primaquine has been researched along with Asymptomatic Colonization in 2 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The median time to recurrence of P." | 2.94 | The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR. ( Adhikari, B; Cobelens, F; Day, NPJ; Dhorda, M; Dondorp, AM; Henriques, G; Imwong, M; Mayxay, M; Mukaka, M; Newton, PN; Peerawaranun, P; Peto, TJ; Phommasone, K; Pongvongsa, T; Promnarate, C; Sirithiranont, P; van Leth, F; von Seidlein, L; White, NJ, 2020) |
| "Both primaquine arms had lower gametocyte prevalences after day 3 compared to the placebo arm, regardless of gametocyte detection method." | 2.82 | Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial. ( Bougouma, EC; Bousema, T; Bradley, J; Diarra, A; Drakeley, C; Eziefula, AC; Gonçalves, BP; Guelbéogo, WM; Lanke, K; Nebie, I; Ouédraogo, A; Pett, H; Siaka, D; Sirima, SB; Tiono, AB, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Phommasone, K | 1 |
| van Leth, F | 1 |
| Imwong, M | 1 |
| Henriques, G | 1 |
| Pongvongsa, T | 1 |
| Adhikari, B | 1 |
| Peto, TJ | 1 |
| Promnarate, C | 1 |
| Dhorda, M | 1 |
| Sirithiranont, P | 1 |
| Mukaka, M | 1 |
| Peerawaranun, P | 1 |
| Day, NPJ | 1 |
| Cobelens, F | 1 |
| Dondorp, AM | 1 |
| Newton, PN | 1 |
| White, NJ | 1 |
| von Seidlein, L | 1 |
| Mayxay, M | 1 |
| Gonçalves, BP | 1 |
| Tiono, AB | 1 |
| Ouédraogo, A | 1 |
| Guelbéogo, WM | 1 |
| Bradley, J | 1 |
| Nebie, I | 1 |
| Siaka, D | 1 |
| Lanke, K | 1 |
| Eziefula, AC | 1 |
| Diarra, A | 1 |
| Pett, H | 1 |
| Bougouma, EC | 1 |
| Sirima, SB | 1 |
| Drakeley, C | 1 |
| Bousema, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Single-blinded Controlled Treatment Trial of Subclinical Vivax Infections With Primaquine in Nong Province, Laos[NCT02802813] | Phase 1/Phase 2 | 41 participants (Actual) | Interventional | 2016-06-14 | Completed | ||
| A Double Blind Randomized Controlled Trial to Assess the Efficacy and Safety of Low Dose Primaquine for Clearance of Gametocytes in Asymptomatic Individuals Infected With P. Falciparum in Burkina Faso[NCT01935882] | Phase 2/Phase 3 | 360 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for primaquine and Asymptomatic Colonization
| Article | Year |
|---|---|
The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Asymptomatic Infections; Female; Humans; Laos; Malar | 2020 |
Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Artemether; Artemisinins; Asymptomatic Infections; Child; Child, Preschool; Double-Bl | 2016 |