primaquine and Aging
primaquine has been researched along with Aging in 4 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was no evidence of symptomatic hemolysis, and adverse events considered related to study drug (n = 4) were mild." | 1.48 | Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. ( Bousema, T; Brown, J; Chen, I; Diarra, K; Diawara, H; Dicko, A; Djimde, M; Gosling, R; Greenhouse, B; Hwang, J; Keita, M; Keita, S; Kone, D; Mahamar, A; Murphy, M; Niemi, M; Pett, H; Roh, ME; Sanogo, K, 2018) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chen, I | 1 |
| Diawara, H | 1 |
| Mahamar, A | 1 |
| Sanogo, K | 1 |
| Keita, S | 1 |
| Kone, D | 1 |
| Diarra, K | 1 |
| Djimde, M | 1 |
| Keita, M | 1 |
| Brown, J | 1 |
| Roh, ME | 1 |
| Hwang, J | 1 |
| Pett, H | 1 |
| Murphy, M | 1 |
| Niemi, M | 1 |
| Greenhouse, B | 1 |
| Bousema, T | 1 |
| Gosling, R | 1 |
| Dicko, A | 1 |
| Betuela, I | 1 |
| Bassat, Q | 1 |
| Kiniboro, B | 1 |
| Robinson, LJ | 1 |
| Rosanas-Urgell, A | 1 |
| Stanisic, D | 1 |
| Siba, PM | 1 |
| Alonso, PL | 1 |
| Mueller, I | 1 |
| BREWER, GJ | 1 |
| POWELL, RD | 1 |
| SWANSON, SH | 1 |
| ALVING, AS | 1 |
| Goldschmidt, L | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining a Tolerable Dose of Primaquine in G6PD-deficient Persons Without Malaria in Mali[NCT02535767] | Phase 1/Phase 2 | 28 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Other Studies
4 other studies available for primaquine and Aging
| Article | Year |
|---|---|
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial.
Topics: Adolescent; Adult; Aging; Antimalarials; Child; Child, Preschool; Dose-Response Relationship, Drug; | 2018 |
Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age.
Topics: Aging; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Chloroquine; Cohort Studies | 2012 |
HEMOLYTIC EFFECT OF PRIMAQUINE. XVII. HEXOKINASE ACTIVITY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT AND NORMAL ERYTHROCYTES.
Topics: Aging; Anemia, Hemolytic; Biomedical Research; Black People; Bloodletting; Erythrocyte Aging; Erythr | 1964 |
Variations in red cell glutathione with aging in male and female primaquine-sensitive Negroes.
Topics: Adult; Aged; Aging; Black People; Computers; Erythrocytes; Female; Glucosephosphate Dehydrogenase De | 1971 |