primaquine has been researched along with Black Fever in 9 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "8-Aminoquinolines are an important class of antiparasitic agents, with broad utility and excellent efficacy, but also limitations due to hematological toxicities, primarily methemoglobinemia and hemolysis." | 3.74 | Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. ( Ager, AL; Bartlett, MS; Croft, SL; Khan, IA; McChesney, JD; Nanayakkara, NP; Walker, LA; Yardley, V, 2008) |
| " However, primaquine exhibits low oral bioavailability due to oxidative deamination of its aliphatic chain." | 1.38 | Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum. ( Gomes, MS; Gomes, P; Matos, J; Moreira, R; Tomás, A; Vale, N; Vale-Costa, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shetty, RV | 1 |
| Blanton, CD | 1 |
| Nanayakkara, NP | 1 |
| Ager, AL | 1 |
| Bartlett, MS | 1 |
| Yardley, V | 1 |
| Croft, SL | 2 |
| Khan, IA | 1 |
| McChesney, JD | 1 |
| Walker, LA | 1 |
| Castanys-Muñoz, E | 1 |
| Pérez-Victoria, JM | 1 |
| Gamarro, F | 1 |
| Castanys, S | 1 |
| Vale-Costa, S | 1 |
| Vale, N | 1 |
| Matos, J | 1 |
| Tomás, A | 1 |
| Moreira, R | 1 |
| Gomes, P | 1 |
| Gomes, MS | 1 |
| Steck, EA | 1 |
| Burghard, H | 1 |
| DeWitt Blanton, C | 1 |
| Rodrigues, JM | 1 |
| Fessi, H | 1 |
| Bories, C | 1 |
| Devissaguet, JP | 1 |
| Gaspar, R | 1 |
| Opperdoes, FR | 1 |
| Préat, V | 1 |
| Roland, M | 1 |
| Zhong, HL | 1 |
| Zhang, NZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for primaquine and Black Fever
| Article | Year |
|---|---|
The chemotherapy of protozoal infections: whither?
Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Disease Models, Animal; Glycolip | 1981 |
Studies on leishmaniasis in China. Historical background, epidemiology, clinical aspects, legislature and control program.
Topics: Animals; China; Humans; Legislation, Medical; Leishmaniasis, Visceral; Liposomes; Primaquine | 1986 |
7 other studies available for primaquine and Black Fever
| Article | Year |
|---|---|
Synthesis of 2-substituted primaquine analogues as potential antimalarials.
Topics: Animals; Antimalarials; Cricetinae; Haplorhini; Leishmaniasis, Visceral; Macaca mulatta; Malaria; Mi | 1978 |
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.
Topics: Aminoquinolines; Animals; Antifungal Agents; Antiprotozoal Agents; Dogs; Female; Hemolysis; Humans; | 2008 |
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Bi | 2008 |
Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Cell Culture Techniques; Cell Survival; Inhibitory C | 2012 |
4,5-disubstituted primaquine analogs as potential antiprotozoan agents.
Topics: Animals; Antiprotozoal Agents; Chemical Phenomena; Chemistry; Cricetinae; Haplorhini; Leishmaniasis, | 1980 |
The activity and ultrastructural localization of primaquine-loaded poly (d,l-lactide) nanoparticles in Leishmania donovani infected mice.
Topics: Animals; Delayed-Action Preparations; Drug Carriers; Female; In Vitro Techniques; Leishmania donovan | 1994 |
Drug targeting with polyalkylcyanoacrylate nanoparticles: in vitro activity of primaquine-loaded nanoparticles against intracellular Leishmania donovani.
Topics: Animals; Cell Line; Cyanoacrylates; Dose-Response Relationship, Drug; Drug Carriers; In Vitro Techni | 1992 |