primaquine has been researched along with Anemia in 28 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primaquine was licenced for anti-relapse therapy in 1952 and became available despite threatening patients having an inborn deficiency of glucose-6-phosphate dehydrogenase (G6PD) with acute haemolytic anaemia." | 6.52 | Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria. ( Baird, K, 2015) |
| "At least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria." | 4.75 | The treatment of malaria. ( Hall, AP, 1976) |
| "Safe treatment of Plasmodium vivax requires diagnosis of both the infection and status of erythrocytic glucose-6-phosphate dehydrogenase (G6PD) activity because hypnozoitocidal therapy against relapse requires primaquine, which causes a mild to severe acute hemolytic anemia in G6PD deficient patients." | 3.81 | G6PD deficiency at Sumba in Eastern Indonesia is prevalent, diverse and severe: implications for primaquine therapy against relapsing Vivax malaria. ( Baird, JK; Baramuli, V; Coutrier, FN; Elvira, R; Elyazar, I; Harahap, AR; Noviyanti, R; Ridenour, C; Sadhewa, A; Satyagraha, AW, 2015) |
| "A practical radical treatment for vivax malaria is essential for control and elimination of the disease." | 2.73 | A randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in Northwest Frontier Province, Pakistan. ( Erasmus, P; Kolaczinski, J; Leslie, T; Mayan, I; Mohammed, N; Rowland, M; Whitty, CJ, 2008) |
| "Primaquine was licenced for anti-relapse therapy in 1952 and became available despite threatening patients having an inborn deficiency of glucose-6-phosphate dehydrogenase (G6PD) with acute haemolytic anaemia." | 2.52 | Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria. ( Baird, K, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (64.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Kagaya, W | 1 |
| Gitaka, J | 1 |
| Chan, CW | 1 |
| Kongere, J | 1 |
| Md Idris, Z | 1 |
| Deng, C | 1 |
| Kaneko, A | 1 |
| Brummaier, T | 1 |
| Gilder, ME | 1 |
| Gornsawun, G | 1 |
| Chu, CS | 1 |
| Bancone, G | 1 |
| Pimanpanarak, M | 1 |
| Chotivanich, K | 1 |
| Nosten, F | 1 |
| McGready, R | 1 |
| Brito-Sousa, JD | 1 |
| Santos, TC | 1 |
| Avalos, S | 1 |
| Fontecha, G | 1 |
| Melo, GC | 1 |
| Val, F | 1 |
| Siqueira, AM | 1 |
| Alecrim, GC | 1 |
| Bassat, Q | 1 |
| Lacerda, MVG | 1 |
| Monteiro, WM | 1 |
| Dos-Santos, JC | 1 |
| Angerami, RN | 1 |
| Castiñeiras, CM | 1 |
| Lopes, SC | 1 |
| Albrecht, L | 1 |
| Garcia, MT | 1 |
| Levy, CE | 1 |
| Moretti, ML | 1 |
| Lacerda, MV | 1 |
| Costa, FT | 1 |
| Satyagraha, AW | 1 |
| Sadhewa, A | 1 |
| Baramuli, V | 1 |
| Elvira, R | 1 |
| Ridenour, C | 1 |
| Elyazar, I | 1 |
| Noviyanti, R | 1 |
| Coutrier, FN | 1 |
| Harahap, AR | 1 |
| Baird, JK | 1 |
| Baird, K | 2 |
| Thanh, PV | 1 |
| Hong, NV | 1 |
| Van, NV | 1 |
| Louisa, M | 1 |
| Xa, NX | 1 |
| Peeters Grietens, K | 1 |
| Hung, le X | 1 |
| Duong, TT | 1 |
| Rosanas-Urgell, A | 1 |
| Speybroeck, N | 1 |
| D'Alessandro, U | 1 |
| Erhart, A | 1 |
| Leslie, T | 1 |
| Mayan, I | 1 |
| Mohammed, N | 1 |
| Erasmus, P | 1 |
| Kolaczinski, J | 1 |
| Whitty, CJ | 2 |
| Rowland, M | 1 |
| Shekalaghe, SA | 1 |
| ter Braak, R | 1 |
| Daou, M | 1 |
| Kavishe, R | 1 |
| van den Bijllaardt, W | 1 |
| van den Bosch, S | 1 |
| Koenderink, JB | 1 |
| Luty, AJ | 1 |
| Drakeley, C | 1 |
| Sauerwein, RW | 1 |
| Bousema, T | 1 |
| Barber, BE | 1 |
| William, T | 1 |
| Jikal, M | 1 |
| Jilip, J | 1 |
| Dhararaj, P | 1 |
| Menon, J | 1 |
| Yeo, TW | 1 |
| Anstey, NM | 1 |
| DERN, RJ | 2 |
| BEUTLER, E | 2 |
| ALVING, AS | 4 |
| KIMBRO, EL | 1 |
| SACHS, MV | 1 |
| TORBERT, JV | 1 |
| KELLERMEYER, RW | 1 |
| TARLOV, A | 1 |
| SCHRIER, S | 1 |
| CARSON, PE | 1 |
| CHARLES, LJ | 1 |
| CHILDS, B | 1 |
| FREZAL, J | 1 |
| NEIMANN, N | 2 |
| DUCAS, J | 1 |
| WITTMER, JF | 1 |
| BREWER, GJ | 1 |
| POWELL, RD | 1 |
| TARLOV, AR | 1 |
| RICOIRLES, J | 1 |
| PIERSON, M | 1 |
| SANTAGOSTINI, F | 1 |
| PALEK, J | 1 |
| BARNARD, DR | 1 |
| JACOB, HS | 1 |
| INGBAR, SH | 1 |
| JANDL, JH | 1 |
| Hall, AP | 1 |
| Miller, MB | 1 |
| Reynolds, RD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Placebo Controlled, Randomised Evaluation of an Eight Week Primaquine Regimen for the Treatment of Vivax Malaria.[NCT00158587] | Phase 3 | 150 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| Mass-Drug Administration With a Gametocytocidal Drug Combination, a Model for a Transmission Blocking Vaccine[NCT00509015] | 6,000 participants (Anticipated) | Interventional | 2008-02-29 | Completed | |||
| Evaluation of the Efficacy and Safety of Primaquine for Clearance of Gametocytes in Uncomplicated Falciparum Malaria in Uganda[NCT01365598] | Phase 3 | 468 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia[NCT01743820] | Phase 2 | 81 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for primaquine and Anemia
| Article | Year |
|---|---|
Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria.
Topics: Anemia; Antimalarials; Chemical and Drug Induced Liver Injury; Glucosephosphate Dehydrogenase Defici | 2015 |
[METHEMOGLOBINEMIA, HEMOLYSIS AND FORMATION OF HEINZ BODIES IN THE ERYTHROCYTES].
Topics: Adenosine Triphosphate; Anemia; Anemia, Hemolytic; Carbohydrate Metabolism; Catalase; Erythrocytes; | 1964 |
ENZYME DEFECTS IN THE HUMAN RED CELL.
Topics: Anemia; Blood Protein Disorders; Drug Therapy; Enzymes; Erythrocytes; Favism; Hemoglobinuria; Hemogl | 1964 |
The treatment of malaria.
Topics: Anemia; Antimalarials; Blackwater Fever; Child; Child, Preschool; Chloroquine; Coma; Drug Combinatio | 1976 |
3 trials available for primaquine and Anemia
| Article | Year |
|---|---|
Confirmed Plasmodium vivax Resistance to Chloroquine in Central Vietnam.
Topics: Adolescent; Adult; Anemia; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Fem | 2015 |
A randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in Northwest Frontier Province, Pakistan.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Antimalarials; Child; Child, Preschool; Drug Adm | 2008 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
21 other studies available for primaquine and Anemia
| Article | Year |
|---|---|
Malaria resurgence after significant reduction by mass drug administration on Ngodhe Island, Kenya.
Topics: Anemia; Animals; Antimalarials; Geography; Hemoglobins; Humans; Islands; Kenya; Malaria; Mass Drug A | 2019 |
Vivax malaria in pregnancy and lactation: a long way to health equity.
Topics: Adolescent; Aminoquinolines; Anemia; Antimalarials; Artemether, Lumefantrine Drug Combination; Femal | 2020 |
Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Antimalarials; Brazil; Child; Child, Preschool; | 2019 |
Imported malaria in a non-endemic area: the experience of the university of Campinas hospital in the Brazilian Southeast.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anemia; Antimalarials; Artemether; Artemisini | 2014 |
G6PD deficiency at Sumba in Eastern Indonesia is prevalent, diverse and severe: implications for primaquine therapy against relapsing Vivax malaria.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Antimalarials; Child; Child, Preschool; Female; | 2015 |
Plasmodium knowlesi malaria in children.
Topics: Adolescent; Age Factors; Anemia; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans | 2011 |
The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Hemolysis; Primaquine | 1954 |
The hemolytic effect of primaquine. III. A study of primaquine-sensitive erythrocytes.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Erythrocytes; Hemolysis; Primaquine; Tracheoph | 1954 |
Mechanism of the hemolytic anemia induced by nitrofurantoin (furadantin); further observations on the incidence and significance of primaquine-sensitive red cells.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Erythrocytes; Humans; Incidence; Nitrofurantoin; Primaquin | 1957 |
Biochemical and genetic aspects of primaquine-sensitive hemolytic anemia.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Humans; Primaquine | 1958 |
Observations on the haemolytic effect of primaquine in 100 Ghanaian children.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Ghana; Humans; Primaquine | 1960 |
Primaquine sensitivity of erythrocytes.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Erythrocytes; Primaquine | 1961 |
[Favism and anemia caused by sensitivity to primaquine].
Topics: Anemia; Antimalarials; Favism; Humans; Primaquine | 1960 |
[Anemia and jaundice caused by hereditary glucose-6-phosphate dehydrogenase deficit].
Topics: Anemia; Anemia, Hemolytic; Favism; Glucosephosphate Dehydrogenase; Humans; Jaundice; Metabolic Disea | 1962 |
AEROMEDICAL ASPECTS OF MALARIA PROPHYLAXIS WITH CHLOROQUINE-PRIMAQUINE.
Topics: Aerospace Medicine; Anemia; Anemia, Hemolytic; Chloroquine; Humans; Malaria; Methemoglobinemia; Moto | 1963 |
HEMOLYTIC EFFECT OF PRIMAQUINE. XVI. GLYOXALASE ACTIVITY OF PRIMAQUINE-SENSITIVE AND NORMAL ERYTHROCYTES.
Topics: Anemia; Anemia, Hemolytic; Black People; Blood Chemical Analysis; Erythrocytes; Esterases; Glucoseph | 1964 |
[HEMOLYTIC ANEMIAS DUE TO HEREDITARY DEFECT OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE].
Topics: Anemia; Anemia, Hemolytic; Classification; Clinical Laboratory Techniques; Drug Hypersensitivity; Fa | 1964 |
[HEMOLYTIC ANEMIA CAUSED BY GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY].
Topics: Anemia; Anemia, Hemolytic; Clinical Laboratory Techniques; Glucosephosphate Dehydrogenase Deficiency | 1963 |
[PHARMACOGENETICS].
Topics: Anemia; Anemia, Hemolytic; Barbiturates; Catalase; Cholinesterases; Genetics, Medical; Glucosephosph | 1964 |
OXIDATIVE HEMOLYSIS AND ERYTHROCYTE METABOLISM IN HEREDITARY ACATALASIA.
Topics: Acatalasia; Anemia; Anemia, Hemolytic; Ascorbic Acid; Azides; Catalase; Cyanides; Erythrocyte Aging; | 1965 |
Treatment and complications of vivax malaria in Vietnam.
Topics: Anemia; Chloroquine; Humans; Malaria; Military Medicine; Plasmodium vivax; Primaquine; United States | 1972 |