Page last updated: 2024-11-03

prilocaine and Sexual Dysfunction, Physiological

prilocaine has been researched along with Sexual Dysfunction, Physiological in 17 studies

Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (52.94)29.6817
2010's8 (47.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gallo, L1
Dinsmore, WW3
Wyllie, MG3
Porst, H1
McCarty, EJ1
Hellstrom, WJ4
Carson, C1
Wyllie, M2
Xin, ZC1
Zhu, YC1
Yuan, YM1
Cui, WS1
Jin, Z1
Li, WR1
Liu, T1
Serefoglu, EC1
Saitz, TR1
Henry, R1
Morales, A1
Busato, W1
Galindo, CC1
Atan, A1
Basar, MM1
Tuncel, A1
Ferhat, M1
Agras, K1
Tekdogan, U1
Hackett, G1
Goldmeier, D1
Waldinger, M1
Dean, J1
Wright, P1
Callander, M1
Wylie, K1
Novak, C1
Keywood, C1
Heath, P1
Gurkan, L1
Oommen, M1
Mercado, MG1
Kimmer, SL1
Holman, JR1
Wanserski, G1
Lo, V1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Research and Clinical Value of New Classification for Premature Ejaculation:Multi-Center Research[NCT02572037]568 participants (Actual)Observational2015-10-31Completed
A Phase IIb, Multi-center, Randomized, Double-blind, Placebo-controlled Study, With Open-label Follow on, to Evaluate the Efficacy, Safety and Tolerability of PSD502 in Subjects With Premature Ejaculation (PE)[NCT00556478]Phase 2/Phase 3256 participants (Actual)Interventional2007-10-31Completed
Evaluation of the Safety and Effectiveness of the vPatch Device for the Management and Treatment of Premature Ejaculation[NCT03942367]59 participants (Actual)Interventional2019-09-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Mean Intravaginal Ejaculatory Latency Time (IELT) From Baseline to Month 3

Summary of mean IELT at Baseline and at month 3 during double-blind treatment (NCT00556478)
Timeframe: 3 months

InterventionSeconds (Geometric Mean)
Double-Blind Active / Open-Label Active140.964
Double-Blind Placebo / Open-Label Active49.615

Mean Intravaginal Ejaculatory Latency Time (IELT): Change From Baseline to During 3 Month Double Blind-treatment

"To evaluate efficacy of treatment with PSD502 compared with placebo in subjects with PE as measured by:~• change in mean IELT from baseline to during the 3 month double-blind treatment~Results provide are ratio (over the 3 months/baseline)." (NCT00556478)
Timeframe: Baseline to 3 Months

Interventionratio (Geometric Mean)
Double-Blind Active / Open-Label Active4.607
Double-Blind Placebo / Open-Label Active1.505

Change in the Index of Premature Ejaculation (IPE) Domains of Ejaculatory Control, Distress and Sexual Satisfaction From Baseline to Month 1

"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 1.~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 1 month

,
InterventionScore (Mean)
Ejaculatory controlDistressSexual satisfaction
Double-Blind Active / Open-Label Active5.72.55.1
Double-Blind Placebo / Open-Label Active1.30.61.8

Change in the Index of Premature Ejaculation (IPE) Domains of Ejaculatory Control, Distress and Sexual Satisfaction From Baseline to Month 2

"Change in the IPE domains of ejaculatory control, distress and sexual satisfaction from Baseline to month 2~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: 2 months

,
InterventionScore (Mean)
ControlSatisfactionDistress
Double-Blind Active / Open-Label Active6.55.82.9
Double-Blind Placebo / Open-Label Active1.41.30.7

Index of Premature Ejaculation (IPE): Change From Baseline to End of Month 3

"To Evaluate Efficacy of Treatment With PSD502 Compared With Placebo in Subjects With PE as measured by:~• changes in all 3 IPE domains from baseline to month 3~Ejaculatory control scores range from 4 to 20 with a higher score indicating greater ejaculatory control Sexual satisfaction scores range from 4 to 20 with a higher score indicating greater sexual satisfaction Distress scores range from 2 to 10 with a higher score indicating less distress" (NCT00556478)
Timeframe: Baseline to 3 Months

,
InterventionScore (Mean)
Ejaculatory controlSexual satisfactionDistress
Double-Blind Active / Open-Label Active7.26.63.5
Double-Blind Placebo / Open-Label Active2.22.10.9

Partner Premature Ejaculation Profile (PEP) at Month 3

Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the partner PEP at month 3. Proportion of partners with at least a 1 point category improvement in partner PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months

,
Interventionpercentage of partners (Number)
ControlDistressSexual satisfactionInterpersonal difficulty
Double-Blind Active / Open-Label Active68.964.962.866.9
Double-Blind Placebo / Open-Label Active40.850.032.950.0

Percentage of Subjects With Mean Intravaginal Ejaculatory Latency Time (IELT) > 1 Minute and >2 Minutes During the 3 Months of Double-blind Treatment

Percentage of subjects with mean IELT > 1 minute and >2 minutes during the 3 months of double-blind treatment as measured by the proportion of subjects (NCT00556478)
Timeframe: 3 months

,
Interventionpercentage of subjects (Number)
IELT > 1 minuteIELT > 2 minutes
Double-Blind Active / Open-Label Active80.257.5
Double-Blind Placebo / Open-Label Active37.814.6

Subject PEP at Month 1

Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 1. Percentage of subjects with at least a 1 point category improvement in subject PEP domain scores at month 1. (NCT00556478)
Timeframe: 1 month

,
Interventionpercentage of participants (Number)
ControlDistressSexual satisfactionInterpersonal difficulty
Double-Blind Active / Open-Label Active59.663.462.772.0
Double-Blind Placebo / Open-Label Active23.527.233.351.9

Subject Premature Ejaculation Profile (PEP) at Month 2

Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 2. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 2. (NCT00556478)
Timeframe: 2 months

,
Interventionpercentage of participants (Number)
ControlDistressSexual satisfactionInterpersonal difficulty
Double-Blind Active / Open-Label Active67.570.169.475.8
Double-Blind Placebo / Open-Label Active24.733.827.342.9

Subject Premature Ejaculation Profile (PEP) at Month 3

Scores for perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse and interpersonal difficulty related to ejaculation based on the subject PEP at month 3. Proportion of subjects with at least a 1 point category improvement in subject PEP domain scores from baseline to month 3. (NCT00556478)
Timeframe: 3 months

,
Interventionpercentage of participants (Number)
ControlDistressSexual satisfactionInterpersonal difficulty
Double-Blind Active / Open-Label Active72.476.973.777.6
Double-Blind Placebo / Open-Label Active24.136.736.759.5

Reviews

9 reviews available for prilocaine and Sexual Dysfunction, Physiological

ArticleYear
[Premature ejaculation].
    Der Urologe. Ausg. A, 2009, Volume: 48, Issue:6

    Topics: Anesthetics, Local; Benzylamines; Ejaculation; Humans; Lidocaine; Male; Marital Therapy; Naphthalene

2009
Premature ejaculation: treatment update.
    International journal of STD & AIDS, 2010, Volume: 21, Issue:2

    Topics: Administration, Oral; Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Benzylamin

2010
The link between penile hypersensitivity and premature ejaculation.
    BJU international, 2011, Volume: 107, Issue:3

    Topics: Administration, Topical; Anesthetics, Local; Case-Control Studies; Clinical Trials as Topic; Coitus;

2011
Available and future therapies for premature ejaculation.
    Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:7

    Topics: Animals; Benzylamines; Drug Therapy, Combination; Drugs, Investigational; Ejaculation; Evidence-Base

2010
Update on treatments for premature ejaculation.
    International journal of clinical practice, 2011, Volume: 65, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Local; Benzylamines; Ejaculation; Humans; Lidocaine; Lidocaine, Pri

2011
Current therapeutic strategies for premature ejaculation and future perspectives.
    Asian journal of andrology, 2011, Volume: 13, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antidepressive Agents; Drug Combinations; Ejaculat

2011
New insights on premature ejaculation: a review of definition, classification, prevalence and treatment.
    Asian journal of andrology, 2012, Volume: 14, Issue:6

    Topics: Animals; Benzylamines; Coitus; Humans; Lidocaine; Male; Naphthalenes; Piperazines; Premature Ejacula

2012
Premature ejaculation: current and future treatments.
    Asian journal of andrology, 2008, Volume: 10, Issue:1

    Topics: Anesthetics, Local; Behavior Therapy; Clomipramine; Ejaculation; Humans; Lidocaine; Male; Prilocaine

2008
It's been a long time coming, but that's good.
    BJU international, 2008, Volume: 101, Issue:7

    Topics: Ejaculation; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Prilocaine; Serotonin

2008

Trials

5 trials available for prilocaine and Sexual Dysfunction, Physiological

ArticleYear
PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study.
    BJU international, 2009, Volume: 103, Issue:7

    Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Coitus; Double-Blind Method; Drug Combinat

2009
Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study.
    The journal of sexual medicine, 2010, Volume: 7, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthetics, Local; Anxiety; Coitus; Double-Blind

2010
Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study.
    BJU international, 2004, Volume: 93, Issue:7

    Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Ejac

2004
Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation.
    Urology, 2006, Volume: 67, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Therapy, Combination; Ejaculation; Humans;

2006
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
    BJU international, 2007, Volume: 99, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin

2007
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
    BJU international, 2007, Volume: 99, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin

2007
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
    BJU international, 2007, Volume: 99, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin

2007
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.
    BJU international, 2007, Volume: 99, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aerosols; Aged; Anesthetics, Local; Drug Therapy, Combin

2007

Other Studies

3 other studies available for prilocaine and Sexual Dysfunction, Physiological

ArticleYear
Patients affected by premature ejaculation due to glans hypersensitivity refuse circumcision as a potential definite treatment for their problem.
    Andrologia, 2014, Volume: 46, Issue:4

    Topics: Adult; Anesthetics, Local; Circumcision, Male; Humans; Hypersensitivity; Lidocaine; Male; Penis; Pre

2014
Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study.
    International journal of impotence research, 2003, Volume: 15, Issue:4

    Topics: Administration, Topical; Adult; Aerosols; Aged; Anesthetics, Local; Ejaculation; Erectile Dysfunctio

2003
Clinical inquiries. What's the best drug treatment for premature ejaculation?
    The Journal of family practice, 2008, Volume: 57, Issue:3

    Topics: Anesthetics, Local; Antidepressive Agents; Clomipramine; Ejaculation; Fluoxetine; Humans; Lidocaine;

2008