primaquine has been researched along with Hematologic Diseases in 5 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Hematologic Diseases: Disorders of the blood and blood forming tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp." | 1.31 | Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline. ( Bolchoz, LJ; Budinsky, RA; Jollow, DJ; McMillan, DC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Setyadi, A | 1 |
| Arguni, E | 1 |
| Kenangalem, E | 1 |
| Hasanuddin, A | 1 |
| Lampah, DA | 1 |
| Thriemer, K | 1 |
| Anstey, NM | 1 |
| Sugiarto, P | 1 |
| Simpson, JA | 1 |
| Price, RN | 1 |
| Douglas, NM | 1 |
| Poespoprodjo, JR | 1 |
| Tingle, MD | 1 |
| Park, BK | 1 |
| Safrin, S | 1 |
| Finkelstein, DM | 1 |
| Feinberg, J | 1 |
| Frame, P | 1 |
| Simpson, G | 1 |
| Wu, A | 1 |
| Cheung, T | 1 |
| Soeiro, R | 1 |
| Hojczyk, P | 1 |
| Black, JR | 1 |
| Barber, BA | 1 |
| Pegram, PS | 1 |
| High, KP | 1 |
| Bolchoz, LJ | 1 |
| Budinsky, RA | 1 |
| McMillan, DC | 1 |
| Jollow, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Trimethoprim / Sulfamethoxazole in the Treatment of Mild-to-Moderate PCP in Patients With AIDS[NCT00000640] | Phase 3 | 290 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for primaquine and Hematologic Diseases
| Article | Year |
|---|---|
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Dapsone; Double-Blind Met | 1996 |
4 other studies available for primaquine and Hematologic Diseases
| Article | Year |
|---|---|
Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia.
Topics: Antimalarials; Female; Hematologic Diseases; Hemolysis; Humans; Indonesia; Infant; Infant, Newborn; | 2019 |
The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasias.
Topics: Animals; Dapsone; Drug-Related Side Effects and Adverse Reactions; Erythrocyte Count; Hematologic Di | 1993 |
Clindamycin/primaquine as prophylaxis for Pneumocystis carinii pneumonia.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antimalarials; CD4 Lymphocyte Count; Clindamyci | 1996 |
Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Biotransformation; Chromatography, High Pressure Liquid; | 2001 |