primaquine has been researched along with Hemoglobinuria in 4 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Hemoglobinuria: The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients with uncomplicated falciparum malaria, G6PD activity of ≥70% of the adjusted male median (AMM) and haemoglobin levels ≥8g/dl are recruited into the study and randomized to either receive standard schizonticidal treatment plus 7-day high dose primaquine (total dose 7mg/kg) or standard care in a 1:1 ratio." | 5.51 | Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA). ( Abate, DT; Alam, MS; Anose, RT; Baird, K; Christian, M; Degaga, TS; Hailu, A; Hossain, MS; Karahalios, A; Kibria, MG; Kidane, FG; Lee, G; Ley, B; Mnjala, H; Price, RN; Rajasekhar, M; Rumaseb, A; Simpson, JA; Sutanto, I; Tego, TT; Thriemer, K; Weston, S; Woyessa, A, 2022) |
| "Myoglobinuria was also observed following the 7." | 1.35 | Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511). ( Armstrong, K; Baskin, S; Briscoe, C; Duniho, S; Gold, M; Kahler, D; Moran, A; Rockwood, G, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thriemer, K | 2 |
| Degaga, TS | 1 |
| Christian, M | 1 |
| Alam, MS | 2 |
| Ley, B | 2 |
| Hossain, MS | 1 |
| Kibria, MG | 2 |
| Tego, TT | 1 |
| Abate, DT | 1 |
| Weston, S | 1 |
| Karahalios, A | 1 |
| Rajasekhar, M | 1 |
| Simpson, JA | 1 |
| Rumaseb, A | 1 |
| Mnjala, H | 1 |
| Lee, G | 1 |
| Anose, RT | 1 |
| Kidane, FG | 1 |
| Woyessa, A | 1 |
| Baird, K | 1 |
| Sutanto, I | 1 |
| Hailu, A | 1 |
| Price, RN | 1 |
| Phru, CS | 1 |
| Chowdhury, MU | 1 |
| Jahan, N | 1 |
| Aktaruzzaman, MM | 1 |
| Rahmat, H | 1 |
| Satyagraha, AW | 1 |
| Prue, AS | 1 |
| Khan, WA | 1 |
| Rockwood, G | 1 |
| Duniho, S | 1 |
| Briscoe, C | 1 |
| Gold, M | 1 |
| Armstrong, K | 1 |
| Kahler, D | 1 |
| Moran, A | 1 |
| Baskin, S | 1 |
| BARNARD, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas - a Randomized Controlled Trial[NCT03916003] | Phase 4 | 500 participants (Actual) | Interventional | 2019-08-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for primaquine and Hemoglobinuria
| Article | Year |
|---|---|
ENZYME DEFECTS IN THE HUMAN RED CELL.
Topics: Anemia; Blood Protein Disorders; Drug Therapy; Enzymes; Erythrocytes; Favism; Hemoglobinuria; Hemogl | 1964 |
1 trial available for primaquine and Hemoglobinuria
| Article | Year |
|---|---|
Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA).
Topics: Antimalarials; Hemoglobinuria; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Plasmodiu | 2022 |
2 other studies available for primaquine and Hemoglobinuria
| Article | Year |
|---|---|
Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh.
Topics: Antimalarials; Blood Transfusion; Child; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hem | 2020 |
Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).
Topics: Animals; Antimalarials; Female; Hemoglobinuria; Immobilization; Kidney; Liver; Lung; Macaca mulatta; | 2008 |