prilocaine has been researched along with Acute Disease in 8 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This communication reports a case of acute toxic methemoglobinemia associated with hypoxia and general motor seizures following dental anesthesia using nitrous oxide and prilocaine hydrochloride." | 3.66 | Acute toxic methemoglobinemia following dental analgesia. ( Ludwig, SC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karabiber, H | 1 |
| Selimoglu, MA | 1 |
| Cetin, M | 1 |
| Tekin, S | 1 |
| Gurbuz, S | 1 |
| Kluger, N | 1 |
| Raison-Peyron, N | 1 |
| Michot, C | 1 |
| Guillot, B | 1 |
| Bessis, D | 1 |
| Gille, J | 1 |
| Gille, M | 1 |
| Gahr, R | 1 |
| Wiedemann, B | 1 |
| Bamgbade, OA | 1 |
| Ludwig, SC | 1 |
| Birmingham, PK | 1 |
| Taddio, A | 1 |
| Ohlsson, A | 1 |
| Einarson, TR | 1 |
| Stevens, B | 1 |
| Koren, G | 1 |
| Black, RJ | 1 |
| Dawson, TA | 1 |
| Strang, WC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Analgesia With the Use of Eutectic Mixture of Local Anesthetics (Lidocaine and Prilocaine) and Oral Solution of Glucose to 25% in Preterm Neonates During Arterial Puncture and / or the Installation of Percutaneous Catheter[NCT00808054] | Phase 4 | 60 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients[NCT05078463] | Phase 2 | 20 participants (Actual) | Interventional | 2021-09-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
3 reviews available for prilocaine and Acute Disease
| Article | Year |
|---|---|
Severe needle phobia in the perianesthesia setting.
Topics: Acute Disease; Adult; Ambulatory Surgical Procedures; Desensitization, Psychologic; Epilepsies, Part | 2007 |
Recent advances in acute pain management.
Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; | 1995 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
1 trial available for prilocaine and Acute Disease
| Article | Year |
|---|---|
[Acute pain management in proximal femoral fractures: femoral nerve block (catheter technique) vs. systemic pain therapy using a clinic internal organisation model].
Topics: Acute Disease; Aged; Aged, 80 and over; Amides; Analgesics, Opioid; Anesthetics, Local; Catheterizat | 2006 |
4 other studies available for prilocaine and Acute Disease
| Article | Year |
|---|---|
Acute central nervous system depression after subcutaneous use of prilocaine in an infant.
Topics: Acute Disease; Anesthetics, Local; Central Nervous System Diseases; Humans; Infant; Injections, Subc | 2012 |
Acute bullous irritant contact dermatitis caused by EMLA® cream.
Topics: Acute Disease; Anesthetics, Local; Blister; Dermatitis, Irritant; Drug Hypersensitivity; Eczema; Emo | 2011 |
Acute toxic methemoglobinemia following dental analgesia.
Topics: Acute Disease; Anesthesia, Dental; Child, Preschool; Humans; Male; Methemoglobinemia; Nitrous Oxide; | 1981 |
Contact sensitivity to lignocaine and prilocaine.
Topics: Acute Disease; Administration, Topical; Adult; Cross Reactions; Dermatitis, Contact; Drug Eruptions; | 1990 |