prilocaine has been researched along with Leg Ulcer in 18 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main objective of this study was to compare the respective analgesic effect of nitrous oxide oxygen mixture (NOOM) inhalation and lidocaïne-prilocaïne cream (LPC) application during the mechanical repeated debridement of chronic arterial and venous leg ulcers." | 9.15 | Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream. ( Aubin, F; Boye, T; Claeys, A; Gaudy-Marqueste, C; Grob, JJ; Pauly, V; Pelletier, F; Richard, MA; Schmutz, JL; Truchetet, F, 2011) |
| "Although the lignocaine (lidocaine)-prilocaine cream EMLA has been extensively studied for the relief of acute treatment-related pain from sharp leg ulcer debridement, no data exist on systemic absorption from prolonged application in patients with chronically painful ulcers." | 9.09 | Plasma concentrations of lignocaine and prilocaine after a 24-h application of analgesic cream (EMLA) to leg ulcers. ( Lillieborg, S; Stymne, B, 2001) |
| "Plasma concentrations of lidocaine and prilocaine were assessed in 8 patients after the application of 8-10 g EMLA 2% cream for 60 min to leg ulcers measuring 31-80 cm2." | 9.06 | Plasma concentrations and analgesic effect of EMLA (lidocaine/prilocaine) cream for the cleansing of leg ulcers. ( Enander Malmros, I; Lillieborg, S; Nilsen, T, 1990) |
| "The pain was rated by each patient on a 100-mm visual analogue scale (VAS)." | 6.69 | Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998) |
| "Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale." | 6.67 | Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990) |
| "This multicentre, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of using Emla (lignocaine/prilocaine) anaesthetic cream to achieve pain control during sharp debridement of chronic leg ulcers of arterial, venous or arteriovenous aetiology." | 5.09 | Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers. ( Baxter, M; Gottschalk, R; Lycka, B; Murphy, F; Nevin, K; Rosenthal, D, 2001) |
| "Although the lignocaine (lidocaine)-prilocaine cream EMLA has been extensively studied for the relief of acute treatment-related pain from sharp leg ulcer debridement, no data exist on systemic absorption from prolonged application in patients with chronically painful ulcers." | 5.09 | Plasma concentrations of lignocaine and prilocaine after a 24-h application of analgesic cream (EMLA) to leg ulcers. ( Lillieborg, S; Stymne, B, 2001) |
| "Plasma concentrations of lidocaine and prilocaine were assessed in 8 patients after the application of 8-10 g EMLA 2% cream for 60 min to leg ulcers measuring 31-80 cm2." | 5.06 | Plasma concentrations and analgesic effect of EMLA (lidocaine/prilocaine) cream for the cleansing of leg ulcers. ( Enander Malmros, I; Lillieborg, S; Nilsen, T, 1990) |
| "Two trials (470 participants with venous leg ulcers) evaluated ibuprofen slow-release foam dressings for persistent venous leg ulcer pain." | 4.88 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Martyn-St James, M; Nelson, EA, 2012) |
| "There is no evidence that ibuprofen dressings offer pain relief, as measured at the first evening of use, to people with painful venous leg ulcers compared with foam dressings or best practice." | 4.86 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2010) |
| "The pain was rated by each patient on a 100-mm visual analogue scale (VAS)." | 2.69 | Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998) |
| "Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale." | 2.67 | Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990) |
| "Pain was defined as either persistent pain or pain at dressing changes or debridement." | 2.42 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2003) |
| "Pain was defined as either persistent pain or pain at dressing changes or debridement." | 2.41 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Purcell, A | 1 |
| Buckley, T | 1 |
| Fethney, J | 1 |
| King, J | 1 |
| Moyle, W | 1 |
| Marshall, AP | 1 |
| Effendy, I | 2 |
| Gelber, A | 1 |
| Lehmann, P | 1 |
| Huledal, G | 1 |
| Lillieborg, S | 3 |
| Briggs, M | 4 |
| Nelson, EA | 4 |
| Claeys, A | 1 |
| Gaudy-Marqueste, C | 1 |
| Pauly, V | 1 |
| Pelletier, F | 1 |
| Truchetet, F | 1 |
| Boye, T | 1 |
| Aubin, F | 1 |
| Schmutz, JL | 1 |
| Grob, JJ | 1 |
| Richard, MA | 1 |
| Kamata, M | 1 |
| Tada, Y | 1 |
| Yazawa, N | 1 |
| Watanabe, T | 1 |
| Kikuchi, K | 1 |
| Sato, S | 1 |
| Martyn-St James, M | 1 |
| Rosenthal, D | 1 |
| Murphy, F | 1 |
| Gottschalk, R | 1 |
| Baxter, M | 1 |
| Lycka, B | 1 |
| Nevin, K | 1 |
| Blanke, W | 1 |
| Hallern, BV | 1 |
| Stahl, M | 1 |
| Meyer, C | 1 |
| Haas, E | 1 |
| Glaenz, T | 1 |
| Zutt, M | 1 |
| Holst, RG | 1 |
| Kristofferson, A | 1 |
| Löffler, H | 1 |
| Boulinguez, S | 1 |
| Sparsa, A | 1 |
| Bouyssou-Gauthier, ML | 1 |
| Bedane, C | 1 |
| Bonnetblanc, JM | 1 |
| Stymne, B | 1 |
| Meaume, S | 1 |
| Holm, J | 1 |
| Andrén, B | 1 |
| Grafford, K | 1 |
| Enander Malmros, I | 1 |
| Nilsen, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556] | Phase 3 | 46 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335] | Phase 4 | 7 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Difficulties with the recruitment) | ||
| Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460] | 21 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for prilocaine and Leg Ulcer
| Article | Year |
|---|---|
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bandages; Debridement; Humans | 2010 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Li | 2003 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Anesthetics, Local; Bandages; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pril | 2000 |
7 trials available for prilocaine and Leg Ulcer
| Article | Year |
|---|---|
The Effectiveness of EMLA as a Primary Dressing on Painful Chronic Leg Ulcers: Effects on Wound Healing and Health-Related Quality of Life.
Topics: Aged; Aged, 80 and over; Australia; Chronic Disease; Cross-Over Studies; Female; Follow-Up Studies; | 2017 |
Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream.
Topics: Administration, Inhalation; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Non-Narcot | 2011 |
Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream.
Topics: Administration, Inhalation; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Non-Narcot | 2011 |
Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream.
Topics: Administration, Inhalation; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Non-Narcot | 2011 |
Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream.
Topics: Administration, Inhalation; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Non-Narcot | 2011 |
Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Disease; Debr | 2001 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Plasma concentrations of lignocaine and prilocaine after a 24-h application of analgesic cream (EMLA) to leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Chronic Disease; Dose-Response R | 2001 |
Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Double-Bli | 1990 |
Plasma concentrations and analgesic effect of EMLA (lidocaine/prilocaine) cream for the cleansing of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Humans; | 1990 |
7 other studies available for prilocaine and Leg Ulcer
| Article | Year |
|---|---|
Plasma concentrations and analgesic efficacy of lidocaine and prilocaine in leg ulcer-related pain during daily application of lidocaine-prilocaine cream (EMLA™) for 10 days.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Chronic Pain; Drug Admini | 2015 |
Drug fever caused by eutectic mixture of local anesthetic cream.
Topics: Debridement; Drug Hypersensitivity; Drug Interactions; Female; Fever; Humans; Leg Ulcer; Lidocaine; | 2011 |
Sharp wound debridement in local anaesthesia using EMLA cream: 6 years' experience in 1084 patients.
Topics: Anesthetics, Combined; Debridement; Humans; Leg Ulcer; Lidocaine; Lidocaine, Prilocaine Drug Combina | 2003 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
[Use of EMLA Creme in leg ulcers: usefulness and limits].
Topics: Anesthetics, Combined; Anesthetics, Local; Debridement; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pri | 1999 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
Adverse effects associated with EMLA cream used as topical anesthetic for the mechanical debridement of leg ulcers.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Epilepsy, Tonic-Clonic; Female; Humans; Le | 2000 |
[Management of leg ulcers in the elderly].
Topics: Age Distribution; Aged; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Lid | 2002 |