primaquine has been researched along with Anemia, Hemolytic in 75 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Anemia, Hemolytic: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 6.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| "This paper reports on 2 hemolytic serious reactions in 2 Arabian patients because of the use of primaquine as presumptive antimalarial treatment given in Cuba to all travellers from countries where malaria is endemic." | 4.79 | [Primaquine and travelers from the Arab world. A report and recommendations]. ( Caña Lugo, C; Fernández Núñez, A; Menéndez Capote, R, 1995) |
| " Primaquine in particular is known to cause methemoglobinemia and hemolytic anemia." | 4.02 | Primaquine overdose in a toddler. ( Pomeranz, E; Ponce, DM; Schaeffer, W; Visclosky, T, 2021) |
| "8 patients with paludism diagnosis due to Plasmodium vivax and deficiency of glucose-6-phosphate dehydrogenase that should receive antipaludism radical treatment with primaquine were studied." | 3.69 | [Hemolysis and primaquine treatment. Preliminary report]. ( Díaz Pérez, L; Luzardo Suárez, C; Menéndez Capote, R, 1997) |
| "Primaquine has the potential to reduce malaria-related anaemia at day 42 and beyond by preventing recurrent parasitaemia." | 2.61 | The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. ( Abreha, T; Alemu, SG; Añez, A; Anstey, NM; Aseffa, A; Assefa, A; Awab, GR; Baird, JK; Barber, BE; Borghini-Fuhrer, I; Chu, CS; Commons, RJ; D'Alessandro, U; Dahal, P; Daher, A; de Vries, PJ; Douglas, NM; Erhart, A; Gomes, MSM; Grigg, MJ; Guerin, PJ; Hien, TT; Hwang, J; Kager, PA; Ketema, T; Khan, WA; Lacerda, MVG; Leslie, T; Ley, B; Lidia, K; Monteiro, WM; Nosten, F; Pereira, DB; Phan, GT; Phyo, AP; Price, RN; Rowland, M; Saravu, K; Sibley, CH; Simpson, JA; Siqueira, AM; Stepniewska, K; Taylor, WRJ; Thriemer, K; Thwaites, G; Tran, BQ; Vieira, JLF; Wangchuk, S; Watson, J; White, NJ; William, T; Woodrow, CJ, 2019) |
| "Testing for G6PD deficiency is not widely available, and so whilst it is widely recommended, primaquine is often not prescribed." | 2.50 | Mass primaquine treatment to eliminate vivax malaria: lessons from the past. ( Ashley, EA; Baranova, AM; Kondrashin, A; Recht, J; Sergiev, VP; White, NJ, 2014) |
| " These data inform discussions on safe and effective primaquine dosing and future malaria elimination strategies for Haiti." | 1.40 | Glucose-6-phosphate dehydrogenase deficiency A- variant in febrile patients in Haiti. ( Carter, TE; Maloy, H; Mulligan, CJ; Okech, BA; Romain, JR; St Victor, Y; von Fricken, M, 2014) |
| "Primaquine is a well-recognized cause of hemolysis in individuals with G6PD deficiency." | 1.35 | Central retinal vein occlusion in an Army ranger with glucose-6-phosphate dehydrogenase deficiency. ( Butler, FK; Hill, GJ; Kotwal, RS; Miles, EA; Murray, CK; Rayfield, JC, 2009) |
| "Primaquine-induced hemolytic anemia is a toxic side effect that is due to premature splenic sequestration of intact erythrocytes." | 1.33 | Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine. ( Bowman, ZS; Jollow, DJ; McMillan, DC; Morrow, JD, 2005) |
| "Primaquine-induced hemolytic anemia is known to result from premature sequestration of damaged (but intact) erythrocytes by the spleen." | 1.33 | Primaquine-induced hemolytic anemia: role of splenic macrophages in the fate of 5-hydroxyprimaquine-treated rat erythrocytes. ( Bowman, ZS; Jollow, DJ; McMillan, DC, 2005) |
| "Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp." | 1.32 | Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine. ( Bowman, ZS; Jollow, DJ; McMillan, DC; Oatis, JE; Whelan, JL, 2004) |
| "Primaquine is an important antimalarial drug that is often dose-limited in therapy by the onset of hemolytic anemia." | 1.31 | Primaquine-induced hemolytic anemia: formation of free radicals in rat erythrocytes exposed to 6-methoxy-8-hydroxylaminoquinoline. ( Bolchoz, LJ; Gelasco, AK; Jollow, DJ; McMillan, DC, 2002) |
| "Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp." | 1.31 | Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline. ( Bolchoz, LJ; Budinsky, RA; Jollow, DJ; McMillan, DC, 2001) |
| " In order to determine their hemolytic toxicity, we dosed rabbits with M8506 and PQ at a dose of 40 mg/kg per day for 4 days, respectively." | 1.29 | [Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits]. ( Ha, S; Shi, X; Yiao, J; Zhan, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (62.67) | 18.7374 |
| 1990's | 6 (8.00) | 18.2507 |
| 2000's | 10 (13.33) | 29.6817 |
| 2010's | 10 (13.33) | 24.3611 |
| 2020's | 2 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Devine, A | 1 |
| Howes, RE | 1 |
| Price, DJ | 1 |
| Moore, KA | 1 |
| Ley, B | 2 |
| Simpson, JA | 2 |
| Dittrich, S | 1 |
| Price, RN | 2 |
| Visclosky, T | 1 |
| Schaeffer, W | 1 |
| Pomeranz, E | 1 |
| Ponce, DM | 1 |
| Dombrowski, JG | 1 |
| Souza, RM | 1 |
| Curry, J | 1 |
| Hinton, L | 1 |
| Silva, NRM | 1 |
| Grignard, L | 1 |
| Gonçalves, LA | 1 |
| Gomes, AR | 1 |
| Epiphanio, S | 1 |
| Drakeley, C | 1 |
| Huggett, J | 1 |
| Clark, TG | 1 |
| Campino, S | 1 |
| Marinho, CRF | 1 |
| Commons, RJ | 1 |
| Thriemer, K | 1 |
| Chu, CS | 1 |
| Douglas, NM | 1 |
| Abreha, T | 1 |
| Alemu, SG | 1 |
| Añez, A | 1 |
| Anstey, NM | 1 |
| Aseffa, A | 1 |
| Assefa, A | 1 |
| Awab, GR | 1 |
| Baird, JK | 2 |
| Barber, BE | 1 |
| Borghini-Fuhrer, I | 1 |
| D'Alessandro, U | 1 |
| Dahal, P | 1 |
| Daher, A | 1 |
| de Vries, PJ | 1 |
| Erhart, A | 1 |
| Gomes, MSM | 1 |
| Grigg, MJ | 1 |
| Hwang, J | 1 |
| Kager, PA | 1 |
| Ketema, T | 1 |
| Khan, WA | 1 |
| Lacerda, MVG | 1 |
| Leslie, T | 1 |
| Lidia, K | 1 |
| Monteiro, WM | 1 |
| Pereira, DB | 1 |
| Phan, GT | 1 |
| Phyo, AP | 1 |
| Rowland, M | 1 |
| Saravu, K | 1 |
| Sibley, CH | 1 |
| Siqueira, AM | 1 |
| Stepniewska, K | 1 |
| Taylor, WRJ | 1 |
| Thwaites, G | 1 |
| Tran, BQ | 1 |
| Hien, TT | 1 |
| Vieira, JLF | 1 |
| Wangchuk, S | 1 |
| Watson, J | 2 |
| William, T | 1 |
| Woodrow, CJ | 1 |
| Nosten, F | 1 |
| Guerin, PJ | 1 |
| White, NJ | 4 |
| Zhang, P | 1 |
| Gao, X | 1 |
| Ishida, H | 1 |
| Amnuaysirikul, J | 1 |
| Weina, PJ | 1 |
| Grogl, M | 1 |
| O'Neil, MT | 1 |
| Li, Q | 1 |
| Caridha, D | 1 |
| Ohrt, C | 2 |
| Hickman, M | 1 |
| Magill, AJ | 2 |
| Ray, P | 1 |
| Rochford, R | 1 |
| Baresel, PC | 1 |
| Campo, B | 1 |
| Sampath, A | 1 |
| Tekwani, BL | 1 |
| Walker, LA | 1 |
| Luzzatto, L | 2 |
| Seneca, E | 1 |
| Kondrashin, A | 1 |
| Baranova, AM | 1 |
| Ashley, EA | 1 |
| Recht, J | 1 |
| Sergiev, VP | 1 |
| Carter, TE | 1 |
| Maloy, H | 1 |
| von Fricken, M | 1 |
| St Victor, Y | 1 |
| Romain, JR | 1 |
| Okech, BA | 1 |
| Mulligan, CJ | 1 |
| Kheng, S | 2 |
| Muth, S | 1 |
| Taylor, WR | 2 |
| Tops, N | 1 |
| Kosal, K | 1 |
| Sothea, K | 1 |
| Souy, P | 1 |
| Kim, S | 1 |
| Char, CM | 1 |
| Vanna, C | 1 |
| Ly, P | 1 |
| Ringwald, P | 1 |
| Khieu, V | 1 |
| Kerleguer, A | 1 |
| Tor, P | 1 |
| Bjorge, S | 1 |
| Menard, D | 2 |
| Christophel, E | 1 |
| Kotwal, RS | 1 |
| Butler, FK | 1 |
| Murray, CK | 1 |
| Hill, GJ | 1 |
| Rayfield, JC | 1 |
| Miles, EA | 1 |
| Qiao, LG | 1 |
| Qi, G | 1 |
| Bolchoz, LJ | 3 |
| Morrow, JD | 2 |
| Jollow, DJ | 6 |
| McMillan, DC | 6 |
| Gelasco, AK | 1 |
| DERN, RJ | 3 |
| BEUTLER, E | 4 |
| ALVING, AS | 6 |
| KIMBRO, EL | 1 |
| SACHS, MV | 1 |
| TORBERT, JV | 1 |
| KELLERMEYER, RW | 1 |
| TARLOV, A | 1 |
| SCHRIER, S | 1 |
| CARSON, PE | 1 |
| CHARLES, LJ | 1 |
| CHILDS, B | 1 |
| NEIMANN, N | 2 |
| DUCAS, J | 1 |
| WITTMER, JF | 1 |
| PANNACCIULLI, IM | 1 |
| TIZIANELLO, A | 3 |
| SALVIDIO, E | 3 |
| AJMAR, F | 2 |
| BREWER, GJ | 4 |
| POWELL, RD | 3 |
| TARLOV, AR | 1 |
| RICOIRLES, J | 1 |
| PIERSON, M | 1 |
| SANTAGOSTINI, F | 1 |
| PALEK, J | 1 |
| BOWDLER, AJ | 1 |
| PRANKERD, TA | 1 |
| GREENBERG, MS | 1 |
| WONG, H | 1 |
| SWANSON, SH | 1 |
| PANNACCIULLI, I | 2 |
| BERRY, DH | 1 |
| VIETTI, TJ | 1 |
| JACOB, HS | 1 |
| INGBAR, SH | 1 |
| JANDL, JH | 1 |
| Bowman, ZS | 3 |
| Oatis, JE | 1 |
| Whelan, JL | 1 |
| Carr, ME | 1 |
| Fandre, MN | 1 |
| Oduwa, FO | 1 |
| Zhang, ZY | 1 |
| Pohl, A | 1 |
| Blechschmidt, E | 1 |
| Moser, K | 1 |
| Gahr, M | 1 |
| Khoo, KK | 1 |
| Shi, X | 1 |
| Zhan, C | 1 |
| Ha, S | 1 |
| Yiao, J | 1 |
| Sin, DD | 1 |
| Shafran, SD | 1 |
| Menéndez Capote, R | 2 |
| Díaz Pérez, L | 1 |
| Luzardo Suárez, C | 1 |
| Hadad Meléndez, P | 1 |
| Martínez, JL | 1 |
| Millán Marcelo, JC | 1 |
| Aguiar Cruz, F | 1 |
| Caña Lugo, C | 1 |
| Fernández Núñez, A | 1 |
| Budinsky, RA | 1 |
| Buchachart, K | 1 |
| Krudsood, S | 1 |
| Singhasivanon, P | 1 |
| Treeprasertsuk, S | 1 |
| Phophak, N | 1 |
| Srivilairit, S | 1 |
| Chalermrut, K | 1 |
| Rattanapong, Y | 1 |
| Supeeranuntha, L | 1 |
| Wilairatana, P | 1 |
| Brittenham, G | 1 |
| Looareesuwan, S | 1 |
| Desforges, JF | 1 |
| Reeve, PA | 1 |
| Toaliu, H | 1 |
| Kaneko, A | 1 |
| Hall, JJ | 1 |
| Ganczakowski, M | 1 |
| Karwacki, JJ | 1 |
| Shanks, GD | 1 |
| Kummalue, T | 1 |
| Watanasook, C | 1 |
| Brown, GV | 1 |
| Cheng, ZF | 1 |
| DiPalma, JR | 1 |
| Newbern, BL | 1 |
| Bearden, JH | 1 |
| Waller, HD | 1 |
| Löhr, GW | 1 |
| Yawata, Y | 1 |
| Kjellstrand, C | 1 |
| Buselmeier, T | 1 |
| Howe, R | 1 |
| Jacob, H | 1 |
| McCurdy, PR | 1 |
| Maldonado, N | 1 |
| Dillon, DE | 1 |
| Conrad, ME | 1 |
| Zarafonetis, CJ | 1 |
| Martelo, OJ | 1 |
| Smoller, M | 1 |
| Saladin, TA | 1 |
| Hochstein, P | 1 |
| George, JN | 1 |
| Miller, DR | 1 |
| Weed, RI | 1 |
| Waser, PG | 1 |
| Goldschmidt, L | 1 |
| Mayer, K | 1 |
| Ley, AB | 1 |
| Stevenson, DD | 1 |
| McGerity, JL | 1 |
| Panizon, F | 1 |
| Chopra, SA | 1 |
| Parravidino, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Artemisinin Combination Treatment Reduce the Radical Curative Efficacy of High Dose Tafenoquine for Plasmodium Vivax Malaria?[NCT05788094] | Phase 4 | 388 participants (Anticipated) | Interventional | 2023-06-26 | Recruiting | ||
| Targeted Chemo-elimination (TCE) to Eradicate Malaria in Areas of Suspected or Proven Artemisinin Resistance in Southeast Asia and South Asia[NCT01872702] | 8,000 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for primaquine and Anemia, Hemolytic
| Article | Year |
|---|---|
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase Deficie | 2019 |
G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Dapsone; Female; Glucosephosphate Dehydrogenase Deficienc | 2014 |
Mass primaquine treatment to eliminate vivax malaria: lessons from the past.
Topics: Anemia, Hemolytic; Antimalarials; Asia; Chemoprevention; Disease Eradication; Drug Therapy; Glucosep | 2014 |
Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common.
Topics: Adult; Anemia, Hemolytic; Animals; Anopheles; Antimalarials; Artemisinins; Drug Therapy, Combination | 2012 |
[METHEMOGLOBINEMIA, HEMOLYSIS AND FORMATION OF HEINZ BODIES IN THE ERYTHROCYTES].
Topics: Adenosine Triphosphate; Anemia; Anemia, Hemolytic; Carbohydrate Metabolism; Catalase; Erythrocytes; | 1964 |
[Red cell enzyme deficiencies - clinical manifestation and pathophysiology (author's transl)].
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Child; Erythrocytes; Favism; Glucos | 1981 |
[Primaquine and travelers from the Arab world. A report and recommendations].
Topics: Adult; Anemia, Hemolytic; Antimalarials; Arabs; Cuba; Glucosephosphate Dehydrogenase Deficiency; Hum | 1995 |
Chemoprophylaxis of malaria.
Topics: Adolescent; Adult; Africa; Anemia, Hemolytic; Asia; Australia; Child; Child, Preschool; Chloroquine; | 1986 |
Glucose-6-phosphate dehydrogenase deficiency: mechanisms of drug-induced hemolysis.
Topics: Anemia, Hemolytic; Aniline Compounds; Animals; Antimalarials; Catalase; Dihydroxyphenylalanine; Eryt | 1971 |
3 trials available for primaquine and Anemia, Hemolytic
| Article | Year |
|---|---|
The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah.
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Child; Chloroquine; Drug Combinations; Female; | 1981 |
The haemolytic effect of various regimens of primaquine with chloroquine in American Negroes with G6PD deficiency and the lack of an effect of various antimalarial suppressive agents on erythrocyte metabolism.
Topics: Anemia, Hemolytic; Antimalarials; Black or African American; Chloroquine; Clinical Trials as Topic; | 1967 |
Studies on the effect of clinical dosages of chlorpromazine and other neurotropics on primaquine-sensitive Negro mental patients.
Topics: Adult; Anemia, Hemolytic; Black or African American; Chlorpromazine; Clinical Trials as Topic; Demen | 1966 |
63 other studies available for primaquine and Anemia, Hemolytic
| Article | Year |
|---|---|
Cost-Effectiveness Analysis of Sex-Stratified
Topics: Adult; Afghanistan; Aminoquinolines; Anemia, Hemolytic; Antimalarials; Chloroquine; Cost-Benefit Ana | 2020 |
Primaquine overdose in a toddler.
Topics: Anemia, Hemolytic; Antimalarials; Child, Preschool; Drug Overdose; Glucosephosphate Dehydrogenase De | 2021 |
G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anemia, Hemolytic; Antimalarials; Brazil; Cross | 2017 |
An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines.
Topics: Acute Disease; Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Disease Mode | 2013 |
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; | 2013 |
Glucose-6-phosphate dehydrogenase deficiency A- variant in febrile patients in Haiti.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anemia, Hemolytic; Antimalarials; Child; Child, | 2014 |
Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Cambodia; Child; Comorbidity | 2015 |
Modelling primaquine-induced haemolysis in G6PD deficiency.
Topics: Anemia, Hemolytic; Antimalarials; Bayes Theorem; Cell Death; Erythrocytes; Female; Glucosephosphate | 2017 |
Central retinal vein occlusion in an Army ranger with glucose-6-phosphate dehydrogenase deficiency.
Topics: Adult; Afghan Campaign 2001-; Anemia, Hemolytic; Antimalarials; Glucosephosphate Dehydrogenase Defic | 2009 |
Primaquine-induced hemolytic anemia: effect of 6-methoxy-8-hydroxylaminoquinoline on rat erythrocyte sulfhydryl status, membrane lipids, cytoskeletal proteins, and morphology.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Cytoskeletal Proteins; Erythrocyte Membrane; Erythrocytes | 2002 |
Primaquine-induced hemolytic anemia: formation of free radicals in rat erythrocytes exposed to 6-methoxy-8-hydroxylaminoquinoline.
Topics: Anemia, Hemolytic; Animals; Erythrocytes; Free Radicals; Male; Primaquine; Quinolines; Rats; Rats, S | 2002 |
The hemolytic effect of primaquine. II. The natural course of the hemolytic anemia and the mechanism of its self-limited character.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Hemolysis; Primaquine | 1954 |
The hemolytic effect of primaquine. III. A study of primaquine-sensitive erythrocytes.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Cell Death; Erythrocytes; Hemolysis; Primaquine; Tracheoph | 1954 |
Mechanism of the hemolytic anemia induced by nitrofurantoin (furadantin); further observations on the incidence and significance of primaquine-sensitive red cells.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Erythrocytes; Humans; Incidence; Nitrofurantoin; Primaquin | 1957 |
Biochemical and genetic aspects of primaquine-sensitive hemolytic anemia.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Humans; Primaquine | 1958 |
Observations on the haemolytic effect of primaquine in 100 Ghanaian children.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Ghana; Humans; Primaquine | 1960 |
Primaquine sensitivity of erythrocytes.
Topics: Anemia; Anemia, Hemolytic; Antimalarials; Erythrocytes; Primaquine | 1961 |
[Anemia and jaundice caused by hereditary glucose-6-phosphate dehydrogenase deficit].
Topics: Anemia; Anemia, Hemolytic; Favism; Glucosephosphate Dehydrogenase; Humans; Jaundice; Metabolic Disea | 1962 |
AEROMEDICAL ASPECTS OF MALARIA PROPHYLAXIS WITH CHLOROQUINE-PRIMAQUINE.
Topics: Aerospace Medicine; Anemia; Anemia, Hemolytic; Chloroquine; Humans; Malaria; Methemoglobinemia; Moto | 1963 |
[SPLEEN AND LIVER, SITES OF HEMOCATHERESIS OF ERYTHROCYTES SENSITIVES TO PRIMAQUINE].
Topics: Anemia, Hemolytic; Chromium Isotopes; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Gluco | 1963 |
HEMOLYTIC EFFECT OF PRIMAQUINE. XVI. GLYOXALASE ACTIVITY OF PRIMAQUINE-SENSITIVE AND NORMAL ERYTHROCYTES.
Topics: Anemia; Anemia, Hemolytic; Black People; Blood Chemical Analysis; Erythrocytes; Esterases; Glucoseph | 1964 |
[HEMOLYTIC ANEMIAS DUE TO HEREDITARY DEFECT OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE].
Topics: Anemia; Anemia, Hemolytic; Classification; Clinical Laboratory Techniques; Drug Hypersensitivity; Fa | 1964 |
[HEMOLYTIC ANEMIA CAUSED BY GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY].
Topics: Anemia; Anemia, Hemolytic; Clinical Laboratory Techniques; Glucosephosphate Dehydrogenase Deficiency | 1963 |
[PHARMACOGENETICS].
Topics: Anemia; Anemia, Hemolytic; Barbiturates; Catalase; Cholinesterases; Genetics, Medical; Glucosephosph | 1964 |
STUDIES IN CONGENITAL NON-SPHEROCYTIC HAEMOLYTIC ANAEMIAS WITH SPECIFIC ENZYME DEFECTS.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Carbohydrate Metabolism; Chromium I | 1964 |
METHEMOGLOBINEMIA AND HEINZ BODY HEMOLYTIC ANEMIA DUE TO PHENAZOPYRIDINE HYDROCHLORIDE.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Azo Compounds; Chromium Isotopes; Erythrocytes; Gl | 1964 |
HEMOLYTIC EFFECT OF PRIMAQUINE. XVII. HEXOKINASE ACTIVITY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT AND NORMAL ERYTHROCYTES.
Topics: Aging; Anemia, Hemolytic; Biomedical Research; Black People; Bloodletting; Erythrocyte Aging; Erythr | 1964 |
THE COURSE OF EXPERIMENTALLY INDUCED HEMOLYTIC ANEMIA IN A PRIMAQUINE-SENSITIVE CAUCASIAN. A CASE STUDY.
Topics: Anemia, Hemolytic; Biomedical Research; Blood Transfusion; Chromium Isotopes; Glucosephosphate Dehyd | 1965 |
CLINICAL MANIFESTATIONS OF PRIMAQUINE-SENSITIVE ANEMIA.
Topics: Adolescent; Anemia, Hemolytic; Black People; Child; Genetics, Medical; Glucosephosphate Dehydrogenas | 1965 |
OXIDATIVE HEMOLYSIS AND ERYTHROCYTE METABOLISM IN HEREDITARY ACATALASIA.
Topics: Acatalasia; Anemia; Anemia, Hemolytic; Ascorbic Acid; Azides; Catalase; Cyanides; Erythrocyte Aging; | 1965 |
Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine.
Topics: Anemia, Hemolytic; Animals; Drug Stability; Electrochemistry; Erythrocytes; Glutathione; Hemolysis; | 2004 |
Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Calcium; Cell Membrane; Cytoskeletal Proteins; Dithiothre | 2005 |
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Comorbidity; Glucosephosphate Dehydrogenase Deficiency; Hem | 2005 |
Primaquine-induced hemolytic anemia: role of splenic macrophages in the fate of 5-hydroxyprimaquine-treated rat erythrocytes.
Topics: Anemia, Hemolytic; Animals; Cell Line; Erythrocytes; Macrophages; Male; Phagocytosis; Primaquine; Ra | 2005 |
[Haemolysis due to primaquine in 3 cases].
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Humans; Malaria; Male; Primaquine | 2006 |
[Glucose-6-phosphate dehydrogenase deficiency and other erythrocyte enzyme abnormalities].
Topics: 5'-Nucleotidase; Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Erythrocytes; Gluc | 1984 |
The hemolytic effect of primaquine V. Primaquine sensitivity as a manifestation of a multiple drug sensitivity.
Topics: Anemia, Hemolytic; Erythrocytes; Hemolysis; Humans; Male; Primaquine | 1981 |
[Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits].
Topics: Anemia, Hemolytic; Animals; Antimalarials; Female; Hemolysis; Male; Methemoglobinemia; Primaquine; R | 1994 |
Dapsone- and primaquine-induced methemoglobinemia in HIV-infected individuals.
Topics: Adult; AIDS-Related Opportunistic Infections; Anemia, Hemolytic; Anti-Infective Agents; Clindamycin; | 1996 |
[Hemolysis and primaquine treatment. Preliminary report].
Topics: Anemia, Hemolytic; Angola; Antimalarials; Contraindications; Cuba; Erythrocytes; Glucosephosphate De | 1997 |
[Determination of glucose-6-phosphate dehydrogenase deficiency to prevent possible drug-induced hemolysis].
Topics: Anemia, Hemolytic; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Meth | 1991 |
Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.
Topics: Anemia, Hemolytic; Animals; Antimalarials; Biotransformation; Chromatography, High Pressure Liquid; | 2001 |
Effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in Thailand.
Topics: Adult; Anemia, Hemolytic; Antimalarials; Chloroquine; Female; Glucosephosphate Dehydrogenase; Hemato | 2001 |
Genetic implications of G-6-PD deficiency.
Topics: Anemia, Hemolytic; Black People; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Het | 1976 |
Acute intravascular haemolysis in Vanuatu following a single dose of primaquine in individuals with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acute Disease; Adolescent; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemo | 1992 |
Primaquine induced hemolysis in a Thai soldier.
Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; | 1989 |
[Hemolytic reaction due to administration of primaquine].
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Child; Child, Preschool; Female; Glucosephosphate Dehydr | 1986 |
Drug-induced hemolysis.
Topics: Anemia, Hemolytic; Black People; Clinical Enzyme Tests; Erythrocytes; Glucosephosphate Dehydrogenase | 1973 |
Iatrogenic acute anemia: primaquine sensitivity.
Topics: Anemia, Hemolytic; Primaquine | 1966 |
[Hemolytic anemias. Enzymopenic hemolytic anemias].
Topics: Adenosine Triphosphatases; Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Child; Deficiency Disea | 1966 |
Hemolysis in dialyzed patients: tap water-induced red blood cell metabolic deficiency.
Topics: Anemia, Hemolytic; Ascorbic Acid; Carbon Radioisotopes; Cell Survival; Chromium Radioisotopes; Eryth | 1972 |
Variants of glucose-6-phosphate dehydrogenase (G-6-PD) associated with G-6-PD deficiency in Puerto Ricans.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Chromatography, Gel; Female; Glucosephosphate Dehy | 1973 |
Malaria in American soldiers.
Topics: Anemia, Hemolytic; Blood Cell Count; Carrier State; Chloroquine; Hematocrit; Hemoglobinometry; Hepat | 1969 |
Abnormalities of the hexose monophosphate shunt.
Topics: Anemia, Hemolytic; Black People; Blood Transfusion; Chromium Isotopes; Dihydrolipoamide Dehydrogenas | 1971 |
Heinz body hemolytic anemias.
Topics: Anemia, Hemolytic; Aspirin; Child; Female; Glucosephosphate Dehydrogenase Deficiency; Heinz Bodies; | 1970 |
[Pharmacogenetics].
Topics: Anemia, Hemolytic; Antipyrine; DNA; Drug-Related Side Effects and Adverse Reactions; Europe; Glucose | 1967 |
Hemolysis of red cells due to sulfone.
Topics: Anemia, Hemolytic; Blood Transfusion; Chromium Isotopes; Dermatitis Herpetiformis; Erythrocyte Aging | 1970 |
Simultaneous drug reactions in the same patient. Chloroquine-Primaquine sensitivity.
Topics: Adolescent; Anemia, Hemolytic; Chloroquine; Drug Hypersensitivity; Edema; Erythrocytes; Glucosephosp | 1970 |
[Pathogenesis of favism].
Topics: Anemia, Hemolytic; Diagnosis, Differential; Favism; Glucosephosphate Dehydrogenase Deficiency; Human | 1967 |
Haemolytic crisis in a Zanzibari Arab girl with G6PD deficiency and sickle cell trait.
Topics: Anemia, Hemolytic; Child; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; | 1968 |
Hemolytic anemia complicating viral hepatitis and G-6-PD deficiency.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Congenital; Aspirin; Glucosephosphate Dehydrogenase Deficiency | 1969 |
Hemolytic effects of standard single dosages of primaquine and chloroquine on G-6-PD-deficient caucasians.
Topics: Anemia, Hemolytic; Black or African American; Chloroquine; Chromium Isotopes; Female; Glucosephospha | 1969 |
The adenosine triphosphate content of glucose-6-phosphate dehydrogenase-deficient and normal erythrocytes, including studies of a glucose-6-phosphate dehydrogenase-deficient man with "elevated erythrocytic ATP".
Topics: Adenosine Triphosphate; Anemia, Hemolytic; Black or African American; Erythrocytes; Glucosephosphate | 1966 |