primaquine has been researched along with Extravascular Hemolysis in 145 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 9.24 | Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens. ( Bancone, G; Charunwatthana, P; Chowwiwat, N; Chu, CS; Keereecharoen, L; Moore, KA; Nosten, F; Phyo, AP; Po, C; Proux, S; Raksapraidee, R; Thitipanawan, N; White, NJ; Wilairisak, P; Win, HH, 2017) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 8.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Primaquine is essential for the radical cure of Plasmodium vivax malaria, but it poses a potential danger of severe hemolysis in G6PD-deficient (G6PDd) patients." | 8.31 | Risk of hemolysis in Plasmodium vivax malaria patients receiving standard primaquine treatment in a population with high prevalence of G6PD deficiency. ( Cui, L; Kim, K; Lakshmi, S; Liu, H; Malla, P; Menezes, L; Wang, C; Yang, Z; Zeng, W, 2023) |
| "Primaquine prevents relapses of Plasmodium vivax malaria but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 8.31 | Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function. ( Anstey, NM; Douglas, NM; Ley, B; Piera, KA; Price, RN; Rumaseb, A, 2023) |
| "Primaquine (PQ) kills Plasmodium vivax hypnozoites but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 8.31 | Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses. ( Brito-Sousa, JD; Chu, C; Commons, RJ; Douglas, NM; Groves, ES; Lacerda, MVG; Monteiro, WM; Price, RN; Thriemer, K; Yilma, D, 2023) |
| "Plasmodium vivax malaria elimination requires radical cure with chloroquine/primaquine." | 8.12 | Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India. ( Ahmed, N; Anvikar, AR; Duparc, S; Grewal Daumerie, P; Pradhan, MM; Pradhan, S; Sahu, P; Sharma, S; Valecha, N; Yadav, CP, 2022) |
| "Primaquine and tafenoquine are the only licensed drugs that effectively kill the hypnozoite stage and are used to prevent Plasmodium vivax malaria relapse." | 8.12 | Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure. ( Boonyuen, U; Chamchoy, K; Krudsood, S; Patrapuvich, R; Sudsumrit, S; Thita, T, 2022) |
| "Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission." | 7.85 | Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms. ( Aguiar, AC; Cunico, W; Drawanz, BB; Figueiredo, FJ; Katsuragawa, TH; Krettli, AU; Neuenfeldt, PD; Sinnis, P; Zavala, F, 2017) |
| "After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria." | 7.78 | Reinventing primaquine for endemic malaria. ( Baird, JK, 2012) |
| "Acute Plasmodium vivax malaria is associated with haemolysis, bone marrow suppression, reticulocytopenia, and post-treatment reticulocytosis leading to haemoglobin recovery." | 7.01 | Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria. ( Baird, JK; Christophel, E; Kerleguer, A; Kheng, S; Kim, S; Luzzatto, L; Menard, D; Mukaka, M; Muth, S; Taylor, WRJ; Tor, P, 2021) |
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 6.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| "Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 5.24 | Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens. ( Bancone, G; Charunwatthana, P; Chowwiwat, N; Chu, CS; Keereecharoen, L; Moore, KA; Nosten, F; Phyo, AP; Po, C; Proux, S; Raksapraidee, R; Thitipanawan, N; White, NJ; Wilairisak, P; Win, HH, 2017) |
| "Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure')." | 4.98 | Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. ( Ashley, EA; Recht, J; White, NJ, 2018) |
| "Primaquine is essential for the radical cure of Plasmodium vivax malaria, but it poses a potential danger of severe hemolysis in G6PD-deficient (G6PDd) patients." | 4.31 | Risk of hemolysis in Plasmodium vivax malaria patients receiving standard primaquine treatment in a population with high prevalence of G6PD deficiency. ( Cui, L; Kim, K; Lakshmi, S; Liu, H; Malla, P; Menezes, L; Wang, C; Yang, Z; Zeng, W, 2023) |
| "Primaquine prevents relapses of Plasmodium vivax malaria but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 4.31 | Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function. ( Anstey, NM; Douglas, NM; Ley, B; Piera, KA; Price, RN; Rumaseb, A, 2023) |
| "Primaquine (PQ) kills Plasmodium vivax hypnozoites but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 4.31 | Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses. ( Brito-Sousa, JD; Chu, C; Commons, RJ; Douglas, NM; Groves, ES; Lacerda, MVG; Monteiro, WM; Price, RN; Thriemer, K; Yilma, D, 2023) |
| "Plasmodium vivax malaria elimination requires radical cure with chloroquine/primaquine." | 4.12 | Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India. ( Ahmed, N; Anvikar, AR; Duparc, S; Grewal Daumerie, P; Pradhan, MM; Pradhan, S; Sahu, P; Sharma, S; Valecha, N; Yadav, CP, 2022) |
| "Primaquine and tafenoquine are the only licensed drugs that effectively kill the hypnozoite stage and are used to prevent Plasmodium vivax malaria relapse." | 4.12 | Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure. ( Boonyuen, U; Chamchoy, K; Krudsood, S; Patrapuvich, R; Sudsumrit, S; Thita, T, 2022) |
| " Therefore, malaria patient treatment using primaquine should be monitored closely for any adverse effects." | 4.12 | Prevalence of G6PD deficiency and distribution of its genetic variants among malaria-suspected patients visiting Metehara health centre, Eastern Ethiopia. ( Adamu, A; Feleke, SM; Gebremichael, SG; Gidey, B; Hailu, A; Kebede, T; Kepple, D; Lo, E; Nega, D; Negash, MT; Shenkutie, TT; Tasew, G; Witherspoon, L, 2022) |
| "Since their first use in the 1920s, 8-aminoquinolines have been known to have important toxicities such as methemoglobinemia and hemolysis." | 4.12 | Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together. ( Shanks, GD, 2022) |
| "Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission." | 3.85 | Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms. ( Aguiar, AC; Cunico, W; Drawanz, BB; Figueiredo, FJ; Katsuragawa, TH; Krettli, AU; Neuenfeldt, PD; Sinnis, P; Zavala, F, 2017) |
| " Primaquine (PQ) is a widely used anti-malarial drug that can trigger haemolysis in individuals with G6PDd." | 3.83 | Glucose-6-phosphate dehydrogenase deficiency prevalence and genetic variants in malaria endemic areas of Colombia. ( Arce-Plata, MI; Arévalo-Herrera, M; Ocampo, ID; Recht, J; Valencia, SH, 2016) |
| "Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria." | 3.80 | Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers. ( Baresel, P; Bartlett, MS; Fronczek, FR; Gettayacamin, M; Herath, HM; McChesney, JD; Melendez, V; Nanayakkara, NP; Ohrt, C; Reichard, GA; Rochford, R; Sahu, R; Tekwani, BL; Tungtaeng, A; van Gessel, Y; Walker, LA; Wickham, KS, 2014) |
| "Administering primaquine (PQ) to treat malaria patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency can pose a serious risk of drug-induced hemolysis (DIH)." | 3.80 | Performance of the CareStart glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in Gressier, Haiti. ( Beau de Rochars, MV; Eaton, WT; Masse, R; Okech, BA; von Fricken, ME; Weppelmann, TA, 2014) |
| "After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria." | 3.78 | Reinventing primaquine for endemic malaria. ( Baird, JK, 2012) |
| "G6PDd is widespread and spatially heterogeneous across most MECs where primaquine would be valuable for malaria control and elimination." | 3.78 | G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. ( Baird, JK; Battle, KE; Dewi, M; Gething, PW; Hay, SI; Hogg, MM; Howes, RE; Nyangiri, OA; Padilla, CD; Patil, AP; Piel, FB, 2012) |
| " We now demonstrate the ability of 2-tert-butylprimaquine to inhibit in vitro beta-hematin formation, to form a complex with heme with a stoichiometry of 1:1, and to enhance heme-induced hemolysis." | 3.74 | 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization. ( Harada, S; Huy, NT; Jain, M; Jain, R; Kamei, K; Kaur, K; Mizunuma, K; Nhien, NT; Uyen, DT, 2007) |
| "8-Aminoquinolines are an important class of antiparasitic agents, with broad utility and excellent efficacy, but also limitations due to hematological toxicities, primarily methemoglobinemia and hemolysis." | 3.74 | Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. ( Ager, AL; Bartlett, MS; Croft, SL; Khan, IA; McChesney, JD; Nanayakkara, NP; Walker, LA; Yardley, V, 2008) |
| "Acute Plasmodium vivax malaria is associated with haemolysis, bone marrow suppression, reticulocytopenia, and post-treatment reticulocytosis leading to haemoglobin recovery." | 3.01 | Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria. ( Baird, JK; Christophel, E; Kerleguer, A; Kheng, S; Kim, S; Luzzatto, L; Menard, D; Mukaka, M; Muth, S; Taylor, WRJ; Tor, P, 2021) |
| "G6PD deficiency was assessed with a phenotypic test and genotyping was performed in male subjects with deficient phenotypes and in all females." | 2.82 | Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects. ( Bancone, G; Chowwiwat, N; Gornsawun, G; Kajeechiwa, L; Kiricharoen, NL; Ling, CL; Moo, PK; Moore, KA; Nosten, F; Nosten, S; Nyo, SN; Poodpanya, L; Rakthinthong, S; Somsakchaicharoen, R; Thinraow, S; Thwin, MM; White, NJ; Wiladphaingern, J, 2016) |
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 2.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| " Another priority is exploring alternative 8-aminoquinoline dosing regimens that are practical and improve safety in G6PD deficient individuals." | 2.58 | Primaquine-induced haemolysis in females heterozygous for G6PD deficiency. ( Bancone, G; Chu, CS; Luzzatto, L; Nosten, F; White, NJ, 2018) |
| "A diagnosis of G6PD deficiency is most often made through enzymatic activity detection, but molecular analysis may be required in females heterozygous for the disorder." | 2.58 | Review and drug therapy implications of glucose-6-phosphate dehydrogenase deficiency. ( Belfield, KD; Tichy, EM, 2018) |
| " All but one death followed multiple dosing to prevent vivax malaria relapse." | 2.50 | Primaquine: the risks and the benefits. ( Ashley, EA; Recht, J; White, NJ, 2014) |
| "Primaquine was officially licensed as an anti-malarial drug by the FDA in 1952." | 2.47 | Primaquine in vivax malaria: an update and review on management issues. ( Fernando, D; Rajapakse, S; Rodrigo, C, 2011) |
| "The amount of false G6PD deficiency detected led to substantial loss of opportunities for radical cure." | 1.62 | Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study). ( Arcanjo, AR; Baia-da-Silva, DC; Bancone, G; Barbosa, LRA; Bassat, Q; Batista, TSB; Brito, MAM; Brito-Sousa, JD; Domingo, GJ; Figueiredo, EFG; Lacerda, MVG; Marques, LLG; Melo, GC; Melo, MM; Mendes, MO; Monteiro, WM; Murta, F; Nakagawa, TH; Recht, J; Rodovalho, S; Sampaio, VS; Santos, APC; Santos, TC; Silva, EL; Silva-Neto, AV; Siqueira, AM; Souza, BKA; Vitor-Silva, S, 2021) |
| "In the north, other G6PD deficiency variants might be more prevalent." | 1.51 | Prevalence of G6PD Viangchan variant in malaria endemic areas in Lao PDR: an implication for malaria elimination by 2030. ( Araki, H; Brey, PT; Hongvanthong, B; Iwagami, M; Jimba, M; Kano, S; Keomalaphet, S; Khattignavong, P; Lorpachan, L; Ong, KIC; Pongvongsa, T; Prasayasith, P; Soundala, P; Xangsayalath, P, 2019) |
| "vivax malaria is limited and unsatisfactory due to at least two drawbacks: the undesirable side effects of primaquine (PQ) and drug resistance to chloroquine." | 1.40 | Evaluation of antimalarial activity and toxicity of a new primaquine prodrug. ( Aguiar, AC; Campos, ML; Chin, CM; da Fonseca, LM; Davanço, MG; de Andrade, CR; Dos Santos, JL; Dos Santos, LA; Krettli, AU; Padilha, EC; Peccinini, RG, 2014) |
| "In this first study to examine G6PD deficiency rates in Haiti, 22." | 1.40 | Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti. ( Alam, MT; Carter, TE; Eaton, WT; Masse, R; Okech, BA; Romain, JR; Schick, L; von Fricken, ME; Weppelmann, TA, 2014) |
| "The prevalence of G6PD deficiency by genotype and enzyme activity was determined in healthy school children in The Gambia." | 1.40 | The prevalence of glucose-6-phosphate dehydrogenase deficiency in Gambian school children. ( Affara, M; Amambua-Ngwa, A; Ceesay, SJ; D'Alessandro, U; Daswani, M; Nishimura, S; Nwakanma, D; Okebe, J; Parr, J; Takem, EN, 2014) |
| "Falciparum malaria is transmitted by anopheline mosquitoes that have fed on blood containing gametocytes of Plasmodium falciparum." | 1.39 | Primaquine to prevent transmission of falciparum malaria. ( White, NJ, 2013) |
| "Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp." | 1.32 | Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine. ( Bowman, ZS; Jollow, DJ; McMillan, DC; Oatis, JE; Whelan, JL, 2004) |
| " In order to determine their hemolytic toxicity, we dosed rabbits with M8506 and PQ at a dose of 40 mg/kg per day for 4 days, respectively." | 1.29 | [Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits]. ( Ha, S; Shi, X; Yiao, J; Zhan, C, 1994) |
| "Rutin was also shown to delay H2O2-induced met-Hb oxidation to ferryl-Hb." | 1.29 | Protective effects of rutin against hemoglobin oxidation. ( Grinberg, LN; Newmark, H; Rachmilewitz, EA, 1994) |
| "Xylitol was explored as a potential agent for treatment of hemolysis in patients with G6PD-deficiency." | 1.25 | The potential use of xylitol in glucose-6-phosphate dehydrogenase deficiency anemia. ( Patterson, JH; Van Eys, J; Wang, YM, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 79 (54.48) | 18.7374 |
| 1990's | 8 (5.52) | 18.2507 |
| 2000's | 6 (4.14) | 29.6817 |
| 2010's | 36 (24.83) | 24.3611 |
| 2020's | 16 (11.03) | 2.80 |
| Authors | Studies |
|---|---|
| Huy, NT | 1 |
| Mizunuma, K | 1 |
| Kaur, K | 1 |
| Nhien, NT | 1 |
| Jain, M | 1 |
| Uyen, DT | 1 |
| Harada, S | 1 |
| Jain, R | 1 |
| Kamei, K | 1 |
| Nanayakkara, NP | 2 |
| Ager, AL | 1 |
| Bartlett, MS | 2 |
| Yardley, V | 1 |
| Croft, SL | 1 |
| Khan, IA | 1 |
| McChesney, JD | 2 |
| Walker, LA | 4 |
| Taylor, WRJ | 3 |
| Kim, S | 2 |
| Kheng, S | 3 |
| Muth, S | 2 |
| Tor, P | 2 |
| Christophel, E | 2 |
| Mukaka, M | 2 |
| Kerleguer, A | 2 |
| Luzzatto, L | 3 |
| Baird, JK | 7 |
| Menard, D | 3 |
| Al Fayez, N | 1 |
| Böttger, R | 1 |
| Rouhollahi, E | 1 |
| Cullis, PR | 1 |
| Witzigmann, D | 1 |
| Li, SD | 1 |
| Wu, KW | 1 |
| Sweeney, C | 1 |
| Dudhipala, N | 1 |
| Lakhani, P | 1 |
| Chaurasiya, ND | 2 |
| Tekwani, BL | 3 |
| Majumdar, S | 1 |
| Anvikar, AR | 1 |
| Sahu, P | 1 |
| Pradhan, MM | 1 |
| Sharma, S | 1 |
| Ahmed, N | 1 |
| Yadav, CP | 1 |
| Pradhan, S | 1 |
| Duparc, S | 1 |
| Grewal Daumerie, P | 1 |
| Valecha, N | 1 |
| Aung, YN | 1 |
| Tun, STT | 1 |
| Vanisaveth, V | 1 |
| Chindavongsa, K | 1 |
| Kanya, L | 1 |
| Ley, B | 4 |
| Alam, MS | 1 |
| Satyagraha, AW | 1 |
| Phru, CS | 1 |
| Thriemer, K | 4 |
| Tadesse, D | 1 |
| Shibiru, T | 1 |
| Hailu, A | 2 |
| Kibria, MG | 1 |
| Hossain, MS | 1 |
| Rahmat, H | 1 |
| Poespoprodjo, JR | 2 |
| Khan, WA | 2 |
| Simpson, JA | 4 |
| Price, RN | 7 |
| Flaherty, S | 1 |
| Strauch, P | 1 |
| Maktabi, M | 1 |
| Pybus, BS | 1 |
| Reichard, G | 1 |
| Rochford, R | 2 |
| Liu, H | 1 |
| Zeng, W | 1 |
| Malla, P | 1 |
| Wang, C | 1 |
| Lakshmi, S | 1 |
| Kim, K | 1 |
| Menezes, L | 1 |
| Yang, Z | 1 |
| Cui, L | 1 |
| Shenkutie, TT | 1 |
| Nega, D | 1 |
| Kepple, D | 1 |
| Witherspoon, L | 1 |
| Lo, E | 1 |
| Negash, MT | 1 |
| Adamu, A | 1 |
| Gebremichael, SG | 1 |
| Gidey, B | 1 |
| Tasew, G | 1 |
| Feleke, SM | 1 |
| Kebede, T | 1 |
| Shanks, GD | 2 |
| Chamchoy, K | 2 |
| Sudsumrit, S | 2 |
| Thita, T | 2 |
| Krudsood, S | 3 |
| Patrapuvich, R | 2 |
| Boonyuen, U | 2 |
| Douglas, NM | 5 |
| Piera, KA | 2 |
| Rumaseb, A | 2 |
| Anstey, NM | 4 |
| Yilma, D | 1 |
| Groves, ES | 1 |
| Brito-Sousa, JD | 3 |
| Monteiro, WM | 6 |
| Chu, C | 1 |
| Commons, RJ | 2 |
| Lacerda, MVG | 4 |
| Bjorge, S | 1 |
| Topps, N | 1 |
| Kosal, K | 1 |
| Sothea, K | 1 |
| Souy, P | 1 |
| Char, CM | 1 |
| Vanna, C | 1 |
| Ly, P | 1 |
| Khieu, V | 1 |
| Pantaleo, A | 1 |
| Murta, F | 1 |
| Vitor-Silva, S | 1 |
| Sampaio, VS | 2 |
| Mendes, MO | 1 |
| Brito, MAM | 1 |
| Batista, TSB | 1 |
| Santos, APC | 1 |
| Marques, LLG | 1 |
| Barbosa, LRA | 1 |
| Melo, MM | 1 |
| Baia-da-Silva, DC | 1 |
| Silva-Neto, AV | 1 |
| Santos, TC | 2 |
| Souza, BKA | 1 |
| Figueiredo, EFG | 1 |
| Silva, EL | 1 |
| Rodovalho, S | 1 |
| Nakagawa, TH | 1 |
| Arcanjo, AR | 1 |
| Siqueira, AM | 4 |
| Melo, GC | 4 |
| Recht, J | 4 |
| Domingo, GJ | 1 |
| Bassat, Q | 4 |
| Bancone, G | 5 |
| Devine, A | 1 |
| Battle, KE | 2 |
| Meagher, N | 1 |
| Howes, RE | 2 |
| Dini, S | 1 |
| Gething, PW | 2 |
| Lubell, Y | 1 |
| Tang, ASO | 1 |
| Soo, XY | 1 |
| Yeo, ST | 1 |
| Mansor, NA | 1 |
| Chew, LP | 1 |
| Chua, HH | 1 |
| Uthman, OA | 1 |
| Graves, PM | 1 |
| Saunders, R | 1 |
| Gelband, H | 1 |
| Richardson, M | 1 |
| Garner, P | 1 |
| Belfield, KD | 1 |
| Tichy, EM | 1 |
| Chu, CS | 3 |
| Nosten, F | 5 |
| White, NJ | 8 |
| Ashley, EA | 2 |
| Avalos, S | 2 |
| Mejia, RE | 1 |
| Banegas, E | 1 |
| Salinas, C | 1 |
| Gutierrez, L | 1 |
| Fajardo, M | 1 |
| Galo, S | 1 |
| Pinto, A | 1 |
| Mejia, A | 1 |
| Fontecha, G | 2 |
| Val, F | 1 |
| Alecrim, GC | 1 |
| Ong, KIC | 1 |
| Iwagami, M | 1 |
| Araki, H | 1 |
| Khattignavong, P | 1 |
| Soundala, P | 1 |
| Keomalaphet, S | 1 |
| Prasayasith, P | 1 |
| Lorpachan, L | 1 |
| Xangsayalath, P | 1 |
| Pongvongsa, T | 1 |
| Hongvanthong, B | 1 |
| Brey, PT | 1 |
| Kano, S | 1 |
| Jimba, M | 1 |
| Setyadi, A | 1 |
| Arguni, E | 1 |
| Kenangalem, E | 1 |
| Hasanuddin, A | 1 |
| Lampah, DA | 1 |
| Sugiarto, P | 1 |
| Abreha, T | 1 |
| Alemu, SG | 1 |
| Añez, A | 1 |
| Aseffa, A | 1 |
| Assefa, A | 1 |
| Awab, GR | 1 |
| Barber, BE | 1 |
| Borghini-Fuhrer, I | 1 |
| D'Alessandro, U | 2 |
| Dahal, P | 1 |
| Daher, A | 1 |
| de Vries, PJ | 1 |
| Erhart, A | 1 |
| Gomes, MSM | 1 |
| Grigg, MJ | 1 |
| Hwang, J | 1 |
| Kager, PA | 1 |
| Ketema, T | 1 |
| Leslie, T | 1 |
| Lidia, K | 1 |
| Pereira, DB | 1 |
| Phan, GT | 1 |
| Phyo, AP | 2 |
| Rowland, M | 1 |
| Saravu, K | 1 |
| Sibley, CH | 1 |
| Stepniewska, K | 1 |
| Thwaites, G | 1 |
| Tran, BQ | 1 |
| Hien, TT | 1 |
| Vieira, JLF | 1 |
| Wangchuk, S | 1 |
| Watson, J | 2 |
| William, T | 1 |
| Woodrow, CJ | 1 |
| Guerin, PJ | 1 |
| Balaji, SN | 1 |
| Trivedi, V | 1 |
| Seneca, E | 1 |
| Franca, GP | 2 |
| Queiroz, AL | 1 |
| Brito, M | 1 |
| Peixoto, HM | 2 |
| Oliveira, MR | 1 |
| Romero, GA | 2 |
| Lacerda, MV | 1 |
| Laothamatas, J | 1 |
| Sammet, CL | 1 |
| Golay, X | 1 |
| Van Cauteren, M | 1 |
| Lekprasert, V | 1 |
| Tangpukdee, N | 1 |
| Leowattana, W | 1 |
| Wilairatana, P | 1 |
| Swaminathan, SV | 1 |
| DeLaPaz, RL | 1 |
| Brown, TR | 1 |
| Looareesuwan, S | 1 |
| Brittenham, GM | 1 |
| von Fricken, ME | 2 |
| Weppelmann, TA | 2 |
| Eaton, WT | 2 |
| Alam, MT | 1 |
| Carter, TE | 1 |
| Schick, L | 1 |
| Masse, R | 2 |
| Romain, JR | 1 |
| Okech, BA | 2 |
| Okebe, J | 1 |
| Amambua-Ngwa, A | 1 |
| Parr, J | 1 |
| Nishimura, S | 1 |
| Daswani, M | 1 |
| Takem, EN | 1 |
| Affara, M | 1 |
| Ceesay, SJ | 1 |
| Nwakanma, D | 1 |
| Beau de Rochars, MV | 1 |
| Herath, HM | 1 |
| Sahu, R | 2 |
| Gettayacamin, M | 1 |
| Tungtaeng, A | 1 |
| van Gessel, Y | 1 |
| Baresel, P | 1 |
| Wickham, KS | 1 |
| Fronczek, FR | 1 |
| Melendez, V | 1 |
| Ohrt, C | 1 |
| Reichard, GA | 1 |
| Eziefula, AC | 1 |
| Pett, H | 1 |
| Grignard, L | 1 |
| Opus, S | 1 |
| Kiggundu, M | 1 |
| Kamya, MR | 1 |
| Yeung, S | 1 |
| Staedke, SG | 1 |
| Bousema, T | 2 |
| Drakeley, C | 2 |
| Davanço, MG | 1 |
| Aguiar, AC | 2 |
| Dos Santos, LA | 1 |
| Padilha, EC | 1 |
| Campos, ML | 1 |
| de Andrade, CR | 1 |
| da Fonseca, LM | 1 |
| Dos Santos, JL | 1 |
| Chin, CM | 1 |
| Krettli, AU | 2 |
| Peccinini, RG | 1 |
| Val, FF | 1 |
| Almeida, AC | 1 |
| Brito, MA | 1 |
| Fuller, D | 1 |
| Maria Regina F, O | 1 |
| Marcus Vinícius G, L | 1 |
| Chowwiwat, N | 2 |
| Somsakchaicharoen, R | 1 |
| Poodpanya, L | 1 |
| Moo, PK | 1 |
| Gornsawun, G | 1 |
| Kajeechiwa, L | 1 |
| Thwin, MM | 1 |
| Rakthinthong, S | 1 |
| Nosten, S | 1 |
| Thinraow, S | 1 |
| Nyo, SN | 1 |
| Ling, CL | 1 |
| Wiladphaingern, J | 1 |
| Kiricharoen, NL | 1 |
| Moore, KA | 2 |
| Valencia, SH | 1 |
| Ocampo, ID | 1 |
| Arce-Plata, MI | 1 |
| Arévalo-Herrera, M | 1 |
| Taylor, WR | 1 |
| Win, HH | 1 |
| Thitipanawan, N | 1 |
| Po, C | 1 |
| Raksapraidee, R | 1 |
| Wilairisak, P | 1 |
| Keereecharoen, L | 1 |
| Proux, S | 1 |
| Charunwatthana, P | 1 |
| Figueiredo, FJ | 1 |
| Neuenfeldt, PD | 1 |
| Katsuragawa, TH | 1 |
| Drawanz, BB | 1 |
| Cunico, W | 1 |
| Sinnis, P | 1 |
| Zavala, F | 1 |
| Shekalaghe, SA | 1 |
| ter Braak, R | 1 |
| Daou, M | 1 |
| Kavishe, R | 1 |
| van den Bijllaardt, W | 1 |
| van den Bosch, S | 1 |
| Koenderink, JB | 1 |
| Luty, AJ | 1 |
| Whitty, CJ | 1 |
| Sauerwein, RW | 1 |
| Alanazi, F | 1 |
| Burgoine, KL | 1 |
| Fernando, D | 1 |
| Rodrigo, C | 1 |
| Rajapakse, S | 1 |
| Ganesan, S | 1 |
| Sun, XD | 1 |
| Wang, J | 1 |
| Wei, C | 1 |
| Piel, FB | 1 |
| Patil, AP | 1 |
| Nyangiri, OA | 1 |
| Dewi, M | 1 |
| Hogg, MM | 1 |
| Padilla, CD | 1 |
| Hay, SI | 1 |
| DERN, RJ | 8 |
| WEINSTEIN, IM | 1 |
| LEROY, GV | 1 |
| TALMAGE, DW | 1 |
| ALVING, AS | 17 |
| BEUTLER, E | 8 |
| FLANAGAN, CL | 1 |
| SCHRIER, SL | 5 |
| KELLERMEYER, RW | 7 |
| CARSON, PE | 6 |
| ICKES, CE | 2 |
| TARLOV, AR | 8 |
| JOHNSON, CF | 1 |
| BREWER, GJ | 6 |
| POWELL, RD | 2 |
| PALEK, J | 1 |
| COHEN, G | 2 |
| HOCHSTEIN, P | 4 |
| PANNACCIULLI, I | 5 |
| TIZIANELLO, A | 4 |
| AJMAR, F | 6 |
| SALVIDIO, E | 6 |
| PANIZON, F | 3 |
| ZACCHELLO, F | 2 |
| JACOB, HS | 1 |
| INGBAR, SH | 1 |
| JANDL, JH | 1 |
| ROBERTSON, DH | 1 |
| Bowman, ZS | 1 |
| Oatis, JE | 1 |
| Whelan, JL | 1 |
| Jollow, DJ | 1 |
| McMillan, DC | 1 |
| Carr, ME | 1 |
| Fandre, MN | 1 |
| Oduwa, FO | 1 |
| Rebholz, CE | 1 |
| Michel, AJ | 1 |
| Maselli, DA | 1 |
| Saipphudin, K | 1 |
| Wyss, K | 1 |
| Oliver, M | 1 |
| Simon, F | 1 |
| de Monbrison, F | 1 |
| Beavogui, AH | 1 |
| Pradines, B | 1 |
| Ragot, C | 1 |
| Moalic, JL | 1 |
| Rapp, C | 1 |
| Picot, S | 1 |
| George, JN | 1 |
| Sears, DA | 1 |
| McCurdy, PR | 2 |
| Conrad, ME | 2 |
| Allakhverdiev, AM | 1 |
| Grinberg, LN | 4 |
| Vaidya, AB | 1 |
| Rajagopalan, TG | 1 |
| Baxi, AJ | 1 |
| Vong, NK | 1 |
| Reilly, Q | 1 |
| Clyde, DF | 1 |
| Shi, X | 1 |
| Zhan, C | 1 |
| Ha, S | 1 |
| Yiao, J | 1 |
| Samuni, A | 1 |
| Rachmilewitz, EA | 1 |
| Newmark, H | 1 |
| Hadad Meléndez, P | 1 |
| Martínez, JL | 1 |
| Millán Marcelo, JC | 1 |
| Aguiar Cruz, F | 1 |
| Ali, NA | 1 |
| al-Naama, LM | 1 |
| Khalid, LO | 1 |
| Brunori, M | 1 |
| Fioretti, E | 1 |
| Rotilio, G | 1 |
| Wang, YM | 2 |
| Lantin, E | 1 |
| VAN Eys, J | 2 |
| Chan, TK | 1 |
| Todd, D | 1 |
| Tso, SC | 1 |
| Bronshteĭn, AM | 2 |
| Ozeretskovskaia, NN | 1 |
| Benediktov, NI | 1 |
| Ibragimov, G | 1 |
| Dzhafarova, S | 1 |
| Reeve, PA | 1 |
| Toaliu, H | 1 |
| Kaneko, A | 1 |
| Hall, JJ | 1 |
| Ganczakowski, M | 1 |
| Ni, YC | 2 |
| Xu, YQ | 2 |
| Karwacki, JJ | 1 |
| Kummalue, T | 1 |
| Watanasook, C | 1 |
| Brossi, A | 1 |
| Gessner, W | 1 |
| Hufford, CD | 1 |
| Baker, JK | 1 |
| Homo, F | 1 |
| Millet, P | 1 |
| Landau, I | 1 |
| Davidson, DE | 1 |
| Decker-Jackson, JE | 1 |
| McCormick, GJ | 1 |
| Canfield, CJ | 1 |
| DiPalma, JR | 1 |
| Levy, MR | 1 |
| Chou, SC | 1 |
| Waller, HD | 3 |
| Löhr, GW | 1 |
| Berry, DH | 1 |
| Maronpot, RR | 1 |
| Jaffe, ER | 1 |
| Ben-Bassat, I | 1 |
| Bensch, K | 1 |
| Seeger, M | 1 |
| Junga, I | 1 |
| Fraser, IM | 2 |
| Vesell, ES | 2 |
| Patterson, JH | 1 |
| Cucinell, SA | 1 |
| Rebert, C | 1 |
| Clyde, D | 1 |
| Charoenlarp, P | 3 |
| Areekul, S | 2 |
| Harinasuta, T | 3 |
| Sirivorasarn, P | 1 |
| Seeler, RA | 1 |
| Miller, RA | 1 |
| Lin, CH | 1 |
| Lin, SK | 1 |
| Kahn, G | 1 |
| Curry, MC | 1 |
| Dustin, R | 1 |
| Yawata, Y | 1 |
| Kjellstrand, C | 1 |
| Buselmeier, T | 1 |
| Howe, R | 1 |
| Jacob, H | 1 |
| Maldonado, N | 1 |
| Dillon, DE | 1 |
| Lüer, S | 1 |
| Benöhr, HC | 1 |
| Gaetani, GF | 1 |
| Garré, C | 2 |
| Bianchi, GL | 1 |
| Pholpothi, T | 1 |
| Eppes, RB | 1 |
| McNamara, JV | 1 |
| DeGowin, RL | 1 |
| Sartori, E | 1 |
| Addis, S | 1 |
| Tudhope, GR | 1 |
| Leece, SP | 1 |
| Gaetani, G | 2 |
| Bianchi, G | 1 |
| Miller, A | 2 |
| Smith, HC | 2 |
| Tilton, BE | 1 |
| Martin, DF | 1 |
| Padilla, GM | 1 |
| Brown, PA | 1 |
| Paravidino, G | 1 |
| Wittels, B | 1 |
| D'Elia, R | 1 |
| Ginn, FL | 1 |
| Trump, BF | 1 |
| Parravidino, G | 1 |
| Ezra, R | 1 |
| Szeinberg, A | 1 |
| Sheba, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094] | Phase 4 | 388 participants (Anticipated) | Interventional | 2023-06-26 | Recruiting | ||
| Evaluation of the Safety of Primaquine in Combination With Dihydroartemisinin-piperaquine in G6PD Deficient Males in The Gambia[NCT02654730] | Phase 2/Phase 3 | 61 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Enrollment took longer than anticipated; it was financially and logistically impossible to recruit the final cohort (G6PDd 0.4mg/kg PQ).) | ||
| Targeted Chemo-elimination (TCE) to Eradicate Malaria in Areas of Suspected or Proven Artemisinin Resistance in Southeast Asia and South Asia[NCT01872702] | 8,000 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Randomised Parallel Open Label Comparison Between 7 and 14 Day Primaquine Combined With 3-day Dihydroartemisinin-piperaquine or 3-day Chloroquine Regimens for Radical Cure of Plasmodium Vivax[NCT01640574] | Phase 3 | 680 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Mass-Drug Administration With a Gametocytocidal Drug Combination, a Model for a Transmission Blocking Vaccine[NCT00509015] | 6,000 participants (Anticipated) | Interventional | 2008-02-29 | Completed | |||
| Evaluation of the Efficacy and Safety of Primaquine for Clearance of Gametocytes in Uncomplicated Falciparum Malaria in Uganda[NCT01365598] | Phase 3 | 468 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia[NCT01743820] | Phase 2 | 81 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for primaquine and Extravascular Hemolysis
| Article | Year |
|---|---|
Safety of primaquine given to people with G6PD deficiency: systematic review of prospective studies.
Topics: Aminoquinolines; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysis; H | 2017 |
Review and drug therapy implications of glucose-6-phosphate dehydrogenase deficiency.
Topics: Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Methyl | 2018 |
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency.
Topics: Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Heterozygote; Humans; M | 2018 |
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Ma | 2018 |
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficie | 2019 |
G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Dapsone; Female; Glucosephosphate Dehydrogenase Deficienc | 2014 |
Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes.
Topics: Caribbean Region; Disease Eradication; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; | 2014 |
G6PD deficiency in Latin America: systematic review on prevalence and variants.
Topics: Antimalarials; Caribbean Region; Contraindications; Female; Geographic Mapping; Glucosephosphate Deh | 2014 |
Primaquine: the risks and the benefits.
Topics: Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria, Falciparum; Pr | 2014 |
Primaquine in vivax malaria: an update and review on management issues.
Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Clinical Trials as Topic; Drug Resistance | 2011 |
[METHEMOGLOBINEMIA, HEMOLYSIS AND FORMATION OF HEINZ BODIES IN THE ERYTHROCYTES].
Topics: Adenosine Triphosphate; Anemia; Anemia, Hemolytic; Carbohydrate Metabolism; Catalase; Erythrocytes; | 1964 |
[New use of primaquine for malaria].
Topics: Antimalarials; France; Hemolysis; Humans; Malaria; Primaquine | 2008 |
[Adverse effects of drugs in hereditary variants in the enzyme apparatus of the body].
Topics: Adenosine Triphosphatases; Adult; Aged; Cholinesterase Inhibitors; Coumarins; Dibucaine; Drug-Relate | 1968 |
5 trials available for primaquine and Extravascular Hemolysis
| Article | Year |
|---|---|
Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria.
Topics: Adolescent; Adult; Aged; Antimalarials; Cambodia; Child; Child, Preschool; Erythrocytes; Female; Gen | 2021 |
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
Topics: Antimalarials; Child; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Female; G | 2014 |
Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects.
Topics: Adult; Antimalarials; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Glucosephos | 2016 |
Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Cohort Studies; Dose-Response Relationshi | 2017 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
127 other studies available for primaquine and Extravascular Hemolysis
| Article | Year |
|---|---|
2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.
Topics: Animals; Antimalarials; Erythrocytes; Hemeproteins; Hemolysis; Humans; Malaria, Falciparum; Parasiti | 2007 |
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.
Topics: Aminoquinolines; Animals; Antifungal Agents; Antiprotozoal Agents; Dogs; Female; Hemolysis; Humans; | 2008 |
Improved Liver Delivery of Primaquine by Phospholipid-Free Small Unilamellar Vesicles with Reduced Hemolytic Toxicity.
Topics: Animals; Antimalarials; Hemolysis; Liver; Malaria; Mice; Phospholipids; Polymers; Primaquine; Unilam | 2022 |
Primaquine Loaded Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Nanoemulsion (NE): Effect of Lipid Matrix and Surfactant on Drug Entrapment, in vitro Release, and ex vivo Hemolysis.
Topics: Drug Carriers; Emulsions; Hemolysis; Humans; Lipids; Nanoparticles; Particle Size; Primaquine; Surfa | 2021 |
Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India.
Topics: Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysi | 2022 |
Cost-effectiveness analysis of G6PD diagnostic test for Plasmodium vivax radical cure in Lao PDR: An economic modelling study.
Topics: Antimalarials; Cost-Benefit Analysis; Diagnostic Tests, Routine; Female; Glucosephosphate Dehydrogen | 2022 |
Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria.
Topics: Antimalarials; Cross-Sectional Studies; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogena | 2022 |
Mechanisms of 8-aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model.
Topics: Aminoquinolines; Animals; Antimalarials; Disease Models, Animal; Glucosephosphate Dehydrogenase Defi | 2022 |
Risk of hemolysis in Plasmodium vivax malaria patients receiving standard primaquine treatment in a population with high prevalence of G6PD deficiency.
Topics: Antimalarials; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; He | 2023 |
Prevalence of G6PD deficiency and distribution of its genetic variants among malaria-suspected patients visiting Metehara health centre, Eastern Ethiopia.
Topics: Antimalarials; Cross-Sectional Studies; Ethiopia; Female; Glucosephosphate Dehydrogenase Deficiency; | 2022 |
Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Primaquine; Quinine | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Topics: Antimalarials; Cytochrome P-450 CYP2D6; Genetic Variation; Glucosephosphate Dehydrogenase; Hemolysis | 2022 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.
Topics: Antimalarials; Australia; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria; Mal | 2023 |
Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses.
Topics: Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Malaria, Vivax; Plasmod | 2023 |
Hemolytic Dynamics of Weekly Primaquine Antirelapse Therapy Among Cambodians With Acute Plasmodium vivax Malaria With or Without Glucose-6-Phosphate Dehydrogenase Deficiency.
Topics: Adolescent; Adult; Antimalarials; Asian People; Chemoprevention; Child; Child, Preschool; Female; Gl | 2019 |
Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study).
Topics: Antimalarials; Brazil; Glucosephosphate Dehydrogenase Deficiency; Health Personnel; Hemolysis; Human | 2021 |
Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Clinical Decision-Making; Cost Savings; C | 2021 |
The mystery of 'saturation gap' and falsely normal G6PD: a case of primaquine-induced haemolysis in Plasmodium vivax malaria infection.
Topics: Antimalarials; Glucosephosphate Dehydrogenase; Hemolysis; Humans; Malaria; Malaria, Vivax; Primaquin | 2021 |
G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Female; Glucosephosphate Dehydrogenase Deficiency; He | 2018 |
Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Antimalarials; Brazil; Child; Child, Preschool; | 2019 |
Prevalence of G6PD Viangchan variant in malaria endemic areas in Lao PDR: an implication for malaria elimination by 2030.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Disease Eradication; Female; Ge | 2019 |
Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia.
Topics: Antimalarials; Female; Hematologic Diseases; Hemolysis; Humans; Indonesia; Infant; Infant, Newborn; | 2019 |
Methemoglobin incites primaquine toxicity through single-electron oxidation and modification.
Topics: Antimalarials; Antioxidants; Catalase; Chromatography, High Pressure Liquid; Erythrocyte Membrane; E | 2013 |
Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adult; Antimalarials; Artemisinins; Chloroquine; Corpus Callosum; Drug Therapy, Combi | 2014 |
Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Glucosephosphate Dehydr | 2014 |
The prevalence of glucose-6-phosphate dehydrogenase deficiency in Gambian school children.
Topics: Adolescent; Alleles; Antimalarials; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Fema | 2014 |
Performance of the CareStart glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in Gressier, Haiti.
Topics: Adolescent; Antimalarials; Child; Contraindications; Enzyme Assays; Female; Glucosephosphate Dehydro | 2014 |
Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.
Topics: Animals; Antimalarials; Dogs; Erythrocyte Transfusion; Erythrocytes; Female; Glucosephosphate Dehydr | 2014 |
Evaluation of antimalarial activity and toxicity of a new primaquine prodrug.
Topics: Aedes; Animals; Antimalarials; Cell Line; Chloroquine; Dipeptides; Glucosephosphate Dehydrogenase; H | 2014 |
Glucose-6-phosphate dehydrogenase deficiency prevalence and genetic variants in malaria endemic areas of Colombia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Child; Child, Preschool; Colombia; Cross- | 2016 |
Modelling primaquine-induced haemolysis in G6PD deficiency.
Topics: Anemia, Hemolytic; Antimalarials; Bayes Theorem; Cell Death; Erythrocytes; Female; Glucosephosphate | 2017 |
Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.
Topics: Animals; Cell Line, Tumor; Chickens; Chlorocebus aethiops; Erythrocytes; Glucosephosphate Dehydrogen | 2017 |
Pravastatin provides antioxidant activity and protection of erythrocytes loaded Primaquine.
Topics: Adult; Antimalarials; Antioxidants; Cells, Cultured; Drug Delivery Systems; Erythrocytes; Hemolysis; | 2010 |
The reality of using primaquine.
Topics: Adult; Antimalarials; Chloroquine; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Mal | 2010 |
Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway.
Topics: Annexins; Calcium; Dose-Response Relationship, Drug; Erythrocytes; Glucosephosphate Dehydrogenase; G | 2012 |
Reinventing primaquine for endemic malaria.
Topics: Antimalarials; Dose-Response Relationship, Drug; Endemic Diseases; Glucosephosphate Dehydrogenase De | 2012 |
[A case of vivax malaria with acute hemolysis from treatment of chloroquine combined with primaquine].
Topics: Antimalarials; Chloroquine; Hemolysis; Humans; Malaria, Vivax; Male; Primaquine; Young Adult | 2012 |
G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.
Topics: Antimalarials; Bayes Theorem; Female; Gene Frequency; Geographic Mapping; Geography, Medical; Glucos | 2012 |
Primaquine to prevent transmission of falciparum malaria.
Topics: Antimalarials; Artemisinins; Drug Resistance; Drug Therapy, Combination; Hemolysis; Humans; Malaria, | 2013 |
The hemolytic effect of primaquine. I. The localization of the drug-induced hemolytic defect in primaquine-sensitive individuals.
Topics: Antimalarials; Biological Phenomena; Cell Death; Hemolysis; Humans; Physiological Phenomena; Primaqu | 1954 |
The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Hemolysis; Primaquine | 1954 |
The hemolytic effect of primaquine. III. A study of primaquine-sensitive erythrocytes.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Erythrocytes; Hemolysis; Primaquine; Tracheoph | 1954 |
The hemolytic effect of primaquine. IV. The relationship of cell age to hemolysis.
Topics: Antimalarials; Cell Death; Hemolysis; Humans; Primaquine | 1954 |
The hemolytic effect of primaquine. V. Primaquine sensitivity as a manifestation of a multiple drug sensitivity.
Topics: Antimalarials; Cell Death; Hemolysis; Humans; Hypersensitivity; Immune System Diseases; Primaquine | 1955 |
The hemolytic effect of primaquine. VI. An in vitro test for sensitivity of erythrocytes to primaquine.
Topics: Antimalarials; Cell Death; Erythrocytes; Hemolysis; In Vitro Techniques; Primaquine | 1955 |
The hemolytic effect of primaquine. VII. Biochemical studies of drug-sensitive erythrocytes.
Topics: Antimalarials; Cell Death; Erythrocytes; Hemolysis; Primaquine | 1955 |
The hemolytic effect of primaquine. IX. Enzymatic abnormalities in primaquine-sensitive erythrocytes.
Topics: Antimalarials; Cell Death; Erythrocytes; Hemolysis; Primaquine | 1958 |
The hemolytic effect of primaquine and related compounds: a review.
Topics: Antimalarials; Cell Death; Hemolysis; Primaquine | 1959 |
The hemolytic effect of primaquine. XIII. Gradient susceptibility to hemolysis of primaquine-sensitive erythrocytes.
Topics: Antimalarials; Cell Death; Disease Susceptibility; Erythrocytes; Hemolysis; Primaquine | 1961 |
The hemolytic effect of primaquine. XI. Decreased catalase activity in primaquine-sensitive erythrocytes.
Topics: Antimalarials; Catalase; Cell Death; Erythrocytes; Hemolysis; Oxidation-Reduction; Primaquine | 1961 |
Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report.
Topics: Adult; Aminoquinolines; Antimalarials; Chloroquine; Hemolysis; Humans; Malaria, Vivax; Male; Primaqu | 1960 |
Methaemoglobin reduction test: a new, simple, in vitro test for identifying primaquine-sensitivity.
Topics: Aminoquinolines; Antimalarials; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Malaria; Methem | 1960 |
The methemoglobin reduction test for primaquine-type sensitivity of erythrocytes. A simplified procedure for detecting a specific hypersusceptibility to drug hemolysis.
Topics: Antimalarials; Erythrocytes; Hemoglobins; Hemolysis; Humans; Metabolic Diseases; Methemoglobin; Oxid | 1962 |
The hemolytic effect of primaquine. XV. Role of methemoglobin.
Topics: Antimalarials; Cell Death; Hemoglobins; Hemolysis; Methemoglobin; Primaquine | 1962 |
HEMOLYTIC EFFECT OF PRIMAQUINE. XVI. GLYOXALASE ACTIVITY OF PRIMAQUINE-SENSITIVE AND NORMAL ERYTHROCYTES.
Topics: Anemia; Anemia, Hemolytic; Black People; Blood Chemical Analysis; Erythrocytes; Esterases; Glucoseph | 1964 |
GENERATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES BY HEMOLYTIC AGENTS.
Topics: Antimalarials; Catalase; Chloroquine; Erythrocytes; Ethanol; Glucosephosphate Dehydrogenase Deficien | 1964 |
IN VIVO GENERATION OF H2O2 IN MOUSE ERYTHROCYTES BY HEMOLYTIC AGENTS.
Topics: Aniline Compounds; Animals; Antimalarials; Catalase; Enzyme Inhibitors; Erythrocytes; Glucosephospha | 1965 |
THE COURSE OF EXPERIMENTALLY INDUCED HEMOLYTIC ANEMIA IN A PRIMAQUINE-SENSITIVE CAUCASIAN. A CASE STUDY.
Topics: Anemia, Hemolytic; Biomedical Research; Blood Transfusion; Chromium Isotopes; Glucosephosphate Dehyd | 1965 |
THE MECHANISM OF HAEMOLYSIS IN FAVISM. SOME ANALOGY IN THE ACTIVITY OF PRIMAQUINE AND FAVA JUICE.
Topics: Blood; Erythrocytes; Favism; Glucosephosphate Dehydrogenase Deficiency; Glucosephosphates; Glutathio | 1965 |
OXIDATIVE HEMOLYSIS AND ERYTHROCYTE METABOLISM IN HEREDITARY ACATALASIA.
Topics: Acatalasia; Anemia; Anemia, Hemolytic; Ascorbic Acid; Azides; Catalase; Cyanides; Erythrocyte Aging; | 1965 |
The hemolytic effect of primaquine. X. Aldolase and glyceraldehyde-3-phosphate dehydrogenase activity in primaquine-sensitive erythrocytes.
Topics: Antimalarials; Cell Death; Erythrocytes; Fructose-Bisphosphate Aldolase; Glyceraldehyde; Hemolysis; | 1959 |
Hemolytic effect of therapeutic drugs. Clinical considerations of the primaquine-type hemolysis.
Topics: Antimalarials; Drug Therapy; Erythrocytes; Hemoglobins; Hemolysis; Metabolic Diseases; Oxidoreductas | 1962 |
The haemolytic effect of primaquine and nitrofurazone in cases of sleeping sickness with the haemolytic trait.
Topics: Animals; Antimalarials; Black People; Cell Death; Hemolysis; Humans; Nitrofurans; Nitrofurazone; Pri | 1961 |
Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine.
Topics: Anemia, Hemolytic; Animals; Drug Stability; Electrochemistry; Erythrocytes; Glutathione; Hemolysis; | 2004 |
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Comorbidity; Glucosephosphate Dehydrogenase Deficiency; Hem | 2005 |
Frequency of malaria and glucose-6-phosphate dehydrogenase deficiency in Tajikistan.
Topics: Adult; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria; Malaria, Vivax; Mal | 2006 |
Nature of hemolytic crises and the fate of G6PD deficient, drug-damaged erythrocytes in Sardinians.
Topics: Blood Transfusion; Chromium Isotopes; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficienc | 1967 |
Primaquine sensitivity in Caucasians: hemolytic reactions induced by primaquine in G-6-PD deficient subjects.
Topics: Adult; Bilirubin; Black or African American; Chromium Isotopes; Erythrocyte Count; Erythrocytes; Glu | 1967 |
[Study of hemolysis in vitro for the purpose of detecting primaquine sensitivity].
Topics: Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; In Vitro Techniques; Met | 1981 |
G-6-PD deficiency and primaquine.
Topics: Chromatography, Gas; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Primaquine | 1983 |
[Effect of ascorbic acid on hemolysis induced in vitro by primaquine].
Topics: Ascorbic Acid; Erythrocytes; Formates; Hemolysis; Humans; In Vitro Techniques; Methemoglobin; Primaq | 1983 |
Danger of haemolysis from primaquine use.
Topics: Chloroquine; Drug Therapy, Combination; Hemolysis; Humans; Malaria; Primaquine | 1982 |
Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug.
Topics: Adolescent; Child; Child, Preschool; Gastrointestinal Diseases; Hemolysis; Humans; Infant; Malaria; | 1981 |
The hemolytic effect of primaquine V. Primaquine sensitivity as a manifestation of a multiple drug sensitivity.
Topics: Anemia, Hemolytic; Erythrocytes; Hemolysis; Humans; Male; Primaquine | 1981 |
Human erythrocyte G6PD deficiency: pathophysiology, prevalence, diagnosis, and management.
Topics: Black People; Blood Transfusion; Chloroquine; Female; Genetic Counseling; Glucosephosphate Dehydroge | 1980 |
[Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits].
Topics: Anemia, Hemolytic; Animals; Antimalarials; Female; Hemolysis; Male; Methemoglobinemia; Primaquine; R | 1994 |
Nitroxide stable radical prevents primaquine-induced lysis of red blood cell.
Topics: Cyclic N-Oxides; Erythrocytes; Free Radicals; Hemolysis; Humans; Oxidation-Reduction; Primaquine | 1994 |
Protective effects of rutin against hemoglobin oxidation.
Topics: Antioxidants; Erythrocytes; Hemoglobins; Hemolysis; Humans; Methemoglobin; Oxidation-Reduction; Prim | 1994 |
[Determination of glucose-6-phosphate dehydrogenase deficiency to prevent possible drug-induced hemolysis].
Topics: Anemia, Hemolytic; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Meth | 1991 |
Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency.
Topics: Anti-Bacterial Agents; Antimalarials; Aspirin; Case-Control Studies; Chloramphenicol; Drug Evaluatio | 1999 |
Effect of drugs on oxidation and precipitation of the isolated chains of human hemoglobin.
Topics: Adrenochrome; Catalase; Chemical Precipitation; Epinephrine; Hemoglobins; Hemolysis; Humans; Macromo | 1978 |
Erythrocytic enzyme activities and drug induced hemolysis in rabbits.
Topics: Animals; Erythrocytes; Glucose; Glutathione; Hemolysis; Humans; In Vitro Techniques; Male; Phenylhyd | 1976 |
Drug-induced haemolysis in glucose-6-phosphate dehydrogenase deficiency.
Topics: Aspirin; Cell Survival; China; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Male; N | 1976 |
[Use of coagulograph H-333 in the diagnosis of drug-induced hemolysis].
Topics: Blood Coagulation Disorders; Blood Coagulation Tests; Hemolysis; Humans; Malaria; Primaquine | 1975 |
[Hemocoagulation disturbances in drug-provoked hemolysis in persons with glucose-6-phosphate dehydrogenase deficiency].
Topics: Adolescent; Adult; Aged; Blood Coagulation; Blood Coagulation Disorders; Child; Drug Evaluation; Fem | 1976 |
Acute intravascular haemolysis in Vanuatu following a single dose of primaquine in individuals with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acute Disease; Adolescent; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemo | 1992 |
[Study on structure-activity relationships of hemolytic toxicity of primaquine derivatives].
Topics: Animals; Hemolysis; In Vitro Techniques; Male; Microsomes, Liver; Primaquine; Rats; Rats, Inbred Str | 1991 |
[In vitro assay for detecting hemolytic toxicity of antimalarials incorporated with microsomal metabolic system].
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Hemolysis; Male; Microsomes, Liver; Primaquine | 1990 |
Primaquine induced hemolysis in a Thai soldier.
Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; | 1989 |
Photooxidation products of primaquine. Structure, antimalarial activity and hemolytic effects.
Topics: Animals; Biotransformation; Cell Survival; Hemolysis; Liver; Methemoglobin; Oxidation-Reduction; Pla | 1987 |
Oxidative activity of hydroxylated primaquine analogs. Non-toxicity to glucose-6-phosphate dehydrogenase-deficient human red blood cells in vitro.
Topics: Adenosine Triphosphate; Adult; Aminoquinolines; Erythrocytes; Glucosephosphate Dehydrogenase Deficie | 1986 |
Effects of nine synthetic putative metabolites of primaquine on activity of the hexose monophosphate shunt in intact human red blood cells in vitro.
Topics: Aminoquinolines; Erythrocytes; Ethylmaleimide; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; | 1986 |
Drug-induced hemolysis.
Topics: Anemia, Hemolytic; Black People; Clinical Enzyme Tests; Erythrocytes; Glucosephosphate Dehydrogenase | 1973 |
Activity and some properties of an acid proteinase from normal and Plasmodium berghei-infected red cells.
Topics: Acid Phosphatase; Animals; Cell-Free System; Chloroquine; Dithiothreitol; Edetic Acid; Erythrocytes; | 1973 |
[Hemolytic anemias. Enzymopenic hemolytic anemias].
Topics: Adenosine Triphosphatases; Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Child; Deficiency Disea | 1966 |
Primaquine-induced hemolysis of normal erythrocytes in vitro: the requirement for energy.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Carbon Dioxide; Carbon Isotopes; Cell Membrane; D | 1970 |
Erythrocyte glucose-6-phosphate dehydrogenase and glutathione deficiency in sheep.
Topics: Age Factors; Animals; Chromium Isotopes; Disease Models, Animal; Erythrocytes; Female; Glucosephosph | 1972 |
Is it bad to be blue?
Topics: Electrophoresis; Erythrocytes; Hemolysis; Humans; Male; Methemoglobin; Methemoglobinemia; NAD; Oxido | 1969 |
Erythrocyte membrane vacuole formation in hereditary spherocytosis.
Topics: Anemia, Hemolytic, Autoimmune; Anemia, Hemolytic, Congenital; Anemia, Sickle Cell; Binding Sites; Ca | 1974 |
Effects of drugs and drug metabolites on erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient individuals.
Topics: Acetanilides; Aniline Compounds; Animals; Antimalarials; Benzene Derivatives; Black People; Cell Mem | 1968 |
The potential use of xylitol in glucose-6-phosphate dehydrogenase deficiency anemia.
Topics: Alcohol Oxidoreductases; Alcohols; Animals; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; | 1971 |
Clinical pharmacology of diformyldapsone.
Topics: Chloroquine; Dapsone; Drug Therapy, Combination; Erythrocytes; Formaldehyde; Glucosephosphate Dehydr | 1974 |
The haemolytic effect of a single dose of 45 mg of primaquine in G-6-PD deficient Thais.
Topics: Adolescent; Adult; Erythrocyte Count; Glucosephosphate Dehydrogenase Deficiency; Haptoglobins; Hemat | 1972 |
Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.
Topics: Chloroquine; Fever; Hemolysis; Hepatomegaly; Humans; Infant; Malaria; Male; Plasmodium vivax; Primaq | 1973 |
Relapses of vivax malaria after a conventional course of primaquine and chloroquine: report of 2 cases.
Topics: Adult; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Glucosephosphate Dehydrogenase; | 1973 |
New approaches to investigating UVL photo protective substances in vitro.
Topics: 1-Propanol; Aminobenzoates; Aniline Compounds; beta-Aminoethyl Isothiourea; Candida albicans; Chlorp | 1973 |
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
Topics: Anemia, Hemolytic; Ascorbic Acid; Carbon Radioisotopes; Cell Survival; Chromium Radioisotopes; Eryth | 1972 |
Variants of glucose-6-phosphate dehydrogenase (G-6-PD) associated with G-6-PD deficiency in Puerto Ricans.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Chromatography, Gel; Female; Glucosephosphate Dehy | 1973 |
[Influence of chloroquine and primaquine on red cell metabolism (author's transl)].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Chloroquine; Erythroc | 1973 |
Influence of riboflavin and of erythrocyte stroma on glutathione reductase activity in normal, glucose 6 phosphate dehydrogenase deficient and low glutathione reductase individuals.
Topics: Cell Membrane; Clinical Enzyme Tests; Deficiency Diseases; Drug Interactions; Enzyme Activation; Ery | 1973 |
The course of primaquine-induced haemolysis in G-6-PD-deficient Thais.
Topics: Adult; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Male; Middle Aged; Primaquine; | 1973 |
Chloroquine-resistant Plasmodium falciparum: protective and hemolytic effects of 4,4'-diaminodiphenylsulfone (DDS) administered daily together with weekly chloroquine and primaquine.
Topics: Adult; Black or African American; Chloroquine; Dapsone; Hemolysis; Humans; Malaria; Male; Plasmodium | 1967 |
The ratio between normal and sensitive erythrocytes in heterozygous glucose-6-phosphate dehydrogenase deficient women.
Topics: Chromium Isotopes; Drug Hypersensitivity; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogena | 1970 |
Red-cell catalase and the production of methaemoglobin, Heinz bodies and changes in osmotic fragility due to drugs.
Topics: Aniline Compounds; Ascorbic Acid; Azides; Blood Glucose; Catalase; Chlorates; Erythrocytes; Glucosep | 1971 |
Effect of primaquine on erythrocytes with NADH-methaemoglobin reductase deficiency and low glutathione reductase activity.
Topics: Blood Protein Electrophoresis; Child; Chromium Isotopes; Dihydrolipoamide Dehydrogenase; Erythrocyte | 1972 |
The influence of glucose and exogenous glutathione on the red cell membrane effect of the antimalarial drugs 1,4-naphthoquinone and beta-naphthol.
Topics: Cell Membrane; Erythrocytes; Glucose; Glutathione; Hemolysis; Humans; In Vitro Techniques; Methemogl | 1971 |
Alterations in normal and G-6-PD deficient human erythrocytes of various ages after exposure to metabolites of hemolytic drugs.
Topics: Adult; Erythrocyte Aging; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Hemo | 1971 |
Hemolysis induced by Prymnesium parvum toxin. Effect of primaquine treatment.
Topics: Animals; Erythrocytes; Eukaryota; Hematocrit; Hemolysis; Kinetics; Mathematics; Potassium; Potassium | 1971 |
The clinical importance of pharmacogenetics.
Topics: Adult; Aged; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalitie | 1969 |
Absence of hemolytic effects of L-DOPA on transfused G6PD-deficient erythrocytes.
Topics: Blood Transfusion; Chromium Isotopes; Dapsone; Dihydroxyphenylalanine; Erythrocytes; Favism; Female; | 1970 |
Modification of phospholipid metabolism in human red cells by primaquine. A possible mechanism in drug-induced hemolysis.
Topics: Carbon Isotopes; Carnitine; Erythrocytes; Fatty Acids; Hemolysis; Humans; Lysophosphatidylcholines; | 1970 |
The intracellular and membrane effects of oxidant agents on normal red cells.
Topics: Cell Membrane; Erythrocytes; Glutathione; Heinz Bodies; Hemoglobinometry; Hemolysis; Humans; Hydroqu | 1970 |
Sites of destruction of red cells in G-6-PD deficient Caucasians and in phenylhydrazine treated patients.
Topics: Blood Transfusion; Chromium Isotopes; Female; Glucosephosphate Dehydrogenase Deficiency; Hematocrit; | 1968 |
[Oxidative hemolysis in the newborn. I. Effects of incubation with oxidizing agents on erythrocyte survival, on reduced glutathione and on formation of Heinz bodies].
Topics: Adult; Erythrocyte Aging; Glutathione Reductase; Heinz Bodies; Hemolysis; Humans; Infant, Newborn; I | 1968 |
Membrane alterations in hemolysis: Internalization of plasmalemma induced by primaquine.
Topics: Cell Membrane; Erythrocytes; Hemolysis; Humans; Microscopy, Electron; Pinocytosis; Primaquine; Surfa | 1969 |
Hemolytic effects of standard single dosages of primaquine and chloroquine on G-6-PD-deficient caucasians.
Topics: Anemia, Hemolytic; Black or African American; Chloroquine; Chromium Isotopes; Female; Glucosephospha | 1969 |
Catalase activity in normal and glucose-6-phosphate dehydrogenase deficient red cells.
Topics: Catalase; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; In Vit | 1965 |