prilocaine has been researched along with Drug Overdose in 7 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The development of safe and effective local anesthetic agents has possibly been the most important advancement in dental science to occur in the last century." | 2.46 | Local anesthetics: pharmacology and toxicity. ( Hersh, EV; Moore, PA, 2010) |
| " They also should follow new recommended dosing guidelines for prilocaine and be aware of symptoms of this adverse reaction." | 2.40 | When patients become cyanotic: acquired methemoglobinemia. ( Lloyd, LM; Wilburn-Goo, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Tunç, M | 1 |
| Sazak, H | 1 |
| Ulus, F | 1 |
| Şahin, Ş | 1 |
| Schmitt, C | 1 |
| Matulic, M | 1 |
| Kervégant, M | 1 |
| Tichadou, L | 1 |
| Boutin, A | 1 |
| Glaizal, M | 1 |
| de Haro, L | 1 |
| Butterworth, J | 1 |
| James, RL | 1 |
| Grimes, J | 1 |
| Meechan, J | 1 |
| Wilburn-Goo, D | 1 |
| Lloyd, LM | 1 |
| Tröger, HD | 1 |
| Urban, R | 1 |
| Weller, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
2 reviews available for prilocaine and Drug Overdose
| Article | Year |
|---|---|
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
When patients become cyanotic: acquired methemoglobinemia.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocaine; Cyanosis; Drug Overdose; Huma | 1999 |
5 other studies available for prilocaine and Drug Overdose
| Article | Year |
|---|---|
Methemoglobinemia following prilocaine administration for bilateral tube thoracostomy in a pediatric case.
Topics: Anesthetics, Local; Child; Drug Overdose; Dyspnea; Empyema; Humans; Male; Methemoglobinemia; Pneumot | 2012 |
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Topics: Anesthetics, Combined; Child, Preschool; Dosage Forms; Drug Overdose; Female; Humans; Lidocaine; Lid | 2012 |
Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Alkanes; Amides; Anesthe | 1997 |
How to avoid local anaesthetic toxicity.
Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Body Weight; Child; Child, P | 1998 |
[Homicide simulating electrocution suicide by spinal anesthesia].
Topics: Adult; Anesthesia, Spinal; Cause of Death; Drug Overdose; Electric Injuries; Female; Heart Arrest; H | 1992 |