primaquine has been researched along with Alloxan Diabetes in 2 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Substance P was depleted to 51% in the control rats (p < 0." | 1.31 | Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. ( Corder, R; Hounsom, L; Patel, J; Tomlinson, DR, 2001) |
| "Primaquine treatment did not affect diabetic rats." | 1.29 | Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. ( Archibald, V; Cameron, NE; Cotter, MA; Dines, KC; Maxfield, EK, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cameron, NE | 1 |
| Cotter, MA | 1 |
| Archibald, V | 1 |
| Dines, KC | 1 |
| Maxfield, EK | 1 |
| Hounsom, L | 1 |
| Corder, R | 1 |
| Patel, J | 1 |
| Tomlinson, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for primaquine and Alloxan Diabetes
| Article | Year |
|---|---|
Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; Motor Neurons; | 1994 |
Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; gamma-Linolenic Acid; Male; Nerve G | 2001 |