dehydrogenase-normal adult volunteers infected with mosquito-bone Chesson strain vivax malaria were treated with chloroquine and primaquine during the initial attack." | 5.04 | Radical cure of Chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine. ( Clyde, DF; McCarthy, VC, 1977) |
| "To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria." | 5.01 | Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. ( Bancone, G; Douglas, NM; Espino, F; Henriques, G; Karahalios, A; Ley, B; Menard, D; Oo, NN; Parikh, S; Pfeffer, DA; Price, RN; Rahmat, H; von Fricken, ME; von Seidlein, L; Winasti Satyagraha, A, 2019) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 4.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents." | 4.91 | Quinoline-based antimalarial hybrid compounds. ( D'hooghe, M; Vandekerckhove, S, 2015) |
| "Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use." | 4.87 | Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations. ( Baird, JK; Berman, J; Melendez, V; Myint, HY; Ohrt, C; Pybus, B; Walker, L, 2011) |
| "We searched scientific publications in MEDLINE via PubMED for relevant articles with a cutoff date of December 2006 using the search terms malaria, chemoprophylaxis, travel, mefloquine, neuropsychiatric adverse events, tolerability, vivax malaria, and primaquine." | 4.84 | Controversies and misconceptions in malaria chemoprophylaxis for travelers. ( Chen, LH; Schlagenhauf, P; Wilson, ME, 2007) |
| " military aviators are currently restricted to the use of chloroquine or doxycycline for malaria prophylaxis." | 4.82 | Military aviators, special operations forces, and causal malaria prophylaxis. ( Chambers, JA, 2003) |
| "Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its use." | 4.82 | Primaquine therapy for malaria. ( Baird, JK; Hoffman, SL, 2004) |
| "This paper reports on 2 hemolytic serious reactions in 2 Arabian patients because of the use of primaquine as presumptive antimalarial treatment given in Cuba to all travellers from countries where malaria is endemic." | 4.79 | [Primaquine and travelers from the Arab world. A report and recommendations]. ( Caña Lugo, C; Fernández Núñez, A; Menéndez Capote, R, 1995) |
| "At least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria." | 4.75 | The treatment of malaria. ( Hall, AP, 1976) |
| "Primaquine prevents relapses of Plasmodium vivax malaria but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 4.31 | Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function. ( Anstey, NM; Douglas, NM; Ley, B; Piera, KA; Price, RN; Rumaseb, A, 2023) |
| " Therefore, malaria patient treatment using primaquine should be monitored closely for any adverse effects." | 4.12 | Prevalence of G6PD deficiency and distribution of its genetic variants among malaria-suspected patients visiting Metehara health centre, Eastern Ethiopia. ( Adamu, A; Feleke, SM; Gebremichael, SG; Gidey, B; Hailu, A; Kebede, T; Kepple, D; Lo, E; Nega, D; Negash, MT; Shenkutie, TT; Tasew, G; Witherspoon, L, 2022) |
| "v infection by Village Malaria Workers (VMWs) were referred to local health centres for point-of-care G6PD testing and initiation of radical cure treatment with 14-day or 8-week primaquine regimens depending on G6PD status." | 4.12 | G6PD testing and radical cure for Plasmodium vivax in Cambodia: A mixed methods implementation study. ( Ir, P; Kak, N; Kheang, ST; Lek, D; Ngeth, E; Ngor, P; Phon, S; Ridley, R; Sovannaroth, S; Yeung, S, 2022) |
| "Primaquine and tafenoquine are the only licensed drugs that effectively kill the hypnozoite stage and are used to prevent Plasmodium vivax malaria relapse." | 4.12 | Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure. ( Boonyuen, U; Chamchoy, K; Krudsood, S; Patrapuvich, R; Sudsumrit, S; Thita, T, 2022) |
| "Primaquine and tafenoquine are the two 8-aminoquinoline (8-AQ) antimalarial drugs approved for malarial radical cure - the elimination of liver stage hypnozoites after infection with Plasmodium vivax." | 4.02 | Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure. ( Burke, PA; Chavas, TEJ; Flaherty, SM; Ho, DK; Huber, HE; Jackson, C; LeGuyader, CLM; Li, Q; Lin, H; Maktabi, M; Pottenger, A; Pybus, B; Rochford, R; Roy, D; Srinivasan, S; Stayton, PS; Strauch, P; Vlaskin, V; Wesche, D; Zhang, J, 2021) |
| "This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease." | 4.02 | Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes. ( Ekowati, J; Hendradi, E; Miatmoko, A; Nehru, NF; Nurjannah, I; Rosita, N; Sari, R, 2021) |
| "We reviewed the clinical efficacy of chloroquine for Plasmodium vivax malaria, the changing trend of parasite clearance time, and fever clearance time during 2000-2016 in South Korea." | 3.96 | Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016. ( Cho, SH; Kwak, YG; Lee, KS; Lee, SE; Park, SY; Park, Y; Park, YS; Shin, HI; Song, JE; Yeom, JS, 2020) |
| "Malaria chemoprevention using mefloquine has become the WHO standard regimen for military personnel who stay in the endemic area for an extended period of time." | 3.91 | Plasmodium ovale Infection After One Year Mefloquine Prophylaxis in A Young Indonesian Soldier: A Case Report. ( Lardo, S; Liwang, F; Ratih, DM, 2019) |
| " Here, we experimentally reduced the Plasmodium load in naturally infected wild house sparrows with the antimalarial primaquine to assess the effects of intensity of infection in the vertebrate hosts on Plasmodium transmission to and by mosquitoes." | 3.91 | Experimental reduction of host Plasmodium infection load affects mosquito survival. ( Figuerola, J; Gangoso, L; Gutiérrez-López, R; Martínez-de la Puente, J; Soriguer, R; Yan, J, 2019) |
| "Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA)." | 3.85 | Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing. ( Banda, CG; Chipasula-Teleka, A; Hayes, DJ; Terlouw, DJ, 2017) |
| "Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P." | 3.85 | Synthesis of primaquine glyco-conjugates as potential tissue schizontocidal antimalarial agents. ( Anand, N; Azad, CS; Bhardwaj, J; Dutta, GP; Puri, SK; Saxena, AK; Saxena, M; Siddiqui, AJ, 2017) |
| "Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission." | 3.85 | Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms. ( Aguiar, AC; Cunico, W; Drawanz, BB; Figueiredo, FJ; Katsuragawa, TH; Krettli, AU; Neuenfeldt, PD; Sinnis, P; Zavala, F, 2017) |
| "The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism." | 3.83 | Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants. ( Hickman, M; Jin, X; Kreishman-Deitrick, M; Li, Q; Luong, TL; Marcsisin, SR; Nelson, J; Paris, R; Potter, B; Potter, C; Pybus, BS; Reichard, G; Smith, PL; Sousa, J; Vuong, C; Xie, L; Zhang, J; Zhang, P, 2016) |
| " Primaquine (PQ) is a widely used anti-malarial drug that can trigger haemolysis in individuals with G6PDd." | 3.83 | Glucose-6-phosphate dehydrogenase deficiency prevalence and genetic variants in malaria endemic areas of Colombia. ( Arce-Plata, MI; Arévalo-Herrera, M; Ocampo, ID; Recht, J; Valencia, SH, 2016) |
| "Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) are at risk for developing hemolytic anemia when given the antimalarial drug primaquine (PQ)." | 3.83 | Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs. ( Baresel, PC; Campo, B; Marcsisin, SR; Reichard, GA; Rochford, R; Sousa, J; Tekwani, BL; Vuong, CT; Walker, LA; Wickham, KS, 2016) |
| "A targeted malaria elimination project, including mass drug administrations (MDA) of dihydroartemisinin/piperaquine plus a single low dose primaquine is underway in villages along the Thailand Myanmar border." | 3.83 | The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border. ( Elvina, E; Kajeechiwa, L; Kyawt, K; Min, JR; Nosten, F; Nosten, S; Oo, PT; Peapah, P; PoWah, W; Shee, PW; Thwin, MM; von Seidlein, L; Wiladphaingern, J; Yee, NL, 2016) |
| "Due to the ability of the 8-aminoquinolines (8AQs) to kill different stages of the malaria parasite, primaquine (PQ) and tafenoquine (TQ) are vital for causal prophylaxis and the eradication of erythrocytic Plasmodium sp." | 3.83 | Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei. ( Berman, J; Caridha, D; Dickson, SP; Hickman, M; Lee, PJ; Li, Q; Marcsisin, SR; Milner, EE; Read, LT; Roncal, N; Vesely, BA; Xie, LH; Zhang, J; Zhang, P, 2016) |
| "Various polymer drug conjugates (13-16) such as primaquine and dihydroartemisinin conjugated 2-propoxy substituted polyphosphazenes (13), primaquine and dihydroartemisinin conjugated 4-acetamidophenoxy substituted polyphosphazenes (14), primaquine and dihydroartemisinin conjugated 4-formyl substituted polyphosphazenes (15) and primaquine and dihydroartemisinin conjugated 4-aminoethylbenzoate substituted polyphosphazenes (16) were synthesized using substituted polyphosphazenes as polymer and primaquine and dihydroartemisinin as combination antimalarial pharmacophores and formulated to nanoparticles to achieve novel controlled combined drug delivery approach for radical cure of malaria." | 3.81 | Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin. ( Bhardwaj, TR; Kumar, S; Murthy, RS; Sharma, R; Singh, RK, 2015) |
| "Control of vivax malaria is challenging due to persistence of hypnozoites causing relapses and safety concerns with primaquine in G6PD deficient individuals." | 3.81 | The footprints of relapsing malaria in southwest Delhi, India. ( Anvikar, AR; Nagpal, BN; Savargaonkar, D; Srivastava, B; Valecha, N, 2015) |
| "A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes." | 3.80 | Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies. ( Clarke, A; Garner, P; Gelband, H; Graves, P; Saunders, R; Sinclair, D; Uthman, OA, 2014) |
| "Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria." | 3.80 | Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers. ( Baresel, P; Bartlett, MS; Fronczek, FR; Gettayacamin, M; Herath, HM; McChesney, JD; Melendez, V; Nanayakkara, NP; Ohrt, C; Reichard, GA; Rochford, R; Sahu, R; Tekwani, BL; Tungtaeng, A; van Gessel, Y; Walker, LA; Wickham, KS, 2014) |
| " Radical cure with primaquine was prescribed after the first bout of malaria for 6 patients." | 3.80 | Compliance to recommendations for the management of curative treatment of Plasmodium vivax/ovale infections. ( Bellanger, AP; Chirouze, C; Faucher, JF; Hoen, B; Hustache-Mathieu, L; Shaniya, N, 2014) |
| "Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria." | 3.80 | Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles. ( Gathirwa, JW; Kalombo, L; Mahanga, GM; Melariri, P; Ogutu, B; Oloo, F; Omwoyo, WN; Swai, H, 2014) |
| "Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure." | 3.80 | Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta). ( Gettyacamin, M; Imerbsin, R; Khemawoot, P; Lanteri, C; Nanayakkara, NP; Ohrt, C; Sampath, A; Saunders, D; Siripokasupkul, R; Teja-Isavadharm, P; Tekwani, BL; Vanachayangkul, P; Walker, L, 2014) |
| "Primaquine phosphate has been used to prevent relapse as a radical cure after the acute-phase treatment of vivax and ovale malaria however." | 3.79 | [Clinical experience of primaquine use for treatment of vivax and ovale malaria in Japanese travelers]. ( Kanagawa, S; Kano, S; Kato, Y; Kobayashi, T; Mizuno, Y; Ohmagari, N; Takeshita, N; Ujiie, M; Yamauchi, Y, 2013) |
| "Glucose-6-phosphate dehydrogenase deficiency (G6PD), an x-linked inherited enzymopathy, is a barrier to malaria control because primaquine cannot be readily applied for radical cure in individuals with the condition." | 3.79 | Prevalence and molecular basis of glucose-6-phosphate dehydrogenase deficiency in Afghan populations: implications for treatment policy in the region. ( Amanzai, O; Beg, MA; Jan, S; Leslie, T; Mohammad, N; Moiz, B; Nasir, A; Siddiqi, AM; Ur Rasheed, H; Vink, M, 2013) |
| "The relatively high level of knowledge about how to diagnose and treat malaria at the grass-root level was undermined by the poor availability of RDTs, ACT and primaquine tablets." | 3.79 | Public health system readiness to treat malaria in Odisha State of India. ( Dandona, L; Hussain, MA; Schellenberg, D, 2013) |
| "Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo." | 3.78 | Novel potent metallocenes against liver stage malaria. ( Cabrita, É; da Cruz, FP; do Rosário, VE; Gomes, P; Gut, J; Matos, J; Moreira, R; Nogueira, F; Prudêncio, M; Rosenthal, PJ, 2012) |
| "Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing the antimalarial drug primaquine phosphate as the only active pharmaceutical ingredient (API) are reviewed." | 3.78 | Biowaiver monographs for immediate-release solid oral dosage forms: primaquine phosphate. ( Abrahamsson, B; Barends, DM; Dressman, JB; Groot, DW; Kopp, S; Nair, A; Polli, JE; Shah, VP, 2012) |
| "After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria." | 3.78 | Reinventing primaquine for endemic malaria. ( Baird, JK, 2012) |
| "Primaquine is a key drug for malaria elimination." | 3.78 | G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. ( Baird, JK; Battle, KE; Dewi, M; Gething, PW; Hay, SI; Hogg, MM; Howes, RE; Nyangiri, OA; Padilla, CD; Patil, AP; Piel, FB, 2012) |
| "In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8-aminoquinoline derivatives was prepared and assessed for antimalarial activities." | 3.77 | Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives. ( Hudson, TH; Kozar, MP; Lin, AJ; Magill, AJ; Melendez, V; Ohrt, C; Shiraki, H, 2011) |
| "Millions of people receive primaquine against sexual plasmodia responsible for malaria transmission." | 3.77 | Consideration of ethics in primaquine therapy against malaria transmission. ( Baird, JK; Surjadjaja, C, 2011) |
| " Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy." | 3.77 | Prophylactic use of antimalarials during pregnancy. ( Bozzo, P; Einarson, A; Irvine, MH, 2011) |
| "Primaquine (PQ) is used for the radical cure of Plasmodium vivax malaria and can cause serious side effects in some individuals." | 3.77 | Increased bioavailability of primaquine using poly(ethylene oxide) matrix extended-release tablets administered to beagle dogs. ( Bertol, CD; Kuminek, G; Oliveira, PR; Rauber, GS; Silva, MA; Stulzer, HK, 2011) |
| " Sexual and asexual parasite dynamics were thus evaluated in patients involved in antimalarial drug efficacy studies by using combined treatment with and without artemisinin derivatives for treating uncomplicated acute Plasmodium falciparum malaria in Antioquia, Colombia." | 3.76 | Dynamics of Plasmodium falciparum parasitemia regarding combined treatment regimens for acute uncomplicated malaria, Antioquia, Colombia. ( Alvarez, G; Blair, S; Piñeros, JG; Ríos, A; Tobón, A, 2010) |
| "New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type, poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA) and poly[alpha,beta-(N-3-hydroxypropyl-DL-aspartamide)] (PHPA), were synthesized, characterized and screened for their antimalarial activity." | 3.75 | Macromolecular prodrugs. XII. Primaquine conjugates: synthesis and preliminary antimalarial evaluation. ( Kos, G; Rajić, Z; Singh, PP; Singh, S; Zorc, B, 2009) |
| " knowlesi infection had uncomplicated malaria that responded to chloroquine and primaquine treatment." | 3.75 | Clinical and laboratory features of human Plasmodium knowlesi infection. ( Cox-Singh, J; Daneshvar, C; Davis, TM; Divis, PC; Rafa'ee, MZ; Singh, B; Zakaria, SK, 2009) |
| "Primaquine is the drug of choice for the radical cure of Plasmodium vivax malaria, but possesses serious side effects." | 3.74 | Synthesis and evaluation of naphthyridine compounds as antimalarial agents. ( Gudise, C; Kong, Y; Meng, L; Smith, E; Wei, L; Zhang, Q; Zhu, S, 2007) |
| "8-Aminoquinolines are an important class of antiparasitic agents, with broad utility and excellent efficacy, but also limitations due to hematological toxicities, primarily methemoglobinemia and hemolysis." | 3.74 | Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. ( Ager, AL; Bartlett, MS; Croft, SL; Khan, IA; McChesney, JD; Nanayakkara, NP; Walker, LA; Yardley, V, 2008) |
| "Primaquine (PQ) is one of the most widely used antimalarial and is the only available drug till date to combat relapsing form of malaria especially in case of Plasmodium vivax and Plasmodium ovale." | 3.74 | Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. ( Singh, KK; Vingkar, SK, 2008) |
| "The costs of mefloquine, chloroquine, doxycycline, primaquine, and atovaquone/proguanil are calculated for various durations of exposure to malaria." | 3.73 | Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis. ( Bryan, JP, 2006) |
| "To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where C-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized." | 3.72 | Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. ( Jain, M; Jain, R; Jena, GB; Kaul, CL; Ramarao, P; Sachdeva, S; Singh, PP; Singh, S; Tikoo, K; Vangapandu, S, 2004) |
| "A new 8-aminoquinoline antimalarial WR 238605 (Tafenoquine), developed initially as a primaquine alternative for prevention of Plasmodium vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely Plasmodium cynomolgi B and Plasmodium fragile in rhesus monkeys." | 3.72 | Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys. ( Dutta, GP; Puri, SK, 2003) |
| "The influence of combinations containing the blood schizontocides chloroquine (CQ) or mefloquine (MEF), together with the 8-aminoquinolines (8AQ) primaquine (PQ) or the new, long-acting compound, tafenoquine (TAF), on the rate of selection of resistance to the individual compounds was examined using the asexual, intra-erythrocytic stages in rodent malaria models." | 3.72 | The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines. ( Peters, W; Robinson, BL; Stewart, LB, 2003) |
| "Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro." | 3.71 | Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine. ( Biswas, S; Dua, VK; Puri, SK; Sharma, VP; Sinha, SN; Valecha, N, 2002) |
| "To investigate the activity of daphnetin(DPNT) against the exo-erythrocytic stage of rodent malaria." | 3.71 | [Effect of daphnetin on the exo-erythrocytic stage of rodent malaria]. ( Liu, YG; Ni, QZ; Ni, YC; Wang, QM; Xu, YQ, 2001) |
| "The spectrum of antimalarial activity of the new macrolide antibiotic azithromycin was evaluated against blood- and sporozoite-induced infections with a chloroquine-resistant strain of Plasmodium yoelii nigeriensis (N-67) in Swiss mice and with simian parasite Plasmodium cynomolgi B in rhesus monkeys." | 3.70 | Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. ( Puri, SK; Singh, N, 2000) |
| " vivax malaria attacks were treated with quinine or chloroquine plus primaquine." | 3.69 | Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. ( Camargo, LM; Cardoso, MA; Ferreira, MU; Szarfarc, SC, 1994) |
| "The aim of this preliminary study was to investigate the potential use of the transdermal route for primaquine administration in the treatment of malaria." | 3.69 | Preliminary evaluation of primaquine activity on rodent malaria model after transdermal administration. ( Couarraze, G; Deharo, E; Landau, I; Mayorga, P, 1997) |
| "Trifluoroacetyl primaquine oxalate (M8506) was compared with primaquine phosphate for tissue schizontocidal action in rodent and simian malaria." | 3.68 | Tissue schizontocidal effect of trifluoroacetyl primaquine in Plasmodium yoelii infected mice and Plasmodium cynomolgi infected monkeys. ( Shao, BR; Ye, XY, 1991) |
| "In searching for efficient, safe and radically curative agent and causal prophylactics for malaria, seven 2-methyl-5-substituted phenoxy-6-methoxy-8-(1-methyl-4-aminobutylamino)-quinolines (II1-7) were synthesized and their antimalarial activities were compared with the corresponding 4-methyl substituted derivatives of primaquine." | 3.68 | [Synthesis of 2-methyl-5-substituted phenoxy-primaquine and antimalarials activity]. ( Deng, RX; Wang, J; Zhong, BH; Zhong, JX, 1990) |
| "The pharmacokinetics of mefloquine (M) were studied in 59 male Thai patients with falciparum malaria." | 3.68 | Pharmacokinetics of mefloquine in combination with sulfadoxine-pyrimethamine and primaquine in male Thai patients with falciparum malaria. ( Back, DJ; Breckenridge, AM; Bunnag, D; Karbwang, J, 1990) |
| "The antimalarial effect of intravenously administered primaquine (PQ) can be improved and its toxicity diminished by linking it to a macromolecular carrier protein." | 3.67 | Carrier-linked primaquine in the chemotherapy of malaria. ( Altszuler, R; Capuano, A; Hofsteenge, J; Moore, S, 1986) |
| "Five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against Plasmodium cynomolgi in Rhesus monkeys and for blood schizonticidal antimalarial activity against Plasmodium berghei in mice." | 3.67 | 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. ( Berrang, B; Carroll, FI; Linn, CP, 1985) |
| "Two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity." | 3.67 | Sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. ( Berrang, B; Carroll, FI; Linn, CP, 1985) |
| "One hundred and ten consecutive patients with falciparum malaria were treated with Fansidar and primaquine." | 3.67 | Clinical efficacy of sulfadoxine-pyrimethamine in the treatment of falciparum malaria in Sabah, Malaysia. ( Tan, HS; Tan, PE, 1984) |
| " Affected individuals may suffer a severe hemolytic crisis when treated with primaquine, an antimalarial." | 3.67 | Glucose-6-phosphate dehydrogenase deficiency in Southeast Asian refugees entering the United States. ( Chin, W; Newman, J; Roberts, JM; Schwartz, IK, 1984) |
| " The malarial drugs primaquine and chloroquine are used as examples of mechanism 2." | 3.67 | Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides. ( Akintonwa, DA, 1984) |
| "9 per cent relapse rate after administration of radical treatment of primaquine / 15 mg daily for 5 days as followed under the National Malaria Eradication Programme." | 3.67 | Efficacy of 5 day radical treatment of primaquine in Plasmodium vivax cases at the BHEL industrial complex, Hardwar (U.P.). ( Dua, VK; Sharma, VP; Sinha, S, 1989) |
| "Three standard antimalarials pyrimethamine, primaquine and quinine were tested against P." | 3.67 | Gametocytocidal and sporontocidal activity of some standard antimalarials on P. berghei (NK 65) infection M. natalensis. ( Pal, NL; Rastogi, M; Sen, AB, 1989) |
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| " The antimalarial drugs quinacrine, primaquine, and quinine are shown to decrease the rate of oxygen consumption of the parasitized erythrocyte suspensions." | 3.67 | Effects of antimalarial drugs on oxygen consumption by erythrocytes infected with Plasmodium berghei: an ESR study. ( Butler, KW; Deslauriers, R; Smith, IC, 1986) |
| "When the terminal amino group in the side chain of primaquine was blocked with an ethoxyacetyl group shown in 2, or eliminated by oxidative deamination to carboxylic acid 3, the antimalarial effect was markedly reduced in a screening assay which measures tissue schizonticidal activity." | 3.67 | Antimalarial activity and inhibition of monoamine oxidases A and B by exo-erythrocytic antimalarials. Optical isomers of primaquine, N-acylated congeners, primaquine metabolites and 5-phenoxy-substituted analogues. ( Abell, CW; Bembenek, ME; Brossi, A; Landau, I; Millet, P, 1987) |
| "The 4-vinyl, 4-ethyl, and three 4-[beta-(arylthio)ethyl] derivatives of primaquine and other 8-aminoquinoline antimalarial agents were prepared for antimalarial evaluation." | 3.66 | Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials. ( Berrang, B; Carroll, FI; Linn, CP; Twine, CE, 1979) |
| "A series of 3-quinolinediamines (1g, 2c, and 3e) structurally related to primaquine and 4-methylprimaquine have been prepared and tested for antimalarial activity against Plasmodium berghei in mice and antileishmanial activity against Leishmania donovani in the hamster." | 3.66 | Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials. ( Khan, MS; LaMontagne, MP, 1979) |
| "A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity." | 3.66 | Antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. A highly effective series of blood and tissue schizonticidal agents. ( Blumbergs, P; LaMontagne, MP; Strube, RE, 1982) |
| "A number of 5-phenylthio and 5-anilino derivatives of primaquine have been prepared which are less toxic but less active than primaquine itself in murine and monkey antimalarial screens." | 3.66 | Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine. ( Chen, EH; Nodiff, EA; Saggiomo, AJ; Tanabe, K; Verma, BL, 1978) |
| "As part of the search for new antimalarial drugs, a screening program was developed using sensitive and chlorguanide triazine (CGT, cycloguanil) resistant strains of the folate-requiring bacteria, Streptococcus faecium durans, Lactobacillus casei, and Pediococcus cerevisiae." | 3.65 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. ( Genther, CS; Smith, CS, 1977) |
| "Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens." | 3.65 | Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine. ( Chen, EH; Nodiff, EA; Saggiomo, AJ; Tanabe, K; Verma, BL, 1977) |
| "This study was designed to investigate the use of primaquine in malaria control in the Khmer Republic (Cambodia)." | 3.65 | Hemoglobin E and glucose-6-phosphate deficiency in the Khmer Air Force (Cambodia). ( Everett, WD; Pearlman, E; Yoshida, A, 1977) |
| " Nanotechnology-based drug delivery methods are highly specific, require a lower dose, offer more bioavailability with prolonged drug release and stay in the body longer." | 3.01 | Role of Nanomedicines in Controlling Malaria: A Review. ( Bohidar, HB; Rawat, K; Sharma, S, 2023) |
| " Additional outcomes included intervention coverage, treatment adherence, occurrence of adverse events, and cumulative incidences 3, 12, and 16 months post-MDA." | 2.87 | A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting-high coverage and safety, but no significant impact on transmission. ( Ali, AS; Ali, SM; Aydin-Schmidt, B; Bennett, A; Björkman, A; Hodzic, L; Islam, A; Jovel, I; Khamis, M; Magnusson, E; Mårtensson, A; Mkali, H; Morris, U; Msellem, MI; Poirot, E; Sachs, MC; Shija, SJ; Tarning, J, 2018) |
| "Chloroquine serves as a drug of choice, with primaquine as a radical cure." | 2.82 | Global scenario of Plasmodium vivax occurrence and resistance pattern. ( Kaur, D; Sehgal, R; Sinha, S, 2022) |
| "vivax malaria were eligible for study." | 2.78 | Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia. ( Baird, JK; Basri, H; Ekawati, LL; Elyazar, I; Farrar, J; Meilia, RA; Nurleila, S; Putri, FA; Setiabudy, R; Sudoyo, H; Sutanto, I; Taylor, WR; Tjahjono, B, 2013) |
| " The impact of MDA with the gametocytocidal drug combination sulphadoxine-pyrimethamine (SP) plus artesunate (AS) plus primaquine (PQ, single dose 0." | 2.76 | A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. ( Bousema, T; Drakeley, C; Gosling, R; Hermsen, R; Masokoto, A; Mosha, F; Mwanziva, C; Okell, L; Sauerwein, R; Semvua, S; Shekalaghe, SA; Teelen, K; ter Braak, R; van den Bijllaardt, W; van den Bosch, S, 2011) |
| "Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half of million deaths annually." | 2.72 | An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins. ( Hoda, N; Madhav, H, 2021) |
| " Despite the dosage employed, the frequency and duration of use, and excretion primarily through the bowels as the active parent compound, primaquine appeared to have little or no significant effect against a variety of common intestinal parasites." | 2.69 | Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention. ( Basri, H; Fryauff, DJ; Jones, TR; Mouzin, E; Prodjodipuro, P; Subianto, B; Widjaja, H, 1998) |
| "Metformin has well known anti-malarial properties." | 2.55 | Malaria and diabetes. ( Aggarwal, S; Dutta, D; Kalra, S; Khandelwal, D; Singla, R, 2017) |
| "Malaria recurrences after an initially successful therapy and malarial fever occurring a long time after infection are well-known problems in malariology." | 2.53 | Clinical implications of a gradual dormancy concept in malaria. ( Franken, G; Holtfreter, MC; Labisch, A; Mehlhorn, H; Richter, J; Walter, S, 2016) |
| "Primaquine is the only treatment licensed for therapy against relapse caused by dormant liver stages occurring in some species, and against the sexual blood stages responsible for transmission to mosquitoes in all species." | 2.48 | Primaquine toxicity forestalls effective therapeutic management of the endemic malarias. ( Baird, JK, 2012) |
| "Effective anti-malarial drug treatment reduces malaria transmission." | 2.44 | The role of anti-malarial drugs in eliminating malaria. ( White, NJ, 2008) |
| "Malaria is the number one disease in the world responsible for 1-3 million deaths each year." | 2.44 | Recent patent reviews on small molecule-based antimalarial drugs. ( Elsohly, MA; Gul, W, 2007) |
| "Primaquine has long been used for management of relapses of malaria, but in the past decade, it has been reexamined for use in malaria prevention in order to stop infection in the liver." | 2.41 | Malaria chemoprophylaxis in the age of drug resistance. II. Drugs that may be available in the future. ( Kain, KC; Keystone, JS; Shanks, GD, 2001) |
| "Vivax malaria was generally a mild infection but falciparum malaria was often severe with 39% of patients experiencing complications including one death." | 2.38 | Malaria in Leicester 1983-1988: a review of 114 cases. ( Kent, J; Nicholson, KG; Wiselka, MJ, 1990) |
| " No severe adverse events associated with the MDA were identified in the pilot; there were severe adverse events in a separate, subsequent campaign." | 1.91 | Acceptability, Feasibility, Drug Safety, and Effectiveness of a Pilot Mass Drug Administration with a Single Round of Sulfadoxine-Pyrimethamine Plus Primaquine and Indoor Residual Spraying in Communities with Malaria Transmission in Haiti, 2018. ( Ashton, R; Battle, KE; Cameron, E; Chang, MA; Cohen, J; Dalexis, PE; Desir, L; Dismer, AM; Drakeley, C; Druetz, T; Eisele, TP; Fouché, B; Hamre, KES; Herman, C; Holmes, K; Impoinvil, D; Lafortune, W; Lemoine, JF; Mérilien, JB; Noland, GS; Pothin, E; Rogier, E; Stresman, G; Telfort, MA; van den Hoogen, L; Williamson, J; Young, AJ, 2023) |
| "Malaria was considered to be cured with 'blue drugs' (referring to dihydroartemisinin-piperaquine)." | 1.91 | Adherence to 14-day radical cure for Plasmodium vivax malaria in Papua, Indonesia: a mixed-methods study. ( Burdam, FH; Devine, A; Gryseels, C; Kenangalem, E; Landuwulang, CUR; Ley, B; Peeters Grietens, K; Poespoprodjo, JR; Price, RN; Rahmalia, A; Ronse, M; Thriemer, K, 2023) |
| "Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world." | 1.91 | Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. ( Aguiar, ACC; Andrade, AO; Araújo, JE; Araújo, MS; Bastos, AS; G Teles, CB; Gazzinelli, RT; Lima, AA; Martinez, LN; Medeiros, JF; Pereira, DB; Pontual, JDC; Santos, NAC; Silva, AMV; Vinetz, JM, 2023) |
| "Malaria is endemic and represents an important public health issue in Brazil." | 1.91 | A fatal respiratory complication of malaria caused by Plasmodium vivax. ( Brasil, P; Bressan, CS; Calvet, GA; Daniel-Ribeiro, CT; de Bruycker-Nogueira, F; de Fátima Ferreira-da-Cruz, M; de Pina-Costa, A; Detepo, PJT; Ferreira, MT; Filippis, AMB; López, AR; Lupi, O; Mamani, RF; Martins, EB; Pacheco-Silva, AB; Silva, MFB; Siqueira, A, 2023) |
| "Plasmodium vivax malaria is considered a major threat to malaria eradication." | 1.91 | Interventions for promoting patients' adherence to 14-day primaquine treatment in a highly malaria-endemic township in Myanmar: a qualitative study among key stakeholders. ( Aung, PL; Cui, L; Kyaw, MP; Lawpoolsri, S; Linn, NYY; Nguitragool, W; Ring, Z; Sattabongkot, J; Win, KM, 2023) |
| "Malaria is a major cause of death in low-income countries." | 1.72 | Effects of Host Genetic Polymorphisms on the Efficacy of the Radical Cure Malaria Drug Primaquine. ( Mohan, M; Nain, M; Sharma, A, 2022) |
| "According to our findings, testing G6PD deficiency and monitoring the potential PQ toxicity in patients who receive PQ are highly recommended." | 1.72 | Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Malaria Patients in Southern Thailand: 8 Years Retrospective Study. ( Buncherd, H; Khammanee, T; Sawangjaroen, N; Thanapongpichat, S; Tun, AW, 2022) |
| "Therefore, G6PD deficiency testing should precede hypnozoite elimination with 8-aminoquinoline." | 1.72 | An Evaluation of a New Quantitative Point-of Care Diagnostic to Measure Glucose-6-phosphate Dehydrogenase Activity. ( Ahn, SK; Bahk, YY; Jeon, HJ; Lee, SK; Na, BK; Shin, HJ, 2022) |
| "Primaquine was effective in preventing P." | 1.72 | Relapse of Plasmodium vivax and Plasmodium ovale Malaria With and Without Primaquine Treatment in a Nonendemic Area. ( Björklund, D; Carlander, C; Färnert, A; Hellgren, U; Hervius Askling, H; Sondén, K; Stenström, C; Wångdahl, A; Wyss, K; Zhang, J, 2022) |
| "Malaria is the most common parasitic disease around the world, especially in tropical and sub-tropical regions." | 1.62 | Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatment. ( Alencar, LMR; Alexis, F; da Silva de Barros, AO; Dos Santos Matos, AP; Dos Santos, CC; Franetich, JF; Iram, SH; Mazier, D; Paumgartten, FJR; Portilho, FL; Ricci-Junior, E; Santos-Oliveira, R, 2021) |
| "Individuals with G6PD deficiency can experience hemolysis when exposed to primaquine." | 1.62 | Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency and Gametocytemia in a Pre-Elimination, Low Malaria Transmission Setting in Southern Zambia. ( Hamapumbu, H; Kobayashi, T; Kurani, S; Moss, WJ; Stevenson, JC; Thuma, PE, 2021) |
| "Malaria is an endemic infection in tropical circles." | 1.62 | Malaria and encephalopathy in a heart transplant recipient: A case report in the context of multiorgan donation. ( Cañas, F; Carrillo, D; David López, J; Flórez, N; Gomez-Mesa, JE; Pinilla-Monsalve, G; Vernaza, A, 2021) |
| "Malaria is a disease that requires new drugs not only to fight Plasmodium but also to reduce symptoms of infection such as fever and inflammation." | 1.56 | Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. ( Bastos, MM; Boechat, N; Carvalho, RCC; Coutinho, JP; Ferreira, MLG; Krettli, AU; Pinheiro, LCS; Rosas, EC; Sa, PM; Seito, LN, 2020) |
| " The medicine primaquine (PQ) is used in the treatment, although several side effects and low oral bioavailability are reported." | 1.56 | Interaction with Modified Cyclodextrin as a Way to Increase the Antimalarial Activity of Primaquine. ( de Carvalho, LB; de Fátima Abreu Venceslau, A; de Matos Alves Pinto, L; Jaime, C; Torres, LH, 2020) |
| "The frequency of G6PD deficiency alleles in males in the Kavango and Zambezi regions of northern Namibia constitute 3." | 1.51 | Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia. ( Ababio, G; Aleksenko, L; Greco, B; Haiyambo, DH; Hatuikulipi, T; Ilunga, A; Misihairabgwi, J; Nangombe, R; Pernica, JM; Quaye, IK; Uusiku, P, 2019) |
| "Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce." | 1.48 | Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection. ( Auer, H; Fuehrer, HP; Groger, M; Lagler, H; Ramharter, M; Veletzky, L; Walochnik, J, 2018) |
| "Primaquine (PQ) has been used for radical cure of P." | 1.48 | Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar. ( Jun, H; Kang, JM; Kim, TI; Kim, TS; Lê, HG; Lee, J; Lin, K; Myint, MK; Na, BK; Sohn, WM; Thái, TL, 2018) |
| "We report a case of babesiosis, caused by Babesia microti, in a missionary who worked in Equatorial Guinea but also visited rural Spain." | 1.48 | Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. ( Arsuaga, M; Dinkessa, AW; González, LM; Gray, J; Montero, E; Padial, ES; Puente, S; Sevilla, E; Trigo, E, 2018) |
| "Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life." | 1.46 | Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine. ( Anstey, NM; Auburn, S; Berriman, M; Huang, GKL; Marfurt, J; Marr, I; Newbold, CI; Otto, TD; Price, RN; Rutledge, GG; Sanders, M; White, NJ, 2017) |
| "Malaria is a reportable disease in Israel." | 1.46 | Plasmodium malariae in Israeli Travelers: A Nationwide Study. ( Grossman, T; Leshem, E; Nadir, E; Paran, Y; Petersiel, N; Schwartz, E; Stein, M; Weinberger, M; Yahav, D; Yavne, Y, 2017) |
| "1." | 1.43 | UK malaria treatment guidelines 2016. ( Beeching, NJ; Bell, DJ; Chiodini, PL; Lalloo, DG; Shingadia, D; Whitty, CJM, 2016) |
| "Mild and severe G6PD deficiency was observed in 14." | 1.42 | Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in southeast Iran: implications for malaria elimination. ( Metanat, Z; Raeisi, A; Sakeni, M; Salimi Khorashad, A; Tabatabaei, SM, 2015) |
| "Malaria is considered as one of the most threatening diseases affecting peacekeeping forces serving in malaria endemic countries." | 1.40 | A retrospective study on imported malaria in Jordan. 1. Malaria among Jordanian UN peacekeeping forces. ( Al-Rashadan, M; Amr, ZS; Bani Hani, R; Kanani, K; Shadfan, B, 2014) |
| "In this first study to examine G6PD deficiency rates in Haiti, 22." | 1.40 | Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti. ( Alam, MT; Carter, TE; Eaton, WT; Masse, R; Okech, BA; Romain, JR; Schick, L; von Fricken, ME; Weppelmann, TA, 2014) |
| " Comparative pharmacokinetic (PK) and liver distribution studies of oral and intravenous PQ and TQ were also performed." | 1.40 | Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. ( Caridha, D; Hickman, M; Li, Q; Melendez, V; O'Neil, M; Pybus, B; Xie, L; Zeng, Q; Zhang, J, 2014) |
| "Of 751 trauma patients with available post-admission data, 42% received primary chemoprophylaxis for four weeks, 33% received primaquine for 14 days, and 17% received both." | 1.40 | Compliance with antimalarial chemoprophylaxis recommendations for wounded United States military personnel admitted to a military treatment facility. ( Aggarwal, D; Carson, ML; Li, P; Lloyd, BA; Murray, CK; Rini, EA; Shaikh, F; Tribble, DR; Warkentien, TE; Weintrob, AC, 2014) |
| " Dosage regimen of primaquine for treatment of both Plasmodium falciparum and Plasmodium vivax malaria may need to be optimized, based on endemic areas with supporting data on G6PD variants." | 1.37 | Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand. ( Chaijaroenkul, W; Hongkaew, Y; Kuesap, J; Na-Bangchang, K; Phompradit, P; Rueangweerayut, R; Yamnuan, R, 2011) |
| "Acute respiratory distress syndrome is a well-known complication in Plasmodium falciparum infection." | 1.35 | Acute respiratory distress syndrome in a case of Plasmodium ovale malaria. ( Cuadros-González, J; Culebras-López, AM; de Pablo-Sánchez, R; Mesa-Latorre, JM; Rojo-Marcos, G, 2008) |
| "Relapses were diagnosed in 18% of all malaria episodes." | 1.33 | Imported non-Plasmodium falciparum malaria: a five-year prospective study in a European referral center. ( Bottieau, E; Clerinx, J; Colebunders, R; Van Den Ende, J; Van Den Enden, E; Van Esbroeck, M; Van Gompel, A, 2006) |
| "Primaquine phosphate has been used for preventing relapse of Plasmodium vivax and P." | 1.33 | Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I. ( Baird, JK; Hill, DR; Lewis, LS; Magill, AJ; Parise, ME; Ryan, ET, 2006) |
| " The results indicate the suitability of this technique in antimalarial drug quality and bioavailability studies." | 1.33 | A simple technique for the detection of anti-malarial drug formulations and their presence in human urine. ( Akida, JA; Lemnge, MM; Lugimbana, L; Malebo, HM; Malle, LN; Segeja, MD, 2006) |
| "However, there are few data on the treatment of malaria in the United States." | 1.32 | Problems in the therapy for imported malaria in the United States. ( Singh, K; Trenholme, GM; Wester, WC, 2003) |
| "Rarely pancytopenia is a manifestation of inappropriate macrophage activation associated with hemophagocytosis." | 1.31 | Pancytopenia resulting from hemophagocytosis in malaria. ( Gal, N; Tamary, H; Zvulunov, A, 2002) |
| "Isolated cases of malaria are increasing in frequency in nonendemic countries." | 1.31 | Erythrocyte Fy antigen phenotyping helps differentiate so-called benign tertian malarias. ( Stephens, I; Wenk, RE, 2000) |
| "The search for short treatments for malaria is still a goal for many developing countries." | 1.31 | [Therapeutic efficacy of different antimalarial regimens in the Costa Rica-Nicaragua border region]. ( Bergonzoli, G; Rivers Cuadra, JC, 2000) |
| "A 65-year-old man with unstable angina pectoris developed malaria prior to coronary artery bypass grafting." | 1.31 | Coronary bypass surgery in patient with malaria. ( Balkanay, M; Kirali, K; Mansuroğlu, D; Omeroğlu, SN; Yakut, C, 2002) |
| " This result suggests that the transdermal route may be a very interesting approach for malaria prophylaxis and should encourage further studies in order to determine the absolute bioavailability of the drug as well as its dose-effect relationship." | 1.30 | Rodent malaria prophylaxis by transdermal delivery of primaquine. ( Coquelin, F; Couarraze, G; Mayorga, P; Miltgen, F, 1998) |
| " While most patients with tertian malaria were cured with the standard chloroquine and primaquine regimen, a higher dosage was required for one case acquired in Papua New Guinea." | 1.30 | Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance. ( Chang, HL; Chang, SC; Chen, YC; Fang, CT; Hsieh, WC; Hsueh, PR; Hung, CC, 1999) |
| "Primaquine was shown to be a safe and effective prophylactic drug against both P." | 1.30 | Primaquine as prophylaxis for malaria for nonimmune travelers: A comparison with mefloquine and doxycycline. ( Regev-Yochay, G; Schwartz, E, 1999) |
| "Despite the encouragement of early treatment, malaria was the major cause of death in children after the neonatal period in 1988." | 1.29 | Malaria treatment in Vanuatu: new national treatment guidelines. ( Reeve, PA, 1994) |
| "Primaquine was acylated with trifluoroacetic anhydride to give 6-methoxy-8-(4-trifluoroacetamido-1-methylbutyl) aminoquinoline (compound 2 in Table) and 5-trifluoro-acetyl-6-methoxy-8-(4-trifluoroacetamido-1-methylbutyl )- aminoquinoline (compound 6), bis (trifluoroacetyl) primaquine, which was subsequently hydrolyzed to yield 5-trifluoroacetyl-6-methoxy-8-(4-amino-1-methylbutyl)-aminoquinoline (compound 11), 5-trifluoroacetyprimaquine or trifluoroacetoprimaquine, coded M8506." | 1.28 | [Studies on the tissue schizonticide of malaria parasite: synthesis of 5-trieluoroacetyl-primaquine and its derivatives]. ( Chen, C; Fang, W; Zheng, XY, 1992) |
| " Because M-8506 is less toxic than primaquine in mice and more effective in radical treatment of simian malaria, further studies on trifluoroacetyl primaquine are worthy to be considered." | 1.28 | [Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine]. ( Shao, BR; Ye, XY, 1990) |
| "Chloroquine was most frequently used among antimalarial agents (in 123 cases, 65% of the total) for suppressing acute attacks." | 1.28 | [Clinical evaluation of antimalarial drugs]. ( Shimada, K; Tanabe, K, 1990) |
| "Blood induced Plasmodium berghei infection in Swiss mice was exposed during successive passages to melfloquine alone or melfoquine in combination with dapsone or primaquine or erythromycin, and the level of resistance to melfoquine in four sub-lines was compared at ED90 level." | 1.28 | Delay in emergence of mefloquine resistance in Plasmodium berghei by use of drug combinations. ( Dutta, GP; Puri, SK, 1989) |
| "The actual situation of the treatment of malaria for the past 10 years in Japan was investigated and analyzed." | 1.27 | Clinical evaluation of antimalarial regimens in Japan. ( Hioki, A; Ishizaki, T; Nakabayashi, T; Ohtomo, H; Tanabe, K, 1987) |
| "3 h, which declined monoexponentially with a half-life of 5." | 1.27 | Pharmacokinetics of primaquine in patients with P. vivax malaria. ( Bharucha, ED; Bhatia, SC; Desai, ND; Doshi, KJ; Gupta, KC; Revankar, SN; Saraph, YS; Satoskar, RS; Subrahmanyam, D; Vaidya, AB, 1986) |
| " The higher dosage of chloroquine caused no exacerbations." | 1.26 | Effect of antimalarial drugs on psoriasis. ( Kuflik, EG, 1980) |
| "Malaria is an increasing hazard of tropical travel." | 1.26 | Imported malaria in adults in Auckland. ( Ellis-Pegler, RB; Palmer, CW, 1982) |
| "Four cases of malaria are described." | 1.26 | [Malaria: 4 case reports with "atypical" symptoms (author's transl)]. ( Haupt, I; Ringelmann, R; Röder-Quehl, M; Schmidt-Heydt, K; Stockinger, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 330 (53.05) | 18.7374 |
| 1990's | 60 (9.65) | 18.2507 |
| 2000's | 61 (9.81) | 29.6817 |
| 2010's | 119 (19.13) | 24.3611 |
| 2020's | 52 (8.36) | 2.80 |
| Authors | Studies |
|---|---|
| Shetty, RV | 2 |
| Blanton, CD | 2 |
| Carroll, FI | 7 |
| Berrang, B | 3 |
| Linn, CP | 6 |
| Twine, CE | 1 |
| Khan, MS | 2 |
| LaMontagne, MP | 4 |
| Berrang, BD | 3 |
| Genther, CS | 1 |
| Smith, CS | 1 |
| Chen, EH | 4 |
| Saggiomo, AJ | 4 |
| Tanabe, K | 6 |
| Verma, BL | 2 |
| Nodiff, EA | 4 |
| Blumbergs, P | 2 |
| Smith, DC | 1 |
| Philip, A | 1 |
| Kepler, JA | 1 |
| Johnson, BH | 1 |
| Hofsteenge, J | 1 |
| Capuano, A | 1 |
| Altszuler, R | 1 |
| Moore, S | 1 |
| Markovac, A | 1 |
| Strube, RE | 1 |
| Dua, VK | 2 |
| Sinha, SN | 1 |
| Biswas, S | 1 |
| Valecha, N | 4 |
| Puri, SK | 12 |
| Sharma, VP | 4 |
| Jain, M | 1 |
| Vangapandu, S | 1 |
| Sachdeva, S | 1 |
| Singh, S | 2 |
| Singh, PP | 2 |
| Jena, GB | 1 |
| Tikoo, K | 1 |
| Ramarao, P | 1 |
| Kaul, CL | 1 |
| Jain, R | 1 |
| Araújo, MJ | 1 |
| Bom, J | 1 |
| Capela, R | 2 |
| Casimiro, C | 1 |
| Chambel, P | 1 |
| Gomes, P | 3 |
| Iley, J | 1 |
| Lopes, F | 5 |
| Morais, J | 1 |
| Moreira, R | 8 |
| de Oliveira, E | 1 |
| do Rosário, V | 2 |
| Vale, N | 2 |
| Zhang, Q | 2 |
| Guan, J | 1 |
| Sacci, J | 1 |
| Ager, A | 1 |
| Ellis, W | 1 |
| Milhous, W | 1 |
| Kyle, D | 1 |
| Lin, AJ | 4 |
| Zhu, S | 1 |
| Gudise, C | 1 |
| Meng, L | 1 |
| Wei, L | 1 |
| Smith, E | 1 |
| Kong, Y | 1 |
| Nanayakkara, NP | 3 |
| Ager, AL | 2 |
| Bartlett, MS | 2 |
| Yardley, V | 1 |
| Croft, SL | 1 |
| Khan, IA | 1 |
| McChesney, JD | 2 |
| Walker, LA | 4 |
| Matos, J | 2 |
| Gut, J | 6 |
| Nogueira, F | 2 |
| Rosenthal, PJ | 8 |
| Cachet, N | 1 |
| Hoakwie, F | 1 |
| Bertani, S | 1 |
| Bourdy, G | 1 |
| Deharo, E | 3 |
| Stien, D | 1 |
| Houel, E | 1 |
| Gornitzka, H | 1 |
| Fillaux, J | 1 |
| Chevalley, S | 1 |
| Valentin, A | 2 |
| Jullian, V | 1 |
| Shiraki, H | 1 |
| Kozar, MP | 4 |
| Melendez, V | 8 |
| Hudson, TH | 1 |
| Ohrt, C | 6 |
| Magill, AJ | 3 |
| Liu, X | 1 |
| Wang, X | 2 |
| Li, Q | 8 |
| O'Neil, MT | 2 |
| Zhang, L | 1 |
| Sathunuru, R | 1 |
| Caridha, D | 6 |
| Pybus, B | 6 |
| Rodrigues, T | 2 |
| Prudêncio, M | 9 |
| Mota, MM | 5 |
| Aminake, MN | 1 |
| Mahajan, A | 1 |
| Kumar, V | 1 |
| Hans, R | 1 |
| Wiesner, L | 2 |
| Taylor, D | 1 |
| de Kock, C | 1 |
| Grobler, A | 1 |
| Smith, PJ | 1 |
| Kirschner, M | 1 |
| Rethwilm, A | 1 |
| Pradel, G | 2 |
| Chibale, K | 3 |
| da Cruz, FP | 2 |
| Lafuente-Monasterio, MJ | 1 |
| Gonçalves, D | 1 |
| Ressurreição, AS | 1 |
| Sitoe, AR | 1 |
| Bronze, MR | 2 |
| Schneider, G | 1 |
| Gamo, FJ | 1 |
| Lauinger, IL | 1 |
| Vivas, L | 1 |
| Perozzo, R | 1 |
| Stairiker, C | 1 |
| Tarun, A | 1 |
| Zloh, M | 1 |
| Zhang, X | 1 |
| Xu, H | 1 |
| Tonge, PJ | 1 |
| Franzblau, SG | 1 |
| Pham, DH | 1 |
| Esguerra, CV | 1 |
| Crawford, AD | 2 |
| Maes, L | 1 |
| Tasdemir, D | 2 |
| Oliveira, R | 1 |
| Guedes, RC | 1 |
| Meireles, P | 1 |
| Albuquerque, IS | 1 |
| Gonçalves, LM | 2 |
| Pires, E | 1 |
| O'Neill, PM | 1 |
| Carballeira, NM | 1 |
| Bwalya, AG | 1 |
| Itoe, MA | 1 |
| Andricopulo, AD | 1 |
| Cordero-Maldonado, ML | 1 |
| Kaiser, M | 1 |
| Guido, RV | 1 |
| Mushtaque, M | 1 |
| Vandekerckhove, S | 1 |
| D'hooghe, M | 1 |
| Cohen, A | 1 |
| Suzanne, P | 1 |
| Lancelot, JC | 1 |
| Verhaeghe, P | 1 |
| Lesnard, A | 1 |
| Basmaciyan, L | 1 |
| Hutter, S | 1 |
| Laget, M | 1 |
| Dumètre, A | 1 |
| Paloque, L | 1 |
| Crozet, MD | 1 |
| Rathelot, P | 1 |
| Dallemagne, P | 1 |
| Lorthiois, A | 1 |
| Sibley, CH | 1 |
| Vanelle, P | 1 |
| Mazier, D | 4 |
| Rault, S | 1 |
| Azas, N | 1 |
| Ribeiro, CJ | 1 |
| Espadinha, M | 1 |
| Machado, M | 2 |
| Santos, MM | 1 |
| Singh, K | 2 |
| Okombo, J | 2 |
| Brunschwig, C | 1 |
| Ndubi, F | 1 |
| Barnard, L | 1 |
| Wilkinson, C | 1 |
| Njogu, PM | 1 |
| Njoroge, M | 2 |
| Laing, L | 1 |
| Reader, J | 2 |
| Botha, M | 1 |
| Nondaba, S | 1 |
| Birkholtz, LM | 2 |
| Lauterbach, S | 2 |
| Churchyard, A | 2 |
| Coetzer, TL | 2 |
| Burrows, JN | 1 |
| Yeates, C | 2 |
| Denti, P | 1 |
| Egan, TJ | 2 |
| Wittlin, S | 2 |
| Bonilla-Ramirez, L | 1 |
| Rios, A | 2 |
| Quiliano, M | 1 |
| Ramirez-Calderon, G | 1 |
| Beltrán-Hortelano, I | 1 |
| Franetich, JF | 3 |
| Corcuera, L | 1 |
| Bordessoulles, M | 1 |
| Vettorazzi, A | 1 |
| López de Cerain, A | 1 |
| Aldana, I | 1 |
| Pabón, A | 1 |
| Galiano, S | 1 |
| Mayoka, G | 1 |
| Gibhard, L | 1 |
| Sanches-Vaz, M | 1 |
| Fontinha, D | 2 |
| van der Watt, M | 1 |
| Bezuidenhout, B | 1 |
| Dodean, RA | 2 |
| Kancharla, P | 2 |
| Li, Y | 3 |
| Read, L | 2 |
| Bane, CE | 2 |
| Vesely, B | 2 |
| Kreishman-Deitrick, M | 3 |
| Black, C | 2 |
| Sciotti, RJ | 2 |
| Olmeda, R | 2 |
| Luong, TL | 3 |
| Gaona, H | 2 |
| Potter, B | 3 |
| Sousa, J | 5 |
| Marcsisin, S | 2 |
| Xie, L | 4 |
| Vuong, C | 3 |
| Zeng, Q | 4 |
| Zhang, J | 8 |
| Zhang, P | 4 |
| Lin, H | 3 |
| Butler, K | 2 |
| Roncal, N | 3 |
| Gaynor-Ohnstad, L | 2 |
| Leed, SE | 2 |
| Nolan, C | 2 |
| Huezo, SJ | 1 |
| Rasmussen, SA | 2 |
| Stephens, MT | 1 |
| Tan, JC | 1 |
| Cooper, RA | 2 |
| Smilkstein, MJ | 2 |
| Pou, S | 2 |
| Winter, RW | 1 |
| Riscoe, MK | 2 |
| Kelly, JX | 2 |
| Tibon, NS | 1 |
| Ng, CH | 1 |
| Cheong, SL | 1 |
| Ceja, FG | 1 |
| Tumwebaze, PK | 1 |
| Mu, J | 1 |
| Bayles, BR | 1 |
| Reynolds, KA | 1 |
| Madhav, H | 1 |
| Hoda, N | 1 |
| Boechat, N | 1 |
| Carvalho, RCC | 1 |
| Ferreira, MLG | 1 |
| Coutinho, JP | 1 |
| Sa, PM | 1 |
| Seito, LN | 1 |
| Rosas, EC | 1 |
| Krettli, AU | 2 |
| Bastos, MM | 1 |
| Pinheiro, LCS | 1 |
| da Silva de Barros, AO | 1 |
| Portilho, FL | 1 |
| Dos Santos Matos, AP | 1 |
| Ricci-Junior, E | 1 |
| Alencar, LMR | 1 |
| Dos Santos, CC | 1 |
| Paumgartten, FJR | 1 |
| Iram, SH | 1 |
| Alexis, F | 1 |
| Santos-Oliveira, R | 1 |
| Al Fayez, N | 1 |
| Böttger, R | 1 |
| Rouhollahi, E | 1 |
| Cullis, PR | 1 |
| Witzigmann, D | 1 |
| Li, SD | 1 |
| Kaagaard, MD | 1 |
| Matos, LO | 1 |
| Holm, AE | 1 |
| Gomes, LC | 1 |
| Wegener, A | 1 |
| Lima, KO | 1 |
| Vieira, IVM | 1 |
| de Souza, RM | 1 |
| Marinho, CRF | 1 |
| Hviid, L | 1 |
| Vestergaard, LS | 1 |
| Dominguez, H | 1 |
| Biering-Sørensen, T | 1 |
| Silvestre, OM | 1 |
| Brainin, P | 1 |
| Nain, M | 2 |
| Mohan, M | 2 |
| Sharma, A | 2 |
| Khammanee, T | 1 |
| Sawangjaroen, N | 1 |
| Buncherd, H | 1 |
| Tun, AW | 1 |
| Thanapongpichat, S | 1 |
| Aung, YN | 1 |
| Tun, STT | 1 |
| Vanisaveth, V | 1 |
| Chindavongsa, K | 1 |
| Kanya, L | 1 |
| Ley, B | 9 |
| Alam, MS | 4 |
| Satyagraha, AW | 4 |
| Phru, CS | 2 |
| Thriemer, K | 6 |
| Tadesse, D | 1 |
| Shibiru, T | 1 |
| Hailu, A | 4 |
| Kibria, MG | 4 |
| Hossain, MS | 3 |
| Rahmat, H | 3 |
| Poespoprodjo, JR | 2 |
| Khan, WA | 2 |
| Simpson, JA | 3 |
| Price, RN | 10 |
| Degaga, TS | 2 |
| Christian, M | 2 |
| Tego, TT | 2 |
| Abate, DT | 2 |
| Weston, S | 2 |
| Karahalios, A | 3 |
| Rajasekhar, M | 2 |
| Rumaseb, A | 4 |
| Mnjala, H | 2 |
| Lee, G | 2 |
| Anose, RT | 2 |
| Kidane, FG | 1 |
| Woyessa, A | 2 |
| Baird, K | 1 |
| Sutanto, I | 4 |
| Bahk, YY | 1 |
| Ahn, SK | 1 |
| Jeon, HJ | 1 |
| Na, BK | 2 |
| Lee, SK | 1 |
| Shin, HJ | 1 |
| Shenkutie, TT | 1 |
| Nega, D | 1 |
| Kepple, D | 1 |
| Witherspoon, L | 1 |
| Lo, E | 1 |
| Negash, MT | 1 |
| Adamu, A | 1 |
| Gebremichael, SG | 1 |
| Gidey, B | 1 |
| Tasew, G | 1 |
| Feleke, SM | 1 |
| Kebede, T | 1 |
| Kaur, D | 1 |
| Sinha, S | 2 |
| Sehgal, R | 1 |
| Adhikari, B | 1 |
| Tripura, R | 1 |
| Dysoley, L | 1 |
| Callery, JJ | 1 |
| Peto, TJ | 1 |
| Heng, C | 1 |
| Vanda, T | 1 |
| Simvieng, O | 1 |
| Cassidy-Seyoum, S | 1 |
| Dondorp, AM | 1 |
| von Seidlein, L | 3 |
| Kheang, ST | 1 |
| Ridley, R | 1 |
| Ngeth, E | 1 |
| Ir, P | 1 |
| Ngor, P | 1 |
| Sovannaroth, S | 1 |
| Lek, D | 1 |
| Phon, S | 1 |
| Kak, N | 1 |
| Yeung, S | 1 |
| Zeng, W | 1 |
| Liu, N | 1 |
| Gao, A | 1 |
| Yuan, M | 1 |
| Ma, R | 1 |
| Jiang, N | 1 |
| Sun, D | 1 |
| Wang, G | 1 |
| Feng, X | 1 |
| Boum, Y | 3 |
| Moukoko, CEE | 3 |
| Parikh, S | 4 |
| Chamchoy, K | 2 |
| Sudsumrit, S | 2 |
| Thita, T | 2 |
| Krudsood, S | 2 |
| Patrapuvich, R | 2 |
| Boonyuen, U | 2 |
| Douglas, NM | 3 |
| Piera, KA | 2 |
| Anstey, NM | 4 |
| Saita, S | 1 |
| Roobsoong, W | 2 |
| Khammaneechan, P | 1 |
| Sukchan, P | 1 |
| Lawpoolsri, S | 3 |
| Sattabongkot, J | 3 |
| Cui, L | 4 |
| Okanurak, K | 1 |
| Phuanukoonnon, S | 1 |
| Parker, DM | 2 |
| Gill, J | 1 |
| Calit, J | 1 |
| Araújo, JE | 2 |
| Deng, B | 1 |
| Miura, K | 1 |
| Gaitán, XA | 1 |
| Araújo, MDS | 1 |
| Medeiros, JF | 2 |
| Long, CA | 1 |
| Simeonov, A | 1 |
| Eastman, RT | 1 |
| Bargieri, DY | 1 |
| Woon, SA | 1 |
| Moore, BR | 1 |
| Laman, M | 1 |
| Tesine, P | 1 |
| Lorry, L | 1 |
| Kasian, B | 1 |
| Yambo, P | 1 |
| Yadi, G | 1 |
| Pomat, W | 1 |
| Batty, KT | 1 |
| Salman, S | 1 |
| Robinson, LJ | 2 |
| Davis, TME | 1 |
| Manning, L | 1 |
| Sharma, S | 1 |
| Rawat, K | 1 |
| Bohidar, HB | 1 |
| Chang, MA | 2 |
| Fouché, B | 2 |
| LaFortune, W | 2 |
| Holmes, K | 2 |
| Rigodon, J | 1 |
| Juin, S | 1 |
| Marseille, S | 1 |
| Rogier, E | 2 |
| Green, M | 1 |
| Kheradmand, T | 1 |
| Moore, SG | 1 |
| Gaul, DA | 1 |
| Boncy, J | 1 |
| Telfort, MA | 2 |
| Aung, TH | 1 |
| Suansomjit, C | 1 |
| Tun, ZM | 1 |
| Hlaing, TM | 1 |
| Kaewkungwal, J | 1 |
| Impoinvil, D | 1 |
| Hamre, KES | 1 |
| Dalexis, PE | 1 |
| Mérilien, JB | 1 |
| Dismer, AM | 1 |
| Desir, L | 1 |
| Herman, C | 1 |
| Noland, GS | 1 |
| Young, AJ | 1 |
| Druetz, T | 1 |
| Ashton, R | 1 |
| Eisele, TP | 1 |
| Cohen, J | 1 |
| van den Hoogen, L | 1 |
| Stresman, G | 1 |
| Drakeley, C | 3 |
| Pothin, E | 1 |
| Cameron, E | 1 |
| Battle, KE | 2 |
| Williamson, J | 1 |
| Lemoine, JF | 1 |
| Rahmalia, A | 1 |
| Landuwulang, CUR | 1 |
| Ronse, M | 1 |
| Kenangalem, E | 1 |
| Burdam, FH | 1 |
| Devine, A | 1 |
| Peeters Grietens, K | 1 |
| Gryseels, C | 1 |
| Palombi, IR | 1 |
| Lawrence, N | 1 |
| White, AM | 1 |
| Gare, CL | 1 |
| Craik, DJ | 1 |
| McMorran, BJ | 1 |
| Malins, LR | 1 |
| Soebandrio, A | 1 |
| Ekawati, LL | 3 |
| Chand, K | 1 |
| Noviyanti, R | 1 |
| Subekti, D | 1 |
| Santy, YW | 1 |
| Crenna-Darusallam, C | 1 |
| Instiaty, I | 1 |
| Budiman, W | 1 |
| Prasetya, CB | 1 |
| Lardo, S | 2 |
| Elyazar, I | 2 |
| Duparc, S | 1 |
| Cedar, E | 1 |
| Rolfe, K | 1 |
| Fernando, D | 1 |
| Berni, A | 1 |
| Jones, S | 1 |
| Kleim, JP | 1 |
| Fletcher, K | 1 |
| Sharma, H | 1 |
| Martin, A | 1 |
| Taylor, M | 1 |
| Goyal, N | 1 |
| Green, JA | 1 |
| Tan, LK | 1 |
| Baird, JK | 14 |
| Andrade, AO | 1 |
| Santos, NAC | 1 |
| Bastos, AS | 1 |
| Pontual, JDC | 1 |
| Silva, AMV | 1 |
| Martinez, LN | 1 |
| Lima, AA | 1 |
| Aguiar, ACC | 1 |
| G Teles, CB | 1 |
| Pereira, DB | 1 |
| Vinetz, JM | 1 |
| Gazzinelli, RT | 1 |
| Araújo, MS | 1 |
| López, AR | 1 |
| Martins, EB | 1 |
| de Pina-Costa, A | 1 |
| Pacheco-Silva, AB | 1 |
| Ferreira, MT | 1 |
| Mamani, RF | 1 |
| Detepo, PJT | 1 |
| Lupi, O | 1 |
| Bressan, CS | 1 |
| Calvet, GA | 1 |
| Silva, MFB | 1 |
| de Fátima Ferreira-da-Cruz, M | 1 |
| de Bruycker-Nogueira, F | 1 |
| Filippis, AMB | 1 |
| Daniel-Ribeiro, CT | 1 |
| Siqueira, A | 1 |
| Brasil, P | 1 |
| Win, KM | 1 |
| Aung, PL | 1 |
| Ring, Z | 1 |
| Linn, NYY | 1 |
| Kyaw, MP | 1 |
| Nguitragool, W | 1 |
| Sadhewa, A | 1 |
| Panggalo, LV | 1 |
| Kiros, FG | 1 |
| Torres, LH | 1 |
| de Carvalho, LB | 1 |
| de Fátima Abreu Venceslau, A | 1 |
| Jaime, C | 1 |
| de Matos Alves Pinto, L | 1 |
| Kobylinski, KC | 2 |
| Jittamala, P | 2 |
| Hanboonkunupakarn, B | 3 |
| Pukrittayakamee, S | 3 |
| Pantuwatana, K | 1 |
| Phasomkusolsil, S | 1 |
| Davidson, SA | 1 |
| Winterberg, M | 1 |
| Hoglund, RM | 1 |
| Mukaka, M | 1 |
| van der Pluijm, RW | 1 |
| Dondorp, A | 1 |
| Day, NPJ | 1 |
| White, NJ | 6 |
| Tarning, J | 4 |
| Chowdhury, MU | 1 |
| Jahan, N | 1 |
| Aktaruzzaman, MM | 1 |
| Prue, AS | 1 |
| Özmen Çapın, BB | 1 |
| Sönmezer, MÇ | 1 |
| Tortop, S | 1 |
| Ünalan, T | 1 |
| Bölek, H | 1 |
| Altıntop, SE | 1 |
| İnkaya, AÇ | 1 |
| Metan, G | 1 |
| Ergüven, S | 1 |
| Winasti Satyagraha, A | 1 |
| von Fricken, ME | 3 |
| Pfeffer, DA | 1 |
| Espino, F | 1 |
| Henriques, G | 1 |
| Oo, NN | 1 |
| Menard, D | 1 |
| Bancone, G | 1 |
| Kagaya, W | 1 |
| Gitaka, J | 1 |
| Chan, CW | 1 |
| Kongere, J | 1 |
| Md Idris, Z | 1 |
| Deng, C | 1 |
| Kaneko, A | 4 |
| Vera, IM | 1 |
| Grilo Ruivo, MT | 1 |
| Lemos Rocha, LF | 1 |
| Marques, S | 1 |
| Bhatia, SN | 1 |
| Mancio-Silva, L | 1 |
| Commons, RJ | 1 |
| McCarthy, JS | 1 |
| Hickey, PW | 1 |
| Mitra, I | 1 |
| Fraser, J | 1 |
| Brett-Major, D | 1 |
| Riddle, MS | 1 |
| Tribble, DR | 2 |
| Park, SY | 1 |
| Park, YS | 1 |
| Park, Y | 1 |
| Kwak, YG | 1 |
| Song, JE | 1 |
| Lee, KS | 1 |
| Cho, SH | 1 |
| Lee, SE | 1 |
| Shin, HI | 1 |
| Yeom, JS | 1 |
| Dembélé, L | 1 |
| Soulard, V | 1 |
| Amanzougaghene, N | 1 |
| Tajeri, S | 1 |
| Bousema, T | 3 |
| van Gemert, GJ | 1 |
| Le Grand, R | 1 |
| Dereuddre-Bosquet, N | 1 |
| Snounou, G | 2 |
| de Souza Pereira, C | 1 |
| Costa Quadros, H | 1 |
| Magalhaes Moreira, DR | 1 |
| Castro, W | 1 |
| Santos De Deus Da Silva, RI | 1 |
| Botelho Pereira Soares, M | 1 |
| Schmitz, V | 1 |
| Dos Santos, HF | 1 |
| Gendrot, M | 1 |
| Fonta, I | 1 |
| Mosnier, J | 1 |
| Pradines, B | 2 |
| Navarro, M | 1 |
| Srinivasan, S | 1 |
| Roy, D | 1 |
| Chavas, TEJ | 1 |
| Vlaskin, V | 1 |
| Ho, DK | 1 |
| Pottenger, A | 1 |
| LeGuyader, CLM | 1 |
| Maktabi, M | 1 |
| Strauch, P | 1 |
| Jackson, C | 1 |
| Flaherty, SM | 1 |
| Huber, HE | 1 |
| Burke, PA | 1 |
| Wesche, D | 1 |
| Rochford, R | 3 |
| Stayton, PS | 1 |
| Kobayashi, T | 2 |
| Kurani, S | 1 |
| Hamapumbu, H | 1 |
| Stevenson, JC | 1 |
| Thuma, PE | 1 |
| Moss, WJ | 1 |
| Raman, J | 1 |
| Barnes, KI | 1 |
| Baker, L | 1 |
| Blaylock, M | 1 |
| Blumberg, L | 1 |
| Frean, J | 1 |
| Misiani, E | 1 |
| Ukpe, IS | 1 |
| Vernaza, A | 1 |
| Pinilla-Monsalve, G | 1 |
| Cañas, F | 1 |
| Carrillo, D | 1 |
| David López, J | 1 |
| Flórez, N | 1 |
| Gomez-Mesa, JE | 1 |
| Miatmoko, A | 1 |
| Nurjannah, I | 1 |
| Nehru, NF | 1 |
| Rosita, N | 1 |
| Hendradi, E | 1 |
| Sari, R | 1 |
| Ekowati, J | 1 |
| Tang, ASO | 1 |
| Soo, XY | 1 |
| Yeo, ST | 1 |
| Mansor, NA | 1 |
| Chew, LP | 1 |
| Chua, HH | 1 |
| Wångdahl, A | 1 |
| Sondén, K | 1 |
| Wyss, K | 2 |
| Stenström, C | 1 |
| Björklund, D | 1 |
| Hervius Askling, H | 1 |
| Carlander, C | 1 |
| Hellgren, U | 1 |
| Färnert, A | 1 |
| Hayes, DJ | 1 |
| Banda, CG | 1 |
| Chipasula-Teleka, A | 1 |
| Terlouw, DJ | 1 |
| Rutledge, GG | 1 |
| Marr, I | 1 |
| Huang, GKL | 1 |
| Auburn, S | 1 |
| Marfurt, J | 1 |
| Sanders, M | 1 |
| Berriman, M | 1 |
| Newbold, CI | 1 |
| Otto, TD | 1 |
| Gunawardena, S | 1 |
| Daniels, RF | 1 |
| Yahathugoda, TC | 1 |
| Weerasooriya, MV | 1 |
| Durfee, K | 1 |
| Volkman, SK | 1 |
| Wirth, DF | 1 |
| Karunaweera, ND | 1 |
| Kalra, S | 1 |
| Khandelwal, D | 1 |
| Singla, R | 1 |
| Aggarwal, S | 1 |
| Dutta, D | 1 |
| Vallières, C | 1 |
| Avery, SV | 1 |
| Weppelmann, TA | 2 |
| Wilfong, TD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas - a Randomized Controlled Trial[NCT03916003] | Phase 4 | 500 participants (Actual) | Interventional | 2019-08-18 | Completed | ||
| Safety, Tolerability and Pharmacokinetics of Tafenoquine After Weekly and Escalating Monthly Doses of Tafenoquine in Healthy Vietnamese Volunteers[NCT05203744] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-05-10 | Not yet recruiting | ||
| Effectiveness of Mass Drug Administration (MDA) for Reducing Seasonal Malaria Transmission Towards Its Elimination in Hotspot Areas in Zanzibar - a Cluster-randomised Controlled Trial[NCT02721186] | 22,500 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| A Clinical Study to Assess the Safety and Feasibility of Controlled Blood-stage Plasmodium Vivax Human Malaria Infection Through Experimental Inoculation of Cryopreserved Infected Erythrocytes in Healthy Thai Adults[NCT05071079] | 16 participants (Anticipated) | Interventional | 2022-05-23 | Recruiting | |||
| Phase 1, Open-Label Study to Evaluate Potential Pharmacokinetic Interaction of Orally Administered Primaquine and Chloroquine in Healthy Thai Adult Subjects[NCT01218932] | Phase 1 | 16 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Impact of Mass Screening and Selective Treatment With Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in High Endemic Area, Belu Regency, Nusa Tenggara Timur Province, Indonesia: a Randomized Cluster Trial[NCT01878357] | Phase 4 | 1,488 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Mass-Drug Administration With a Gametocytocidal Drug Combination, a Model for a Transmission Blocking Vaccine[NCT00509015] | 6,000 participants (Anticipated) | Interventional | 2008-02-29 | Completed | |||
| Comparison of the Effectiveness of Two Scheme Treatments to Treat Plasmodium Vivax Cases in Patients Living in Communities With Persistence of Transmission in Oaxaca and Chiapas, Mexico[NCT02394197] | Phase 4 | 153 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094] | Phase 4 | 388 participants (Anticipated) | Interventional | 2023-06-26 | Recruiting | ||
| Adapting Novel Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi in Sarawak, Malaysia[NCT03988296] | 116 participants (Actual) | Observational | 2019-06-11 | Completed | |||
| Evaluation of the Efficacy and Safety of Primaquine for Clearance of Gametocytes in Uncomplicated Falciparum Malaria in Uganda[NCT01365598] | Phase 3 | 468 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites[NCT01082341] | Phase 1/Phase 2 | 27 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Evaluation of Reproducibility of a Sporozoite Challenge Model for Plasmodium Vivax in Human Volunteers[NCT00367380] | Phase 2 | 18 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection[NCT02691910] | Phase 2/Phase 3 | 204 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Safety and Protective Efficacy of a Synthetic Vaccine Derived From the CS Protein of Plasmodium Vivax: a Double-blind, Placebo-controlled, Randomized Clinical Trial in naïve and Pre-immune Colombian Volunteers[NCT04739917] | Phase 2 | 120 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Thick blood smear was performed to patients daily on days 7 to 23, and every other day until day 29. Any prove of P. vivax infection was considered positive and confirmed later by real time polymerase chain reaction (rPCR). (NCT00367380)
Timeframe: Twenty eight days
| Intervention | days (Mean) |
|---|---|
| Group 1 | 11 |
| Group 2 | 11 |
| Group 3 | 9 |
56 reviews available for primaquine and Malaria
| Article | Year |
|---|---|
Targeting the liver stage of malaria parasites: a yet unmet goal.
Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Re | 2012 |
Reemergence of chloroquine (CQ) analogs as multi-targeting antimalarial agents: a review.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria | 2015 |
Quinoline-based antimalarial hybrid compounds.
Topics: Animals; Antimalarials; Drug Discovery; Humans; Malaria; Plasmodium; Quinolines | 2015 |
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular St | 2020 |
An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins.
Topics: Animals; Antimalarials; Drug Development; Drug Resistance; Humans; Malaria; Molecular Targeted Thera | 2021 |
Global scenario of Plasmodium vivax occurrence and resistance pattern.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine | 2022 |
Role of Nanomedicines in Controlling Malaria: A Review.
Topics: Animals; Antimalarials; Antiparasitic Agents; Female; Humans; Malaria; Malaria, Falciparum; Nanomedi | 2023 |
Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Topics: Diagnostic Tests, Routine; Endemic Diseases; Female; Glucosephosphate Dehydrogenase; Glucosephosphat | 2019 |
Advances and roadblocks in the treatment of malaria.
Topics: Antimalarials; Artemisinins; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Malaria, F | 2022 |
Malaria and diabetes.
Topics: Animals; Antimalarials; Diabetes Mellitus, Type 2; Female; Glucosephosphate Dehydrogenase Deficiency | 2017 |
A review of progress towards sub-national malaria elimination in Matabeleland South Province, Zimbabwe (2011-2015): a qualitative study.
Topics: Antimalarials; Artemisinins; Case Management; Disease Eradication; Humans; Incidence; Insect Control | 2018 |
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Ma | 2018 |
Malaria Elimination: Time to Target All Species.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Disease Eradication; Host-Parasite Interactions; Hum | 2018 |
Clinical implications of a gradual dormancy concept in malaria.
Topics: Aminoquinolines; Antimalarials; Humans; Liver; Malaria; Parasitemia; Plasmodium; Plasmodium falcipar | 2016 |
The role of early detection and treatment in malaria elimination.
Topics: Antimalarials; Artemisinins; Diagnostic Tests, Routine; Disease Eradication; Disease Transmission, I | 2016 |
Clinical practice. Malaria prevention in short-term travelers.
Topics: Adult; Animals; Antimalarials; Child; DEET; Drug Resistance; Endemic Diseases; Female; Humans; Malar | 2008 |
The role of anti-malarial drugs in eliminating malaria.
Topics: Aminoquinolines; Animals; Antimalarials; Artemisinins; Drug Therapy, Combination; Health Policy; Hum | 2008 |
Malaria: prevention in travellers.
Topics: Antimalarials; Bedding and Linens; Chloroquine; Humans; Malaria; Mefloquine; Primaquine; Travel | 2010 |
Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.
Topics: Aminoquinolines; Antimalarials; Drug Interactions; Drug Therapy, Combination; Humans; Malaria; Plasm | 2011 |
Review: Malaria chemoprophylaxis for travelers to Latin America.
Topics: Antimalarials; Atovaquone; Drug Combinations; Drug Therapy, Combination; Humans; Latin America; Mala | 2011 |
Primaquine toxicity forestalls effective therapeutic management of the endemic malarias.
Topics: Antimalarials; Endemic Diseases; Humans; Malaria; Primaquine | 2012 |
Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety.
Topics: Antimalarials; Atovaquone; Chloroquine; Doxycycline; Humans; Malaria; Mefloquine; Naphthoquinones; P | 2001 |
Military aviators, special operations forces, and causal malaria prophylaxis.
Topics: Aminoquinolines; Antimalarials; Atovaquone; Aviation; Chloroquine; Doxycycline; Drug Combinations; H | 2003 |
Primaquine therapy for malaria.
Topics: Animals; Antimalarials; Drug Resistance; Humans; Malaria; Plasmodium; Primaquine | 2004 |
Effectiveness of antimalarial drugs.
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; | 2005 |
Controversies and misconceptions in malaria chemoprophylaxis for travelers.
Topics: Antimalarials; Consensus; Health Knowledge, Attitudes, Practice; Humans; Internationality; Malaria; | 2007 |
Recent patent reviews on small molecule-based antimalarial drugs.
Topics: Aminoquinolines; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Biological Assay; Flavon | 2007 |
[New use of primaquine for malaria].
Topics: Antimalarials; France; Hemolysis; Humans; Malaria; Primaquine | 2008 |
Malaria prophylaxis in travellers: the current position.
Topics: Africa; Amodiaquine; Antimalarials; Asia; Chloroquine; Culicidae; Drug Resistance; Female; Humans; I | 1984 |
Resistance of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia; Chloroquine; DNA; Drug Resistance; Drug Synergism; Hemin; Mala | 1984 |
The chemotherapy of protozoal infections: whither?
Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Disease Models, Animal; Glycolip | 1981 |
[Progress in immunodiagnosis and chemotherapy of protozoan infections].
Topics: Amebiasis; Animals; Antibodies; Babesiosis; Chloroquine; Drug Resistance, Microbial; Giardiasis; Hum | 1983 |
Practical therapeutics malaria chemoprophylaxis.
Topics: Adult; Africa, Eastern; Aminoquinolines; Antimalarials; Child; Chloroquine; Drug Combinations; Drug | 1984 |
New answers through chemotherapy?
Topics: Aminoquinolines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Disease Models, Animal; Drug | 1984 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; | 1981 |
Antimalarial drug resistance: an increasing problem.
Topics: Aminoquinolines; Animals; Antimalarials; Aotus trivirgatus; Chloroquine; Drug Resistance, Microbial; | 1982 |
Advances in chemotherapy.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Evaluation, Preclinical; Drug Therapy, Combi | 1982 |
[The treatment of malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malar | 1997 |
[Primaquine and travelers from the Arab world. A report and recommendations].
Topics: Adult; Anemia, Hemolytic; Antimalarials; Arabs; Cuba; Glucosephosphate Dehydrogenase Deficiency; Hum | 1995 |
Malaria prevention in travelers.
Topics: Animals; Antimalarials; Bedding and Linens; Chloroquine; Doxycycline; Humans; Malaria; Malaria, Falc | 1999 |
The evolution of tafenoquine--antimalarial for a new millennium?
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Primaquine | 1999 |
Chemotherapeutic malaria control as a selective primary health care activity in the Solomon Islands.
Topics: Adult; Antimalarials; Child; Chloroquine; Humans; Malaria; Melanesia; Primaquine; Primary Prevention | 1999 |
[Malaria in Norway--diagnosis, treatment and prevention].
Topics: Antimalarials; Chloroquine; Humans; Insect Bites and Stings; Malaria; Malaria, Falciparum; Mefloquin | 2000 |
Malaria chemoprophylaxis in the age of drug resistance. II. Drugs that may be available in the future.
Topics: Aminoquinolines; Animals; Antimalarials; Drug Resistance; Humans; Malaria; Plasmodium; Primaquine; T | 2001 |
Malaria prophylaxis/radical cure: recent experiences of the Australian Defence Force.
Topics: Aminoquinolines; Antimalarials; Australia; Controlled Clinical Trials as Topic; Endemic Diseases; Hu | 2001 |
The treatment of malaria.
Topics: Anemia; Antimalarials; Blackwater Fever; Child; Child, Preschool; Chloroquine; Coma; Drug Combinatio | 1976 |
Malaria in Leicester 1983-1988: a review of 114 cases.
Topics: Adolescent; Adult; Animals; Chloroquine; England; Female; Humans; Malaria; Male; Plasmodium falcipar | 1990 |
[Research on primaquine].
Topics: Animals; Humans; Malaria; Primaquine | 1987 |
Chemoprophylaxis of malaria.
Topics: Adolescent; Adult; Africa; Anemia, Hemolytic; Asia; Australia; Child; Child, Preschool; Chloroquine; | 1986 |
Recent advances in malaria research: parasite biology, chemotherapy and host/parasite relationships.
Topics: Adult; Animals; Antibodies, Monoclonal; Antigens, Protozoan; Antimalarials; Child; Child, Preschool; | 1985 |
Recent advances in antimalarial chemotherapy and drug resistance.
Topics: Agglutination; Amodiaquine; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Cross Reacti | 1974 |
The present status of chloroquine in the drug treatment of malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Primaquine; Proguanil; Pyrimet | 1972 |
The problem of drug-resistant malaria.
Topics: Amodiaquine; Anopheles; Antimalarials; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Insect | 1972 |
Development of new antimalarial drugs.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Humans; | 1972 |
Chemotherapy of the drug-resistant malarias.
Topics: Chloroquine; Cinchona; Drug Resistance, Microbial; Malaria; Mutation; Phytotherapy; Plants, Medicina | 1969 |
Malaria. Chemoprophylaxis and chemotherapy.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Synergism; Humans | 1971 |
34 trials available for primaquine and Malaria
| Article | Year |
|---|---|
Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA).
Topics: Antimalarials; Hemoglobinuria; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Plasmodiu | 2022 |
Ultra-short course, high-dose primaquine to prevent Plasmodium vivax infection following uncomplicated pediatric malaria: A randomized, open-label, non-inferiority trial of early versus delayed treatment.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Child; Humans; Malaria; Malari | 2023 |
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study.
Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Malaria, Vivax | 2023 |
Primaquine radical cure in patients with Plasmodium falciparum malaria in areas co-endemic for P falciparum and Plasmodium vivax (PRIMA): a multicentre, open-label, superiority randomised controlled trial.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Australia; Humans; Malaria; Ma | 2023 |
A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting-high coverage and safety, but no significant impact on transmission.
Topics: Antimalarials; Artemisinins; Female; Humans; Incidence; Malaria; Male; Mass Drug Administration; Pre | 2018 |
Pharmacokinetic interactions between primaquine and chloroquine.
Topics: Adult; Antimalarials; Chloroquine; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Ma | 2014 |
A multimedia consent tool for research participants in the Gambia: a randomized controlled trial.
Topics: Adult; Animals; Antimalarials; Comprehension; Female; Focus Groups; Gambia; Health Literacy; Humans; | 2015 |
Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections.
Topics: Administration, Oral; Adult; Antimalarials; Borneo; Chloroquine; Drug Therapy, Combination; Female; | 2010 |
A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, P | 2011 |
A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, P | 2011 |
A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, P | 2011 |
A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, P | 2011 |
Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Drug Administration Schedule; Drug Dosage Calculatio | 2013 |
Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate.
Topics: Adolescent; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinat | 2007 |
Effect of primaquine on gametocytes of Plasmodium falciparum in Thailand.
Topics: Blood; Humans; Malaria; Plasmodium falciparum; Primaquine; Thailand | 1980 |
Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys.
Topics: Aminoquinolines; Animals; Antimalarials; Macaca mulatta; Malaria; Plasmodium; Primaquine; Structure- | 1983 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; | 1981 |
The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah.
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Child; Chloroquine; Drug Combinations; Female; | 1981 |
[Halofantrine in the treatment of imported malaria in nonimmune travelers].
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Drug Therapy, Combination; Drug Tolerance; Female; | 1993 |
Lymphocyte proliferative response and subset profiles during extended periods of chloroquine or primaquine prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Cross-Sectional Studies; Humans; Indonesia; Lymphocyte Activation | 1996 |
Lymphocyte response to tetanus toxoid among Indonesian men immunized with tetanus-diphtheria during extended chloroquine or primaquine prophylaxis.
Topics: Adult; Antimalarials; Chloroquine; Diphtheria Toxoid; Diphtheria-Tetanus Vaccine; Humans; Immune Tol | 1997 |
Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis.
Topics: Adult; Antibodies, Bacterial; Antibody Formation; Antimalarials; Chloroquine; Diphtheria Toxoid; Dip | 1998 |
Intestinal parasite infections after extended use of chloroquine or primaquine for malaria prevention.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Feces; Humans; Indonesia; Intestinal Diseases, Parasi | 1998 |
Lymphocyte response to tetanus toxin T-cell epitopes: effects of tetanus vaccination and concurrent malaria prophylaxis.
Topics: Adult; Amino Acid Sequence; Antimalarials; Chloroquine; Epitopes, T-Lymphocyte; Humans; Lymphocyte A | 1999 |
Field trials of a rapid test for G6PD deficiency in combination with a rapid diagnosis of malaria.
Topics: Acridine Orange; Antimalarials; Case-Control Studies; Contraindications; Female; Fluorescent Dyes; G | 1999 |
Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in nonimmune Colombian soldiers.
Topics: Antimalarials; Chloroquine; Colombia; Double-Blind Method; Humans; Malaria; Malaria, Falciparum; Mal | 1999 |
Malaria prophylaxis/radical cure: recent experiences of the Australian Defence Force.
Topics: Aminoquinolines; Antimalarials; Australia; Controlled Clinical Trials as Topic; Endemic Diseases; Hu | 2001 |
Radical cure of Chesson strain vivax malaria in man by 7, not 14, days of treatment with primaquine.
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Follow-Up Studies; Humans; Malaria; Male; Plasmodi | 1977 |
[Combined use of pyronaridine, sulfadoxine and primaquine in areas with chloroquine-resistant falciparum malaria].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Na | 1987 |
A clinical trial of mefloquine in the treatment of Plasmodium vivax malaria.
Topics: Adult; Chloroquine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Malaria; Mefloquine | 1985 |
Combined chloroquine-primaquine therapy against vivax malaria.
Topics: Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Malaria; Plasmodium vivax | 1974 |
Sensitivity of four Central American strains of Plasmodium vivax to primaquine.
Topics: Animals; Central America; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; | 1974 |
Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya.
Topics: Adult; Amodiaquine; Anopheles; Antimalarials; Blood; Chloroquine; Clinical Trials as Topic; Dapsone; | 1970 |
Characterization of a drug resistant strain of Plasmodium falciparum from the Philippines.
Topics: Adult; Anopheles; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Malaria | 1971 |
Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Humans; Malaria; Male; Methemo | 1971 |
Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum.
Topics: Adult; Black or African American; Black People; Clinical Trials as Topic; Humans; Malaria; Malaysia; | 1969 |
Diformyl diaminodiphenyl sufone (DFD) as an antimalarial in man.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Formates; Humans; Malaria; Mal | 1970 |
534 other studies available for primaquine and Malaria
| Article | Year |
|---|---|
Synthesis of 2-substituted primaquine analogues as potential antimalarials.
Topics: Animals; Antimalarials; Cricetinae; Haplorhini; Leishmaniasis, Visceral; Macaca mulatta; Malaria; Mi | 1978 |
Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials.
Topics: Aminoquinolines; Animals; Antimalarials; Dose-Response Relationship, Drug; Haplorhini; Macaca mulatt | 1979 |
Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials.
Topics: Aminoquinolines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Cricetinae; Haplorhini; Leis | 1979 |
Synthesis of 4-alkyl and 4-(beta-alkylvinyl) derivatives of primaquine as potential antimalarials.
Topics: Animals; Haplorhini; Macaca mulatta; Malaria; Mice; Plasmodium; Plasmodium berghei; Primaquine | 1979 |
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Ac | 1977 |
Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.
Topics: Animals; Antimalarials; Haplorhini; Macaca mulatta; Malaria; Mice; Plasmodium berghei; Primaquine | 1977 |
Antimalarials. 16. Synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials.
Topics: Aminoquinolines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Malaria; Mice; Plasmodium be | 1989 |
Peptide derivatives of primaquine as potential antimalarial agents.
Topics: Animals; Antimalarials; Macaca mulatta; Malaria; Mice; Plasmodium berghei; Primaquine | 1988 |
Carrier-linked primaquine in the chemotherapy of malaria.
Topics: Animals; Disulfides; Drug Stability; Lethal Dose 50; Malaria; Mice; Plasmodium berghei; Primaquine; | 1986 |
Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine.
Topics: Animals; Antimalarials; Malaria; Mice; Primaquine; Structure-Activity Relationship | 1987 |
4,5-Disubstituted primaquine analogues as potential antimalarial agents.
Topics: Animals; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Primaquine; Structure-Activity Rela | 1986 |
4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents.
Topics: Animals; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Mice; Plasmodium; Primaquine; Struc | 1985 |
Sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents.
Topics: Aminoquinolines; Animals; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Mice; Plasmodium; | 1985 |
Antimalarials. 13. 5-Alkoxy analogues of 4-methylprimaquine.
Topics: Animals; Antimalarials; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Mice; Plasmodium ber | 1982 |
Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics.
Topics: Aminoquinolines; Animals; Antimalarials; Antiprotozoal Agents; Chemical Phenomena; Chemistry; Haplor | 1980 |
Antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. A highly effective series of blood and tissue schizonticidal agents.
Topics: Animals; Antimalarials; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Plasmodium; Primaqui | 1982 |
Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine.
Topics: Animals; Antimalarials; Chemical Phenomena; Chemistry; Macaca mulatta; Malaria; Mice; Plasmodium; Pr | 1982 |
Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine.
Topics: Animals; Antimalarials; Culicidae; Germ Cells; Malaria; Mice; Oocysts; Oxidation-Reduction; Plasmodi | 2002 |
Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.
Topics: Animals; Antimalarials; Malaria; Methemoglobin; Mice; Plasmodium berghei; Plasmodium falciparum; Pla | 2004 |
Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials.
Topics: Animals; Anopheles; Antimalarials; Drug Stability; Humans; Imidazolidines; In Vitro Techniques; Mala | 2005 |
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives.
Topics: Administration, Oral; Animals; Antimalarials; Carbamates; Guanidines; Imidazoles; Imidazolidines; Ma | 2005 |
Synthesis and evaluation of naphthyridine compounds as antimalarial agents.
Topics: Animals; Antimalarials; Disease Models, Animal; Inhibitory Concentration 50; Malaria; Molecular Stru | 2007 |
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.
Topics: Aminoquinolines; Animals; Antifungal Agents; Antiprotozoal Agents; Dogs; Female; Hemolysis; Humans; | 2008 |
Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity.
Topics: Animals; Antimalarials; Chromatography, Thin Layer; Drug Design; Humans; Hydrogen-Ion Concentration; | 2008 |
Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).
Topics: Animals; Antimalarials; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Humans; Magnetic Reso | 2009 |
Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Humans; In Vitro T | 2011 |
Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives.
Topics: Administration, Oral; Animals; Antimalarials; Guanidines; Imidazolidines; Imidazolines; Macaca mulat | 2011 |
Antimalarial activities of new guanidylimidazole and guanidylimidazoline derivatives.
Topics: Animals; Antimalarials; Crystallography, X-Ray; Guanidines; Humans; Imidazoles; Imidazolines; In Vit | 2011 |
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antimalarials; Dose-Response Relations | 2012 |
Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.
Topics: Antimalarials; Cell Line, Tumor; Humans; Imines; Liver; Malaria; Parasitic Sensitivity Tests; Plasmo | 2013 |
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
Topics: Animals; Antimalarials; Disease Models, Animal; Enzyme Inhibitors; Fatty Acid Synthase, Type II; Hep | 2013 |
Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.
Topics: Animals; Antimalarials; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; | 2014 |
2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dose-Response Relationship, Drug; Fatty Acid Synthase, Typ | 2014 |
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
Topics: Animals; Antimalarials; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Eryth | 2015 |
Novel squaramides with in vitro liver stage antiplasmodial activity.
Topics: Antiprotozoal Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Live | 2016 |
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Topics: Animals; Antimalarials; Benzimidazoles; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; | 2017 |
Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies.
Topics: Animals; Antimalarials; Chloroquine; Female; Hep G2 Cells; Humans; Life Cycle Stages; Malaria; Mice, | 2018 |
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Topics: Animals; Antimalarials; Benzimidazoles; Disease Models, Animal; Drug Design; ERG1 Potassium Channel; | 2019 |
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Mal | 2019 |
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Administration, Oral; Animals; Antimalarials; Cell Survival; Disease Models, Animal; Fema | 2020 |
Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Cell Line; Cell Survival; Chloroquine; Drug Design | 2020 |
Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatment.
Topics: Animals; Drug Delivery Systems; Female; Liver; Malaria; Mice; Pharmaceutical Preparations; Plasmodiu | 2021 |
Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity.
Topics: Animals; Antimalarials; Hemolysis; Liver; Malaria; Mice; Phospholipids; Polymers; Primaquine; Unilam | 2022 |
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
Effects of Host Genetic Polymorphisms on the Efficacy of the Radical Cure Malaria Drug Primaquine.
Topics: Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Malaria, Vivax; Plasmodiu | 2022 |
Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Malaria Patients in Southern Thailand: 8 Years Retrospective Study.
Topics: Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Malaria, | 2022 |
Cost-effectiveness analysis of G6PD diagnostic test for Plasmodium vivax radical cure in Lao PDR: An economic modelling study.
Topics: Antimalarials; Cost-Benefit Analysis; Diagnostic Tests, Routine; Female; Glucosephosphate Dehydrogen | 2022 |
Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria.
Topics: Antimalarials; Cross-Sectional Studies; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogena | 2022 |
An Evaluation of a New Quantitative Point-of Care Diagnostic to Measure Glucose-6-phosphate Dehydrogenase Activity.
Topics: Antimalarials; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Ma | 2022 |
Prevalence of G6PD deficiency and distribution of its genetic variants among malaria-suspected patients visiting Metehara health centre, Eastern Ethiopia.
Topics: Antimalarials; Cross-Sectional Studies; Ethiopia; Female; Glucosephosphate Dehydrogenase Deficiency; | 2022 |
Glucose 6 Phosphate Dehydrogenase (G6PD) quantitation using biosensors at the point of first contact: a mixed method study in Cambodia.
Topics: Antimalarials; Biosensing Techniques; Cambodia; Glucosephosphate Dehydrogenase; Glucosephosphate Deh | 2022 |
G6PD testing and radical cure for Plasmodium vivax in Cambodia: A mixed methods implementation study.
Topics: Adult; Antimalarials; Cambodia; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Defic | 2022 |
Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) and clinical implication for safe use of primaquine in malaria-endemic areas of Hainan Province, China.
Topics: China; Ethnicity; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Male; Minority | 2022 |
Moving towards malaria elimination with safer treatment for children with G6PD deficiency.
Topics: Child; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; M | 2023 |
Moving towards malaria elimination with safer treatment for children with G6PD deficiency.
Topics: Child; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; M | 2023 |
Moving towards malaria elimination with safer treatment for children with G6PD deficiency.
Topics: Child; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; M | 2023 |
Moving towards malaria elimination with safer treatment for children with G6PD deficiency.
Topics: Child; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; M | 2023 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Community acceptability, participation, and adherence to mass drug administration with primaquine for Plasmodium vivax elimination in Southern Thailand: a mixed methods approach.
Topics: Antimalarials; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Hum | 2023 |
Single-Nucleotide Polymorphisms in Glucose-6-Phosphate Dehydrogenase and their Relevance for the Deployment of Primaquine as a Radical Cure for Malaria.
Topics: Antimalarials; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Ma | 2023 |
Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc.
Topics: Animals; Antimalarials; Culicidae; High-Throughput Screening Assays; Humans; Malaria; Malaria, Falci | 2023 |
Investigation of Four Cases of Stevens-Johnson Syndrome among Participants in a Mass Drug Administration Campaign with Sulfadoxine-Pyrimethamine and Primaquine in Haiti, 2020.
Topics: Antimalarials; COVID-19; Drug Combinations; Haiti; Humans; Malaria; Mass Drug Administration; Pandem | 2023 |
Prevalence of G6PD deficiency and diagnostic accuracy of a G6PD point-of-care test among a population at risk of malaria in Myanmar.
Topics: Cross-Sectional Studies; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase De | 2023 |
Acceptability, Feasibility, Drug Safety, and Effectiveness of a Pilot Mass Drug Administration with a Single Round of Sulfadoxine-Pyrimethamine Plus Primaquine and Indoor Residual Spraying in Communities with Malaria Transmission in Haiti, 2018.
Topics: Cross-Sectional Studies; Feasibility Studies; Haiti; Humans; Insecticides; Malaria; Mass Drug Admini | 2023 |
Adherence to 14-day radical cure for Plasmodium vivax malaria in Papua, Indonesia: a mixed-methods study.
Topics: Antimalarials; Humans; Indonesia; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine | 2023 |
Development of Antiplasmodial Peptide-Drug Conjugates Using a Human Protein-Derived Cell-Penetrating Peptide with Selectivity for Infected Cells.
Topics: Antimalarials; Cell-Penetrating Peptides; Humans; Malaria; Malaria, Falciparum; Pharmaceutical Prepa | 2023 |
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; P | 2023 |
A fatal respiratory complication of malaria caused by Plasmodium vivax.
Topics: Adult; Antimalarials; Female; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine | 2023 |
Interventions for promoting patients' adherence to 14-day primaquine treatment in a highly malaria-endemic township in Myanmar: a qualitative study among key stakeholders.
Topics: Antimalarials; Humans; Malaria; Malaria, Vivax; Medication Adherence; Myanmar; Plasmodium vivax; Pri | 2023 |
Interaction with Modified Cyclodextrin as a Way to Increase the Antimalarial Activity of Primaquine.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Antimalarials; Biological Availability; Del | 2020 |
Safety, Pharmacokinetics, and Mosquito-Lethal Effects of Ivermectin in Combination With Dihydroartemisinin-Piperaquine and Primaquine in Healthy Adult Thai Subjects.
Topics: Adolescent; Adult; Animals; Anopheles; Antimalarials; Artemisinins; Drug Interactions; Drug Therapy, | 2020 |
Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh.
Topics: Antimalarials; Blood Transfusion; Child; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hem | 2020 |
[The Importance of Awareness for Malaria Regarding Prophylaxis and Early Diagnosis: Two Imported Malaria Cases in Turkey].
Topics: Adult; Africa South of the Sahara; Antimalarials; Artemether, Lumefantrine Drug Combination; Communi | 2019 |
Malaria resurgence after significant reduction by mass drug administration on Ngodhe Island, Kenya.
Topics: Anemia; Animals; Antimalarials; Geography; Hemoglobins; Humans; Islands; Kenya; Malaria; Mass Drug A | 2019 |
Targeting liver stage malaria with metformin.
Topics: Animals; Antimalarials; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2019 |
Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency.
Topics: Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; | 2020 |
Deployment and Travel Medicine Knowledge, Attitudes, Practices, and Outcomes Study (KAPOS): Malaria Chemoprophylaxis Prescription Patterns in the Military Health System.
Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug | 2020 |
Increasing Malaria Parasite Clearance Time after Chloroquine Therapy, South Korea, 2000-2016.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Malaria; Malaria, Vivax; Parasites; | 2020 |
Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium; Primaquine | 2020 |
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent.
Topics: Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Gold; Humans; Malaria; Molecular Struc | 2021 |
Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure.
Topics: Aminoquinolines; Animals; Antimalarials; Liver; Malaria; Malaria, Vivax; Mice; Mice, Inbred NOD; Mic | 2021 |
Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency and Gametocytemia in a Pre-Elimination, Low Malaria Transmission Setting in Southern Zambia.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Female; Gametogenesis; Germ Cells; Glucos | 2021 |
Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic.
Topics: Administration, Intravenous; Antigens, Protozoan; Antimalarials; Artemether, Lumefantrine Drug Combi | 2020 |
Malaria and encephalopathy in a heart transplant recipient: A case report in the context of multiorgan donation.
Topics: Adult; Animals; Antimalarials; Brain Diseases; Female; Heart Transplantation; Humans; Malaria; Prima | 2021 |
Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes.
Topics: Antimalarials; Chemistry, Pharmaceutical; Chloroquine; Cholesterol; Drug Compounding; Drug Liberatio | 2021 |
The mystery of 'saturation gap' and falsely normal G6PD: a case of primaquine-induced haemolysis in Plasmodium vivax malaria infection.
Topics: Antimalarials; Glucosephosphate Dehydrogenase; Hemolysis; Humans; Malaria; Malaria, Vivax; Primaquin | 2021 |
Relapse of Plasmodium vivax and Plasmodium ovale Malaria With and Without Primaquine Treatment in a Nonendemic Area.
Topics: Antimalarials; Chronic Disease; Humans; Malaria; Malaria, Vivax; Plasmodium ovale; Plasmodium vivax; | 2022 |
Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing.
Topics: Adolescent; Antimalarials; Child; Drug Dosage Calculations; Humans; Infant; Malaria; Models, Biologi | 2017 |
Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Drug Combinations; Dr | 2017 |
Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.
Topics: Adult; Antimalarials; Chloroquine; Fever; Humans; Liberia; Malaria; Malaria, Vivax; Male; Molecular | 2017 |
The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials.
Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Malaria; Oxygen; Primaquine; Protein Biosynth | 2017 |
Field Trial of the CareStart Biosensor Analyzer for the Determination of Glucose-6-Phosphate Dehydrogenase Activity in Haiti.
Topics: Alleles; Antimalarials; Biosensing Techniques; Child; Female; Genotype; Glucosephosphate Dehydrogena | 2017 |
Glucose-6-phosphate dehydrogenase deficiency and the use of primaquine: top-down and bottom-up estimation of professional costs.
Topics: Adult; Antimalarials; Brazil; Glucosephosphate Dehydrogenase Deficiency; Hospital Costs; Hospitaliza | 2017 |
Plasmodium malariae in Israeli Travelers: A Nationwide Study.
Topics: Adult; Africa; Aged; Antimalarials; Female; Humans; Israel; Malaria; Male; Middle Aged; Plasmodium m | 2017 |
A young man with severe acute haemolytic anaemia.
Topics: Antimalarials; Chloroquine; Drug Therapy, Combination; Glucosephosphate Dehydrogenase Deficiency; Hu | 2017 |
Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection.
Topics: Adolescent; Antimalarials; Artemether, Lumefantrine Drug Combination; Austria; Communicable Diseases | 2018 |
Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.
Topics: Animals; Anopheles; Brazil; Chloroquine; Dose-Response Relationship, Drug; Drug Combinations; Female | 2018 |
Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar.
Topics: Adolescent; Adult; Alleles; Asian People; Female; Genotype; Glucosephosphate Dehydrogenase Deficienc | 2018 |
Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014.
Topics: Adult; Antiprotozoal Agents; Artemisinins; Atovaquone; Azithromycin; Babesia microti; Babesiosis; Di | 2018 |
[Diagnosis and Treatment of the First Imported Case of Plasmodium knowlesi Infection in China].
Topics: Animals; Antimalarials; Artemisinins; China; Chloroquine; Erythrocytes; Hemeproteins; Humans; Malari | 2016 |
Baculovirus-Induced Fast-Acting Innate Immunity Kills Liver-Stage
Topics: Animals; Baculoviridae; Cells, Cultured; Cytotoxicity, Immunologic; Immunity, Innate; Immunotherapy, | 2018 |
Single-dose radical cure for Plasmodium vivax.
Topics: Aminoquinolines; Humans; Malaria; Plasmodium vivax; Primaquine; Travel | 2019 |
Primaquine for all: is it time to simplify malaria treatment in co-endemic areas?
Topics: Antimalarials; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine | 2019 |
Mixed Infection with
Topics: Adult; Antimalarials; Chloroquine; DNA, Protozoan; Humans; Malaria; Male; Plasmodium falciparum; Pla | 2019 |
Plasmodium ovale Infection After One Year Mefloquine Prophylaxis in A Young Indonesian Soldier: A Case Report.
Topics: Antimalarials; Artemisinins; Chemoprevention; Congo; Drug Therapy, Combination; Humans; Indonesia; M | 2019 |
Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia.
Topics: Antimalarials; Child; Child, Preschool; Cross-Sectional Studies; Female; Gene Frequency; Genotype; G | 2019 |
Diagnosis of malaria in a traveler 9 months after returning from West Africa by
Topics: Africa, Western; Antimalarials; Atovaquone; Drug Combinations; Germany; Humans; Malaria; Male; Middl | 2019 |
Experimental reduction of host Plasmodium infection load affects mosquito survival.
Topics: Animals; Culex; Host-Parasite Interactions; Malaria; Parasite Load; Primaquine; Sparrows; Survival A | 2019 |
Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon.
Topics: Adolescent; Adult; Aged; Brazil; Child; Child, Preschool; Cross-Sectional Studies; Disease Susceptib | 2013 |
[Clinical experience of primaquine use for treatment of vivax and ovale malaria in Japanese travelers].
Topics: Adult; Antimalarials; Asian People; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malar | 2013 |
Possible options for malaria chemoprophylaxis on the horizon.
Topics: Aminoquinolines; Antimalarials; Azithromycin; Chemoprevention; Doxycycline; Drug Therapy, Combinatio | 1999 |
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Topics: Animals; Antimalarials; Cytochrome P-450 CYP2D6; Hydroxylation; Malaria; Male; Mice; Mice, Inbred BA | 2013 |
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Topics: Animals; Antimalarials; Cytochrome P-450 CYP2D6; Hydroxylation; Malaria; Male; Mice; Mice, Inbred BA | 2013 |
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Topics: Animals; Antimalarials; Cytochrome P-450 CYP2D6; Hydroxylation; Malaria; Male; Mice; Mice, Inbred BA | 2013 |
The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Topics: Animals; Antimalarials; Cytochrome P-450 CYP2D6; Hydroxylation; Malaria; Male; Mice; Mice, Inbred BA | 2013 |
Prevalence and molecular basis of glucose-6-phosphate dehydrogenase deficiency in Afghan populations: implications for treatment policy in the region.
Topics: Adolescent; Afghanistan; Animals; Antimalarials; Child; Child, Preschool; Cross-Sectional Studies; D | 2013 |
A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages.
Topics: Animals; Antimalarials; Blood; Chimera; Chloroquine; Disease Models, Animal; Female; Liver; Malaria; | 2013 |
Public health system readiness to treat malaria in Odisha State of India.
Topics: Adult; Antimalarials; Artemisinins; Cross-Sectional Studies; Diagnostic Tests, Routine; Health Servi | 2013 |
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium.
Topics: Animals; Antimalarials; Chloroquine; Drug Carriers; Erythrocytes; Female; Malaria; Mice; Mice, Inbre | 2014 |
Realistically, how far are we from a universal malaria drug?
Topics: Antimalarials; Artemisinins; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Malaria; P | 2014 |
A retrospective study on imported malaria in Jordan. 1. Malaria among Jordanian UN peacekeeping forces.
Topics: Adult; Antimalarials; Cote d'Ivoire; Doxycycline; Drug Therapy, Combination; Endemic Diseases; Eritr | 2014 |
Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Glucosephosphate Dehydr | 2014 |
Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections.
Topics: Aminoquinolines; Animals; Antimalarials; Area Under Curve; Flow Cytometry; Half-Life; Liver; Malaria | 2014 |
Compliance with antimalarial chemoprophylaxis recommendations for wounded United States military personnel admitted to a military treatment facility.
Topics: Adult; Afghanistan; Antimalarials; Doxycycline; Female; Hospitalization; Humans; Malaria; Male; Mili | 2014 |
A case of quadruple malaria infection imported from Mozambique to Japan.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Base Sequence; Coinfe | 2014 |
Causal prophylactic efficacy of primaquine, tafenoquine, and atovaquone-proguanil against Plasmodium cynomolgi in a rhesus monkey model.
Topics: Aminoquinolines; Animals; Antimalarials; Atovaquone; Disease Models, Animal; Drug Combinations; Maca | 2014 |
Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.
Topics: Aminoquinolines; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Primaqui | 2014 |
Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.
Topics: Animals; Antimalarials; Dogs; Erythrocyte Transfusion; Erythrocytes; Female; Glucosephosphate Dehydr | 2014 |
Plasmodium malariae infection: a case of missed diagnosis.
Topics: Artemisinins; Artesunate; Azure Stains; Child; Chromatography, Affinity; Diagnostic Errors; Drug Com | 2014 |
Compliance to recommendations for the management of curative treatment of Plasmodium vivax/ovale infections.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Guideline Adherence; Humans; Malaria; Malaria, | 2014 |
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles.
Topics: Animals; Antimalarials; Drug Carriers; Emulsions; Lipids; Malaria; Mice; Nanoparticles; Parasitemia; | 2014 |
Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Administration Schedule; Drug Ther | 2014 |
Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin.
Topics: Animals; Antimalarials; Artemisinins; Humans; Malaria; Mice; Molecular Structure; Nanoparticles; Org | 2015 |
Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.
Topics: Adamantane; Animals; Anopheles; Antimalarials; Artemether; Artemisinins; Ethanolamines; Female; Fluo | 2015 |
Missing malaria? Potential obstacles to diagnosis and hypnozoite eradication.
Topics: Antimalarials; Australia; Humans; Malaria; Polymerase Chain Reaction; Primaquine; Travel | 2014 |
Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in southeast Iran: implications for malaria elimination.
Topics: Adolescent; Antimalarials; Child; Cross-Sectional Studies; Female; Glucosephosphate Dehydrogenase De | 2015 |
Synthesis and Evaluation of Substituted Poly(organophosphazenes) as a Novel Nanocarrier System for Combined Antimalarial Therapy of Primaquine and Dihydroartemisinin.
Topics: Animals; Antimalarials; Artemisinins; Drug Carriers; Drug Delivery Systems; Electrochemistry; Erythr | 2015 |
Assessment of real-time method to detect liver parasite burden under different experimental conditions in mice infected with Plasmodium yoelii sporozoites.
Topics: Animals; Antimalarials; Atovaquone; Liver; Malaria; Mice; Parasite Load; Plasmodium yoelii; Primaqui | 2015 |
Fever in the returning traveller: the importance of sensitivity.
Topics: Adult; Antimalarials; Cameroon; Chloroquine; Diagnosis, Differential; Fever; Follow-Up Studies; Huma | 2015 |
[13-year old girl with fever 6 months after returning from sub-Saharan Africa].
Topics: Adolescent; Africa; Chloroquine; Developing Countries; Female; Fever of Unknown Origin; Germany; Hum | 2015 |
Late relapse of imported Plasmodium ovale malaria: a case report.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Cote d'Ivoire; Drug C | 2015 |
The footprints of relapsing malaria in southwest Delhi, India.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; India; Infant; Malaria; Male; Pr | 2015 |
UK malaria treatment guidelines 2016.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Breast Feeding; Child; Child, Preschool; Female; Hum | 2016 |
Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model.
Topics: Animals; Antimalarials; Artemisinins; Chemoprevention; Chloroquine; Female; Immunization; Malaria; M | 2016 |
You're the Flight Surgeon. Malaria prevention in U.S. Air Force aviators.
Topics: Aerospace Medicine; Antimalarials; Doxycycline; Humans; Malaria; Military Personnel; Primaquine | 2016 |
Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants.
Topics: Animals; Antidepressive Agents; Antimalarials; Cells, Cultured; Cytochrome P-450 CYP2D6; Disease Mod | 2016 |
Glucose-6-phosphate dehydrogenase deficiency prevalence and genetic variants in malaria endemic areas of Colombia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Colombia; Cross- | 2016 |
Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.
Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocyte Transfusion; Erythrocytes; Glucosephosph | 2016 |
[The first monkey malaria in Turkey: a case of Plasmodium knowlesi].
Topics: Adult; Animals; Anopheles; Antimalarials; Chloroquine; Erythrocytes; Humans; Malaria; Male; Mosquito | 2016 |
The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai-Myanmar border.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimalarials; Artemisinins; Child; Child, Pres | 2016 |
Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei.
Topics: Aminoquinolines; Animals; Antimalarials; Chemoprevention; Cytochrome P-450 CYP2D6; Disease Models, A | 2016 |
Synthesis of primaquine glyco-conjugates as potential tissue schizontocidal antimalarial agents.
Topics: Animals; Antimalarials; Female; Glycoconjugates; Macaca mulatta; Malaria; Malaria, Vivax; Male; Mice | 2017 |
Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.
Topics: Animals; Cell Line, Tumor; Chickens; Chlorocebus aethiops; Erythrocytes; Glucosephosphate Dehydrogen | 2017 |
Acute respiratory distress syndrome in a case of Plasmodium ovale malaria.
Topics: Adult; Animals; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium ovale; Primaquine; Res | 2008 |
Macromolecular prodrugs. XII. Primaquine conjugates: synthesis and preliminary antimalarial evaluation.
Topics: Animals; Antimalarials; Chemistry, Pharmaceutical; Drug Carriers; Female; Glucosamine; Malaria; Male | 2009 |
Monkey malaria in humans: a diagnostic dilemma with conflicting laboratory data.
Topics: Adult; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Humans; Malaria; Male; Plasmodium knowle | 2009 |
Clinical and laboratory features of human Plasmodium knowlesi infection.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Blood Chemical Analysis; Chloroquine; Female; Hemog | 2009 |
[Update on primaquine].
Topics: Antimalarials; Chagas Disease; Humans; Malaria; Pneumonia, Pneumocystis; Primaquine | 2009 |
Dynamics of Plasmodium falciparum parasitemia regarding combined treatment regimens for acute uncomplicated malaria, Antioquia, Colombia.
Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Artesunate; Clinical Protocols; Colombia | 2010 |
Consideration of ethics in primaquine therapy against malaria transmission.
Topics: Antimalarials; Erythrocytes; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficien | 2011 |
Transfusion-related Plasmodium ovale malaria complicated by acute respiratory distress syndrome (ARDS) in a non-endemic country.
Topics: Antimalarials; Doxycycline; Female; Humans; Intensive Care Units; Malaria; Middle Aged; Plasmodium o | 2011 |
Variant Plasmodium ovale isolated from a patient infected in Ghana.
Topics: Animals; Antimalarials; Chloroquine; Cysteine Proteases; Cytochromes b; Denmark; Electron Transport | 2011 |
Plasmodium knowlesi malaria in children.
Topics: Adolescent; Age Factors; Anemia; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans | 2011 |
Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy.
Topics: Animals; Antimalarials; Artemisinins; Cell Line; Humans; Malaria; Mice; Parasitemia; Plasmodium berg | 2011 |
Prophylactic use of antimalarials during pregnancy.
Topics: Antimalarials; Atovaquone; Chemoprevention; Chloroquine; Doxycycline; Drug Combinations; Female; Hum | 2011 |
Novel potent metallocenes against liver stage malaria.
Topics: Animals; Antimalarials; Erythrocytes; Ferrous Compounds; Genes, Reporter; Green Fluorescent Proteins | 2012 |
Biowaiver monographs for immediate-release solid oral dosage forms: primaquine phosphate.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Humans; Malaria; Permeability | 2012 |
Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand.
Topics: Adolescent; Adult; Case-Control Studies; Endemic Diseases; Ethnicity; Female; Gene Frequency; Geneti | 2011 |
Increased bioavailability of primaquine using poly(ethylene oxide) matrix extended-release tablets administered to beagle dogs.
Topics: Animals; Antimalarials; Biological Availability; Delayed-Action Preparations; Dogs; Drug Carriers; F | 2011 |
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies | 2012 |
[Plan to improve malaria control towards its elimination in Mesoamerica].
Topics: Animals; Antimalarials; Central America; Chloroquine; Community Participation; Developing Countries; | 2011 |
Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.
Topics: Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Disease Management; Disease Models, Animal; | 2012 |
'Not another UTI ... '.
Topics: Aged, 80 and over; Antimalarials; Fever; Humans; Malaria; Male; Plasmodium ovale; Primaquine; Recurr | 2012 |
Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: clearance after immunization, susceptibility to primaquine, and contribution to blood-stage infection.
Topics: Animals; Anopheles; Antimalarials; Cell Line; Female; Immunization; Insect Bites and Stings; Malaria | 2012 |
Perspectives: The missing pieces.
Topics: Animals; Anopheles; Antigens, Protozoan; Antimalarials; Artemisinins; Biomedical Research; Drug Resi | 2012 |
Source of clinical malaria in mixed-species infections.
Topics: Artemisinins; Chloroquine; Coinfection; Ethanolamines; Fluorenes; Humans; Malaria; Male; Plasmodium | 2012 |
Reinventing primaquine for endemic malaria.
Topics: Antimalarials; Dose-Response Relationship, Drug; Endemic Diseases; Glucosephosphate Dehydrogenase De | 2012 |
G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.
Topics: Antimalarials; Bayes Theorem; Female; Gene Frequency; Geographic Mapping; Geography, Medical; Glucos | 2012 |
Pancytopenia resulting from hemophagocytosis in malaria.
Topics: Animals; Antimalarials; Child; Diagnosis, Differential; Female; Histiocytosis, Non-Langerhans-Cell; | 2002 |
Plasmodium ovale malaria acquired in central Spain.
Topics: Aged; Animals; Antimalarials; Female; Humans; Malaria; Plasmodium ovale; Primaquine; Spain | 2002 |
[Effect of daphnetin on the exo-erythrocytic stage of rodent malaria].
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; | 2001 |
Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys.
Topics: Aminoquinolines; Animals; Antimalarials; Female; Macaca mulatta; Malaria; Male; Monkey Diseases; Par | 2003 |
The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug | 2003 |
Cooperative actions to achieve malaria control without the use of DDT.
Topics: Animals; Anopheles; Antimalarials; Canada; Chloroquine; Cost-Benefit Analysis; DDT; Drug Combination | 2003 |
[Chemotherapy of malaria and the new antimalarials, daraprim and primaquine].
Topics: Antimalarials; Malaria; Primaquine; Pyrimethamine; Quinolines; Uricosuric Agents | 1953 |
[Comparative gametocidal effect of primaquine and plasmoquine in experimental research with animals].
Topics: Aminoquinolines; Animals; Malaria; Primaquine; Quinolines; Uricosuric Agents | 1953 |
Studies in human malaria. XXXI. Comparison of primaquine, isopentaquine, SN-3883, and pamaquine as curative agents against Chesson strain vivax malaria.
Topics: Aminoquinolines; Antimalarials; Humans; Malaria; Malaria, Vivax; Primaquine | 1953 |
Korean vivax malaria. II. Curative treatment with pamaquine and primaquine.
Topics: Aminoquinolines; Antimalarials; Asian People; Humans; Malaria; Malaria, Vivax; Primaquine | 1953 |
Korean vivax malaria. III. Curative effect and toxicity of primaquine in doses from 10 to 30 mg. daily.
Topics: Antimalarials; Asian People; Humans; Malaria; Malaria, Vivax; Primaquine | 1953 |
Korean vivax malaria. IV. Curative effect of 15 milligrams of primaquine daily for 7 days.
Topics: Antimalarials; Asian People; Humans; Malaria; Malaria, Vivax; Primaquine | 1953 |
Korean vivax malaria. V. Cure of the infection by primaquine administered during long-term latency.
Topics: Antimalarials; Asian People; Humans; Malaria; Malaria, Vivax; Primaquine | 1953 |
A clinical study of primaquine (S. N. 13,272) in the treatment of malaria among the Miskito Indians of Nicaragua.
Topics: Antimalarials; Biomedical Research; Humans; Malaria; Nicaragua; Primaquine | 1953 |
Relapse of vivax malaria treated with primaquine and report of one case of cyanosis (methemoglobinemia) due to primaquine.
Topics: Antimalarials; Chronic Disease; Cyanosis; Humans; Malaria; Malaria, Vivax; Methemoglobinemia; Primaq | 1954 |
The suppressive treatment of malaria in a rural village with primaquine and plaquenil.
Topics: Antimalarials; Environment; Hydroxychloroquine; Malaria; Primaquine; Quinolines; Rural Population | 1954 |
The use of primaquine for the treatment of malaria in Korean veterans.
Topics: Antimalarials; Disease; Humans; Malaria; Military Personnel; Primaquine; Veterans | 1954 |
Preliminary report on the antirelapse properties of pyrimethamine (daraprim) and primaquine.
Topics: Humans; Malaria; Primaquine; Pyrimethamine | 1953 |
The effect of continuous and intermittent primaquine therapy on the relapse rate of Chesson strain vivax malaria.
Topics: Antimalarials; Chronic Disease; Humans; Malaria; Malaria, Vivax; Primaquine; Recurrence | 1954 |
When to use the 8-aminoquinolines in the treatment of malaria, especially primaquine.
Topics: Aminoquinolines; Antimalarials; Malaria; Primaquine; Quinolines; Uricosuric Agents | 1954 |
Antirelapse treatment with primaquine and pyrimethamine.
Topics: Antimalarials; Humans; Malaria; Primaquine; Pyrimethamine | 1954 |
Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Malaria, Vivax; Primaquine; Quinine | 1955 |
The antimalarial action of primaquine against the blood and tissue stages of falciparum malaria (Panama, P-F-6 strain).
Topics: Antimalarials; Humans; Malaria; Malaria, Falciparum; Panama; Primaquine | 1955 |
[Action of combined primaquine-pyrimethamine. I. Experimental study on pigeons (Columba livia) infected with Plasmodium relictum].
Topics: Animals; Antimalarials; Columbidae; Malaria; Plasmodium; Primaquine; Pyrimethamine | 1957 |
Induced primaquine resistance in vivax malaria.
Topics: Antimalarials; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine | 1961 |
Observations on the treatment of 678 malaria cases with primaquine in an area free from maiaria transmission in Mysore State, India.
Topics: Antimalarials; Humans; India; Malaria; Primaquine | 1960 |
[Pyrimethamine-primaquine in the treatment of acute malaria. (Study in 20 cases)].
Topics: Antimalarials; Humans; Malaria; Primaquine; Pyrimethamine | 1960 |
Methaemoglobin reduction test: a new, simple, in vitro test for identifying primaquine-sensitivity.
Topics: Aminoquinolines; Antimalarials; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Malaria; Methem | 1960 |
Primaquine sensitivity simulating malaria in a white male.
Topics: Antimalarials; Humans; Malaria; Male; Primaquine | 1961 |
Nephrosis in Nigerian children. Role of Plasmodium malariae, and effect of antimalarial treatment.
Topics: Antimalarials; Child; Chloroquine; Humans; Malaria; Nephrotic Syndrome; Plasmodium malariae; Primaqu | 1963 |
Radical cure of malaria and operational difficulties in its implementation.
Topics: Chloroquine; Humans; Malaria; Primaquine | 1962 |
Mass administration of an antimalarial drug combining 4-aminoquinoline and 8-aminoquinoline in Tanganyika.
Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Culicidae; Humans; Malaria; Primaquine | 1962 |
Primaquine and quinocide as curative agents against sporozoite-induced Chesson strain vivax malaria.
Topics: Aminoquinolines; Animals; Humans; Malaria; Malaria, Vivax; Primaquine; Quinolines; Sporozoites | 1962 |
AEROMEDICAL ASPECTS OF MALARIA PROPHYLAXIS WITH CHLOROQUINE-PRIMAQUINE.
Topics: Aerospace Medicine; Anemia; Anemia, Hemolytic; Chloroquine; Humans; Malaria; Methemoglobinemia; Moto | 1963 |
GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY IN WEST NEW GUINEA.
Topics: Blood Specimen Collection; Child; Epidemiology; Erythrocytes; Ethnology; Genetics, Medical; Glucosep | 1963 |
FLUORESCENT ANTIBODY STUDIES IN HUMAN MALARIA. II. DEVELOPMENT AND PERSISTENCE OF ANTIBODIES TO PLASMODIUM FALCIPARUM.
Topics: Amodiaquine; Antibodies; Antigen-Antibody Reactions; Chloroquine; Fluorescent Antibody Technique; Hu | 1964 |
[PHARMACOGENETICS].
Topics: Anemia; Anemia, Hemolytic; Barbiturates; Catalase; Cholinesterases; Genetics, Medical; Glucosephosph | 1964 |
[A PATIENT WITH TROPICAL MALARIA].
Topics: Amodiaquine; Antimalarials; Chloroquine; Dosage Forms; Drug Resistance; Drug Resistance, Microbial; | 1964 |
[ON THE DETECTION OF PLASMODIUM MALARIAE IN THE STERNAL MARROW].
Topics: Bone Marrow; Bone Marrow Examination; Chloroquine; Drug Therapy; Humans; Malaria; Plasmodium malaria | 1964 |
CHLOROQUINE-RESISTANT STRAIN OF PLASMODIUM FALCIPARUM FROM KHAO MAI KHAEO, THAILAND.
Topics: Chloroquine; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Malaria; Plasmodium | 1965 |
LATENT INFECTIONS WITH PLASMODIUM OVALE MALARIA.
Topics: Africa, Western; Aminoquinolines; Canada; Chloroquine; Communicable Diseases; Diagnosis; Drug Therap | 1965 |
Studies on Plasmodium berghei Vincke and Lips, 1948. XXXI. Selection of a primaquine resistant strain.
Topics: Antimalarials; Immunologic Tests; Lip; Malaria; Plasmodium; Plasmodium berghei; Primaquine | 1961 |
Problems in the therapy for imported malaria in the United States.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Diagnosis, Differential; Female; | 2003 |
Two worlds of malaria.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Life Cycle St | 2003 |
Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report.
Topics: Aminoquinolines; Antimalarials; Humans; Malaria; Malaria, Vivax; Naphthalenes; Primaquine | 1950 |
ARMY giving primaquine treatment to all returning servicemen.
Topics: Humans; Malaria; Primaquine; Quinine | 1952 |
PRIMAQUINE 15 mg. for 14 days cures "high percentage".
Topics: Humans; Malaria; Primaquine; Quinine | 1952 |
Primaquine; a new drug for the radical cure of relapsing vivax malaria.
Topics: Humans; Malaria; Malaria, Vivax; Primaquine; Quinolines | 1952 |
COUNCIL on Pharmacy and Chemistry: status of primaquine; report to the Council.
Topics: Malaria; Pharmaceutical Services; Pharmacies; Pharmacy; Primaquine; Quinolines | 1952 |
Mass therapy of subclinical vivax malaria with primaquine.
Topics: Malaria; Malaria, Vivax; Primaquine; Quinolines; Uricosuric Agents | 1952 |
Cure of Korean vivax malaria with pamaquine and primaquine.
Topics: Aminoquinolines; Asian People; Humans; Malaria; Malaria, Vivax; Primaquine; Quinolines; Uricosuric A | 1952 |
Toxicity of primaquine in Caucasians.
Topics: Malaria; Primaquine; Quinolines; Uricosuric Agents | 1952 |
Toxicity of primaquine in Negroes.
Topics: Black People; Humans; Malaria; Primaquine; Quinolines; Uricosuric Agents | 1952 |
PRIMAQUINE for vivax malaria.
Topics: Humans; Malaria; Malaria, Vivax; Primaquine; Quinolines; Uricosuric Agents | 1952 |
A large focus of naturally acquired Plasmodium knowlesi infections in human beings.
Topics: Adult; Animals; Chloroquine; DNA, Protozoan; Erythrocytes; Humans; Macaca; Malaria; Malaysia; Monkey | 2004 |
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Comorbidity; Glucosephosphate Dehydrogenase Deficiency; Hem | 2005 |
Plasmodium cynomolgi: gametocytocidal activity of the anti-malarial compound CDRI 80/53 (elubaquine) in rhesus monkeys.
Topics: Animals; Anopheles; Antimalarials; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 2005 |
Glucose-6-phosphate dehydrogenase (G6PD) mutations in Cambodia: G6PD Viangchan (871G>A) is the most common variant in the Cambodian population.
Topics: Cambodia; DNA Mutational Analysis; DNA Primers; Ethnicity; Genetic Testing; Glucosephosphate Dehydro | 2005 |
Failure of primaquine therapy for the treatment of Plasmodium ovale malaria.
Topics: Adolescent; Adult; Antimalarials; Humans; Malaria; Male; Plasmodium ovale; Primaquine; Recurrence; T | 2005 |
Do apoptotic Plasmodium-infected hepatocytes initiate protective immune responses?
Topics: Animals; Antigens, Protozoan; Antimalarials; Apoptosis; Dendritic Cells; Hepatocytes; Immunization; | 2006 |
Frequency of malaria and glucose-6-phosphate dehydrogenase deficiency in Tajikistan.
Topics: Adult; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria; Malaria, Vivax; Mal | 2006 |
Imported non-Plasmodium falciparum malaria: a five-year prospective study in a European referral center.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Europe; Female; Geography; Humans; Malaria; | 2006 |
[Haemolysis due to primaquine in 3 cases].
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Humans; Malaria; Male; Primaquine | 2006 |
Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I.
Topics: Adult; Antimalarials; Centers for Disease Control and Prevention, U.S.; Child; Clinical Trials as To | 2006 |
Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis.
Topics: Antimalarials; Drug Costs; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Primaquine | 2006 |
Prevalence of glucose-6-phosphate dehydrogenase deficiency in U.S. Army personnel.
Topics: Adult; Endemic Diseases; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Defi | 2006 |
Operational feasibility of rapid diagnostic kits & blister packs use for malaria control in high transmission areas of Orissa & Chhattisgarh.
Topics: Adolescent; Adult; Aged; Antimalarials; Chloroquine; Communicable Disease Control; Cross-Sectional S | 2007 |
Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum.
Topics: Animals; Annexin A5; Blotting, Western; Cell Membrane; Cytoplasm; Endocytosis; Erythrocyte Membrane; | 2007 |
Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine.
Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Drug Stability; Emulsions; Lip | 2008 |
Clinical inquiries. When should travelers begin malaria prophylaxis?
Topics: Antimalarials; Chloroquine; Contraindications; Doxycycline; Humans; Insect Repellents; Insecticides; | 2007 |
Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman.
Topics: Adult; Animals; Antimalarials; Chloroquine; Female; Humans; Malaria; Plasmodium ovale; Pregnancy; Pr | 2007 |
Congenital malaria in the United States: a review of cases from 1966 to 2005.
Topics: Female; Humans; Infant, Newborn; Malaria; Malaria, Vivax; Population Surveillance; Pregnancy; Pregna | 2007 |
A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.
Topics: Amodiaquine; Antimalarials; Biological Assay; Biological Availability; Chloroquine; Chromatography, | 2006 |
Malaria prophylaxis and treatment in G-6-PD deficiency. An observation on the toxicity of primaquine and chloroquine.
Topics: Adult; Child; Child, Preschool; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hema | 1967 |
Splenectomy in "big spleen disease".
Topics: Adult; Blood Cell Count; Follow-Up Studies; Hemoglobins; Humans; Malaria; Male; Middle Aged; Primaqu | 1967 |
Chemotherapy of sporozoite- and blood-induced Plasmodium berghei infections with selected antimalarial agents.
Topics: Animals; Chloroquine; Cricetinae; Dapsone; Malaria; Mice; Primaquine; Pyrimethamine; Quinine; Rats | 1967 |
Malaria cases up; current treatment suggestions offered.
Topics: Chloroquine; Humans; Malaria; Primaquine | 1967 |
Changes in malaria incidence after mass drug administration in Nicaragua.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Health Education; Humans; Infant; M | 1983 |
Mass drug administration for control of malaria.
Topics: Antimalarials; Chloroquine; Humans; Malaria; Nicaragua; Primaquine | 1983 |
The chemotherapy of rodent malaria, XXXIV. Causal prophylaxis Part III: Ultrastructural changes induced in exo-erythrocytic schizonts of Plasmodium yoelii yoelii by primaquine.
Topics: Animals; Culicidae; Liver; Malaria; Mice; Microscopy, Electron; Plasmodium; Primaquine; Rats; Rats, | 1983 |
[Establishment of monkey model of Plasmodium cynomolgi-Anopheles stephensi system and its use for tissue shizontocide test].
Topics: Animals; Anopheles; Antimalarials; Disease Models, Animal; Macaca; Macaca mulatta; Malaria; Plasmodi | 1982 |
[Toxicity and repository antimalarial activity of octanoyl primaquine].
Topics: Animals; Antimalarials; Dogs; Female; Macaca mulatta; Malaria; Male; Mice; Muscles; Primaquine | 1982 |
[Manifestation of glucose-6-phosphate dehydrogenase deficiency caused by primaquine in malaria therapy].
Topics: Child; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Male; Pedigree; Plasmodium vivax; | 1983 |
Primaquine-chloroquine prophylaxis against malaria in Southeast-Asian refugees entering South Australia.
Topics: Asia, Southeastern; Australia; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Muscle Cramp | 1984 |
[Malaria: a study of 5 cases].
Topics: Adult; Chloroquine; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Plasmodium vi | 1984 |
Clinical efficacy of sulfadoxine-pyrimethamine in the treatment of falciparum malaria in Sabah, Malaysia.
Topics: Adolescent; Adult; Antimalarials; Child; Drug Combinations; Drug Resistance, Microbial; Female; Foll | 1984 |
[Relapses and indirect fluorescent antibody level in vivax malaria patients after chloroquine and chloroquine-primaquine treatment].
Topics: Antibodies; Chloroquine; Fluorescent Antibody Technique; Humans; Malaria; Plasmodium vivax; Primaqui | 1984 |
[The radical efficacy of pyronaridine-primaquine combination in tertian malaria].
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Drug Therapy, Combination; | 1984 |
[Synthesis of 2,5-bis-substituted phenoxy derivatives of primaquine for radical treatment of vivax malaria].
Topics: Animals; Antimalarials; Malaria; Mice; Plasmodium vivax; Primaquine | 1984 |
Results of 3-day radical treatment of Plasmodium vivax in North Arcot and South Arcot Districts of Tamil Nadu.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Therapy, Combination; Humans; | 1984 |
Correction of error regarding malaria treatment in Disease-A-Month.
Topics: Humans; Malaria; Primaquine | 1984 |
A Pakistani woman who arrived with diarrhea.
Topics: Blood; Chloroquine; Diagnosis, Differential; Diarrhea; Female; Humans; Malaria; Middle Aged; New Yor | 1984 |
Effect of antimalarial drugs on psoriasis.
Topics: Adult; Antimalarials; Chloroquine; Dermatitis, Exfoliative; Female; Humans; Malaria; Male; Middle Ag | 1980 |
Primaquine, malaria chemotherapy and G-6-PD deficiency.
Topics: Australia; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Primaquine | 1984 |
Glucose-6-phosphate dehydrogenase deficiency in Southeast Asian refugees entering the United States.
Topics: Adult; Asia, Southeastern; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Male; Primaqu | 1984 |
Theoretical aspects of enzyme induction and inhibition leading to the reversal of resistance to biocides.
Topics: Adult; Chemical Phenomena; Chemistry; Child; Chlorfenvinphos; Chloroquine; Cytochrome P-450 Enzyme S | 1984 |
Erroneous primaquine dose in "Tropical Diseases in North America" (Disease-a-Month)
Topics: Child; Humans; Malaria; Primaquine | 1984 |
A note on an interesting case of treatment of Plasmodium vivax curative therapy relapses in a four year old child from Aurangabad, Maharashtra State, India.
Topics: Child, Preschool; Female; Humans; India; Malaria; Plasmodium vivax; Primaquine; Recurrence | 1982 |
[Treatment of malaria with a combination of 3 drugs on São Luís Island, Maranhão, Brazil].
Topics: Antimalarials; Brazil; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Plasmodium falciparu | 1981 |
[Treatment of malaria with a combination of 3 drugs on the Island of São Luis, Maranhão, Brazil].
Topics: Antimalarials; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; | 1981 |
[Focus of malaria in the metropolitan region of Recife].
Topics: Anopheles; Brazil; Chloroquine; Disease Outbreaks; Drug Therapy, Combination; Humans; Malaria; Plasm | 1981 |
Imported malaria in adults in Auckland.
Topics: Adolescent; Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Kenya; Malaria; Male; Mi | 1982 |
4,5-disubstituted primaquine analogs as potential antiprotozoan agents.
Topics: Animals; Antiprotozoal Agents; Chemical Phenomena; Chemistry; Cricetinae; Haplorhini; Leishmaniasis, | 1980 |
[Synthesis of organic salts of primaquine and experimental observations on their radical cure activity against malaria (author's transl)].
Topics: Animals; Antimalarials; Chickens; Haplorhini; Malaria; Mice; Primaquine | 1981 |
Treatment of malaria.
Topics: Dapsone; Drug Therapy, Combination; Humans; Malaria; Primaquine; Pyrimethamine | 1980 |
Danger of haemolysis from primaquine use.
Topics: Chloroquine; Drug Therapy, Combination; Hemolysis; Humans; Malaria; Primaquine | 1982 |
Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity.
Topics: Acridines; Animals; Antimalarials; Carboxy-Lyases; Chloroquine; Enzyme Repression; Erythrocyte Membr | 1981 |
Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug.
Topics: Adolescent; Child; Child, Preschool; Gastrointestinal Diseases; Hemolysis; Humans; Infant; Malaria; | 1981 |
Development of new derivatives of primaquine by association with lysosomotropic carriers.
Topics: Animals; Carrier Proteins; Liposomes; Malaria; Male; Mice; Primaquine; Technology, Pharmaceutical | 1981 |
New tissue schizontocidal antimalarial drugs.
Topics: Aminoquinolines; Animals; Antimalarials; Drug Evaluation, Preclinical; Macaca mulatta; Malaria; Mice | 1981 |
Malaria chemoprophylaxis.
Topics: Anopheles; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falci | 1980 |
Frequency of relapse and primaquine resistance in Southeast Asian vivax malaria.
Topics: Asia, Southeastern; Drug Resistance, Microbial; Humans; Malaria; Plasmodium vivax; Primaquine; Recur | 1980 |
Primaquine liposomes in the chemotherapy of experimental murine malaria.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Liposomes; Malaria; Male; M | 1980 |
Malaria in southeast Queensland in 1979.
Topics: Adolescent; Adult; Australia; Child; Child, Preschool; Chloroquine; Dapsone; Female; Humans; Infant; | 1980 |
Response to 600 mg amodiaquine base with 45 mg primaquine as presumptive treatment in chloroquine resistant Plasmodium falciparum infection in Assam.
Topics: Adolescent; Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; India; Infan | 1980 |
Malaria in Cape Town. A report of 3 cases and a review of current therapy and prophylaxis.
Topics: Adolescent; Adult; Child; Child, Preschool; Chloroquine; Diagnosis, Differential; Drug Administratio | 1981 |
Malaria in children.
Topics: Child, Preschool; Chloroquine; Female; Humans; Malaria; Male; Ohio; Plasmodium vivax; Primaquine; Tr | 1981 |
Blood schizontocidal activity of antibiotics against Plasmodium berghei sensitive as well as resistant to chloroquine, pyrimethamine and primaquine.
Topics: Animals; Anti-Bacterial Agents; Chloroquine; Drug Resistance; Malaria; Mice; Plasmodium berghei; Pri | 1981 |
Sustained-release implants in the chemotherapy of experimental rodent malaria I. A comparison of the effects of some antimalarials in polydimethylsiloxane matrices.
Topics: Animals; Antimalarials; Chloroquine; Dimethylpolysiloxanes; Drug Implants; Malaria; Male; Mefloquine | 1981 |
Results of treatment with 600 mg. base of chloroquine and 45 mg base of primaquine in P. falciparum in Greater Nicobar and Little Andaman Islands.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine | 1981 |
Observations on early and late post-sporozoite tissue stages in primate malaria. II. The hypnozoite of Plasmodium cynomolgi bastianellii from 3 to 105 days after infection, and detection of 36- to 40-hour pre-erythrocytic forms.
Topics: Animals; Fluorescent Antibody Technique; Liver; Macaca mulatta; Malaria; Plasmodium; Primaquine; Tim | 1982 |
Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei.
Topics: Animals; Antibody Formation; Chloroquine; Female; Immunization; Malaria; Mice; Mice, Inbred A; Plasm | 1982 |
Plasmodium cynomolgi infections in the rhesus monkey.
Topics: Animals; Anopheles; Antimalarials; Female; Insect Vectors; Macaca; Macaca mulatta; Malaria; Male; Mo | 1982 |
[A case of methemoglobinemia and agranulocytosis during the treatment of malaria (pl. ovale) with arequine and primaquine].
Topics: Adult; Agranulocytosis; Antimalarials; Chloroquine; Humans; Malaria; Male; Methemoglobinemia; Primaq | 1982 |
[Prevention of recurrence of malaria with primaquine].
Topics: Adult; Child; Child, Preschool; Chloroquine; Follow-Up Studies; Humans; Malaria; Male; Middle Aged; | 1982 |
Comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen.
Topics: Animals; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Macaca mulatta; Malar | 1981 |
Malaria in Cape Town.
Topics: Adult; Child; Chloroquine; Humans; Malaria; Primaquine | 1981 |
[Observation of therapeutic effect of single-dose combined administration of Qinghaosu, sulphomethoxine, pyrimethamine and primaquine in the treatment of chloroquine-resistant malignant malaria (author's transl)].
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistanc | 1981 |
Fever and Chills.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Primaquine | 1980 |
[A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii].
Topics: Albumins; Animals; Antimalarials; Drug Carriers; Drug Delivery Systems; Female; Liver; Malaria; Male | 1995 |
Malaria treatment in Vanuatu: new national treatment guidelines.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Female; H | 1994 |
Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.
Topics: Animals; Fluorescent Antibody Technique; Humans; Liver; Malaria; Plasmodium berghei; Primaquine; Rat | 1995 |
Malaria in Kansas, 1988-1993.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance; Female; Humans; Kansas; Malaria; | 1994 |
[Effect of trifluoroacetoprimaquine on erythrocytic schizonts of rodent malaria].
Topics: Animals; Antimalarials; Drug Resistance, Multiple; Erythrocytes; Female; Malaria; Male; Mice; Plasmo | 1994 |
[Synthesis of 4-methyl-5-substituted phenoxy-primaquine analogues and preliminary evaluation on their antimalarial activity].
Topics: Animals; Antimalarials; Malaria; Mice; Plasmodium berghei; Primaquine | 1994 |
Malaria prophylaxis revisited.
Topics: Africa; Contraindications; Humans; Malaria; Primaquine; Travel | 1994 |
Malaria in US Marines returning from Somalia.
Topics: Cohort Studies; Disease Outbreaks; Doxycycline; Humans; Incidence; Malaria; Mefloquine; Military Per | 1994 |
Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon.
Topics: Adolescent; Adult; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Animals; Brazil; Child; Child | 1994 |
Unexpected high primaquine concentrations in acutely ill malaria patients.
Topics: Acute Disease; Humans; Malaria; Malaria, Vivax; Primaquine; Time Factors | 1993 |
[Response to the previous comments by P. M. Shah].
Topics: Animals; Chloroquine; Humans; Malaria; Plasmodium; Primaquine | 1993 |
Preliminary evaluation of primaquine activity on rodent malaria model after transdermal administration.
Topics: Administration, Cutaneous; Animals; Antimalarials; Disease Models, Animal; Drug Evaluation; Malaria; | 1997 |
Update on prevention of malaria for travelers.
Topics: Animals; Antimalarials; Chloroquine; Doxycycline; Drug Resistance; Global Health; Guidelines as Topi | 1997 |
Rodent malaria prophylaxis by transdermal delivery of primaquine.
Topics: Administration, Cutaneous; Animals; Antimalarials; Drug Evaluation, Preclinical; Malaria; Mice; Para | 1998 |
Adverse effects of antimalarial prophylactic drugs: an important consideration in the risk-benefit equation.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Atovaquone; Azithromycin; Chloroquine; Drug Therapy, | 1998 |
Prevention of malaria and diarrhea in travelers.
Topics: Antimalarials; Diarrhea; Humans; Malaria; Primaquine; Travel | 1999 |
Primaquine prophylaxis against malaria.
Topics: Antimalarials; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Primaquine | 1999 |
[Prevention of malaria].
Topics: Anti-Bacterial Agents; Antimalarials; Chloroquine; Doxycycline; Female; Humans; Malaria; Malaria, Fa | 1999 |
Imported malaria: successful treatment of 31 patients in the era of chloroquine resistance.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Resistance; Fem | 1999 |
Primaquine as prophylaxis for malaria for nonimmune travelers: A comparison with mefloquine and doxycycline.
Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Antimalarials; Doxycycline; Female; Follow-Up Studies; | 1999 |
Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Azithromycin; Chloroquine; Doxycycline; Erythromycin; | 2000 |
Erythrocyte Fy antigen phenotyping helps differentiate so-called benign tertian malarias.
Topics: Animals; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Duffy Blood-Group Sys | 2000 |
[Therapeutic efficacy of different antimalarial regimens in the Costa Rica-Nicaragua border region].
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Costa Rica; Humans; Malaria; Middle Aged; Nicaragua; | 2000 |
Malaria in a Trinidadian man.
Topics: Animals; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium malariae; Primaquine; Seconda | 2000 |
[Does the brief treatment with antimalarials favorably influence drug resistance and recurrences?].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Malaria, Falciparum; Malaria, | 2001 |
Treating malaria may be too expensive.
Topics: Antimalarials; Australia; Humans; Malaria; Prescription Fees; Primaquine | 2001 |
[Primaquine].
Topics: Contraindications; Humans; Malaria; Pneumonia, Pneumocystis; Primaquine | 2001 |
[Synthesis of primaquine analogues and their antimalarial activity in mice].
Topics: Aminoquinolines; Animals; Antimalarials; Malaria; Mice; Plasmodium yoelii; Primaquine | 1998 |
Coronary bypass surgery in patient with malaria.
Topics: Aged; Angina, Unstable; Coronary Artery Bypass; Coronary Artery Disease; Humans; Malaria; Male; Post | 2002 |
Development of effective antisporozoite immunity by natural bites of Plasmodium-berghei-infected mosquitoes in rats under prophylactic treatment with various drug regimens.
Topics: Animals; Antibodies; Chloroquine; Cross Reactions; Culicidae; Malaria; Plasmodium berghei; Primaquin | 1978 |
Antimalarial activities of various 4-quinolonemethanols with special attention to WR-142,490 (mefloquine).
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Therap | 1978 |
[An epidemiological consideration of the status of infection in 29 patients with malaria (author's transl)].
Topics: Adult; Aged; Chloroquine; Female; Humans; Japan; Malaria; Male; Middle Aged; Plasmodium falciparum; | 1978 |
The development of a "high volume tissue schizonticidal drug screen" based upon mortality of mice inoculated with sporozoites of Plasmodium berghei.
Topics: Animals; Antimalarials; Apicomplexa; Disease Models, Animal; Drug Evaluation, Preclinical; Haplorhin | 1979 |
[Biological diagnosis of malaria and amebiasis].
Topics: Acetamides; Amebiasis; Chloroquine; Emetine; Entamoeba histolytica; Feces; Humans; Malaria; Methods; | 1977 |
Hemoglobin E and glucose-6-phosphate deficiency in the Khmer Air Force (Cambodia).
Topics: Cambodia; Glycogen Storage Disease Type I; Hematocrit; Hemoglobin E; Hemoglobins, Abnormal; Humans; | 1977 |
Plasmodium vivax: correlation of circumsporozoite precipitation (CSP) reaction with sporozoite-induced protective immunity in man.
Topics: Adult; Anopheles; Antibodies; Chloroquine; Humans; Immunization; Malaria; Male; Plasmodium vivax; Pr | 1977 |
The prevention and treatment of malaria.
Topics: Adult; Australia; Child; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; | 1977 |
Efficacy of 5-day radical treatment of P. vivax infection in Tamil Nadu.
Topics: Adult; Child; Chloroquine; Follow-Up Studies; Humans; India; Malaria; Plasmodium vivax; Primaquine; | 1977 |
Comparison of treatment schedules for Plasmodium vivax infections in the Solomon Islands.
Topics: Adolescent; Adult; Child; Chloroquine; Drug Administration Schedule; Female; Humans; Malaria; Male; | 1977 |
The chemotherapy of rodent malaria, XXVIII. The development of resistance to mefloquine (WR 142,490).
Topics: Animals; Antimalarials; Drug Combinations; Drug Resistance, Microbial; Malaria; Mice; Piperidines; P | 1977 |
Malaria in a Honduras hunter.
Topics: Adult; Chloroquine; Honduras; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Travel | 1978 |
[Malaria; a summary].
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodiu | 1978 |
Field evaluation of primaquine in the control of Plasmodium vivax.
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Humans; Infant; Malaria; Plasmodium vivax; | 1978 |
[Malaria introduced into Switzerland from 1974-1976].
Topics: Adult; Chloroquine; Humans; Malaria; Neurologic Manifestations; Plasmodium falciparum; Plasmodium vi | 1978 |
Primaquine phosphate is the drug of choice.
Topics: Humans; Malaria; Plasmodium vivax; Primaquine | 1978 |
Liposomes in the chemotherapy of experimental murine malaria.
Topics: Animals; Liposomes; Malaria; Male; Mice; Plasmodium berghei; Primaquine | 1979 |
Chloroquine resistance in P. falciparum in Assam State.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; India; In | 1979 |
Comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers.
Topics: Animals; Female; Haplorhini; Lethal Dose 50; Macaca mulatta; Malaria; Male; Mice; Primaquine; Stereo | 1977 |
Synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials.
Topics: Animals; Antimalarials; Haplorhini; Malaria; Mice; Primaquine | 1977 |
Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine.
Topics: Animals; Antimalarials; Haplorhini; Macaca mulatta; Malaria; Mice; Plasmodium berghei; Primaquine | 1978 |
Radical cure of infections with Plasmodium cynomolgi: a function of total 8-aminoquinoline dose.
Topics: Aminoquinolines; Animals; Antimalarials; Blood; Chloroquine; Female; Haplorhini; Macaca mulatta; Mal | 1977 |
[Malaria: 4 case reports with "atypical" symptoms (author's transl)].
Topics: Adult; Chloroquine; Drug Resistance; Enteritis; Female; Humans; Lung; Malaria; Male; Middle Aged; Pr | 1978 |
Malaria in the Solomon Islands.
Topics: DDT; Humans; Malaria; Melanesia; Philately; Primaquine | 1978 |
Treatment of P. falciparum with chloroquine and primaquine in Dharmapuri District, Tamil Nadu.
Topics: Adult; Child; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; | 1975 |
Malaria guidelines: CDC recommended treatment schedules, 1974.
Topics: Antimalarials; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine | 1976 |
A comparison of two different methods for the selection of primaquine resistance in Plasmodium berghei berghei.
Topics: Animals; Drug Resistance; Malaria; Methods; Mice; Plasmodium berghei; Primaquine | 1976 |
Treatment of P. falciparum infection with chloroquine and primaquine in Salem and Sathyamangalam towns of Tamil Nadu.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine | 1976 |
Chemotherapy of Plasmodium vivax in Saimiri and Aotus models.
Topics: Administration, Oral; Animals; Chloroquine; Disease Models, Animal; Drug Combinations; Drug Evaluati | 1975 |
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
Topics: Amodiaquine; Animals; Antimalarials; Dapsone; Disease Models, Animal; Dose-Response Relationship, Dr | 1976 |
The quartan malarial nephrotic syndrome.
Topics: Azathioprine; Capillaries; Child; Child, Preschool; Fluorescent Antibody Technique; Humans; Infant; | 1976 |
Plasmodium ovale malaria in Canada following transfusion.
Topics: Antibodies; Canada; Chloroquine; Female; Humans; Malaria; Middle Aged; Primaquine; Transfusion React | 1977 |
An unusual reaction to chloroquine-primaquine.
Topics: Adult; Chloroquine; Coproporphyrins; Female; Humans; Malaria; Porphyrias; Primaquine; Uroporphyrins | 1976 |
Letter: Unexplained fever.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; P | 1975 |
Rodent systems (Plasmodium berghei-Anopheles Stephensi) for screening compounds for potential causal prophylaxis.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Female; Malaria; Mice; | 1975 |
Letter: Prevention of chloroquine-resistant falciparum malaria.
Topics: Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Malaria; Plasmo | 1975 |
The treatment of malaria.
Topics: Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodiu | 1975 |
[Use of coagulograph H-333 in the diagnosis of drug-induced hemolysis].
Topics: Blood Coagulation Disorders; Blood Coagulation Tests; Hemolysis; Humans; Malaria; Primaquine | 1975 |
[Hemocoagulation disturbances in drug-provoked hemolysis in persons with glucose-6-phosphate dehydrogenase deficiency].
Topics: Adolescent; Adult; Aged; Blood Coagulation; Blood Coagulation Disorders; Child; Drug Evaluation; Fem | 1976 |
Acute intravascular haemolysis in Vanuatu following a single dose of primaquine in individuals with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acute Disease; Adolescent; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemo | 1992 |
[Studies on the tissue schizonticide of malaria parasite: synthesis of 5-trieluoroacetyl-primaquine and its derivatives].
Topics: Aminoquinolines; Animals; Antimalarials; Malaria; Mice; Plasmodium yoelii; Primaquine; Rats | 1992 |
[Studies on the tissue schizonticide of malaria parasite: synthesis of derivatives of 2-substituted phenoxyprimaquine, 4-methylprimaquine and quinoxaline].
Topics: Animals; Antimalarials; Malaria; Mice; Plasmodium yoelii; Primaquine | 1992 |
Susceptibility of Macaca fascicularis monkeys from Mauritius to different species of Plasmodium.
Topics: Animals; Chloroquine; Disease Susceptibility; Drug Therapy, Combination; Macaca fascicularis; Malari | 1992 |
Differential sensitivity of the pre-erythrocytic stages of Plasmodium cynomolgi B to the prophylactic action of primaquine.
Topics: Animals; Drug Administration Schedule; Macaca mulatta; Malaria; Plasmodium cynomolgi; Primaquine | 1992 |
Recurrent plasmodium ovale infection from Papua New Guinea--chloroquine resistance or inadequate primaquine therapy?
Topics: Adult; Humans; Malaria; Male; New Guinea; Primaquine; Recurrence | 1991 |
Drug use and design in the nineties.
Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Hu | 1991 |
[Studies on tissue schizonticide of malaria parasite: synthesis of 2-substituted benzyloxy (or methoxy)-5-substituted phenoxy analogues of primaquine].
Topics: Animals; Antimalarials; Malaria; Mice; Molecular Structure; Plasmodium yoelii; Primaquine | 1991 |
Tissue schizontocidal effect of trifluoroacetyl primaquine in Plasmodium yoelii infected mice and Plasmodium cynomolgi infected monkeys.
Topics: Aminoquinolines; Animals; Antimalarials; Dose-Response Relationship, Drug; Macaca mulatta; Malaria; | 1991 |
Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.
Topics: Adult; Aged; Amodiaquine; Antibodies, Anti-Idiotypic; Chloroquine; Dose-Response Relationship, Immun | 1991 |
[An unusual case of imported malaria].
Topics: Animals; Chloroquine; Female; Humans; Malaria; Middle Aged; Plasmodium; Primaquine; Serologic Tests; | 1991 |
[Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine].
Topics: Aminoquinolines; Animals; Antimalarials; Drug Therapy, Combination; Female; Malaria; Male; Mice; Nap | 1990 |
Experimental studies on combinations of pyronaridine/primaquine versus chloroquine/primaquine.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Napht | 1990 |
Recommendations for the prevention of malaria among travelers.
Topics: Adult; Animals; Antimalarials; Breast Feeding; Centers for Disease Control and Prevention, U.S.; Chi | 1990 |
Committee to advise on tropical medicine and travel (CATMAT).
Topics: Canada; Encephalitis, Japanese; Humans; Malaria; Meningitis, Meningococcal; Primaquine; Public Healt | 1990 |
Recommendations from the Committee to Advise on Tropical Medicine and Travel.
Topics: Canada; Child, Preschool; Contraindications; Encephalitis, Japanese; Humans; Malaria; Meningitis, Me | 1990 |
[Look systematically for malaria in exposed children].
Topics: Adoption; Animals; Child, Preschool; Chloroquine; Emigration and Immigration; Female; Humans; Infant | 1990 |
Radical treatment of vivax malaria in Madhya Pradesh, India.
Topics: Adult; Animals; Child; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium vi | 1990 |
[Clinical evaluation of antimalarial drugs].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Evaluation; Female; Humans; Malaria; Male; Plasmodi | 1990 |
Relapse pattern of Plasmodium vivax in Kheda district, Gujarat.
Topics: Animals; Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium vivax; Primaquin | 1990 |
[Synthesis of 2-methyl-5-substituted phenoxy-primaquine and antimalarials activity].
Topics: Animals; Antimalarials; Malaria; Plasmodium berghei; Plasmodium yoelii; Primaquine; Structure-Activi | 1990 |
Pharmacokinetics of mefloquine in combination with sulfadoxine-pyrimethamine and primaquine in male Thai patients with falciparum malaria.
Topics: Adolescent; Adult; Animals; Drug Resistance; Drug Therapy, Combination; Half-Life; Humans; Malaria; | 1990 |
[A case from practice(196). Malaria].
Topics: Adult; Humans; Malaria; Male; Primaquine | 1990 |
Causal prophylactic activity of a new 8-aminoquinoline derivative against Plasmodium cynomolgi B in rhesus monkeys.
Topics: Animals; Antimalarials; Macaca mulatta; Malaria; Primaquine | 1990 |
Delay in emergence of mefloquine resistance in Plasmodium berghei by use of drug combinations.
Topics: Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Erythromycin; Malaria; | 1989 |
Chloroquine-resistant Plasmodium vivax.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Humans; Malaria; Male; Plasmodium vivax; Primaquine | 1989 |
Chemotherapeutic malaria control operation by single dose of Fansidar plus primaquine in North Sumatra, Indonesia.
Topics: Age Factors; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Humans; Indonesi | 1989 |
Development of a magnetisable solid-phase fluoroimmunoassay for primaquine and carboxyprimaquine.
Topics: Administration, Oral; Adult; Animals; Chemical Phenomena; Chemistry; Fluoroimmunoassay; Humans; Mala | 1989 |
Primaquine induced hemolysis in a Thai soldier.
Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; | 1989 |
Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys.
Topics: Aminoquinolines; Animals; Antimalarials; Drug Evaluation, Preclinical; Macaca mulatta; Malaria; Mole | 1989 |
Low response of Colombian strains of Plasmodium vivax to classical antimalarial therapy.
Topics: Adult; Aged; Amodiaquine; Animals; Chloroquine; Colombia; Drug Resistance; Drug Therapy, Combination | 1989 |
Efficacy of 5 day radical treatment of primaquine in Plasmodium vivax cases at the BHEL industrial complex, Hardwar (U.P.).
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Chloroquine; Female; Humans; Infant; Malaria; M | 1989 |
Gametocytocidal and sporontocidal activity of some standard antimalarials on P. berghei (NK 65) infection M. natalensis.
Topics: Animals; Disease Models, Animal; Female; Malaria; Muridae; Plasmodium berghei; Primaquine; Pyrimetha | 1989 |
Gametocytocidal effect of primaquine in a chemotherapeutic malaria control trial in North Sumatra, Indonesia.
Topics: Animals; Drug Resistance; Drug Therapy, Combination; Humans; Indonesia; Malaria; Parasite Egg Count; | 1989 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
Effects of antimalarial drugs on oxygen consumption by erythrocytes infected with Plasmodium berghei: an ESR study.
Topics: Animals; Antimalarials; Depression, Chemical; Electron Spin Resonance Spectroscopy; Erythrocytes; Ma | 1986 |
Swellengrebel lecture. Hypnozoites and 'relapses' in Plasmodium vivax and in vivax-like malaria.
Topics: Animals; History, 19th Century; History, 20th Century; Humans; Liver; Malaria; Pan troglodytes; Plas | 1988 |
Hypnozoites in Bradford.
Topics: Animals; Child, Preschool; Chloroquine; England; Fever; Humans; Infant, Newborn; Malaria; Male; Plas | 1988 |
[Combined use of artemether with other antimalarials in the treatment of falciparum malaria].
Topics: Adolescent; Adult; Artemether; Artemisinins; Child; Child, Preschool; Drug Therapy, Combination; Hum | 1987 |
[Development of a qinghaosu-resistant line of Plasmodium berghei ANKA and N strain].
Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Drug Resistance, Microbia | 1986 |
Seven patients with relapses of Plasmodium vivax or P. ovale despite primaquine treatment.
Topics: Adult; Female; Humans; Infant; Malaria; Male; Patient Compliance; Plasmodium; Plasmodium vivax; Prim | 1987 |
Clinical evaluation of antimalarial regimens in Japan.
Topics: Animals; Antimalarials; Chloroquine; Drug Therapy, Combination; Humans; Japan; Malaria; Plasmodium f | 1987 |
[Toxicity and tissue schizontocidal activity of primaquine combined with pyronaridine in laboratory animals].
Topics: Animals; Antimalarials; Drug Therapy, Combination; Macaca mulatta; Malaria; Mice; Naphthyridines; Pl | 1988 |
Clinical pharmacology looks at tropical medicine.
Topics: Amodiaquine; Anthelmintics; Antimalarials; Chloroquine; Diethylcarbamazine; Filariasis; Filaricides; | 1987 |
Observations on early and late post-sporozoite tissue stages in primate malaria. IV. Pre-erythrocytic schizonts and/or hypnozoites of Chesson and North Korean strains of Plasmodium vivax in the chimpanzee.
Topics: Animals; Anopheles; Aotus trivirgatus; Chloroquine; Humans; Kinetics; Liver; Malaria; Pan troglodyte | 1986 |
Polyresistant malaria in Gurkha soldiers returning from Papua New Guinea: treatment and prevention.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Ethnicity; Hong Kong; Humans; Malaria; Male; | 1986 |
Health education and community participation in mass drug administration for malaria in Nicaragua.
Topics: Advertising; Antimalarials; Chloroquine; Female; Health Education; History, 20th Century; Humans; Ma | 1986 |
Erythrocytic glucose-6-phosphate dehydrogenase deficiency and its significance with special emphasis on malaria.
Topics: Child; Child, Preschool; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehy | 1986 |
[Experimental studies on the biological characteristics of Plasmodium vivax in south Yunnan].
Topics: Animals; Anopheles; China; Chloroquine; Humans; Malaria; Plasmodium vivax; Primaquine; Recurrence | 1986 |
Pharmacokinetics of primaquine in patients with P. vivax malaria.
Topics: Adolescent; Adult; Biological Availability; Biotransformation; Humans; Kinetics; Malaria; Male; Plas | 1986 |
Antimalarial activity and inhibition of monoamine oxidases A and B by exo-erythrocytic antimalarials. Optical isomers of primaquine, N-acylated congeners, primaquine metabolites and 5-phenoxy-substituted analogues.
Topics: Animals; Antimalarials; In Vitro Techniques; Malaria; Monoamine Oxidase Inhibitors; Plasmodium; Prim | 1987 |
Tissue schizontocidal activity of minocycline against a relapsing malaria parasite Plasmodium cynomolgi B.
Topics: Animals; Female; Macaca mulatta; Malaria; Male; Minocycline; Plasmodium; Primaquine; Recurrence; Tet | 1987 |
The effect of malaria infection on primaquine elimination in the isolated perfused rat liver.
Topics: Animals; In Vitro Techniques; Kinetics; Liver; Malaria; Perfusion; Primaquine; Rats; Rats, Inbred St | 1987 |
Plasmodium vivax malaria in children.
Topics: Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria; Plasmodium vivax; P | 1985 |
Enhancement of the curative activity of primaquine by concomitant administration of mirincamycin.
Topics: Animals; Antimalarials; Chloroquine; Clindamycin; Drug Therapy, Combination; Female; Macaca mulatta; | 1985 |
Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells.
Topics: Amines; Animals; Cell Line; Chloroquine; Humans; Liver; Lysosomes; Malaria; Plasmodium berghei; Prim | 1985 |
Malaria.
Topics: Adult; Fever of Unknown Origin; Humans; Malaria; Male; Plasmodium vivax; Primaquine | 1985 |
[The combined use of artemether, sulfadoxine, pyrimethamine and primaquine in the treatment of chloroquine-resistant falciparum malaria].
Topics: Adult; Animals; Antimalarials; Artemether; Artemisinins; Child; Chloroquine; Drug Resistance, Microb | 1985 |
[Preliminary use of delimiting the boundry of endemic foci and eliminating their source in the prevention and treatment of malaria].
Topics: China; Chloroquine; Disease Reservoirs; Humans; Malaria; Plasmodium vivax; Primaquine; Retrospective | 1985 |
Mass drug administration in Andhra Pradesh in areas under Plasmodium falciparum containment programme.
Topics: Chloroquine; Drug Therapy, Combination; Humans; India; Malaria; Plasmodium falciparum; Primaquine; R | 1985 |
[Sensitivity of Plasmodium falciparum to piperaquine in Baoting County, Hainan Island].
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; China; Drug Synergism; Gametogenesis; Hum | 1985 |
Mixed malarial infection due to Plasmodium falciparum and P vivax.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Plasmo | 1985 |
Mixed malarial infection due to Plasmodium falciparum and P vivax.
Topics: Adult; Drug Resistance, Microbial; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; P | 1985 |
Activities of the tetrahydrofuran derivative, BA-41,799, against Plasmodium cynomolgi infections in rhesus monkeys.
Topics: Animals; Antimalarials; Furans; Macaca mulatta; Malaria; Male; Primaquine; Time Factors | 1985 |
Shaking chills and fever.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Male; Plasmodium; Primaquine | 1985 |
Chloroquine dosage for prevention of malaria mortality and the use of primaquine to slow down the spread of resistance.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Primaquine | 1985 |
Induced malaria in narcotic addicts.
Topics: Adult; Animals; Anopheles; California; Chloroquine; Disease Reservoirs; Disease Vectors; Heroin; Hum | 1971 |
Choroquine-resistant Plasmodium falciparum malaria in the United Kingdom.
Topics: Adult; Chloroquine; England; Humans; Malaria; Malaysia; Male; Penicillin Resistance; Penicillins; Pl | 1968 |
Drug-resistant malaria.
Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine | 1969 |
Experience with mixed infections of Plasmodium falciparum and vivax.
Topics: Antimalarials; Chloroquine; Dapsone; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plas | 1973 |
Gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. I. Effect of single and multiple doses of primaquine on Plasmodium cynomolgi.
Topics: Administration, Oral; Animals; Anopheles; Blood; Feeding Behavior; Haplorhini; Macaca; Malaria; Plas | 1973 |
Activity and some properties of an acid proteinase from normal and Plasmodium berghei-infected red cells.
Topics: Acid Phosphatase; Animals; Cell-Free System; Chloroquine; Dithiothreitol; Edetic Acid; Erythrocytes; | 1973 |
Accidental human infection with Plasmodium cynomolgi bastianellii.
Topics: Adult; Animals; Anopheles; Chloroquine; Environmental Exposure; Female; Haplorhini; Humans; Insect V | 1973 |
[Prevention and treatment of malaria. 1. Analysis of 73 cases of malaria in Japan].
Topics: Adult; Chloroquine; Humans; Japan; Malaria; Middle Aged; Primaquine; Quinine | 1973 |
Improved therapy for Vietnam acquired vivax malaria.
Topics: Chloroquine; Drug Therapy, Combination; Humans; Malaria; Male; Military Medicine; Plasmodium vivax; | 1974 |
Malaria in rural Malaya.
Topics: Child; Humans; Malaria; Malaysia; Primaquine; Rural Population | 1970 |
[Mass treatment with pyrimethamine and primaquine for malaria eradication in Sambú, Panama].
Topics: Humans; Malaria; Panama; Primaquine; Pyrimethamine | 1971 |
[Attempt at preventing the hemolytic action of primaquine in persons with a gluose-6-phosphate dehydrogenase activity deficit in the erythrocytes by the simultaneous administration of xylitol and riboflavin].
Topics: Adolescent; Adult; Azerbaijan; Child; Drug Therapy, Combination; Erythrocytes; Glucosephosphate Dehy | 1973 |
Cytochrome oxidase activity in a normal and some drug-resistant strains of Plasmodium berghei--a cytochemical study. I. Asexual erythrocytic stages.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Electron Transport Complex IV; Erythrocytes; Histo | 1969 |
Letter: Malaria in Birmingham 1968-73.
Topics: Humans; Malaria; Primaquine; Time Factors; United Kingdom | 1974 |
Mass drug administration as a supplementary attack measure in malaria eradication programme.
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Combinations; Humans; Indian Oce | 1974 |
Malaria in laos. 3. Primaquine sensitivity of the Laotians and the Japanese.
Topics: Asian People; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; | 1972 |
The chemoprophylactic use of diformyl diaminodiphenyl sulfone (DFD) in falciparum malaria.
Topics: Adult; Anopheles; Antimalarials; Blood Cell Count; Chloroquine; Dapsone; Drug Resistance, Microbial; | 1972 |
Malaria--again a diagnostic consideration.
Topics: Chloroquine; Diagnosis, Differential; Erythrocytes; Humans; Malaria; Plasmodium falciparum; Plasmodi | 1972 |
Malaria.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Fluorescent Antibody Technique; Humans; Immu | 1972 |
Response of drug-resistant Plasmodium falciparum to combined therapy in Panama.
Topics: Adult; Amodiaquine; Child; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Malaria; Panama; | 1972 |
The haemolytic effect of a single dose of 45 mg of primaquine in G-6-PD deficient Thais.
Topics: Adolescent; Adult; Erythrocyte Count; Glucosephosphate Dehydrogenase Deficiency; Haptoglobins; Hemat | 1972 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Malaria.
Topics: Adult; Animals; Antigen-Antibody Complex; Chloroquine; Disease Vectors; Female; Humans; Malaria; Pla | 1973 |
Relapses of vivax malaria after a conventional course of primaquine and chloroquine: report of 2 cases.
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; | 1973 |
Ferrokinetics in patients with malaria: normoblasts and iron incorporation in vitro.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Count; Cells, Cultured; Chloroquine; Erythro | 1973 |
Five day primaquine therapy--an evaluation of radical curative activity against vivax malaria infection.
Topics: Chloroquine; Evaluation Studies as Topic; Humans; India; Malaria; Male; Pakistan; Plasmodium vivax; | 1973 |
[Letter: Treatment of malaria].
Topics: Antimalarials; Humans; Malaria; Plasmodium vivax; Primaquine | 1973 |
Letter: Transfusion-induced malaria.
Topics: Antimalarials; Blood Transfusion; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaqui | 1973 |
Malaria in New York City. IV. 1960-1971.
Topics: Adolescent; Adult; Africa, Western; Age Factors; Amodiaquine; Child; Child, Preschool; Chloroquine; | 1974 |
The chemotherapy and prophylaxis of malaria.
Topics: Adolescent; Adult; Amodiaquine; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Fe | 1973 |
A survey of imported malaria in Western Australia including four cases of drug resistance.
Topics: Adolescent; Adult; Australia; Brain Diseases; Chloroquine; Drug Resistance, Microbial; Emigration an | 1974 |
Malaria in Birmingham 1968-73.
Topics: Adult; Africa; Asia; Chloroquinolinols; Disseminated Intravascular Coagulation; England; Female; Hum | 1974 |
Chemoprophylaxis of malaria for travelers.
Topics: Africa; Antimalarials; Asia; Central America; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug | 1974 |
Considerations on the use of sulphones and sulphonamides with a pyrimidine derivative.
Topics: Adult; Amodiaquine; Child; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; | 1974 |
Suspected chloroquine-resistant P. falciparum in Indonesia: A case report.
Topics: Adult; Chloroquine; Drug Resistance, Microbial; Female; Humans; Indonesia; Malaria; Plasmodium falci | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falcipa | 1974 |
Imported malaria.
Topics: Animals; DDT; Emigration and Immigration; Humans; Korea; Malaria; Military Personnel; Plasmodium fal | 1974 |
Treatment and complications of vivax malaria in Vietnam.
Topics: Anemia; Chloroquine; Humans; Malaria; Military Medicine; Plasmodium vivax; Primaquine; United States | 1972 |
Studies on the characterization of plasmodium vivax strains from Central America.
Topics: Animals; Central America; Chloroquine; Haplorhini; Humans; Lincomycin; Malaria; Plasmodium vivax; Pr | 1972 |
Treating the traveler. A brief guide to emporiatrics.
Topics: Cholera; Cholera Vaccines; Counseling; Diarrhea; Gastroenteritis; Hepatitis A; Humans; Immunization; | 1973 |
[Letter: Primary long latency in malaria].
Topics: Chloroquine; Malaria; Primaquine; Recurrence; Time Factors | 1973 |
Letter: Primaquine in treatment of malaria.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Malaria; Primaquine; Transfusion Reaction; Unite | 1974 |
Effects of pyrimethamine, chlorguanide, and primaquine against exoerythrocytic forms of a strain of chloroquine-resistant Plasmodium falciparum from Thailand.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Primaquine; Proguanil | 1967 |
Cure of vivax malaria.
Topics: Chloroquine; Humans; Malaria; Plasmodium vivax; Primaquine | 1968 |
The sporogonous of Plasmodium vivax in Anopheles mosquitoes as a system for evaluating the prophylactic and curative capabilities of potential antimalarial compounds.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Naphthoquinones; Oxytetracycline; Penicilli | 1968 |
Chloroquine resistance in Plasmodium falciparum malaria on the Pacific coast of Colombia.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Chloroquine; Colombia; Drug Resistanc | 1968 |
A clinical view of the biology of Plasmodia.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Plasmodium falc | 1969 |
Acute falciparum malaria. Field experience with quinine-pyrimethamine combined therapy.
Topics: Chloroquine; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Primaquine | 1969 |
Malaria in American soldiers.
Topics: Anemia, Hemolytic; Blood Cell Count; Carrier State; Chloroquine; Hematocrit; Hemoglobinometry; Hepat | 1969 |
Vietnam malaria. Clinical experience with 50 patients.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Primaquine; Quin | 1970 |
Malaria in soldiers returning from Vietnam. Epidemiologic, therapeutic, and clinical studies.
Topics: Adult; Black or African American; Black People; Chloroquine; Chronic Disease; Hospitalization; Human | 1970 |
Fluorescent-antibody patterns in naturally acquired vivax malaria.
Topics: Chloroquine; Fluorescent Antibody Technique; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Pr | 1970 |
[The quantitative analysis of effects of exogenous and endogenous factors on sporozoites and tissue forms of malaria in small animals (Plasmodium cathemerium, P. berghei yoelii)].
Topics: Animals; Canaries; Female; Malaria; Malaria, Avian; Mice; Plasmodium malariae; Primaquine | 1970 |
Gametocytemia in falciparum malaria. Eradication of gametocytemia with primaquine.
Topics: Adolescent; Adult; Animals; Anopheles; Disease Vectors; Humans; Malaria; Male; Plasmodium falciparum | 1971 |
[Results of radical therapy in cases of tertian malaria in persons returning from the tropics].
Topics: Adult; Chloroquine; Drug Synergism; Humans; Malaria; Male; Middle Aged; Plasmodium vivax; Primaquine | 1970 |
The reappearance of malaria in the USA.
Topics: Blood Donors; Chloroquine; Disease Reservoirs; Drug Resistance, Microbial; Humans; Malaria; Plasmodi | 1970 |
Eradication of gametocytes to prevent introduction of falciparum malaria.
Topics: Chloroquine; Female; Genetics, Microbial; Humans; Malaria; Male; Ovum; Plasmodium falciparum; Primaq | 1971 |
Gametocytemia in falciparum malaria.
Topics: Humans; Malaria; Plasmodium falciparum; Primaquine | 1971 |
An Australian experience with malaria.
Topics: Australia; Chloroquine; Humans; Malaria; Malaysia; Military Personnel; New Guinea; Plasmodium vivax; | 1971 |
Plasmodium vivax from Vietnam. Response to chloroquine-primaquine.
Topics: Administration, Oral; Chloroquine; Humans; Malaria; Male; Plasmodium vivax; Primaquine; Vietnam | 1971 |
Malaria revisited.
Topics: Chloroquine; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Primaquine | 1971 |
Chloroquine-resistant Plasmodium falciparum: protective and hemolytic effects of 4,4'-diaminodiphenylsulfone (DDS) administered daily together with weekly chloroquine and primaquine.
Topics: Adult; Black or African American; Chloroquine; Dapsone; Hemolysis; Humans; Malaria; Male; Plasmodium | 1967 |
The army malaria research program.
Topics: Animals; Drug Resistance, Microbial; Haplorhini; Humans; Malaria; Military Medicine; Plasmodium falc | 1969 |
Malaria research at the National Institute of Allergy and Infectious Diseases.
Topics: Animals; Chloroquine; Disease Models, Animal; Haplorhini; Humans; Malaria; National Institutes of He | 1969 |
Morphological effects of 8-aminoquinolines on the exoerythrocytic stages of Plasmodium fallax.
Topics: Animals; Culture Techniques; Malaria; Microbial Sensitivity Tests; Microscopy, Electron; Plasmodium; | 1969 |
[Chemotherapeutic activity of standard antimalarials in a simplified test for Plasmodium vinckey infection in the NMPI mouse].
Topics: Animals; Antimalarials; Chloroquine; Long-Term Care; Malaria; Mice; Plasmodium; Primaquine; Pyrimeth | 1970 |
[Causal preventive activity of standard antimalarials in rodent malaria (Plasmodium berghei yoelii)].
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Mice; Mice, Inbred Strains; Plasmodium; Pri | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaqui | 1972 |
The chemotherapy of rodent malaria. XIV. The action of some sulphonamides alone or with folic reductase inhibitors against malaria vectors and parasites. 4. The response of normal and drug-resistant strains of Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Malaria; Male; Mice; Prima | 1971 |
The chemotherapy of rodent malaira. XV. Fine-structural studies on the sporogonic stages of Plasmodium berghei following exposure to primaquine.
Topics: Animals; Anopheles; Cytoplasm; Malaria; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Mito | 1971 |
Chronic ill-health from unrecognized malaria.
Topics: Adult; Africa, Eastern; Arrhythmias, Cardiac; Chronic Disease; Female; Fluorescent Antibody Techniqu | 1965 |
Vivax malaria complicated by aphasia and hemiparesis.
Topics: Adult; Aphasia; Body Temperature; Cerebrovascular Disorders; Chloroquine; Hematocrit; Hemiplegia; Hu | 1963 |
Imported falciparum malaria with inadequate response to chloroquine.
Topics: Adult; Ambulatory Care; Chloroquine; Communicable Disease Control; Humans; Japan; Malaria; Male; Pla | 1966 |
[Symptomatology, diagnosis and therapy of malaria].
Topics: Chloroquine; Diagnosis, Differential; Erythrocytes; Humans; Malaria; Plasmodium; Primaquine; Quinine | 1969 |
Plasmodium vinckei: production of chloroquine-resistant strain.
Topics: Animals; Antimalarials; Arsenicals; Chloroquine; Cytoplasm; Drug Resistance, Microbial; Malaria; Met | 1969 |
Plasmodium fallax: high-resolution autoradiography of exoerythrocytic stages treated with Primaquine in vitro.
Topics: Animals; Autoradiography; Culture Techniques; Malaria; Microscopy, Electron; Mitochondria; Mitochond | 1970 |
Relapse after standard treatment of malaria.
Topics: Adult; Chloroquine; Chronic Disease; Humans; Malaria; Male; Primaquine | 1970 |
Drug sensitivity of exoerythrocytic stages of rodent malaria parasites.
Topics: Animals; Malaria; Plasmodium; Primaquine; Proguanil; Rats | 1970 |
Single step production of pyrimethamine-resistant P. berghei.
Topics: Animals; Cricetinae; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium; Primaquine; Pyrime | 1970 |
Drug sensitivity of exo-erythrocytic stages in pyrimethamine-resistant Plasmodium berghei.
Topics: Animals; Antimalarials; Drug Resistance, Microbial; Malaria; Male; Mice; Microbial Sensitivity Tests | 1970 |
The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Malaria; Male; Mice; Plasmodium; Primaquine; Proguanil | 1970 |
[New 6-aminoquinolines with antimalarial activity. Test results on schizontocidal and causalprophylactic effects in rodent- and avian malaria (Plasmodium vinckei, P. berghei and P. cathemerium)].
Topics: Amines; Animals; Antimalarials; Canaries; Chloroquine; Drug Resistance, Microbial; Injections, Intra | 1970 |
Scope and limitations of pharmacogenetics.
Topics: Animals; Barbiturates; Cholinesterases; Dextrans; Favism; Genes; Genetics; Genetics, Medical; Glucos | 1968 |
Primaquine-induced changes in morphology of exoerythrocytic stages of malaria.
Topics: Animals; Brain; Culture Techniques; Erythrocytes; Malaria; Microscopy, Electron; Mitochondria; Plasm | 1968 |
[Management of acute malaria].
Topics: Amodiaquine; Antimalarials; Chloroquine; Humans; Injections, Intramuscular; Malaria; Primaquine; Tro | 1968 |
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.
Topics: Antimalarials; Chloroquine; Cyanosis; Dapsone; Diseases in Twins; Erythrocytes; Female; Hematocrit; | 1968 |
Characteristics and cross-resistance patterns of chloroquine-resistant Plasmodium berghei infections in mice.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Female; Hemat | 1968 |
The chemotherapy of rodent malaria. IV. Host-parasite relationships. 4. The relationship between haemozoin formation and host-cell age in chloroquine- and primaquine-resistant strains of Plasmodiun berghei.
Topics: Animals; Chloroquine; Cytoplasm; Drug Resistance, Microbial; Erythrocyte Aging; Hemoglobins; Malaria | 1968 |
The chemotherapy of rodent malaria. V. Dynamics of drug resistance. I. Methods for studying the acquisition and loss of resistance to chloroquine by Plasmodiun berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Erythrocytes; Malaria; Male; Methods; Mice; Plasmo | 1968 |
Causal prophylactic effect of Menoctone (a new hydroxynaphthoquinone) against sporozoite-induced Plasmodium berghei infection in mice.
Topics: Animals; Antimalarials; Chloroquine; Cricetinae; Malaria; Mice; Naphthoquinones; Plasmodium; Primaqu | 1968 |
The Plasmodium chabaudi-mouse system in chemotherapy studies.
Topics: Animals; Antimalarials; Chloroquine; Injections, Intravenous; Malaria; Male; Mice; Plasmodium; Prima | 1969 |
Repository drugs. 8. Ester and amide congeners of amodiaquine, hydroxychloroquine, oxychloroquine, primaquine, quinacrine, and related substances as potential long-acting antimalarial agents.
Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Delayed-Action Preparations; Est | 1969 |
Malaria imported to the United States from Vietnam. Chemoprophylaxis evaluated in returning soldiers.
Topics: Adult; Attitude to Health; Chloroquine; Humans; Malaria; Male; Military Medicine; Primaquine; United | 1969 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. II. Triazine resistance.
Topics: Animals; Dapsone; In Vitro Techniques; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethami | 1965 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrime | 1965 |
Transfusion malaria. Seven affected infants.
Topics: Chloroquine; Female; Greece; Humans; Iatrogenic Disease; Infant; Malaria; Male; Primaquine; Transfus | 1966 |
Anaemia in pregnancy associated with "big spleen disease".
Topics: Adolescent; Adult; Anemia, Hypochromic; Chloroquine; Female; Humans; Liver; Malaria; Pregnancy; Preg | 1966 |
An assessment of the sporozoite inoculation rate as a measure of malaria transmission in the Ubembe area of North-east Tanzania.
Topics: Animals; Anopheles; Child; Child, Preschool; Chloroquine; Humans; Hyperthermia, Induced; Malaria; Pr | 1966 |