primaquine has been researched along with Carcinoma, Hepatocellular in 12 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| " The dose-response characteristics of the effect of primaquine on receptor recycling are identical to those of the effects on protein secretion and virus budding." | 1.27 | Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. ( Du Maine, A; Schwartz, AL; Slot, JW; Strous, GJ; Zijderhand-Bleekemolen, JE, 1985) |
| "primaquine, inhibit acidification and iron release from transferrin." | 1.27 | Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells. ( Wu, CH; Wu, GY, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chattopadhyay, R | 1 |
| Velmurugan, S | 1 |
| Chakiath, C | 1 |
| Andrews Donkor, L | 1 |
| Milhous, W | 1 |
| Barnwell, JW | 1 |
| Collins, WE | 1 |
| Hoffman, SL | 1 |
| Schwartz, AL | 7 |
| Bolognesi, A | 1 |
| Fridovich, SE | 1 |
| Underhill, DM | 1 |
| Owensby, DA | 1 |
| Morton, PA | 1 |
| Reif, JS | 1 |
| Fallon, RJ | 1 |
| Bates, MD | 1 |
| Meshnick, SR | 1 |
| Sigler, CI | 1 |
| Leland, P | 1 |
| Hollingdale, MR | 2 |
| Strous, GJ | 4 |
| van Kerkhof, P | 1 |
| van Bokhoven, A | 1 |
| de Pont, JJ | 1 |
| Slot, JW | 4 |
| Geuze, HJ | 3 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Du Maine, A | 1 |
| Zijderhand-Bleekemolen, JE | 2 |
| Wu, GY | 1 |
| Wu, CH | 1 |
| Braulke, T | 1 |
| Hasilik, A | 1 |
| von Figura, K | 1 |
12 other studies available for primaquine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Establishment of an in vitro assay for assessing the effects of drugs on the liver stages of Plasmodium vivax malaria.
Topics: Animals; Anopheles; Antimalarials; Carcinoma, Hepatocellular; Cryopreservation; Disease Models, Anim | 2010 |
Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran | 1984 |
Endocytosis and lysosomal delivery of tissue plasminogen activator-inhibitor 1 complexes in Hep G2 cells.
Topics: Ammonium Chloride; beta-N-Acetylhexosaminidases; Carcinoma, Hepatocellular; Chloroquine; Endocytosis | 1992 |
Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells.
Topics: alpha-Fetoproteins; Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cel | 1991 |
In vitro effects of primaquine and primaquine metabolites on exoerythrocytic stages of Plasmodium berghei.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Infant, Newborn; Liver Neoplasms; Oxidation-Reduction; P | 1990 |
Effect of primaquine on the topology of Na,K-ATPase and the receptor for asialoglycoproteins.
Topics: Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cell Line; Humans; Liver Neoplasms; Primaqui | 1988 |
Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells.
Topics: Antibodies; Carcinoma, Hepatocellular; Cell Line; Endocytosis; Golgi Apparatus; Humans; Liver Neopla | 1985 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells.
Topics: Asialoglycoprotein Receptor; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Cel | 1985 |
Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line; Humans; Iron; Kinetics; Liver Neoplasms; | 1986 |
Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cell Line; Cell Membran | 1987 |
On the effects of weak bases and monensin on sorting and processing of lysosomal enzymes in human cells.
Topics: Ammonium Chloride; Carcinoma, Hepatocellular; Cathepsin D; Cell Line; Chloroquine; Fibroblasts; Huma | 1987 |