primaquine has been researched along with AIDS-Related Opportunistic Infections in 19 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes." | 1.35 | Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study. ( Atzori, C; Benfield, T; Helweg-Larsen, J; Miller, RF, 2009) |
| "Pulmonary Pneumocystis carinii infections are relatively common in patients with the acquired immunodeficiency syndrome (AIDS)." | 1.30 | Atypical Pneumocystis carinii infection in AIDS: massive cervical lymphadenitis and fever of unknown origin. ( Kallen, AJ; Wallace, MR, 1998) |
| "Pneumocystis carinii pneumonia has been the most common life-threatening opportunistic infection in patients with acquired immunodeficiency syndrome." | 1.29 | Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia. ( Glatt, AE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (84.21) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Helweg-Larsen, J | 2 |
| Benfield, T | 2 |
| Atzori, C | 2 |
| Miller, RF | 2 |
| Mitchell, B | 1 |
| Pastor, C | 1 |
| Lumbreras, C | 1 |
| Lizasoain, M | 1 |
| Black, JR | 2 |
| Feinberg, J | 2 |
| Murphy, RL | 1 |
| Fass, RJ | 1 |
| Finkelstein, D | 1 |
| Akil, B | 1 |
| Safrin, S | 2 |
| Carey, JT | 1 |
| Stansell, J | 1 |
| Plouffe, JF | 1 |
| Glatt, AE | 1 |
| Smith, N | 1 |
| Blanshard, C | 1 |
| Smith, D | 1 |
| Gazzard, B | 1 |
| Toma, E | 2 |
| Fournier, S | 1 |
| Dumont, M | 1 |
| Bolduc, P | 1 |
| Deschamps, H | 1 |
| Zouiten, F | 1 |
| Bouslama, K | 1 |
| Gastli, M | 1 |
| Tiouiri, H | 1 |
| Battikh, R | 1 |
| Ben Salem, N | 1 |
| Ben Chaabane, T | 1 |
| Chaker, E | 1 |
| Ben Rachid, MS | 1 |
| Zribi, A | 1 |
| Goebel, FD | 1 |
| Bogner, JR | 1 |
| Korraa, H | 1 |
| Saadeh, C | 1 |
| Finkelstein, DM | 1 |
| Frame, P | 1 |
| Simpson, G | 1 |
| Wu, A | 1 |
| Cheung, T | 1 |
| Soeiro, R | 1 |
| Hojczyk, P | 1 |
| Sin, DD | 1 |
| Shafran, SD | 1 |
| Deresinski, SC | 1 |
| Morris-Jones, SD | 1 |
| Easterbrook, PJ | 1 |
| Kallen, AJ | 1 |
| Wallace, MR | 1 |
| Thorne, A | 1 |
| Singer, J | 1 |
| Raboud, J | 1 |
| Lemieux, C | 1 |
| Trottier, S | 1 |
| Bergeron, MG | 1 |
| Tsoukas, C | 1 |
| Falutz, J | 1 |
| Lalonde, R | 1 |
| Gaudreau, C | 1 |
| Therrien, R | 1 |
| Masur, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00000717] | 50 participants | Interventional | Completed | ||||
| A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Trimethoprim / Sulfamethoxazole in the Treatment of Mild-to-Moderate PCP in Patients With AIDS[NCT00000640] | Phase 3 | 290 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for primaquine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
A background and critical analysis of the treatment of pneumocystis carinii pneumonia (PCP) in HIV/AIDS.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Anti-Inflammatory Agents; Antiprotozoa | 2007 |
Second-line salvage treatment of AIDS-associated Pneumocystis jirovecii pneumonia: a case series and systematic review.
Topics: AIDS-Related Opportunistic Infections; Clindamycin; Cohort Studies; Humans; Pentamidine; Pneumocysti | 2008 |
[Current alternatives in the treatment of Pneumocystis carinii pneumonia in patients with AIDS].
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; Clindamycin; Dapsone; Eflornit | 1994 |
[Therapy and prevention of pneumocystis carinii pneumonia].
Topics: AIDS-Related Opportunistic Infections; Animals; Antifungal Agents; Atovaquone; Clindamycin; Clinical | 1995 |
Options in the management of pneumonia caused by Pneumocystis carinii in patients with acquired immune deficiency syndrome and intolerance to trimethoprim/sulfamethoxazole.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Ag | 1996 |
Treatment of Pneumocystis carinii pneumonia in adults with AIDS.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifunga | 1997 |
Current issues in the treatment and prophylaxis of Pneumocystis carinii pneumonia in HIV infection.
Topics: Adrenal Cortex Hormones; Adult; AIDS-Related Opportunistic Infections; Child; Clindamycin; Drug Ther | 1997 |
Prophylaxis and therapy for Pneumocystis pneumonia--where are we?
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; Clind | 1992 |
4 trials available for primaquine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adolescent; Adult; AIDS-Related Opportunis | 1994 |
Clindamycin/primaquine versus trimethoprim-sulfamethoxazole as primary therapy for Pneumocystis carinii pneumonia in AIDS: a randomized, double-blind pilot trial.
Topics: Adult; AIDS-Related Opportunistic Infections; Clindamycin; Double-Blind Method; Drug Therapy, Combin | 1993 |
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Dapsone; Double-Blind Met | 1996 |
Clindamycin with primaquine vs. Trimethoprim-sulfamethoxazole therapy for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS: a multicenter, double-blind, randomized trial (CTN 004). CTN-PCP Study Group.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Double-Blind Metho | 1998 |
7 other studies available for primaquine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; | 2009 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Dapso | 1994 |
Toxicity of clindamycin and primaquine treatment of AIDS-related Pneumocystis carinii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Clindamycin; Drug Therapy, Combination; Humans; Pneumonia, Pn | 1993 |
[Clindamycin and primaquine in the treatment of pulmonary pneumocystosis in a HIV-positive female patient].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Drug | 1993 |
Dapsone- and primaquine-induced methemoglobinemia in HIV-infected individuals.
Topics: Adult; AIDS-Related Opportunistic Infections; Anemia, Hemolytic; Anti-Infective Agents; Clindamycin; | 1996 |
Atypical Pneumocystis carinii infection in AIDS: massive cervical lymphadenitis and fever of unknown origin.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Clindamycin; Female; Fever of U | 1998 |