primaquine has been researched along with Liver Neoplasms in 13 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Liver Neoplasms: Tumors or cancer of the LIVER.
Excerpt | Relevance | Reference |
---|---|---|
" The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
" The dose-response characteristics of the effect of primaquine on receptor recycling are identical to those of the effects on protein secretion and virus budding." | 1.27 | Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. ( Du Maine, A; Schwartz, AL; Slot, JW; Strous, GJ; Zijderhand-Bleekemolen, JE, 1985) |
"primaquine, inhibit acidification and iron release from transferrin." | 1.27 | Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells. ( Wu, CH; Wu, GY, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (69.23) | 18.7374 |
1990's | 4 (30.77) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Schwartz, AL | 7 |
Bolognesi, A | 1 |
Fridovich, SE | 1 |
Underhill, DM | 1 |
Owensby, DA | 1 |
Morton, PA | 1 |
el-Mofty, MM | 1 |
Khudoley, VV | 1 |
Sakr, SA | 1 |
Abdel-Gawad, HS | 1 |
Reif, JS | 1 |
Fallon, RJ | 1 |
Bates, MD | 1 |
Meshnick, SR | 1 |
Sigler, CI | 1 |
Leland, P | 1 |
Hollingdale, MR | 2 |
van den Bosch, RA | 1 |
du Maine, AP | 1 |
Geuze, HJ | 4 |
van der Ende, A | 1 |
Strous, GJ | 5 |
van Kerkhof, P | 1 |
van Bokhoven, A | 1 |
de Pont, JJ | 1 |
Slot, JW | 4 |
McCann, PP | 1 |
Sjoerdsma, A | 1 |
Du Maine, A | 1 |
Zijderhand-Bleekemolen, JE | 2 |
Wu, GY | 1 |
Wu, CH | 1 |
Braulke, T | 1 |
Hasilik, A | 1 |
von Figura, K | 1 |
13 other studies available for primaquine and Liver Neoplasms
Article | Year |
---|---|
Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran | 1984 |
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis | 1992 |
The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
Topics: Animals; Antimalarials; Bufonidae; Chloroquine; Disease Models, Animal; Drug Combinations; Female; K | 1992 |
Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells.
Topics: alpha-Fetoproteins; Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cel | 1991 |
In vitro effects of primaquine and primaquine metabolites on exoerythrocytic stages of Plasmodium berghei.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Infant, Newborn; Liver Neoplasms; Oxidation-Reduction; P | 1990 |
Recycling of 5'-nucleotidase in a rat hepatoma cell line.
Topics: 5'-Nucleotidase; Animals; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Golgi Apparatus; Immun | 1988 |
Effect of primaquine on the topology of Na,K-ATPase and the receptor for asialoglycoproteins.
Topics: Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cell Line; Humans; Liver Neoplasms; Primaqui | 1988 |
Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells.
Topics: Antibodies; Carcinoma, Hepatocellular; Cell Line; Endocytosis; Golgi Apparatus; Humans; Liver Neopla | 1985 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells.
Topics: Asialoglycoprotein Receptor; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Cel | 1985 |
Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line; Humans; Iron; Kinetics; Liver Neoplasms; | 1986 |
Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran | 1987 |
On the effects of weak bases and monensin on sorting and processing of lysosomal enzymes in human cells.
Topics: Ammonium Chloride; Carcinoma, Hepatocellular; Cathepsin D; Cell Line; Chloroquine; Fibroblasts; Huma | 1987 |