Page last updated: 2024-11-03

prilocaine and Anxiety

prilocaine has been researched along with Anxiety in 20 studies

Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery."9.06Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987)
"To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal."7.96Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020)
"The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures."5.11Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments. ( Ekbom, K; Jakobsson, J; Marcus, C, 2005)
"The efficacy of lignocaine-prilocaine cream (EMLA) and amethocaine gel (Ametop) in reducing the pain and distress of venepuncture was compared in a single-blind randomized study of 34 children aged 1-14 y."5.09Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children. ( Choy, L; Collier, J; Watson, AR, 1999)
"5% prilocaine) in reducing distress, anxiety, and pain associated with phlebotomy in pediatric outpatients."5.08EMLA cream as a topical anesthetic before office phlebotomy in children. ( Schwartz, R; Sheridan, MJ; Young, SS, 1996)
"Emla cream combined with nitrous oxide is effective for venous cannulation in providing satisfactory analgesia and in controlling anxiety elicited by the vision of needle."5.08[Combination of Emla cream and nitrous oxide for venous cannulation in children]. ( Benaguida, M; Benslama, A; Idali, B; Mjahed, K; Sadraoui, A, 1997)
"The local analgesic efficacy of EMLA Cream (a eutectic mixture of lidocaine and prilocaine; Astra Pharmaceuticals, Sweden) in reducing the pain at Venous cannulation was investigated in a randommized blind study in 75 children scheduled for elective surgery."5.06Our experience with EMLA Cream (for painless venous cannulation in children). ( Johl, KS; Wig, J, 1990)
"The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery."5.06Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987)
"To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal."3.96Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020)
"Some children report significant pain with peripheral intravenous catheter (IV) insertion, despite the appropriate use of topical lidocaine anesthetics."3.74Predictors of topical anesthetic effectiveness in children. ( Floria-Santos, M; Hanrahan, K; Kleiber, C; McCarthy, AM; Murray, JC; Schutte, DL, 2007)
"Pain was assessed by visual analogue scale (VAS) and anxiety levels by the State-Trait Anxiety Inventory (STAI-I and STA-II)."2.77No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial. ( Boyacioglu, S; Cengiz, C; Kuzu, MA; Ozdemir, B; Pampal, HK, 2012)
"FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety."1.39Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology. ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013)
"In fact, the nurse coached more, and trends suggested that children coped more with typical care than with EMLA."1.30Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations. ( Blount, RL; Cohen, LL; Cohen, RJ; Schaen, ER; Zaff, JF, 1999)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's9 (45.00)18.2507
2000's5 (25.00)29.6817
2010's3 (15.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Tulaci, KG1
Arslan, E1
Tulaci, RG1
Yazici, H1
Carson, C1
Wyllie, M1
Cengiz, C1
Pampal, HK1
Ozdemir, B1
Boyacioglu, S1
Kuzu, MA1
Leboulleux, S1
Borget, I1
Labro, S1
Bidault, S1
Vielh, P1
Hartl, D1
Dauchy, S1
Chougnet, CN1
Girard, E1
Azoulay, S1
Mirghani, H1
Berdelou, A1
Lumbroso, J1
Deandreis, D1
Baudin, E1
Schlumberger, M1
Laurent, S1
Hee, HI1
Goy, RW1
Ng, AS1
Zempsky, WT1
Cravero, JP1
Meechan, JG1
Ekbom, K1
Jakobsson, J1
Marcus, C1
Kleiber, C1
Schutte, DL1
McCarthy, AM1
Floria-Santos, M1
Murray, JC1
Hanrahan, K1
Gianoutsos, MP1
Hunter-Smith, D1
Smith, JG1
Hogan, D1
McEwan, L1
Vetter, TR1
Lander, J1
Hodgins, M1
Nazarali, S1
McTavish, J1
Ouellette, J1
Friesen, E1
Young, SS1
Schwartz, R1
Sheridan, MJ1
Mjahed, K1
Sadraoui, A1
Benslama, A1
Idali, B1
Benaguida, M1
Koh, JL1
Fanurik, D1
Stoner, PD1
Schmitz, ML1
VonLanthen, M1
Choy, L1
Collier, J1
Watson, AR1
Cohen, LL1
Blount, RL1
Cohen, RJ1
Schaen, ER1
Zaff, JF1
Southwell, GC1
Wig, J1
Johl, KS1
Manner, T1
Kanto, J1
Iisalo, E1
Lindberg, R1
Viinamäki, O1
Scheinin, M1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460]21 participants (Actual)Interventional2010-04-30Completed
A Comparison of Amethocaine Creams Versus Liposomal Lidocaine Cream as Pain Reliever Prior to Venipuncture in Children at the Paediatric Emergency Department.[NCT00353002]0 participants (Actual)Interventional2006-07-31Withdrawn
A Randomized, Placebo-Controlled Trial to Evaluate Pain and Anxiety During Venipuncture in Pediatric Patients With or Without Pre-treatment by a Topical Anesthetic[NCT00676364]Phase 4114 participants (Actual)Interventional2003-03-31Completed
Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department[NCT05934669]Phase 490 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Topical Analgesia Before Inhalational Anaesthesia: A Retrospective Observational Study[NCT04959409]500 participants (Actual)Observational2020-08-01Completed
Understanding Pediatric Symptoms and Other Symptoms[NCT00166231]156 participants (Actual)Observational2004-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Anxiety of Venipuncture

Participant anxiety was measured by the study participant and the objective observer before (anticipatory), during (venipuncture) and after (recovery) venipuncture using a validated visual analog scale (VAS). The VAS is a validated scale that is used to detect small changes in many types of observations. The scale ranges from 0-100 scores on a scale, and here the higher scores indicate higher anxiety levels. Only the participant's mean venipuncture (during venipuncture) anxiety scores are presented in outcome measure results here. (NCT00676364)
Timeframe: During venipuncture

Interventionscores on a scale (Mean)
ControI Group Receiving Placebo Cream43.1
Investigational Group40.5

Pain From Venipuncture

"Pain was measured immediately after venipuncture by the participant using the six-point FACES scale. FACES in not an acronym, but rather a description of a pain scale that uses pictures of faces in various states of pain. The FACES pain scale is a common scale used to measure pain with scores on a scale. The scale we used had six points from zero (0) to five (5) indicating different levels of pain. Lower scores indicate lower levels of pain, and higher scores indicate higher levels of pain." (NCT00676364)
Timeframe: Pain was measured immediately after venipuncture.

Interventionscores on a scale (Mean)
ControI Group Receiving Placebo Cream2.2
Investigational Group Receiving 4% Lidocaine Cream2.1

Trials

13 trials available for prilocaine and Anxiety

ArticleYear
Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study.
    The journal of sexual medicine, 2010, Volume: 7, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthetics, Local; Anxiety; Coitus; Double-Blind

2010
No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2012, Volume: 14, Issue:7

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anxiety; Female; Humans; Lidoca

2012
Effective reduction of anxiety and pain during venous cannulation in children: a comparison of analgesic efficacy conferred by nitrous oxide, EMLA and combination.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:3

    Topics: Adolescent; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Local

2003
Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments.
    Archives of disease in childhood, 2005, Volume: 90, Issue:10

    Topics: Adolescent; Analgesics; Anesthetics, Inhalation; Anxiety; Catheterization; Child; Female; Humans; Li

2005
Oral premedication for local anesthesia in plastic surgery: prospective, randomized, blind comparison of lorazepam and temazepam.
    Plastic and reconstructive surgery, 1994, Volume: 93, Issue:5

    Topics: Administration, Oral; Aged; Aged, 80 and over; Anesthesia, Local; Anxiety; Double-Blind Method; Epin

1994
A comparison of EMLA cream versus nitrous oxide for pediatric venous cannulation.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:6

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Anxiety; Catheterization, Per

1995
Determinants of success and failure of EMLA.
    Pain, 1996, Volume: 64, Issue:1

    Topics: Administration, Topical; Adolescent; Adolescent Behavior; Anesthetics; Anxiety; Bandages; Catheteriz

1996
Determinants of success and failure of EMLA.
    Pain, 1996, Volume: 64, Issue:1

    Topics: Administration, Topical; Adolescent; Adolescent Behavior; Anesthetics; Anxiety; Bandages; Catheteriz

1996
Determinants of success and failure of EMLA.
    Pain, 1996, Volume: 64, Issue:1

    Topics: Administration, Topical; Adolescent; Adolescent Behavior; Anesthetics; Anxiety; Bandages; Catheteriz

1996
Determinants of success and failure of EMLA.
    Pain, 1996, Volume: 64, Issue:1

    Topics: Administration, Topical; Adolescent; Adolescent Behavior; Anesthetics; Anxiety; Bandages; Catheteriz

1996
EMLA cream as a topical anesthetic before office phlebotomy in children.
    Southern medical journal, 1996, Volume: 89, Issue:12

    Topics: Adolescent; Ambulatory Care; Anesthetics, Local; Anxiety; Child; Child, Preschool; Double-Blind Meth

1996
[Combination of Emla cream and nitrous oxide for venous cannulation in children].
    Annales francaises d'anesthesie et de reanimation, 1997, Volume: 16, Issue:5

    Topics: Administration, Cutaneous; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Combined; Anesthe

1997
Efficacy of parental application of eutectic mixture of local anesthetics for intravenous insertion.
    Pediatrics, 1999, Volume: 103, Issue:6

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Anxiety; Child; Child, Preschool; Female; Humans;

1999
Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children.
    Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:9

    Topics: Adolescent; Analgesia; Anesthetics, Combined; Anesthetics, Local; Anxiety; Child; Child, Preschool;

1999
Our experience with EMLA Cream (for painless venous cannulation in children).
    Indian journal of physiology and pharmacology, 1990, Volume: 34, Issue:2

    Topics: Anesthetics, Local; Anxiety; Catheterization, Peripheral; Child; Child, Preschool; Drug Combinations

1990
Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication.
    Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:8

    Topics: Administration, Cutaneous; Anesthetics, Local; Anxiety; Catecholamines; Catheterization, Peripheral;

1987

Other Studies

7 other studies available for prilocaine and Anxiety

ArticleYear
Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:5

    Topics: Anxiety; Humans; Pain; Prilocaine; Rhinoplasty; Tramadol

2020
Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:9

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care Facilities;

2013
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Differences between men and women regarding attitudes toward dental local anesthesia among junior students at a United Kingdom dental school.
    Anesthesia progress, 2005,Summer, Volume: 52, Issue:2

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthesiology; Anesthetics, Local; Anxiety; Attitude to Heal

2005
Predictors of topical anesthetic effectiveness in children.
    The journal of pain, 2007, Volume: 8, Issue:2

    Topics: Administration, Topical; Age Factors; Anesthetics, Local; Anxiety; Catheterization, Peripheral; Chil

2007
Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1999, Volume: 18, Issue:6

    Topics: Anesthetics, Local; Anxiety; Child; Child Behavior; Female; Humans; Immunization; Lidocaine; Lidocai

1999
Physiological responses under dental sedation and anaesthesia.
    Dental anaesthesia and sedation, 1976, Volume: 5, Issue:3

    Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate;

1976