prilocaine has been researched along with Pocket, Periodontal in 14 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six Canadian dental schools investigated the ability of a thermosetting gel containing 25 mg/g prilocaine and 25 mg/g lidocaine as active agents to produce analgesia in periodontal pockets utilizing a randomized, double-blind, placebo-controlled study." | 5.10 | A placebo-controlled multi-centred evaluation of an anaesthetic gel (Oraqix) for periodontal therapy. ( Donaldson, D; Gelskey, SC; Landry, RG; Matthews, DC; Sandhu, HS, 2003) |
| "Oraqix, a novel non-injectable anesthetic gel containing lidocaine and prilocaine and a thermosetting agent has been developed to provide localized anesthesia in periodontal pockets during scaling/root planing (SRP)." | 5.10 | Plasma levels of lidocaine, o-toluidine, and prilocaine after application of 8.5 g Oraqix in patients with generalized periodontitis: effect on blood methemoglobin and tolerability. ( Abdel-Rehim, M; Herdevall, BM; Huledal, G; Klinge, B; Persson, L, 2003) |
| "The efficacy of a novel anesthetic gel (lidocaine 25 mg/g plus prilocaine 25 mg/g in thermosetting agents) for non-invasive periodontal pocket anesthesia was evaluated." | 5.09 | Intrapocket anesthesia for scaling and root planing: results of a double-blind multicenter trial using lidocaine prilocaine dental gel. ( Geurs, NC; Jeffcoat, MK; MacNeill, SR; Magnusson, I; Mickels, N; Roberts, F; Robinson, P; Salamati, A; Yukna, R, 2001) |
| "Forty volunteers with moderate to severe chronic periodontitis were recruited, of which at least three sextants required periodontal therapy." | 2.94 | Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT. ( Farago, PV; Moraes, GS; Pilatti, GL; Pinto, SCS; Pochapski, MT; Santos, FA; Santos, IBD, 2020) |
| "There were no reports of numbness of the tongue, lip, or cheek, neither were there any adverse local reactions in the oral mucosa." | 2.70 | The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing. ( Friskopp, J; Isacsson, G; Nilsson, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Moraes, GS | 1 |
| Santos, IBD | 1 |
| Pinto, SCS | 1 |
| Pochapski, MT | 1 |
| Farago, PV | 1 |
| Pilatti, GL | 1 |
| Santos, FA | 1 |
| Derman, SH | 2 |
| Lowden, CE | 2 |
| Kaus, P | 1 |
| Noack, MJ | 2 |
| Hellmich, M | 1 |
| Pandit, N | 1 |
| Gupta, R | 1 |
| Chandoke, U | 1 |
| Gugnani, S | 1 |
| Winning, L | 1 |
| Polyzois, I | 1 |
| Nylund, K | 1 |
| Kelly, A | 1 |
| Claffey, N | 1 |
| Donaldson, D | 2 |
| Gelskey, SC | 1 |
| Landry, RG | 1 |
| Matthews, DC | 1 |
| Sandhu, HS | 1 |
| Magnusson, I | 3 |
| Geurs, NC | 2 |
| Harris, PA | 1 |
| Hefti, AF | 1 |
| Mariotti, AJ | 1 |
| Mauriello, SM | 1 |
| Soler, L | 1 |
| Offenbacher, S | 1 |
| Herdevall, BM | 1 |
| Klinge, B | 1 |
| Persson, L | 1 |
| Huledal, G | 2 |
| Abdel-Rehim, M | 1 |
| Jeffcoat, MK | 2 |
| Otterbom, IL | 1 |
| Henriksson, J | 1 |
| DiMatteo, A | 1 |
| Scherlund, M | 1 |
| Malmsten, M | 1 |
| Holmqvist, P | 1 |
| Brodin, A | 1 |
| Friskopp, J | 2 |
| Nilsson, M | 1 |
| Isacsson, G | 1 |
| MacNeill, SR | 1 |
| Mickels, N | 1 |
| Roberts, F | 1 |
| Robinson, P | 1 |
| Salamati, A | 1 |
| Yukna, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
10 trials available for prilocaine and Pocket, Periodontal
| Article | Year |
|---|---|
Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Chronic Periodontitis; Dental Scaling; Double-B | 2020 |
Influence of intra-pocket anesthesia gel on treatment outcome in periodontal patients: a randomized controlled trial.
Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Carticaine; Dental Scaling; | 2014 |
Comparative evaluation of topical and electronic anesthesia during scaling and root planing.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; | 2010 |
A placebo-controlled trial to evaluate an anesthetic gel when probing in patients with advanced periodontitis.
Topics: Adult; Age Factors; Aged; Anesthetics, Local; Chronic Periodontitis; Dental Anxiety; Dental Instrume | 2012 |
A placebo-controlled multi-centred evaluation of an anaesthetic gel (Oraqix) for periodontal therapy.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Confidence Intervals; Den | 2003 |
Intrapocket anesthesia for scaling and root planing in pain-sensitive patients.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Dental Scaling; Double-Blind Method; Female; Fo | 2003 |
Plasma levels of lidocaine, o-toluidine, and prilocaine after application of 8.5 g Oraqix in patients with generalized periodontitis: effect on blood methemoglobin and tolerability.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Female; | 2003 |
Quantification and analysis of pain in nonsurgical scaling and/or root planing.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Double-Bl | 2004 |
The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Dental Scalin | 2001 |
Intrapocket anesthesia for scaling and root planing: results of a double-blind multicenter trial using lidocaine prilocaine dental gel.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthesia, Local; Anes | 2001 |
4 other studies available for prilocaine and Pocket, Periodontal
| Article | Year |
|---|---|
Pocket-depths-related effectiveness of an intrapocket anaesthesia gel in periodontal maintenance patients.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Combined; Anesth | 2014 |
Efficacy of an intrapocket anesthetic for scaling and root planing procedures: a review of three multicenter studies.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Clinical Trials as Topic; Dental | 2005 |
Thermosetting microemulsions and mixed micellar solutions as drug delivery systems for periodontal anesthesia.
Topics: Anesthesia, Dental; Anesthetics, Local; Chromatography, Gel; Diffusion; Drug Delivery Systems; Emuls | 2000 |
Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Aniline Compounds; Chroma | 2001 |