primaquine has been researched along with Acquired Immunodeficiency Syndrome in 15 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole." | 2.67 | Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia. ( Pohle, HD; Rohde, I; Ruf, B, 1991) |
| "Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes." | 1.35 | Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study. ( Atzori, C; Benfield, T; Helweg-Larsen, J; Miller, RF, 2009) |
| "Pneumocystis carinii pneumonia has been the most common life-threatening opportunistic infection in patients with acquired immunodeficiency syndrome." | 1.29 | Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia. ( Glatt, AE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (80.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aminake, MN | 1 |
| Mahajan, A | 1 |
| Kumar, V | 1 |
| Hans, R | 1 |
| Wiesner, L | 1 |
| Taylor, D | 1 |
| de Kock, C | 1 |
| Grobler, A | 1 |
| Smith, PJ | 1 |
| Kirschner, M | 1 |
| Rethwilm, A | 1 |
| Pradel, G | 1 |
| Chibale, K | 1 |
| Dos-Santos, JC | 1 |
| Angerami, RN | 1 |
| Castiñeiras, CM | 1 |
| Lopes, SC | 1 |
| Albrecht, L | 1 |
| Garcia, MT | 1 |
| Levy, CE | 1 |
| Moretti, ML | 1 |
| Lacerda, MV | 1 |
| Costa, FT | 1 |
| Helweg-Larsen, J | 1 |
| Benfield, T | 1 |
| Atzori, C | 1 |
| Miller, RF | 1 |
| Dean, RA | 1 |
| Ochieng, W | 1 |
| Black, J | 1 |
| Queener, SF | 1 |
| Bartlett, MS | 1 |
| Dumaual, NG | 1 |
| Black, JR | 2 |
| Feinberg, J | 2 |
| Murphy, RL | 2 |
| Fass, RJ | 2 |
| Finkelstein, D | 1 |
| Akil, B | 1 |
| Safrin, S | 1 |
| Carey, JT | 1 |
| Stansell, J | 1 |
| Plouffe, JF | 1 |
| Glatt, AE | 1 |
| Zouiten, F | 1 |
| Bouslama, K | 1 |
| Gastli, M | 1 |
| Tiouiri, H | 1 |
| Battikh, R | 1 |
| Ben Salem, N | 1 |
| Ben Chaabane, T | 1 |
| Chaker, E | 1 |
| Ben Rachid, MS | 1 |
| Zribi, A | 1 |
| Kantor, GS | 1 |
| Vildé, JL | 1 |
| Remington, JS | 1 |
| Costantino, M | 1 |
| Carey, J | 1 |
| Sattler, FR | 1 |
| Ruf, B | 1 |
| Rohde, I | 1 |
| Pohle, HD | 1 |
| Toma, E | 1 |
| Kay, R | 1 |
| DuBois, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00000717] | 50 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for primaquine and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adolescent; Adult; AIDS-Related Opportunis | 1994 |
Clindamycin and primaquine as primary treatment for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Clindamycin; Humans; Injections, Intraveno | 1991 |
Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clindamycin; Drug Therapy, Combination; Female; Humans; M | 1991 |
Clindamycin/primaquine for treatment of Pneumocystis carinii pneumonia in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Humans; Pneumonia, Pneum | 1991 |
11 other studies available for primaquine and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antimalarials; Dose-Response Relations | 2012 |
Imported malaria in a non-endemic area: the experience of the university of Campinas hospital in the Brazilian Southeast.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anemia; Antimalarials; Artemether; Artemisini | 2014 |
Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; | 2009 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection.
Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; Drug Combinations; Electro | 1994 |
Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Dapso | 1994 |
[Clindamycin and primaquine in the treatment of pulmonary pneumocystosis in a HIV-positive female patient].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Drug | 1993 |
Primaquine-induced methemoglobinemia during treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Methemoglobinemia; Middle Aged; Pneumonia, Pneumoc | 1992 |
Role of clindamycin with or without another agent for treatment of pneumocystosis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Humans; Pneumonia, Pneum | 1992 |
[Some aspects of the treatment of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Dapsone; HIV Infections; Humans; Primaquine; Trimet | 1991 |
Clindamycin/primaquine therapy and secondary prophylaxis against Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Clindamycin; Drug Administration Sc | 1990 |