primaquine has been researched along with American Trypanosomiasis in 8 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "American trypanosomiasis (Chagas' disease) is an endemic parasitic disease afflicting more than 20 million people in Latin America." | 1.30 | Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine. ( Chung, MC; Colli, W; Ferreira, EI; Gonçalves, MF; Miranda, MT, 1997) |
| "Primaquine has been used to treat Chagas' disease in humans and has been reported to be active against extracellular Trypanosoma cruzi." | 1.27 | Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi. ( McCabe, RE, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oliver, M | 1 |
| Wolf, A | 1 |
| Théfenne, H | 1 |
| Demaison, X | 1 |
| Rapp, C | 1 |
| Simon, F | 1 |
| HEWITT, R | 1 |
| ENTWISTLE, J | 1 |
| GILL, E | 1 |
| PIZZI, T | 1 |
| Beveridge, E | 1 |
| Caldwell, IC | 1 |
| Latter, VS | 1 |
| Neal, RA | 1 |
| Udall, V | 1 |
| Waldron, MM | 1 |
| Kinnamon, KE | 1 |
| Poon, BT | 1 |
| Hanson, WL | 1 |
| Waits, VB | 1 |
| Chung, MC | 1 |
| Gonçalves, MF | 1 |
| Colli, W | 1 |
| Ferreira, EI | 2 |
| Miranda, MT | 1 |
| La-Scalea, MA | 1 |
| Chin, CM | 1 |
| Cruz, ML | 1 |
| Serrano, SH | 1 |
| McCabe, RE | 1 |
8 other studies available for primaquine and American Trypanosomiasis
| Article | Year |
|---|---|
[Update on primaquine].
Topics: Antimalarials; Chagas Disease; Humans; Malaria; Pneumonia, Pneumocystis; Primaquine | 2009 |
Quantitative determinations of critical mortality periods in untreated and treated infections with the B strain of Trypanosoma cruzi in mice.
Topics: Animals; Chagas Disease; Mice; Primaquine; Trypanosoma cruzi; Trypanosomiasis; United States | 1963 |
Effect of primaquine on experimental Trypanosoma cruzi infection.
Topics: Chagas Disease; Primaquine; Trypanosoma cruzi; Trypanosomiasis | 1951 |
The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).
Topics: Aminoquinolines; Animals; Chagas Disease; Culture Techniques; Female; Fetus; Furazolidone; Guinea Pi | 1980 |
Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
Topics: Animals; Chagas Disease; Chemistry, Pharmaceutical; Female; Mice; Primaquine; Trypanocidal Agents; T | 1996 |
Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine.
Topics: Animals; Cells, Cultured; Chagas Disease; Dipeptides; Kidney; Macaca mulatta; Primaquine; Prodrugs; | 1997 |
Dissociation and electrooxidation of primaquine diphosphate as an approach to the study of anti-chagas prodrugs mechanism of action.
Topics: Antiprotozoal Agents; Chagas Disease; Electrochemistry; Electrodes; Electron Transport; Hydrogen-Ion | 2001 |
Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Cytoplasm; Drug Therapy, Combination; Extracellular Space; Ketoc | 1988 |