Page last updated: 2024-11-03

primaquine and Liver Neoplasms

primaquine has been researched along with Liver Neoplasms in 13 studies

Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
" The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester."3.67Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985)
" The dose-response characteristics of the effect of primaquine on receptor recycling are identical to those of the effects on protein secretion and virus budding."1.27Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. ( Du Maine, A; Schwartz, AL; Slot, JW; Strous, GJ; Zijderhand-Bleekemolen, JE, 1985)
"primaquine, inhibit acidification and iron release from transferrin."1.27Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells. ( Wu, CH; Wu, GY, 1986)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's4 (30.77)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schwartz, AL7
Bolognesi, A1
Fridovich, SE1
Underhill, DM1
Owensby, DA1
Morton, PA1
el-Mofty, MM1
Khudoley, VV1
Sakr, SA1
Abdel-Gawad, HS1
Reif, JS1
Fallon, RJ1
Bates, MD1
Meshnick, SR1
Sigler, CI1
Leland, P1
Hollingdale, MR2
van den Bosch, RA1
du Maine, AP1
Geuze, HJ4
van der Ende, A1
Strous, GJ5
van Kerkhof, P1
van Bokhoven, A1
de Pont, JJ1
Slot, JW4
McCann, PP1
Sjoerdsma, A1
Du Maine, A1
Zijderhand-Bleekemolen, JE2
Wu, GY1
Wu, CH1
Braulke, T1
Hasilik, A1
von Figura, K1

Other Studies

13 other studies available for primaquine and Liver Neoplasms

ArticleYear
Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells.
    The Journal of cell biology, 1984, Volume: 98, Issue:2

    Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran

1984
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
    Blood, 1992, Dec-01, Volume: 80, Issue:11

    Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis

1992
The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
    Nutrition and cancer, 1992, Volume: 18, Issue:2

    Topics: Animals; Antimalarials; Bufonidae; Chloroquine; Disease Models, Animal; Drug Combinations; Female; K

1992
Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells.
    Experimental cell research, 1991, Volume: 192, Issue:2

    Topics: alpha-Fetoproteins; Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cel

1991
In vitro effects of primaquine and primaquine metabolites on exoerythrocytic stages of Plasmodium berghei.
    The American journal of tropical medicine and hygiene, 1990, Volume: 42, Issue:6

    Topics: Animals; Carcinoma, Hepatocellular; Humans; Infant, Newborn; Liver Neoplasms; Oxidation-Reduction; P

1990
Recycling of 5'-nucleotidase in a rat hepatoma cell line.
    The EMBO journal, 1988, Volume: 7, Issue:11

    Topics: 5'-Nucleotidase; Animals; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Golgi Apparatus; Immun

1988
Effect of primaquine on the topology of Na,K-ATPase and the receptor for asialoglycoproteins.
    Progress in clinical and biological research, 1988, Volume: 268B

    Topics: Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cell Line; Humans; Liver Neoplasms; Primaqui

1988
Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells.
    The EMBO journal, 1985, Volume: 4, Issue:4

    Topics: Antibodies; Carcinoma, Hepatocellular; Cell Line; Endocytosis; Golgi Apparatus; Humans; Liver Neopla

1985
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
    Experimental parasitology, 1985, Volume: 60, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms;

1985
Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells.
    The Journal of cell biology, 1985, Volume: 101, Issue:2

    Topics: Asialoglycoprotein Receptor; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Cel

1985
Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells.
    The Journal of biological chemistry, 1986, Dec-25, Volume: 261, Issue:36

    Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line; Humans; Iron; Kinetics; Liver Neoplasms;

1986
Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.
    The Journal of cell biology, 1987, Volume: 104, Issue:6

    Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran

1987
On the effects of weak bases and monensin on sorting and processing of lysosomal enzymes in human cells.
    European journal of cell biology, 1987, Volume: 43, Issue:3

    Topics: Ammonium Chloride; Carcinoma, Hepatocellular; Cathepsin D; Cell Line; Chloroquine; Fibroblasts; Huma

1987