prilocaine has been researched along with Seizures in 14 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 5.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| "Seizures have been reported with lidocaine at its lowest effective dose (1." | 4.85 | Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications. ( Guay, J, 2009) |
| " We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity." | 3.79 | Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013) |
| " Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death." | 3.74 | The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008) |
| "Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 1.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| "The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase." | 1.25 | Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Larson, A | 1 |
| Stidham, T | 1 |
| Banerji, S | 1 |
| Kaufman, J | 1 |
| Cho, YS | 1 |
| Chung, BY | 1 |
| Park, CW | 1 |
| Kim, HO | 1 |
| Guay, J | 1 |
| Copeland, SE | 1 |
| Ladd, LA | 1 |
| Gu, XQ | 1 |
| Mather, LE | 1 |
| Englesson, S | 2 |
| Akerman, B | 1 |
| Aström, A | 1 |
| Ross, S | 1 |
| Telc, A | 1 |
| Wynn, RL | 1 |
| McFarland, SA | 1 |
| Meyer, EA | 1 |
| Coffman, WB | 1 |
| Mumford, R | 1 |
| Kern, C | 1 |
| Gamulin, Z | 1 |
| Capron, F | 1 |
| Perry, D | 1 |
| Capolaghi, B | 1 |
| Rincon, E | 1 |
| Baker, RL | 1 |
| Iglesias, AJ | 1 |
| Duarte, AM | 1 |
| Matousek, M | 1 |
| Löfström, B | 1 |
| Essman, WB | 1 |
| Dobbs, EC | 1 |
| Ross, NM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Versus Late Deflation of Distal Tourniquet in Intravenous Regional Anesthesia With and Without Ketorolac in Hand & Forearm Surgery[NCT05234619] | 80 participants (Anticipated) | Interventional | 2022-01-01 | Active, not recruiting | |||
| A Randomized Controlled Trial to Investigate the Efficacy of a Bier's Block Compared to a Mini-bier's Block in Patients Undergoing Hand Surgery[NCT03761329] | 280 participants (Actual) | Interventional | 2018-11-12 | Completed | |||
| Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for prilocaine and Seizures
| Article | Year |
|---|---|
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Adverse events associated with intravenous regional anesthesia (Bier block): a systematic review of complications.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Local; Bupivacaine; Dose-Response Rela | 2009 |
Aspects of the pharmacology of local anaesthetic agents.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood Pressure; Central Nervous System; Epine | 1970 |
12 other studies available for prilocaine and Seizures
| Article | Year |
|---|---|
Seizures and methemoglobinemia in an infant after excessive EMLA application.
Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Infant; Lidoca | 2013 |
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Dermatitis, Atopic; Female; Humans; L | 2016 |
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca | 2008 |
Intravenous toxicity--subjective symptoms and acid-base influences on the toxicity of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Anesthetics, Local; Animals; Bicarbonates; Carbon Dioxide; Cell Membrane; Dog | 1966 |
Studies on the absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species.
Topics: Anesthetics, Local; Animals; Brain; Carbon Isotopes; Cats; Female; Kidney; Lidocaine; Liver; Lung; M | 1966 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Generalised convulsions after intravenous regional anaesthesia with prilocaine.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Humans; Male; Middle Aged; Prilocaine; Seizures | 1994 |
[Convulsive crisis and methemoglobinemia after the application of anesthetic cream].
Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Eczema; Female; Humans; Lidocaine; Lido | 1998 |
CNS toxicity after topical application of EMLA cream on a toddler with molluscum contagiosum.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Central Nervous System; Female; | 2000 |
Central nervous system effects of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides; | 1975 |
Prilocaine as an anticonvulsant: protective effects against electroshock-induced convulsions in mice.
Topics: Analysis of Variance; Aniline Compounds; Animals; Anticonvulsants; Brain; Central Nervous System; El | 1968 |
Convulsive properties of the anilide-derived local anesthetic drugs.
Topics: Animals; Epinephrine; Lidocaine; Mepivacaine; Prilocaine; Rats; Seizures | 1968 |