primaquine has been researched along with Acquired Immune Deficiency Syndrome in 15 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole." | 2.67 | Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia. ( Pohle, HD; Rohde, I; Ruf, B, 1991) |
| "Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes." | 1.35 | Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study. ( Atzori, C; Benfield, T; Helweg-Larsen, J; Miller, RF, 2009) |
| "Pneumocystis carinii pneumonia has been the most common life-threatening opportunistic infection in patients with acquired immunodeficiency syndrome." | 1.29 | Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia. ( Glatt, AE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (80.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aminake, MN | 1 |
| Mahajan, A | 1 |
| Kumar, V | 1 |
| Hans, R | 1 |
| Wiesner, L | 1 |
| Taylor, D | 1 |
| de Kock, C | 1 |
| Grobler, A | 1 |
| Smith, PJ | 1 |
| Kirschner, M | 1 |
| Rethwilm, A | 1 |
| Pradel, G | 1 |
| Chibale, K | 1 |
| Dos-Santos, JC | 1 |
| Angerami, RN | 1 |
| Castiñeiras, CM | 1 |
| Lopes, SC | 1 |
| Albrecht, L | 1 |
| Garcia, MT | 1 |
| Levy, CE | 1 |
| Moretti, ML | 1 |
| Lacerda, MV | 1 |
| Costa, FT | 1 |
| Helweg-Larsen, J | 1 |
| Benfield, T | 1 |
| Atzori, C | 1 |
| Miller, RF | 1 |
| Dean, RA | 1 |
| Ochieng, W | 1 |
| Black, J | 1 |
| Queener, SF | 1 |
| Bartlett, MS | 1 |
| Dumaual, NG | 1 |
| Black, JR | 2 |
| Feinberg, J | 2 |
| Murphy, RL | 2 |
| Fass, RJ | 2 |
| Finkelstein, D | 1 |
| Akil, B | 1 |
| Safrin, S | 1 |
| Carey, JT | 1 |
| Stansell, J | 1 |
| Plouffe, JF | 1 |
| Glatt, AE | 1 |
| Zouiten, F | 1 |
| Bouslama, K | 1 |
| Gastli, M | 1 |
| Tiouiri, H | 1 |
| Battikh, R | 1 |
| Ben Salem, N | 1 |
| Ben Chaabane, T | 1 |
| Chaker, E | 1 |
| Ben Rachid, MS | 1 |
| Zribi, A | 1 |
| Kantor, GS | 1 |
| Vildé, JL | 1 |
| Remington, JS | 1 |
| Costantino, M | 1 |
| Carey, J | 1 |
| Sattler, FR | 1 |
| Ruf, B | 1 |
| Rohde, I | 1 |
| Pohle, HD | 1 |
| Toma, E | 1 |
| Kay, R | 1 |
| DuBois, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00000717] | 50 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for primaquine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adolescent; Adult; AIDS-Related Opportunis | 1994 |
Clindamycin and primaquine as primary treatment for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Clindamycin; Humans; Injections, Intraveno | 1991 |
Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Clindamycin; Drug Therapy, Combination; Female; Humans; M | 1991 |
Clindamycin/primaquine for treatment of Pneumocystis carinii pneumonia in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Humans; Pneumonia, Pneum | 1991 |
11 other studies available for primaquine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Antimalarials; Dose-Response Relations | 2012 |
Imported malaria in a non-endemic area: the experience of the university of Campinas hospital in the Brazilian Southeast.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anemia; Antimalarials; Artemether; Artemisini | 2014 |
Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; | 2009 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection.
Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; Drug Combinations; Electro | 1994 |
Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Dapso | 1994 |
[Clindamycin and primaquine in the treatment of pulmonary pneumocystosis in a HIV-positive female patient].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Drug | 1993 |
Primaquine-induced methemoglobinemia during treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Methemoglobinemia; Middle Aged; Pneumonia, Pneumoc | 1992 |
Role of clindamycin with or without another agent for treatment of pneumocystosis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Humans; Pneumonia, Pneum | 1992 |
[Some aspects of the treatment of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Dapsone; HIV Infections; Humans; Primaquine; Trimet | 1991 |
Clindamycin/primaquine therapy and secondary prophylaxis against Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Clindamycin; Drug Administration Sc | 1990 |