prilocaine and Allergy, Drug studies

Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

Research Excerpts

Excerpt	Relevance	Reference
"Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics."	1.30	Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine. ( Guler, N; Sumer, M; Uckan, S; Ungor, M, 1998)
"A young woman was found to have a true type I hypersensitivity to lignocaine."	1.30	Allergic reactions to lignocaine. ( Ball, IA, 1999)
"In 87 of the 90 patients with suspected anaphylactoid reactions to local anesthetic agents, negative skin reactions to at least one of the agents allowed intrabuccal challenge and subsequent recommendation of an agent for future use."	1.29	Skin testing after anaphylactoid reactions to dental local anesthetics. A comparison with controls. ( Challacombe, SJ; Hodgson, TA; Shirlaw, PJ, 1993)
"A case of anaphylactoid reaction with late onset to prilocaine and a positive intracutaneous test is reported."	1.26	Hypersensitivity to prilocaine. ( Göransson, K, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (32.14)	18.7374
1990's	10 (35.71)	18.2507
2000's	5 (17.86)	29.6817
2010's	3 (10.71)	24.3611
2020's	1 (3.57)	2.80

Authors	Studies
Selmanoglu, A	1
Güvenir, H	1
Celik, IK	1
Karaatmaca, B	1
Toyran, M	1
Civelek, E	1
Misirlioglu, ED	1
Sambrook, PJ	1
Smith, W	1
Elijah, J	1
Goss, AN	1
Kluger, N	1
Raison-Peyron, N	1
Michot, C	1
Guillot, B	1
Bessis, D	1
Kamata, M	1
Tada, Y	1
Yazawa, N	1
Watanabe, T	1
Kikuchi, K	1
Sato, S	1
Evans, LA	1
Pointing, J	1
Wills, EJ	1
Michalopoulos, J	1
Adelstein, S	1
Hawkins, JM	1
Moore, PA	1
Parker, JF	1
Vats, A	1
Bauer, G	1
Babajews, AV	1
Ivanyi, L	1
Yeoman, CM	1
Thakur, BK	1
Murali, MR	1
Bosco, DA	1
Haas, DA	1
Young, ER	1
Harrop, KL	1
Hodgson, TA	1
Shirlaw, PJ	1
Challacombe, SJ	1
Gourrier, E	1
Karoubi, P	1
el Hanache, A	1
Merbouche, S	1
Mouchnino, G	1
Leraillez, J	1
Meechan, J	1
Uckan, S	1
Guler, N	1
Sumer, M	1
Ungor, M	1
Ezsias, A	2
Ball, IA	1
Dilraj, A	1
Cutts, FT	1
Bennett, JV	1
Coovadia, HM	1
Lorette, G	1
Rood, JP	1
Göransson, K	1
Van der Bijl, P	1
Roelofse, JA	1
Smith, RB	1
Everett, WG	1
Bateman, PP	1
Aldrete, JA	1
O'Higgins, JW	1
Geddes, IC	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia[NCT00482573]			Phase 1	31 participants (Actual)	Interventional	2004-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Local anesthesia: advances in agents and techniques. Dental clinics of North America, 2002, Volume: 46, Issue:4 Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Carticaine; Chemistry, Pharm	2002
Physiology and pharmacology of local anesthetic agents. International ophthalmology clinics, 1973,Summer, Volume: 13, Issue:2 Topics: Administration, Topical; Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Ce	1973

Article	Year
Immediate local anesthetic reactions and diagnostic test results in pediatric patients. Allergologia et immunopathologia, 2021, Volume: 49, Issue:3 Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Hypersensitivity; Female; Humans; Hype	2021
Severe adverse reactions to dental local anaesthetics: systemic reactions. Australian dental journal, 2011, Volume: 56, Issue:2 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anesthesia, Den	2011
Acute bullous irritant contact dermatitis caused by EMLA® cream. Contact dermatitis, 2011, Volume: 65, Issue:3 Topics: Acute Disease; Anesthetics, Local; Blister; Dermatitis, Irritant; Drug Hypersensitivity; Eczema; Emo	2011
Drug fever caused by eutectic mixture of local anesthetic cream. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:5 Topics: Debridement; Drug Hypersensitivity; Drug Interactions; Female; Fever; Humans; Leg Ulcer; Lidocaine;	2011
Recurrent facial swelling following dental procedures. The Medical journal of Australia, 2002, Nov-04, Volume: 177, Issue:9 Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Edema; Face; Humans; Hypersens	2002
EMLA toxicity after application for allergy skin testing. Pediatrics, 2004, Volume: 113, Issue:2 Topics: Anesthetics, Local; Child, Preschool; Drug Hypersensitivity; Eczema; Female; Humans; Lidocaine; Lido	2004
The relationship between in vivo and in vitro reactivity of patients with a history of allergy to local anaesthetics. British dental journal, 1982, Jun-01, Volume: 152, Issue:11 Topics: Adolescent; Adult; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; I	1982
Hypersensitivity to prilocaine. British dental journal, 1982, Jul-20, Volume: 153, Issue:2 Topics: Anesthesia, Dental; Drug Hypersensitivity; Female; Humans; Middle Aged; Prilocaine; Skin Tests	1982
EMLA cream-induced allergic contact dermatitis: a role for prilocaine as an immunogen. The Journal of allergy and clinical immunology, 1995, Volume: 95, Issue:3 Topics: Aged; Dermatitis, Allergic Contact; Drug Combinations; Drug Hypersensitivity; Female; Humans; Lidoca	1995
An anaphylactoid reaction following local anesthesia: a case report. Anesthesia & pain control in dentistry, 1993,Spring, Volume: 2, Issue:2 Topics: Adult; Anaphylaxis; Anesthesia, Dental; Diagnosis, Differential; Drug Hypersensitivity; Female; Huma	1993
Skin testing after anaphylactoid reactions to dental local anesthetics. A comparison with controls. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 75, Issue:6 Topics: Adolescent; Adult; Aged; Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distributio	1993
How to avoid local anaesthetic toxicity. British dental journal, 1998, Apr-11, Volume: 184, Issue:7 Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Body Weight; Child; Child, P	1998
Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1998, Volume: 86, Issue:1 Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp;	1998
Lignocaine and anaesthetic allergy. British dental journal, 1998, Nov-14, Volume: 185, Issue:9 Topics: Adult; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Incidence; Lidocaine; Prilocaine;	1998
Allergic reactions to lignocaine. British dental journal, 1999, Mar-13, Volume: 186, Issue:5 Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Diagnosis, Differential; Drug Hype	1999
Adverse reactions possibly associated with the use of Emla cream. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:4 Topics: Anesthetics, Combined; Anesthetics, Local; Child; Drug Hypersensitivity; Female; Humans; Lidocaine;	1999
[The use of EMLA cream in pediatrics]. Annales de dermatologie et de venereologie, 1999, Volume: 126, Issue:3 Topics: Anesthetics, Combined; Anesthetics, Local; Child; Drug Hypersensitivity; Humans; Lidocaine; Lidocain	1999
Adverse reaction to dental local anaesthetic injection--'allergy' is not the cause. British dental journal, 2000, Oct-14, Volume: 189, Issue:7 Topics: Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Immunologic Tests; In	2000
Local anaesthetics. British dental journal, 2000, Dec-23, Volume: 189, Issue:12 Topics: Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Humans; Lidocaine; Maximum Tolerated	2000
Hypersensitivity to prilocaine. Dermatologica, 1976, Volume: 152, Issue:3 Topics: Anaphylaxis; Drug Hypersensitivity; Humans; Male; Middle Aged; Prilocaine	1976
Anaphylactoid reactions to prilocaine. Anaesthesia, 1988, Volume: 43, Issue:3 Topics: Aged; Aged, 80 and over; Anaphylaxis; Anesthesia, Intravenous; Drug Hypersensitivity; Female; Humans	1988
Adverse reactions to local anaesthetics: a possible role for Citanest? The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika, 1986, Volume: 41, Issue:10 Topics: Adolescent; Adult; Aged; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Prilocaine; Skin	1986
Multiple allergy to local anaesthetics including prilocaine. The Medical journal of Australia, 1974, Sep-21, Volume: 2, Issue:12 Topics: Adult; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Prilocaine; Skin Tests	1974
Evaluation of patients with history of allergy to local anesthetic drugs. Southern medical journal, 1971, Volume: 64, Issue:9 Topics: Adolescent; Adult; Aged; Anesthetics, Local; Child; Drug Hypersensitivity; Female; Humans; Lidocaine	1971
Local anaesthetics. Laval medical, 1971, Volume: 42, Issue:8 Topics: Amides; Anesthetics, Local; Brain Edema; Cardiovascular Diseases; Central Nervous System Diseases; C	1971

prilocaine and Allergy, Drug

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