prilocaine has been researched along with Methemoglobinemia in 146 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated in vivo and in vitro kinetics of o-toluidine-induced methemoglobinemia and the influence of ascorbic acid on resulting methemoglobin concentrations." | 9.10 | [Methemoglobinemia due to prilocaine after plexus anesthesia. Reduction by prophylactic administration of ascorbic acid?]. ( Bauer, M; Janneck, U; Kortgen, A; Vetsch, A, 2003) |
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 9.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| "Limited information is currently available on methemoglobinemia caused by the administration of prilocaine in children undergoing dental procedures in Japan." | 8.12 | Methemoglobinemia Induced by Prilocaine in a Child With Noonan Syndrome. ( Ando, S; Kohase, H; Kono, R; Nagasaka, H; Oono, Y; Takagi, S, 2022) |
| "Neonatal methemoglobinemia is a rare and potentially fatal complication of local anesthetics, particularly prilocaine, administered to the mother during childbirth." | 8.02 | [Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine]. ( Alers, NO; Leijten, A; Ten Brink, F; van de Laar, R; van der Heijden, HHACM; Wieland, BV, 2021) |
| "This is a case report of methemoglobinemia presumably caused by the combined use of prilocaine (propitocaine) and nitroglycerin under general anesthesia." | 7.96 | A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia. ( Fujisawa, T; Hojo, T; Kimura, Y; Ohiwa, D, 2020) |
| "Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia." | 7.79 | Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation. ( Fukami, T; Higuchi, R; Nakajima, M; Yokoi, T, 2013) |
| "This paper reports two cases of transient neonatal methemoglobinemia caused by maternal pudendal anesthesia with prilocaine." | 7.79 | Transient neonatal methemoglobinemia caused by maternal pudendal anesthesia in delivery with prilocaine: report of two cases. ( Comert, S; Uslu, S, 2013) |
| " Following surgery the patient developed methemoglobinemia which was treated with tolonium chloride." | 7.77 | [Ventricular fibrillation with tolonium chloride: axillary brachial plexus anesthesia led to cessation of circulation]. ( Hoffmann, C; Klut, I; Koch, T; Radke, OC, 2011) |
| "It has not yet been clarified whether prilocaine-induced methemoglobinemia is a problem in patients with chronic anemia." | 7.67 | [Supraclavicular plexus blockade using prilocaine in patients with chronic anemia]. ( Viell, B; Wald-Oboussier, G, 1989) |
| "A case of methemoglobinemia after injection of prilocaine in a patient who had Shwachman syndrome (Shwachman-Diamond syndrome) is presented." | 7.67 | Prilocaine-induced methemoglobinemia in a child with Shwachman syndrome. ( Hays, GL; Klos, CP, 1985) |
| "A case report of methemoglobinemia induced by an overdosage of prilocaine is given." | 7.67 | [Methemoglobinemia following blockade of the brachial plexus with prilocaine (Xylonest)]. ( Bergmann, J; Steinhoff, H; Thiessen, F, 1984) |
| "Methemoglobinemia is reviewed briefly with particular reference to prilocaine." | 7.66 | Life-threatening toxic methemoglobinemia induced by prilocaine. ( Kinni, ME; Kreutz, RW, 1983) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 6.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 5.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| "Prilocaine is a widely used local anesthetic and can cause methemoglobinemia in infants even in therapeutic doses." | 5.37 | [Acute cyanosis after transcatheter balloon valvuloplasty: toxic methemoglobinemia due to local prilocaine use]. ( Dindar, A; Ergül, Y; Kalkandelen, S; Nişli, K, 2011) |
| "Methemoglobinemia is a rare but potentially lethal complication of local anesthetics." | 5.35 | Methemoglobinemia due to application of prilocaine during circumcision and the effect of ascorbic acid. ( Boran, P; Tokuc, G; Yegin, Z, 2008) |
| "Methemoglobinemia is an uncommon disorder in which hemoglobin is not oxidized and not capable of binding oxygen." | 5.29 | Prilocaine-induced methemoglobinemia--Wisconsin, 1993. ( , 1994) |
| "Methemoglobinemia was suspected in a healthy 19-year-old woman, when the pulse oximeter reading (SpO2) was 88% after a plexus brachialis block with 550 mg (35 ml, 1." | 5.28 | Prilocaine-induced methemoglobinemia evidenced by pulse oximetry. ( Bardoczky, GI; D'Hollander, A; Wathieu, M, 1990) |
| "This study investigated in vivo and in vitro kinetics of o-toluidine-induced methemoglobinemia and the influence of ascorbic acid on resulting methemoglobin concentrations." | 5.10 | [Methemoglobinemia due to prilocaine after plexus anesthesia. Reduction by prophylactic administration of ascorbic acid?]. ( Bauer, M; Janneck, U; Kortgen, A; Vetsch, A, 2003) |
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 5.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| "Limited information is currently available on methemoglobinemia caused by the administration of prilocaine in children undergoing dental procedures in Japan." | 4.12 | Methemoglobinemia Induced by Prilocaine in a Child With Noonan Syndrome. ( Ando, S; Kohase, H; Kono, R; Nagasaka, H; Oono, Y; Takagi, S, 2022) |
| "Neonatal methemoglobinemia is a rare and potentially fatal complication of local anesthetics, particularly prilocaine, administered to the mother during childbirth." | 4.02 | [Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine]. ( Alers, NO; Leijten, A; Ten Brink, F; van de Laar, R; van der Heijden, HHACM; Wieland, BV, 2021) |
| "This is a case report of methemoglobinemia presumably caused by the combined use of prilocaine (propitocaine) and nitroglycerin under general anesthesia." | 3.96 | A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia. ( Fujisawa, T; Hojo, T; Kimura, Y; Ohiwa, D, 2020) |
| " We present the case of an infant with extensive vascular malformations treated with EMLA cream who developed seizures and methemoglobinemia from lidocaine and prilocaine toxicity." | 3.79 | Seizures and methemoglobinemia in an infant after excessive EMLA application. ( Banerji, S; Kaufman, J; Larson, A; Stidham, T, 2013) |
| "This paper reports two cases of transient neonatal methemoglobinemia caused by maternal pudendal anesthesia with prilocaine." | 3.79 | Transient neonatal methemoglobinemia caused by maternal pudendal anesthesia in delivery with prilocaine: report of two cases. ( Comert, S; Uslu, S, 2013) |
| " Following surgery the patient developed methemoglobinemia which was treated with tolonium chloride." | 3.77 | [Ventricular fibrillation with tolonium chloride: axillary brachial plexus anesthesia led to cessation of circulation]. ( Hoffmann, C; Klut, I; Koch, T; Radke, OC, 2011) |
| " Methemoglobinemia was suspected and treated with ascorbine acid and methylene blue." | 3.77 | [Toxic methemoglobinemia]. ( Bender, P; Neuhaus, H, 2011) |
| " Due to the application of EMLA(R) on the injured skin and exceeding the recommended doses of prilocaine and lidocaine the child developed symptomatic methemoglobinemia." | 3.75 | [Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries]. ( Book, A; Fehlandt, C; Krija, M; Pappert, D; Radke, M, 2009) |
| "We describe a 3-year-old child with mollusca contagiosa whose caregiver applied a eutectic mixture of 5% lidocaine and prilocaine (EMLA) in excessive amounts with the subsequent development of adverse reactions, including methemoglobinemia and hypoxemia." | 3.71 | Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa. ( Jackson, JB; Touma, S, 2001) |
| "These results demonstrate that if oxidant drugs (acetaminophen, phytomenadione, or EMLA cream) did not increase blood methemoglobinemia in neonatal piglets, their association with iNO caused an increase in methemoglobin." | 3.70 | Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets. ( Klosowski, S; Kongolo, G; Lequien, P; Martin-Ponthieu, A; Rakza, T; Riou, Y; Storme, L; Zerimech, F, 2000) |
| " Methemoglobinemia was diagnosed, due to prilocaine-lignocaine cream used for local anesthesia, associated to partial G6PD deficiency." | 3.69 | [Pulse oximetry and methemoglobinemia]. ( Cloup, M; Doz, F; Hubert, P; Jouvet, P; Moretti, S; Schleiermacher, G; Zucker, JM, 1996) |
| "EMLA (eutectic mixture of lidocaine and prilocaine) cream is currently not recommended for use in infants < 1 month of age because of the potential risk of methemoglobinemia as a result of the o-toluidine metabolite of prilocaine." | 3.69 | Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision. ( Gazarian, M; Kent, G; Klein, J; Koren, G; Taddio, A, 1995) |
| "It has not yet been clarified whether prilocaine-induced methemoglobinemia is a problem in patients with chronic anemia." | 3.67 | [Supraclavicular plexus blockade using prilocaine in patients with chronic anemia]. ( Viell, B; Wald-Oboussier, G, 1989) |
| "A case of methemoglobinemia after injection of prilocaine in a patient who had Shwachman syndrome (Shwachman-Diamond syndrome) is presented." | 3.67 | Prilocaine-induced methemoglobinemia in a child with Shwachman syndrome. ( Hays, GL; Klos, CP, 1985) |
| "Methemoglobinemia is reviewed briefly with particular reference to prilocaine." | 3.66 | Life-threatening toxic methemoglobinemia induced by prilocaine. ( Kinni, ME; Kreutz, RW, 1983) |
| "This communication reports a case of acute toxic methemoglobinemia associated with hypoxia and general motor seizures following dental anesthesia using nitrous oxide and prilocaine hydrochloride." | 3.66 | Acute toxic methemoglobinemia following dental analgesia. ( Ludwig, SC, 1981) |
| " While safe and well-tolerated when used appropriately, an overdose of these anesthetics increases the risk for local anesthetic systemic toxicity (LAST), which in severe cases can present with seizures, cardiac dysrhythmias, and ultimately cardiovascular collapse." | 2.82 | Local anesthetic systemic toxicity in the pediatric patient. ( Baker, KA; McMahon, K; Paster, J, 2022) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 2.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "The objective of the study was to investigate the clinical effectiveness of increasing the dosage of prilocaine for a combined 3-in-1/sciatic nerve block from 500 to 650 mg (open study with 29 patients compared with 30 patients from a former study) and to validate these findings in a second stage (randomised study comparing two groups of 30 patients each)." | 2.68 | [Combined 3-in-1 sciatic block. Prilocaine 500 mg vs. 650 mg]. ( Missler, B; Wagner, F, 1997) |
| "Mepivacaine was selected for routine use since prilocaine induced methaemoglobinaemia." | 2.67 | Comparison of two local anaesthetics in transvaginal ultrasound-guided oocyte retrieval. ( Camus, M; De Munck, L; Devroey, P; Erard, P; Gepts, E; Godoy, H; Van Steirteghem, AC, 1993) |
| "Prilocaine was chosen as the medium-long acting LA because it has the lowest toxicity of this group and for pharmacological reasons." | 2.66 | [Clinical effectiveness and systemic toxicity of various mixtures of prilocaine and bupivacaine in axillary plexus block]. ( Börner, P; Tryba, M, 1988) |
| " They also should follow new recommended dosing guidelines for prilocaine and be aware of symptoms of this adverse reaction." | 2.40 | When patients become cyanotic: acquired methemoglobinemia. ( Lloyd, LM; Wilburn-Goo, D, 1999) |
| "Methemoglobinemia is a rare but potentially lethal complication of local anesthetics." | 1.46 | Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia. ( Arslan, Z; Bas, AY; Celik, IH; Demirel, N; Erol, S, 2017) |
| "Prilocaine was administered during the procedure." | 1.46 | A rare cause of cyanosis and hypoxia that should not be forgotten after implantable cardioverter defibrillator implantation. ( Aytemir, K; Bahadır, N; Canpolat, U; Şahiner, L, 2017) |
| "We report a case of generalized seizures and methemoglobinemia after topical application of EMLA for curettage of molluscum contagiosum lesions in a 3." | 1.43 | Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis. ( Cho, YS; Chung, BY; Kim, HO; Park, CW, 2016) |
| "Prilocaine is a widely used local anesthetic and can cause methemoglobinemia in infants even in therapeutic doses." | 1.37 | [Acute cyanosis after transcatheter balloon valvuloplasty: toxic methemoglobinemia due to local prilocaine use]. ( Dindar, A; Ergül, Y; Kalkandelen, S; Nişli, K, 2011) |
| "Methemoglobinemia is a fatal complication of local anesthesia." | 1.36 | Severe methemoglobinemia after dental anesthesia: a warning about propitocaine-induced methemoglobinemia in neonates. ( Doko, Y; Fujii, K; Hatano, Y; Iranami, H; Shimogai, M; Yamazaki, A, 2010) |
| "Mild methemoglobinemia is a known side-effect of one of the constituents of EMLA cream, this topical local anesthetic is used with great caution in neonates." | 1.29 | [Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance]. ( Dhabhi, S; el Hanache, A; Gourrier, E; Karoubi, P; Leraillez, J; Merbouche, S; Mouchnino, G, 1995) |
| " The present report describes our method and experience with this type of anesthesia in approximately 500 patients, including pharmacokinetic and -dynamic aspects." | 1.28 | [Intravenous regional anesthesia of the foot using prilocaine. Clinical aspects, pharmacokinetic and pharmacodynamic studies]. ( Bachmann-M, B; Biscoping, J; Hempelmann, G; Schürg, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (32.19) | 18.7374 |
| 1990's | 43 (29.45) | 18.2507 |
| 2000's | 24 (16.44) | 29.6817 |
| 2010's | 25 (17.12) | 24.3611 |
| 2020's | 7 (4.79) | 2.80 |
| Authors | Studies |
|---|---|
| McMahon, K | 1 |
| Paster, J | 1 |
| Baker, KA | 1 |
| Gok, M | 1 |
| Aydemir, YG | 1 |
| Takagi, S | 1 |
| Ando, S | 1 |
| Kono, R | 1 |
| Oono, Y | 1 |
| Nagasaka, H | 1 |
| Kohase, H | 1 |
| Woo, NL | 1 |
| Cherian, S | 1 |
| Heaney, M | 1 |
| Wahl, G | 1 |
| Hojo, T | 1 |
| Kimura, Y | 1 |
| Ohiwa, D | 1 |
| Fujisawa, T | 1 |
| Mayer, JM | 1 |
| Capellen, CF | 1 |
| Holzbach, T | 1 |
| Wieland, BV | 1 |
| Leijten, A | 1 |
| van der Heijden, HHACM | 1 |
| van de Laar, R | 1 |
| Ten Brink, F | 1 |
| Alers, NO | 1 |
| Canpolat, U | 1 |
| Bahadır, N | 1 |
| Şahiner, L | 1 |
| Aytemir, K | 1 |
| Gunes, H | 1 |
| Sonmez, FT | 1 |
| Guneysu, F | 1 |
| Kandis, H | 1 |
| Saritas, A | 1 |
| Erol, S | 1 |
| Arslan, Z | 1 |
| Celik, IH | 1 |
| Bas, AY | 1 |
| Demirel, N | 1 |
| Larson, A | 1 |
| Stidham, T | 1 |
| Banerji, S | 1 |
| Kaufman, J | 1 |
| Higuchi, R | 1 |
| Fukami, T | 1 |
| Nakajima, M | 1 |
| Yokoi, T | 1 |
| Uslu, S | 1 |
| Comert, S | 1 |
| Selder, J | 1 |
| Veenstra, J | 1 |
| Gutenberg, LL | 1 |
| Chen, JW | 1 |
| Trapp, L | 2 |
| Shamriz, O | 1 |
| Cohen-Glickman, I | 1 |
| Reif, S | 1 |
| Shteyer, E | 1 |
| Erkuran, MK | 1 |
| Duran, A | 1 |
| Kurt, BB | 1 |
| Ocak, T | 1 |
| Cho, YS | 1 |
| Chung, BY | 1 |
| Park, CW | 1 |
| Kim, HO | 1 |
| Kizilyildiz, BS | 1 |
| Sönmez, B | 1 |
| Karaman, K | 1 |
| Caksen, H | 2 |
| Berksun, H | 1 |
| Akpek, EA | 1 |
| Arslan, G | 1 |
| Moreno Higueras, M | 1 |
| López Robles, MC | 1 |
| Giner Escobar, MP | 1 |
| Cantero Hinojosa, J | 1 |
| Boran, P | 1 |
| Tokuc, G | 1 |
| Yegin, Z | 1 |
| Gaigl, Z | 1 |
| Seitz, CS | 1 |
| Trautmann, A | 1 |
| Book, A | 1 |
| Fehlandt, C | 1 |
| Krija, M | 1 |
| Radke, M | 1 |
| Pappert, D | 1 |
| Guay, J | 1 |
| Tekbas, G | 1 |
| Oguzkurt, L | 1 |
| Ozkan, U | 1 |
| Gurel, K | 1 |
| Peker, E | 1 |
| Cagan, E | 1 |
| Dogan, M | 2 |
| Aktar, F | 1 |
| Bektas, S | 1 |
| Kirimi, E | 1 |
| Ceylan, A | 1 |
| Soeding, P | 1 |
| Deppe, M | 1 |
| Gehring, H | 1 |
| Doko, Y | 1 |
| Iranami, H | 1 |
| Fujii, K | 1 |
| Yamazaki, A | 1 |
| Shimogai, M | 1 |
| Hatano, Y | 1 |
| Tentindo, G | 1 |
| Rosenberg, M | 1 |
| Will, J | 1 |
| Akbayram, S | 1 |
| Akgün, C | 1 |
| Gündogdu, M | 1 |
| Oner, AF | 1 |
| Ergül, Y | 1 |
| Nişli, K | 1 |
| Kalkandelen, S | 1 |
| Dindar, A | 1 |
| Bender, P | 1 |
| Neuhaus, H | 1 |
| Radke, OC | 1 |
| Hoffmann, C | 1 |
| Klut, I | 1 |
| Koch, T | 2 |
| Sambrook, PJ | 1 |
| Smith, W | 1 |
| Elijah, J | 1 |
| Goss, AN | 1 |
| Tunç, M | 1 |
| Sazak, H | 1 |
| Ulus, F | 1 |
| Şahin, Ş | 1 |
| Schmitt, C | 1 |
| Matulic, M | 1 |
| Kervégant, M | 1 |
| Tichadou, L | 1 |
| Boutin, A | 1 |
| Glaizal, M | 1 |
| de Haro, L | 1 |
| Sinisterra, S | 1 |
| Miravet, E | 1 |
| Alfonso, I | 1 |
| Soliz, A | 1 |
| Papazian, O | 1 |
| SCOTT, DB | 1 |
| OWEN, JA | 1 |
| RICHMOND, J | 1 |
| DALY, DJ | 1 |
| DAVENPORT, J | 1 |
| NEWLAND, MC | 1 |
| HJELM, M | 1 |
| HOLMDAHL, MH | 1 |
| Hahn, IH | 1 |
| Hoffman, RS | 1 |
| Nelson, LS | 1 |
| Kortgen, A | 1 |
| Janneck, U | 1 |
| Vetsch, A | 1 |
| Bauer, M | 1 |
| Sivasli, E | 1 |
| Gursoy, T | 1 |
| Yurdakok, M | 1 |
| Pérez-Caballero Macarrón, C | 1 |
| Pérez Palomino, A | 1 |
| Moreno Fernández, L | 1 |
| Aygencel, SG | 1 |
| Akinci, E | 1 |
| Pamukcu, G | 1 |
| Vasters, FG | 1 |
| Eberhart, LH | 1 |
| Kranke, P | 1 |
| Wulf, H | 1 |
| Morin, AM | 1 |
| Kreeftenberg, HG | 1 |
| Braams, R | 1 |
| Nauta, P | 1 |
| Elsaie, ML | 1 |
| Adams, V | 1 |
| Marley, J | 1 |
| McCarroll, C | 1 |
| Shachor-Meyouhas, Y | 1 |
| Galbraith, R | 1 |
| Shavit, I | 1 |
| Poppers, PJ | 5 |
| Adamson, DH | 2 |
| Spoerel, WE | 2 |
| Eberhard, RS | 1 |
| Climie, CR | 1 |
| McLean, S | 1 |
| Starmer, GA | 1 |
| Thomas, J | 1 |
| Thiessen, F | 1 |
| Bergmann, J | 1 |
| Steinhoff, H | 1 |
| Kreutz, RW | 1 |
| Kinni, ME | 1 |
| Duncan, PG | 1 |
| Kobrinsky, N | 1 |
| Voorbrood, BS | 1 |
| Monnens, LA | 1 |
| Boon, JM | 1 |
| Ludwig, SC | 1 |
| Gourrier, E | 3 |
| Leraillez, J | 3 |
| Dumont, L | 1 |
| Mardirosoff, C | 1 |
| Dumont, C | 1 |
| Mattys, M | 1 |
| Massaut, J | 1 |
| Boudreau, GA | 1 |
| Rudlof, B | 2 |
| Durstewitz-Knierim, D | 1 |
| Ridderskamp, I | 1 |
| Scharenberg, C | 1 |
| Brandt, L | 2 |
| Heber, G | 1 |
| Hasenburg, A | 1 |
| Jaspers, V | 1 |
| Spätling, L | 1 |
| Nioloux, C | 1 |
| Floch-Tudal, C | 1 |
| Jaby-Sergent, MP | 1 |
| Lejeune, C | 1 |
| Godoy, H | 1 |
| Erard, P | 1 |
| De Munck, L | 1 |
| Camus, M | 1 |
| Gepts, E | 1 |
| Van Steirteghem, AC | 1 |
| Devroey, P | 1 |
| Ozbek, N | 1 |
| Sarikayalar, F | 1 |
| Tse, S | 1 |
| Barrington, K | 1 |
| Byrne, P | 1 |
| Karoubi, P | 2 |
| el Hanache, A | 2 |
| Merbouche, S | 2 |
| Mouchnino, G | 2 |
| Dhabhi, S | 1 |
| Lampert, R | 1 |
| Johnson, PL | 1 |
| Eifert, B | 1 |
| Hahn, R | 1 |
| Maier, B | 1 |
| Konrad, F | 1 |
| Georgieff, M | 1 |
| Litman, SJ | 1 |
| Vitkun, SA | 1 |
| Moretti, S | 1 |
| Jouvet, P | 1 |
| Schleiermacher, G | 1 |
| Hubert, P | 1 |
| Doz, F | 1 |
| Zucker, JM | 1 |
| Cloup, M | 1 |
| Gazarian, M | 1 |
| Taddio, A | 3 |
| Klein, J | 1 |
| Kent, G | 1 |
| Koren, G | 3 |
| Puthoff, TD | 1 |
| Visconti, JA | 1 |
| Tschampel, MM | 1 |
| Law, RM | 1 |
| Halpern, S | 1 |
| Martins, RF | 1 |
| Reich, H | 1 |
| Innanen, V | 1 |
| Ohlsson, A | 1 |
| Stevens, B | 2 |
| Craig, K | 1 |
| Rastogi, P | 1 |
| Ben-David, S | 1 |
| Shennan, A | 1 |
| Mulligan, P | 1 |
| Kumar, AR | 1 |
| Dunn, N | 1 |
| Naqvi, M | 1 |
| Wagner, F | 1 |
| Missler, B | 1 |
| Prineas, S | 1 |
| Wilkins, BH | 1 |
| Halliday, RJ | 1 |
| Elsner, P | 1 |
| Dummer, R | 1 |
| Capron, F | 1 |
| Perry, D | 1 |
| Capolaghi, B | 1 |
| Ergenekon, E | 1 |
| Atalay, Y | 1 |
| Koç, E | 1 |
| Türkyilmaz, C | 1 |
| Wilburn-Goo, D | 1 |
| Lloyd, LM | 1 |
| Johnston, C | 1 |
| Jack, A | 1 |
| Narciso, J | 1 |
| Stremler, R | 1 |
| Aranda, J | 1 |
| Frey, B | 1 |
| Kehrer, B | 1 |
| Eltzschig, H | 1 |
| Rohrbach, M | 1 |
| Schroeder, TH | 1 |
| Riou, Y | 1 |
| Storme, L | 1 |
| Klosowski, S | 1 |
| Rakza, T | 1 |
| Kongolo, G | 1 |
| Zerimech, F | 1 |
| Martin-Ponthieu, A | 1 |
| Lequien, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Fractional Carbon Dioxide Laser Assisted Delivery of Topical Anesthetics: a Randomized Controlled Pilot Study[NCT02246179] | Phase 4 | 10 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time[NCT03279757] | Phase 4 | 15 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Laser Type and Laser Settings[NCT02938286] | Phase 4 | 15 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
6 reviews available for prilocaine and Methemoglobinemia
| Article | Year |
|---|---|
Local anesthetic systemic toxicity in the pediatric patient.
Topics: Anesthetics, Local; Child; Female; Humans; Infant; Lidocaine; Lidocaine, Prilocaine Drug Combination | 2022 |
Methemoglobinemia induced by lidocaine-prilocaine cream.
Topics: Anesthetics, Combined; Anesthetics, Local; Child; Cyanosis; Enzyme Inhibitors; Female; Humans; Lidoc | 2014 |
Methemoglobinemia related to local anesthetics: a summary of 242 episodes.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Anesthetics, Local; Benzocaine; Chi | 2009 |
Acquired methemoglobinemia revisited.
Topics: Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Enzyme Inhibitors; Hemogl | 2010 |
When patients become cyanotic: acquired methemoglobinemia.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocaine; Cyanosis; Drug Overdose; Huma | 1999 |
Methemoglobinemia.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Evidence-Based Medicine; Glucosephosphate D | 2001 |
15 trials available for prilocaine and Methemoglobinemia
| Article | Year |
|---|---|
Methemoglobin levels in generally anesthetized pediatric dental patients receiving prilocaine versus lidocaine.
Topics: Analysis of Variance; Anesthesia, Dental; Anesthesia, General; Anesthetics, Local; Chi-Square Distri | 2013 |
Methemoglobin levels during epidural anesthesia for renal transplantation--comparison of prilocaine with bupivacaine.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Blood Gas Analysis; Bupivacaine; Female; Hemodynami | 2008 |
[Methemoglobinemia due to prilocaine after plexus anesthesia. Reduction by prophylactic administration of ascorbic acid?].
Topics: Adult; Anesthetics, Local; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Female; Hu | 2003 |
Comparison of two local anaesthetics in transvaginal ultrasound-guided oocyte retrieval.
Topics: Adult; Female; Fertilization in Vitro; Humans; Mepivacaine; Methemoglobinemia; Oocytes; Pain Measure | 1993 |
[The use of pulse oximetry in prilocaine induced methemoglobinemia].
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Female; | 1995 |
[Combined "3-in-1"/sciatic nerve block. Block effectiveness, serum level and side effects using 700 mg mepivacaine 1% without and with adrenaline and prilocaine 1%].
Topics: Adult; Anesthetics, Local; Ankle; Dose-Response Relationship, Drug; Double-Blind Method; Epinephrine | 1996 |
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Crying; Double-Blind Method; Drug Combina | 1997 |
Use of EMLA cream in a department of neonatology.
Topics: Anesthetics, Local; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; Hospital Departments; | 1996 |
[Combined 3-in-1 sciatic block. Prilocaine 500 mg vs. 650 mg].
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Female; Humans; Male; Methemoglobinemia; Middle Aged; N | 1997 |
Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
Topics: Anesthetics, Combined; Anesthetics, Local; Heel; Humans; Infant, Newborn; Infant, Premature; Lidocai | 1999 |
[Clinical effectiveness and systemic toxicity of various mixtures of prilocaine and bupivacaine in axillary plexus block].
Topics: Adolescent; Adult; Aged; Axilla; Bupivacaine; Clinical Trials as Topic; Dose-Response Relationship, | 1988 |
[Comparison of prilocaine 2% versus lidocaine 2% with adrenaline in peridural anesthesia. A clinical double-blind study].
Topics: Adult; Analgesia; Anesthesia, Epidural; Clinical Trials as Topic; Double-Blind Method; Epinephrine; | 1985 |
Review of the properties of two new local anaesthetics, prilocaine and lidocaine.
Topics: Adjuvants, Anesthesia; Anesthesia, Local; Anesthesia, Spinal; Animals; Brain; Clinical Trials as Top | 1966 |
Choice of anesthetic agents for intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Benzoates; Central Nervous System; Clinical Trials | 1969 |
[Studies of the dose dependency of methemoglobin development after administration of prilocaine (Citanest)].
Topics: Adolescent; Adult; Anesthesia, Local; Body Weight; Cyanosis; Factor Analysis, Statistical; Female; H | 1968 |
125 other studies available for prilocaine and Methemoglobinemia
| Article | Year |
|---|---|
Methaemoglobinaemia in pregnancy with chronic kidney disease an uncommon case: A case report.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Female; Humans; Methemoglobinemia; Pregnancy; Prilocai | 2022 |
Methemoglobinemia Induced by Prilocaine in a Child With Noonan Syndrome.
Topics: Anesthetics, Local; Child; Dental Caries; Felypressin; Female; Humans; Methemoglobin; Methemoglobine | 2022 |
Methaemoglobinaemia secondary to topical prilocaine toxicity: A cautionary circumcision tale.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Lidocaine; Male; Methemoglobinemia; Prilocaine | 2021 |
A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia.
Topics: Anesthesia, General; Anesthetics, Local; Humans; Methemoglobinemia; Nitroglycerin; Prilocaine; Think | 2020 |
[Liposuction with consequences: what to consider when using prilocaine].
Topics: Female; Humans; Lipectomy; Methemoglobinemia; Prilocaine | 2021 |
[Unexplained cyanosis in two newborns: neonatal methemoglobinemia after maternal perineal infiltration of prilocaine].
Topics: Anesthetics, Local; Cyanosis; Humans; Infant, Newborn; Lidocaine; Methemoglobinemia; Prilocaine | 2021 |
A rare cause of cyanosis and hypoxia that should not be forgotten after implantable cardioverter defibrillator implantation.
Topics: Anesthetics, Local; Arrhythmias, Cardiac; Cyanosis; Defibrillators, Implantable; Female; Humans; Hyp | 2017 |
Prilocaine-induced Methemoglobinemia.
Topics: Anesthetics, Local; Ascorbic Acid; Female; Humans; Methemoglobinemia; Methylene Blue; Prilocaine; Tr | 2017 |
Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia.
Topics: Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Cyanosis; Female; Fetal Blood; Human | 2017 |
Seizures and methemoglobinemia in an infant after excessive EMLA application.
Topics: Administration, Topical; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Infant; Lidoca | 2013 |
Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation.
Topics: Adult; Animals; Carboxylesterase; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Down-Regulation; | 2013 |
Transient neonatal methemoglobinemia caused by maternal pudendal anesthesia in delivery with prilocaine: report of two cases.
Topics: Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Female; Humans; Infant, Newborn; Mal | 2013 |
[Methaemoglobinaemia after using EMLA cream].
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Female; Humans; Lidocaine | 2013 |
Methemoglobinemia after local anesthesia with prilocaine: a case report.
Topics: Adult; Anesthetics, Local; Catheters, Indwelling; Critical Care; Female; Humans; Methemoglobinemia; | 2015 |
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Topics: Administration, Topical; Anesthetics, Local; Child, Preschool; Dermatitis, Atopic; Female; Humans; L | 2016 |
Toxic methemoglobinemia due to prilocaine use.
Topics: Anesthetics, Local; Ascorbic Acid; Circumcision, Male; Cyanosis; Humans; Infant; Male; Methemoglobin | 2010 |
[Methemoglobinemia induced by local anesthetic administration previous to laser depilation].
Topics: Adult; Anesthetics, Local; Female; Hair Removal; Humans; Lasers; Lidocaine; Methemoglobinemia; Prilo | 2008 |
Methemoglobinemia due to application of prilocaine during circumcision and the effect of ascorbic acid.
Topics: Anesthetics, Local; Antioxidants; Ascorbic Acid; Circumcision, Male; Humans; Infant; Injections, Int | 2008 |
Methemoglobinemia due to local anesthesia with low-dose prilocaine.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Female; Humans; Methemoglobinemia; Prilocaine | 2009 |
[Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries].
Topics: Administration, Topical; Anesthetics, Local; Bandages; Burns; Cyanosis; Diagnosis, Differential; Hum | 2009 |
Prilocain-induced methemoglobinemia after endovenous laser ablation.
Topics: Aged; Anesthetics, Local; Female; Humans; Laser Therapy; Methemoglobinemia; Prilocaine | 2010 |
Methemoglobinemia due to local anesthesia with prilocaine for circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Methemoglo | 2010 |
Pulse-oximetric measurement of prilocaine-induced methemoglobinemia in regional anesthesia.
Topics: Anesthesia, Conduction; Humans; Methemoglobinemia; Oximetry; Prilocaine; Prospective Studies | 2010 |
Severe methemoglobinemia after dental anesthesia: a warning about propitocaine-induced methemoglobinemia in neonates.
Topics: Anesthesia, Dental; Anesthetics, Local; Female; Humans; Infant, Newborn; Methemoglobinemia; Postoper | 2010 |
Methemoglobinemia and local anesthesia: what every dentist should know.
Topics: Anesthesia, Dental; Anesthetics, Local; Antidotes; Benzocaine; Cyanosis; Disease Susceptibility; Hum | 2010 |
Acquired methemoglobinemia due to application of prilocaine during circumcision.
Topics: Anesthetics, Local; Antioxidants; Ascorbic Acid; Circumcision, Male; Cyanosis; Humans; Infant; Male; | 2012 |
[Acute cyanosis after transcatheter balloon valvuloplasty: toxic methemoglobinemia due to local prilocaine use].
Topics: Anesthetics, Local; Ascorbic Acid; Catheterization; Cyanosis; Female; Humans; Infant; Methemoglobine | 2011 |
[Toxic methemoglobinemia].
Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Bupivacaine; Critical Care; Diagnosis, Different | 2011 |
[Ventricular fibrillation with tolonium chloride: axillary brachial plexus anesthesia led to cessation of circulation].
Topics: Anesthetics, Local; Blood Gas Analysis; Brachial Plexus; Critical Care; Electrocardiography; Hand In | 2011 |
Severe adverse reactions to dental local anaesthetics: systemic reactions.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den | 2011 |
Methemoglobinemia following prilocaine administration for bilateral tube thoracostomy in a pediatric case.
Topics: Anesthetics, Local; Child; Drug Overdose; Dyspnea; Empyema; Humans; Male; Methemoglobinemia; Pneumot | 2012 |
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Topics: Anesthetics, Combined; Child, Preschool; Dosage Forms; Drug Overdose; Female; Humans; Lidocaine; Lid | 2012 |
Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.
Topics: Administration, Inhalation; Anesthetics, Combined; Anesthetics, Local; Female; Humans; Infant; Lidoc | 2002 |
METHAEMOGLOBINAEMIA DUE TO PRILOCAINE.
Topics: Anesthetics; Anesthetics, Local; Cyanosis; Humans; Lidocaine; Methemoglobinemia; Prilocaine; Toxicol | 1964 |
METHAEMOGLOBINAEMIA FOLLOWING THE USE OF PRILOCAINE ("CITANEST"). A PRELIMINARY REPORT.
Topics: Anesthesia; Anesthesia, Obstetrical; Anesthetics; Anesthetics, Local; Aniline Compounds; Cyanosis; F | 1964 |
BIOCHEMICAL EFFECTS OF AROMATIC AMINES. II. CYANOSIS, METHAEMOGLOBINAEMIA AND HEINZ-BODY FORMATION INDUCED BY A LOCAL ANAESTHETIC AGENT (PRILOCAINE).
Topics: Alanine Transaminase; Amines; Anesthesia, Local; Anesthetics, Local; Bilirubin; Blood; Creatine; Cre | 1965 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity.
Topics: Adult; Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2004 |
Which local anesthesia should be used in neonatal circumcision in newborns?
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Methemoglobinemia; Prilocaine | 2005 |
[Probable methemoglobinemia following EMLA administration].
Topics: Anesthetics, Local; Child; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methem | 2005 |
Prilocaine induced methemoglobinemia.
Topics: Adult; Anesthetics, Local; Cyanosis; Female; Hair Removal; Humans; Methemoglobinemia; Prilocaine | 2006 |
Risk factors for prilocaine-induced methaemoglobinaemia following peripheral regional anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthetics, Local; Female; Humans; Knee; Male; Met | 2006 |
Methemoglobinemia after low-dose prilocaine in an adult patient receiving barbiturate comedication.
Topics: Adolescent; Anesthetics, Combined; Barbiturates; Female; Humans; Methemoglobinemia; Prilocaine | 2007 |
Cardiovascular collapse developing after topical anesthesia.
Topics: Administration, Topical; Adult; Anesthetics, Local; Arrhythmias, Cardiac; Cardiovascular System; Fem | 2007 |
Prilocaine induced methaemoglobinaemia in a medically compromised patient. Was this an inevitable consequence of the dose administered?
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Dental Care for Chronically Ill; Dose-Res | 2007 |
Application of topical analgesia in triage: a potential for harm.
Topics: Administration, Topical; Anesthetics, Local; Emergency Nursing; Enzyme Inhibitors; Female; Humans; I | 2008 |
Practical and theoretical considerations on the use of prilocaine in obstetrics.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange | 1966 |
Methaemoglobin levels during continuous epidural analgesia using prilocaine (Citanest).
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Cyanosis; Female; Fetal Death; Humans; Methemoglobin; M | 1966 |
The significance of methaemoglobinaemia induced by prilocaine (Citanest).
Topics: Anesthetics, Local; Cyanosis; Humans; Methemoglobin; Methemoglobinemia; Oxygen Consumption; Prilocai | 1967 |
Methaemoglobinaemia in mother and foetus following continuous epidural analgesia with prilocaine. Clinical and experimental data.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Blood Preservation; Cats; | 1967 |
Evaluation of a local anesthetic agent. Prilocaine hydrochloride (Citanest).
Topics: Anesthesia, Conduction; Anesthetics, Local; Humans; Methemoglobinemia; Prilocaine | 1967 |
[Methemoglobinemia following blockade of the brachial plexus with prilocaine (Xylonest)].
Topics: Adult; Brachial Plexus; Humans; Male; Methemoglobinemia; Nerve Block; Prilocaine | 1984 |
Life-threatening toxic methemoglobinemia induced by prilocaine.
Topics: Adult; Cyanosis; Diagnosis, Differential; Female; Humans; Methemoglobinemia; Prilocaine; Respiratory | 1983 |
Prilocaine-induced methemoglobinemia in a newborn infant.
Topics: Cleft Lip; Cleft Palate; Cyanosis; Dihydrolipoamide Dehydrogenase; Erythrocytes; Female; Humans; Inf | 1983 |
[Methemoglobinemia in 2 newborn infants as a result of the use of prilocaine (Citanest)].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Methemogl | 1982 |
Acute toxic methemoglobinemia following dental analgesia.
Topics: Acute Disease; Anesthesia, Dental; Child, Preschool; Humans; Male; Methemoglobinemia; Nitrous Oxide; | 1981 |
[Risk of methemoglobinemia after Emla application in premature infants].
Topics: Anesthetics, Local; Drug Combinations; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidoca | 1995 |
Methaemoglobinemia induced by a low dose of prilocaïne during interscalenic block.
Topics: Adult; Arteriovenous Shunt, Surgical; Female; Humans; Methemoglobinemia; Nerve Block; Oximetry; Pril | 1995 |
EMLA's safety for small infants.
Topics: Anesthetics, Local; Drug Combinations; Humans; Infant; Infant, Newborn; Lidocaine; Lidocaine, Priloc | 1995 |
[Increase of prilocaine-induced methemoglobinemia following anesthesia induction].
Topics: Anesthesia, General; Brachial Plexus; Carcinogens; Humans; Methemoglobinemia; Middle Aged; Nerve Blo | 1995 |
[Methemoglobinemia in the newborn infant--caused by prilocaine?-- A case report].
Topics: Adult; Anesthesia, Obstetrical; Carbon Dioxide; Female; Humans; Infant, Newborn; Infant, Newborn, Di | 1995 |
[Local anesthesia with Emla cream and risk of methemoglobinemia in a premature infant].
Topics: Anesthetics, Local; Dose-Response Relationship, Drug; Drug Combinations; Humans; Infant, Newborn; In | 1995 |
From the Centers for Disease Control and Prevention. Prilocaine-induced methemoglobinemia--Wisconsin, 1993.
Topics: Adolescent; Adult; Female; Humans; Methemoglobinemia; Prilocaine; Surgery, Oral; Wisconsin | 1994 |
Prilocaine-induced methemoglobinemia--Wisconsin, 1993.
Topics: Adolescent; Adult; Female; Humans; Methemoglobinemia; Prilocaine; Surgery, Oral; Wisconsin | 1994 |
Toxic methaemoglobinaemia after circumcision.
Topics: Anesthesia, Local; Circumcision, Male; Humans; Infant; Male; Methemoglobinemia; Postoperative Compli | 1993 |
Methemoglobinemia associated with prilocaine use in neonatal circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Methemoglobinemia; Prilocaine | 1995 |
[Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance].
Topics: Administration, Cutaneous; Anesthetics, Local; Dose-Response Relationship, Drug; Drug Combinations; | 1995 |
Pulse oximetry signals local anesthetic-induced methemoglobinemia.
Topics: Adult; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Humans; Intra | 1994 |
Use of EMLA cream in the treatment of post-herpetic neuralgia.
Topics: Administration, Topical; Aged; Anesthetics, Local; Drug Combinations; Female; Herpesviridae Infectio | 1996 |
[Pulse oximetry and methemoglobinemia].
Topics: Anesthetics, Local; Blood Gas Monitoring, Transcutaneous; Child, Preschool; Drug Combinations; Human | 1996 |
Penile absorption of EMLA cream in piglets: implications for use of EMLA in neonatal circumcision.
Topics: Absorption; Anesthetics, Local; Animals; Animals, Newborn; Circumcision, Male; Cross-Over Studies; D | 1995 |
Use of Emla prior to circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc | 1996 |
Measurement of methemoglobin after EMLA analgesia for newborn circumcision.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidoc | 1996 |
Methemoglobinemia associated with a prilocaine-lidocaine cream.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc | 1997 |
Circumcision blues.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Male; Methemoglobinemia; Prilocaine | 1997 |
Signs of methaemoglobinaemia after topical application of EMLA cream in an infant with haemangioma.
Topics: Anesthesia, Local; Anesthetics, Combined; Female; Hemangioma; Humans; Infant, Newborn; Lidocaine; Li | 1997 |
[Convulsive crisis and methemoglobinemia after the application of anesthetic cream].
Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Eczema; Female; Humans; Lidocaine; Lido | 1998 |
Methaemoglobinaemia in a premature infant secondary to prilocaine.
Topics: Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Methemoglobinemia; P | 1999 |
Toxic methaemoglobin concentrations in premature infants after application of a prilocaine-containing cream and peridural prilocaine.
Topics: Anesthesia, Caudal; Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Infant, Prematur | 1999 |
Methaemoglobinaemia after peribulbar blockade: an unusual complication in opthalmic surgery.
Topics: Adult; Anesthetics, Local; Female; Humans; Methemoglobinemia; Prilocaine; Retinal Detachment | 2000 |
Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets.
Topics: Acetaminophen; Administration, Inhalation; Animals; Animals, Newborn; Drug Evaluation, Preclinical; | 2000 |
Methaemoglobinaemia secondary to topical lignocaine/ prilocaine in a circumcised neonate.
Topics: Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; L | 2000 |
Lidocaine + prilocaine before 3 months of age: new indication. Correct use is crucial.
Topics: Administration, Cutaneous; Age Factors; Blood Specimen Collection; Circumcision, Male; Drug Therapy, | 2000 |
Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa.
Topics: Administration, Topical; Anesthetics, Combined; Child, Preschool; Female; Follow-Up Studies; Humans; | 2001 |
Topical anesthetics update: EMLA and beyond.
Topics: Anesthetics, Local; Drug Combinations; Drug Costs; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Dr | 2001 |
Citanest Forte--its use in oral surgery.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Female; Humans; Male; Met | 1975 |
A study into the incidence of methaemoglobinaemia after 'three-in-one' block with prilocaine.
Topics: Adult; Aged; Female; Femoral Nerve; Humans; Methemoglobinemia; Middle Aged; Nerve Block; Oximetry; P | 1992 |
Chemically induced methaemoglobinaemia in a neonate.
Topics: Anesthesia, Local; Humans; Infant, Newborn; Methemoglobinemia; Prilocaine | 1992 |
Prilocaine associated methaemoglobinaemia and the pulse oximeter.
Topics: Anesthesia, General; Female; Humans; Methemoglobinemia; Middle Aged; Oximetry; Prilocaine | 1991 |
[Fetal methemoglobinemia caused by prilocaine--is use of prilocaine for pudendal block still justified?].
Topics: Administration, Intravaginal; Anesthesia, Local; Anesthesia, Obstetrical; Female; Humans; Infant, Ne | 1991 |
Spurious pulse oximeter desaturation due to methaemoglobinaemia.
Topics: Adult; Female; Humans; Methemoglobinemia; Monitoring, Intraoperative; Oximetry; Oxygen; Prilocaine | 1991 |
Methaemoglobinaemia in children treated with prilocaine-lignocaine cream.
Topics: Child; Humans; Lidocaine; Methemoglobinemia; Ointments; Prilocaine | 1990 |
Inverse relationship between age-dependent erythrocyte activity of methaemoglobin reductase and prilocaine-induced methaemoglobinaemia during infancy.
Topics: Age Factors; Anesthetics, Local; Cytochrome-B(5) Reductase; Drug Combinations; Erythrocytes; Female; | 1990 |
Prilocaine-induced methemoglobinemia evidenced by pulse oximetry.
Topics: Adult; Anesthetics, Local; Female; Humans; Methemoglobinemia; Monitoring, Physiologic; Oximetry; Pri | 1990 |
[Methemoglobinemia in a newborn infant following pudendal anesthesia in labor with prilocaine. A case report].
Topics: Adult; Anesthesia, Local; Anesthesia, Obstetrical; Female; Humans; Infant, Newborn; Maternal-Fetal E | 1990 |
[Comments on the paper by G. Wald-Oboussier and B. Veill. Supraclavicular plexus blockade using prilocaine in patients with chronic anemia].
Topics: Anemia; Cervical Plexus; Chronic Disease; Humans; Methemoglobinemia; Nerve Block; Prilocaine | 1990 |
[Intravenous regional anesthesia of the foot using prilocaine. Clinical aspects, pharmacokinetic and pharmacodynamic studies].
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthesia, Intravenous; Foot; Humans; Methemoglobi | 1990 |
Methaemoglobinaemia in children treated with prilocaine-lignocaine cream.
Topics: Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Humans; Infant; Lidocaine; Lidocaine | 1990 |
[Supraclavicular plexus blockade using prilocaine in patients with chronic anemia].
Topics: Aged; Anemia; Brachial Plexus; Chronic Disease; Female; Humans; Kidney Failure, Chronic; Methemoglob | 1989 |
Methemoglobinemia following neonatal circumcision.
Topics: Circumcision, Male; Humans; Infant, Newborn; Male; Methemoglobinemia; Nerve Block; Prilocaine | 1989 |
[Methemoglobinemia after arthroscopy of the knee under prilocaine].
Topics: Arthroscopy; Humans; Knee Joint; Methemoglobinemia; Prilocaine | 1986 |
Neonatal cyanosis, methaemoglobinaemia and haemolytic anaemia.
Topics: Anemia, Hemolytic; Cyanosis; Humans; Iatrogenic Disease; Infant, Newborn; Jaundice, Neonatal; Male; | 1988 |
Report of adverse drug reaction editorial comment. Prilocaine hydrochloride and neonatal methemoglobinemia.
Topics: Anesthesia, Local; Episiotomy; Humans; Infant, Newborn; Methemoglobinemia; Prilocaine | 1988 |
[Behavior of plasma concentrations of prilocaine following intravenous regional anesthesia and their relation to methemoglobinemia].
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Arm; Humans; Methemoglobinemia; Prilocaine; Tourniq | 1988 |
Comparison of lidocaine and prilocaine for intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Drug Evaluation; Humans; Lidocaine; Methemoglobinem | 1988 |
Plasma concentrations of prilocaine and lidocaine and methaemoglobin formation in infants after epicutaneous application of a 5% lidocaine-prilocaine (EMLA).
Topics: Administration, Topical; Female; Hemoglobins; Humans; Infant; Lidocaine; Male; Methemoglobinemia; Oi | 1987 |
Prilocaine-induced methemoglobinemia in a child with Shwachman syndrome.
Topics: Anesthesia, Dental; Anesthesia, Local; Child, Preschool; Female; Growth Disorders; Humans; Methemogl | 1985 |
[Remarks on the paper by F. Thiessen, J. Bergmann and H. Steinhoff: Methemoglobinemia following blockade of the brachial plexus with prilocaine (Xylonest)].
Topics: Humans; Methemoglobinemia; Nerve Block; Prilocaine | 1985 |
Methemoglobinemia associated with a prilocaine-lidocaine cream and trimetoprim-sulphamethoxazole. A case report.
Topics: Administration, Topical; Drug Combinations; Drug Synergism; Humans; Infant; Lidocaine; Male; Methemo | 1985 |
Neonatal methemoglobinemia following epidural anesthesia.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Humans; Infant, Newborn; Methemoglobinemia; P | 1971 |
Methaemoglobinaemia following prilocaine local anaesthesia.
Topics: Anesthesia, Local; Cardiac Catheterization; Circumcision, Male; Cyanosis; Diagnosis, Differential; D | 1972 |
Neonatal methaemoglobinaemia and prilocaine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Male; Methemoglobinemi | 1972 |
Methemoglobinemia induced by high doses of prilocaine.
Topics: Adult; Anesthesia, Dental; Female; Humans; Injections; Male; Mandible; Methemoglobinemia; Methylene | 1974 |
[Prilocaine--methemoglobinemia].
Topics: Humans; Infant, Newborn; Methemoglobinemia; Prilocaine | 1973 |
Local anaesthetics.
Topics: Amides; Anesthetics, Local; Brain Edema; Cardiovascular Diseases; Central Nervous System Diseases; C | 1971 |
[Formation of methemoglobin by local anesthetics].
Topics: Anesthesia, Dental; Anesthesia, Local; Cyanosis; Humans; Methemoglobin; Methemoglobinemia; Prilocain | 1968 |
Continuous intrapartum lumbar epidural block: a comparative study employing propitocaine 2 percent, lidocaine 1.5 percent with epinephrine, and 1.5 percent lidocaine.
Topics: Anemia; Anesthesia, Conduction; Anesthesia, Epidural; Anesthesia, Obstetrical; Epinephrine; Female; | 1971 |
Maternal and foetal methaemoglobinaemia caused by prilocaine.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Anura; Ascorbic Acid; Cats | 1969 |
Newborn methemoglobinemia following propitocaine intrapartum epidural block. First case report.
Topics: Adult; Anesthesia, Obstetrical; Blood Protein Electrophoresis; Female; Hemoglobinometry; Humans; Inf | 1970 |
New developments in epidural anesthesia for obstetrics.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Epinephrine; Female; Fetus; Humans; Lidocaine; Mepivaca | 1970 |
The effect of methylene blue on neural tissue.
Topics: Action Potentials; Anesthesia, Spinal; Animals; Anura; Cats; Meninges; Methemoglobinemia; Methylene | 1970 |
Stereospecificity of the enzymatic biotransformation of the enantiomers of prilocaine (Citanest).
Topics: Animals; Biotransformation; Carbon Isotopes; Cats; Injections, Intravenous; Injections, Subcutaneous | 1970 |
Passage of procaine hydrochloride and para-aminobenzoic acid across the human placenta.
Topics: Adjuvants, Anesthesia; Aminobenzoates; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, | 1968 |
Prilocaine as an anticonvulsant: protective effects against electroshock-induced convulsions in mice.
Topics: Analysis of Variance; Aniline Compounds; Animals; Anticonvulsants; Brain; Central Nervous System; El | 1968 |
[Clinical effect of xylitol on methemoglobinemia due to local anesthetics].
Topics: Alcohols; Anesthesia, Local; Humans; Methemoglobin; Methemoglobinemia; Prilocaine; Xylitol | 1968 |
Influence of enzyme inducer on methaemoglobinaemia caused by prilocaine.
Topics: Animals; Cats; Dogs; Methemoglobin; Methemoglobinemia; Phenobarbital; Prilocaine; Rabbits; Rats | 1968 |