prilocaine and Ache
prilocaine has been researched along with Ache in 423 studies
Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children who received lidocaine-prilocaine emulsion reported less pain (mean FPS score = 1." | 10.17 | Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. ( Abu-Saad, HH; Arts, SE; Champion, GD; Crawford, MR; Fisher, RJ; Juniper, KH; Ziegler, JB, 1994) |
| "To compare effectiveness of ice pack to topical lidocaine-prilocaine for pain reduction during axillary laser hair removal." | 9.69 | Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial. ( Alam, M; Anvery, N; Brieva, JC; Christensen, RE; Dirr, MA; Geisler, A; Roongpisuthipong, W; Schaeffer, M; Waldman, A, 2023) |
| "Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia." | 9.69 | Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial. ( Gao, J; Li, T; Li, Y; Wang, M; Zhang, E; Zhang, H; Zhang, L; Zhao, X, 2023) |
| "To compare the effectiveness of suppository diclofenac (100mg), cervical lidocaine 25mg -prilocaine 25mg cream (5% EMLA) and placebo in pain relief for hysterosalpingography." | 9.41 | Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo. ( Agboghoroma, OC; Babandi, RM; Durojaiye, KW; Essiet, EA; Jimoh, KO, 2021) |
| "The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women." | 9.24 | Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial. ( Abbas, AM; Abdellah, MS; Abdellah, NH; Abdelmagied, AM; Ali, MK; Bahloul, M; Khalaf, M, 2017) |
| "This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection." | 9.20 | A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection. ( Irkoren, S; Karaca, H; Ozkan, HS, 2015) |
| "Topical capsaicin 8% was developed for the treatment of peripheral neuropathic pain." | 9.17 | Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study. ( Knolle, E; Kovacs, GG; Medwed, S; Scharbert, G; Schemper, M; Zadrazil, M, 2013) |
| "Topical capsaicin and eutectic mixture of local anesthetics (EMLA) have been found to be equally effective in minimizing the pain of venipuncture." | 9.17 | A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain. ( Agarwal, A; Gupta, D; Kishore, K; Rastogi, S; Singh, PK; Singh, U, 2013) |
| "Lidocaine showed significantly reduced pain compared to placebo at all assessment points." | 9.16 | Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. ( Augustin, M; Herberger, K; Krause, K; Maier, K; Radtke, M; Zschocke, I, 2012) |
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 9.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| "To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections." | 9.15 | Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011) |
| "The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers." | 9.14 | A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009) |
| "Our findings suggest that the combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block provides better pain control than the 2 modalities alone during the sampling part of transrectal ultrasound guided prostate biopsy with no increase in the complication rate." | 9.14 | Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial. ( Autorino, R; Barbone, F; De Maria, M; Di Lorenzo, G; Giannarini, G; Manassero, F; Mogorovich, A; Morelli, G; Selli, C; Valent, F, 2009) |
| "Perianal anesthesia with lidocaine-prilocaine cream may solely be sufficient to decrease the pain during prostate biopsy." | 9.14 | Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study. ( Kandirali, E; Metin, A; Semercioz, A; Serin, E; Ulukaradag, E; Uysal, B, 2009) |
| "The purpose of this study was to compare the effectiveness of topically applied lidocaine-prilocaine (EMLA) cream with local anesthetic infiltration in the reduction of pain during perineal suturing after childbirth." | 9.14 | Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial. ( Cromi, A; Franchi, M; Gaudino, F; Ghezzi, F; Scarperi, S; Siesto, G, 2009) |
| "To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy." | 9.13 | Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial. ( Briganti, A; Dehò, F; Di Girolamo, V; Gallina, A; Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Salonia, A; Scattoni, V, 2008) |
| " Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9." | 9.13 | EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008) |
| "Topical application of EMLA and Oraqix before palatal anesthetic infiltration is associated with less pain than with benzocaine gel." | 9.12 | Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection. ( Al-Melh, MA; Andersson, L, 2007) |
| "To compare the efficacy and side effects of transdermal diclofenac patch with eutectic mixture of local anesthetic (EMLA) cream in attenuating venous cannulation pain." | 9.12 | Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain. ( Agarwal, A; Gautam, S; Gupta, D; Singh, U, 2007) |
| " We evaluated the patient's perception of pain/discomfort experienced during the procedure in terms of the type of anesthesia used: periprostatic infiltration with 2% lidocaine, or intrarectal instillation of lidocaine-prilocain cream." | 9.11 | Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream. ( Adamakis, I; Alamanis, C; Giannopoulos, A; Haritopoulos, K; Mitropoulos, D; Stravodimos, K, 2004) |
| ") ketamine sedation administered by nonanesthetist physicians for painful procedures." | 9.11 | Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005) |
| "To compare the efficacy of topical eutectic mixture of local anesthetics (EMLA) versus topical lidocaine (LMX) in pain control for Nd:YAG 1,064 nm laser hair removal." | 9.11 | Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal. ( Guardiano, RA; Norwood, CW, 2005) |
| "5% are significantly more effective than 20% benzocaine in reducing pain from needle stick in the maxillary vestibular mucosa." | 9.11 | Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. ( Abu Al-Melh, M; Andersson, L; Behbehani, E, 2005) |
| "Topical lidocaine-prilocaine (EMLA) effectively decreases the pain associated with minor procedures including immunization, although the effect on the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTaP-IPV-Hib) and hepatitis B vaccines has not been assessed." | 9.10 | Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in ( Halperin, BA; Halperin, SA; Houston, T; McGrath, P; Smith, B, 2002) |
| "We conducted a randomized, double blinded, placebo controlled trial to evaluate the effectiveness of EMLA cream together with intraperitoneal lidocaine for pain relief in postpartum tubal ligation." | 9.10 | EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization. ( Apidechakul, P; Ariyanon, P; Latthikaviboon, U; Limsakul, A; Parakkamodom, S; Permpolprasert, L; Pethpaisit, N; Santivarangkana, T; Sirilertmakasakul, P; Visalyaputra, S, 2002) |
| "Prilocaine plain has been described in the literature as causing less pain on injection than bupivacaine with epinephrine, possibly because of the higher pH of the prilocaine anesthetic solution." | 9.10 | Injection pain of bupivacaine with epinephrine vs. prilocaine plain. ( Gordon, MK; Overton, DA; Schmitt, MM; Wahl, MJ, 2002) |
| "Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain." | 9.10 | The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003) |
| "Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0." | 9.10 | Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003) |
| "A double-randomized, blinded crossover trial was performed to assess the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics (EMLA) for pain relief during pediatric venipuncture procedures." | 9.10 | A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. ( Cunningham, BB; Eichenfield, LF; Fallon-Friedlander, S; Funk, A, 2002) |
| "This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia." | 9.09 | Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. ( Eleazer, PD; Kramp, LF; Scheetz, JP, 1999) |
| "To compare the relative efficacy of oral sucrose versus EMLA cream for pain relief during venepuncture, 51 full-term newborns (38M, 13F; postnatal age <4 d) in a stable condition were randomly allocated to one of four treatment groups: placebo (2 ml spring water); 2 ml sucrose 24% w/v; 1 g lidocaine-prilocaine 5% cream (EMLA); or EMLA plus sucrose." | 9.09 | Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. ( Abad, F; Díaz-Gómez, NM; Domenech, E; Feria, M; González, D; Robayna, M, 2001) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 9.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| " Our aim was to compare EMLA and placebo to assess the efficacy of EMLA in decreasing the pain of venipuncture in children premedicated with oral midazolam 0." | 9.08 | [Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam]. ( Cassinello, F; de Stefano, J; Herrero, E; Martín-Celemín, R; Palencia, J; Pérez-Gallardo, A, 1995) |
| "The efficacy of tetracaine cream versus that of lidocaine-prilocaine cream for the prevention of pain in children undergoing venipuncture was studied." | 9.08 | Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. ( Egberts, AC; Lenderink, AW; Rijnvos, WP; ter Pelkwijk, NJ; van Kan, HJ, 1997) |
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 9.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| "A prospective, randomised, double-masked, placebo-controlled study was carried out on 169 patients undergoing cataract extraction to compare the topical anaesthetic cream amethocaine with EMLA (eutetic mixture of local anaesthetic, lignocaine and prilocaine) and placebo in reducing pain during retrobulbar injection." | 9.07 | A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Villada, J; Watson, A, 1994) |
| "A randomized double-blind study was made of 60 children aged 5 to 11 years to assess the efficacy of a eutectic mixture of local anaesthetics (EMLA), lidocaine and prilocaine, and placebo cream in reducing venepuncture pain." | 9.07 | Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children. ( Lurngnateetape, A; Tritrakarn, T, 1994) |
| "To determine whether use of lidocaine-prilocaine 5% cream (EMLA) decreases pain associated with diphtheria-pertussis-tetanus (DPT) vaccination in infants." | 9.07 | Use of lidocaine-prilocaine cream for vaccination pain in infants. ( Goldbach, M; Ipp, M; Koren, G; Nulman, I; Taddio, A, 1994) |
| "A randomised, placebo controlled, double-masked study was undertaken in 115 patients undergoing cataract surgery to assess the efficacy of the anaesthetic cream EMLA (eutetic mixture of local anaesthetic, lignocaine-prilocaine) in alleviating the pain of retrobulbar injection." | 9.07 | A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Watson, A, 1991) |
| "A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch." | 9.06 | A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990) |
| "The aim of the study was to evaluate the effect of a lidocaine-prilocaine cream (EMLA cream, Astra) in relieving pain during arterial cannulation." | 9.06 | EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream. ( Danielson, K; Engberg, G; Henneberg, S; Nilsson, A, 1990) |
| "The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery." | 9.06 | Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987) |
| "The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner." | 9.06 | Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation. ( Korpela, R; Maunuksela, EL, 1986) |
| "A 5% lidocaine-prilocaine local anaesthetic cream, EMLA (Eutectic Mixture of Local Anaesthetics), has proved to be an effective remedy for alleviation of venipuncture pain when applied to intact skin for 60 min." | 9.05 | [Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream]. ( Dohlwitz, A; Uppfeldt, A, 1985) |
| "To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children." | 8.81 | Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children. ( Gurguis, MG; Koren, G; Taddio, A, 2002) |
| "When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection." | 8.31 | Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023) |
| "To compare the onset, anesthesia depth, and duration of topical 10% lidocaine and EMLA cream." | 8.12 | Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial. ( Deewongkij, P; Junputipong, N; Kamanamool, N; Rojhirunsakool, S; Udompataikul, M, 2022) |
| "To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal." | 7.96 | Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020) |
| "The objective of the present study was to investigate the pain on injection of articaine with adrenaline, prilocaine with phenylpressin , and lidocaine with adrenaline." | 7.74 | A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline. ( Celebi, N; Misir, F; Muğlali, M; Sumer, M, 2008) |
| "The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years." | 7.67 | Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA). ( Edmar, B; Gisslén, H; Lillieborg, S; Nordin, P; Rosdahl, I, 1988) |
| " In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low." | 6.71 | Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005) |
| "The pain was rated by each patient on a 100-mm visual analogue scale (VAS)." | 6.69 | Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 6.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "Pain was assessed by determination of heart rate, respiratory rate, and behavioral distress scoring." | 6.69 | A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision. ( deBlieck, E; Fortune, K; Generelli, P; Howard, CR; Howard, FM; tenHoopen, C; Zolnoun, D, 1999) |
| "Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale." | 6.67 | Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990) |
| "Pain was evaluated using a three-graded verbal rating scale." | 6.66 | A lignocaine-prilocaine cream reduces venipuncture pain. ( Möller, C, 1985) |
| "Pain was registered on a 10-cm visual analogue scale." | 6.66 | Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture. ( Carlsson, P; Hallén, B; Uppfeldt, A, 1985) |
| "Children who received lidocaine-prilocaine emulsion reported less pain (mean FPS score = 1." | 6.17 | Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. ( Abu-Saad, HH; Arts, SE; Champion, GD; Crawford, MR; Fisher, RJ; Juniper, KH; Ziegler, JB, 1994) |
| "To compare effectiveness of ice pack to topical lidocaine-prilocaine for pain reduction during axillary laser hair removal." | 5.69 | Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial. ( Alam, M; Anvery, N; Brieva, JC; Christensen, RE; Dirr, MA; Geisler, A; Roongpisuthipong, W; Schaeffer, M; Waldman, A, 2023) |
| "Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia." | 5.69 | Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial. ( Gao, J; Li, T; Li, Y; Wang, M; Zhang, E; Zhang, H; Zhang, L; Zhao, X, 2023) |
| " We affirm the fact that the combination of EMLA + Sucrose + RB is highly effective for managing pain during circumcision and further reduction of already low scores might not be possible." | 5.51 | Music as an adjunct to combination analgesia for neonatal circumcision: A randomized controlled trial. ( Abi-Gerges, C; Charafeddine, L; El-Hout, Y; Fayad, J; Hafez, B; Lakissian, Z; Sharara-Chami, R; Tamim, H; Tazian, V; Zaghal, A, 2022) |
| "To compare the effectiveness of suppository diclofenac (100mg), cervical lidocaine 25mg -prilocaine 25mg cream (5% EMLA) and placebo in pain relief for hysterosalpingography." | 5.41 | Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo. ( Agboghoroma, OC; Babandi, RM; Durojaiye, KW; Essiet, EA; Jimoh, KO, 2021) |
| "Facial burns are quite common among children." | 5.36 | Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients. ( Kargi, E; Tekerekoğlu, B, 2010) |
| "Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents." | 5.35 | Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009) |
| "Neonatal Infant Pain Scale scores were significantly lower in the intervention groups (EMLA + sucrose, mean [SD]: 3." | 5.24 | Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial. ( Charafeddine, L; El-Hout, Y; Lakissian, Z; Milad, N; Sharara-Chami, R, 2017) |
| "The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women." | 5.24 | Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial. ( Abbas, AM; Abdellah, MS; Abdellah, NH; Abdelmagied, AM; Ali, MK; Bahloul, M; Khalaf, M, 2017) |
| " The network meta-analysis revealed that "bicarbonate-buffered lidocaine with epinephrine" led to a significant decrease in injection pain (preference question) compared to "prilocaine with felypressin" and "lidocaine with epinephrine," whereas no significant differences were detected in the analysis of injection pain measured using the VAS." | 5.22 | Patient Comfort with Various Local Infiltration Anesthetics for Minor Oculoplastic Surgery: A Systematic Review and Network Meta-Analysis. ( Chen, C; Chiu, WK; Kang, YN; Liou, CM; Liu, HM; Wu, TJ, 2022) |
| "This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection." | 5.20 | A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection. ( Irkoren, S; Karaca, H; Ozkan, HS, 2015) |
| "We investigated the efficacy of 5% lidocaine 25 mg-prilocaine 25 mg/g cream (EMLA(®) ) applied to the uterine cervix for reducing pain during diagnostic or operative hysteroscopy, using a visual analogue scale (VAS) for pain in a prospective randomized, non-blinded, controlled study in 92 successive patients." | 5.17 | Lidocaine-prilocaine (EMLA(®) ) cream as analgesia in hysteroscopy practice: a prospective, randomized, non-blinded, controlled study. ( Arnau, B; Canals, M; Jiménez, E; Jovell, E; Mir, V; Redón, S, 2013) |
| "Topical capsaicin 8% was developed for the treatment of peripheral neuropathic pain." | 5.17 | Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study. ( Knolle, E; Kovacs, GG; Medwed, S; Scharbert, G; Schemper, M; Zadrazil, M, 2013) |
| "To compare the clinical efficacy between locally applied diclofenac diethylamine gel, EMLA cream and systemically given diclofenac sodium for the pain relief during extracorporeal shock wave lithotripsy (SWL) using Dornier Delta Compact Lithotripter." | 5.17 | Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy. ( Liu, J; Zang, YJ, 2013) |
| "Lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain." | 5.17 | Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2013) |
| "Topical capsaicin and eutectic mixture of local anesthetics (EMLA) have been found to be equally effective in minimizing the pain of venipuncture." | 5.17 | A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain. ( Agarwal, A; Gupta, D; Kishore, K; Rastogi, S; Singh, PK; Singh, U, 2013) |
| "Lidocaine showed significantly reduced pain compared to placebo at all assessment points." | 5.16 | Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. ( Augustin, M; Herberger, K; Krause, K; Maier, K; Radtke, M; Zschocke, I, 2012) |
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 5.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| " access, and blood sampling pain and stress affect hormone values, treatment with N(2)O or midazolam influence the glucose and stress hormone levels differently." | 5.16 | Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children. ( Ekbom, K; Jakobsson, J; Kalman, S; Marcus, C, 2012) |
| "The objective of the study was to compare the efficacy of dimethyl sulfoxide (DMSO) mixed with lignocaine and eutectic mixture of local anesthetics (EMLA) cream as topically applied surface anesthetics in relieving pain during shock wave lithotripsy (SWL) in a prospective randomized study." | 5.15 | Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy. ( Ganesamoni, R; Kumar, S; Mandal, AK; Prasad, S; Singh, SK, 2011) |
| "To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections." | 5.15 | Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011) |
| " The purpose of this study was to evaluate efficacy of lidocaine/prilocaine cream in decreasing the pain of injection for sentinel lymph node biopsy." | 5.15 | Do topical anesthetics reduce periareolar injectional pain before sentinel lymph node biopsy? ( Cusick, TE; Helmer, SD; O'Connor, JM; Osland, JS; Tenofsky, PL, 2011) |
| "The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers." | 5.14 | A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009) |
| "Breast-feeding in infants under age 6 months and use of sucrose or lidocaine-prilocaine in children age 6 to 48 months significantly reduced crying time and pain scores compared with controls." | 5.14 | Interventions to reduce pain during vaccination in infancy. ( Dallar, Y; Dilli, D; Küçük, IG, 2009) |
| "Our findings suggest that the combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block provides better pain control than the 2 modalities alone during the sampling part of transrectal ultrasound guided prostate biopsy with no increase in the complication rate." | 5.14 | Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial. ( Autorino, R; Barbone, F; De Maria, M; Di Lorenzo, G; Giannarini, G; Manassero, F; Mogorovich, A; Morelli, G; Selli, C; Valent, F, 2009) |
| "Perianal anesthesia with lidocaine-prilocaine cream may solely be sufficient to decrease the pain during prostate biopsy." | 5.14 | Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study. ( Kandirali, E; Metin, A; Semercioz, A; Serin, E; Ulukaradag, E; Uysal, B, 2009) |
| "In this prospective and randomized study, we aimed to compare the efficacy of a eutectic mixture of local anesthetics (EMLA) cream, diclofenac sodium (DS) and EMLA in combination with DS (EMLA+DS) for pain management during extracorporeal shock wave lithotripsy (ESWL)." | 5.14 | Comparison of three analgesic treatment protocols for pain management during extracorporeal shock wave lithotripsy. ( Eryildirim, B; Faydaci, G; Kuyumcuoğlu, U; Tarhan, F; Uruç, F, 2009) |
| "The purpose of this study was to compare the effectiveness of topically applied lidocaine-prilocaine (EMLA) cream with local anesthetic infiltration in the reduction of pain during perineal suturing after childbirth." | 5.14 | Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial. ( Cromi, A; Franchi, M; Gaudino, F; Ghezzi, F; Scarperi, S; Siesto, G, 2009) |
| "To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2." | 5.14 | Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. ( Hadash, A; Kassis, I; Knaani-Levinz, H; Shachor-Meyouhas, Y; Shavit, I, 2009) |
| "No differences in overall pain sensation between the substances were detected during and after liposuction except a more rapid onset with lidocaine (less pain after 15 min, p < 0." | 5.14 | Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia. ( Augustin, M; Herberger, K; Maier, K; Sattler, G; Sommer, B, 2010) |
| "To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy." | 5.13 | Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial. ( Briganti, A; Dehò, F; Di Girolamo, V; Gallina, A; Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Salonia, A; Scattoni, V, 2008) |
| " Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9." | 5.13 | EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008) |
| "Topical application of EMLA and Oraqix before palatal anesthetic infiltration is associated with less pain than with benzocaine gel." | 5.12 | Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection. ( Al-Melh, MA; Andersson, L, 2007) |
| "To compare the efficacy and side effects of transdermal diclofenac patch with eutectic mixture of local anesthetic (EMLA) cream in attenuating venous cannulation pain." | 5.12 | Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain. ( Agarwal, A; Gautam, S; Gupta, D; Singh, U, 2007) |
| "We evaluated the efficacy of topical Myolaxin (capsaican ointment, Geno, Mumbai) ointment over EMLA (eutectic mixture of lignocaine, prilocaine; Neon, Goa) cream for attenuating venous cannulation pain in this prospective, randomised, double blind study." | 5.12 | Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study. ( Agarwal, A; Dhiraaj, S; Gupta, D; Singh, PK; Tandon, M; Yadav, G, 2007) |
| " We evaluated the patient's perception of pain/discomfort experienced during the procedure in terms of the type of anesthesia used: periprostatic infiltration with 2% lidocaine, or intrarectal instillation of lidocaine-prilocain cream." | 5.11 | Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream. ( Adamakis, I; Alamanis, C; Giannopoulos, A; Haritopoulos, K; Mitropoulos, D; Stravodimos, K, 2004) |
| "Intravenous cannulation in children aged 6-12 years is less painful after a 90-min application of a Lidocaine/ Prilocaine cream followed by a 30-min interval without cream, than cannulation immediately after a 60-min application." | 5.11 | Improved application of Lidocaine/Prilocaine cream in children. A randomized and prospectively controlled study of two application regimes. ( Culmsee, M; Gad, LN; Lysgaard, AB; Olsen, KS, 2004) |
| "Although the equimolecular mixture of oxygen and nitrous oxide (EMONO) seems a good choice to relieve procedure-related pain in children, it has not been evaluated for insertion of central venous catheters in children." | 5.11 | Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children. ( Abdeladhim, AB; Abdelkefi, A; Abdennebi, YB; Aouf, S; Béjaoui, M; Ladeb, S; Mellouli, F; Othman, TB; Torjman, L, 2004) |
| ") ketamine sedation administered by nonanesthetist physicians for painful procedures." | 5.11 | Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005) |
| "To compare the efficacy of topical eutectic mixture of local anesthetics (EMLA) versus topical lidocaine (LMX) in pain control for Nd:YAG 1,064 nm laser hair removal." | 5.11 | Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal. ( Guardiano, RA; Norwood, CW, 2005) |
| "5% are significantly more effective than 20% benzocaine in reducing pain from needle stick in the maxillary vestibular mucosa." | 5.11 | Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. ( Abu Al-Melh, M; Andersson, L; Behbehani, E, 2005) |
| "The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures." | 5.11 | Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments. ( Ekbom, K; Jakobsson, J; Marcus, C, 2005) |
| "Topical anaesthesia with prilocaine-lidocaine cream significantly reduced pain at transrectal probe insertion and during the biopsy procedure." | 5.11 | Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo. ( Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Scattoni, V, 2005) |
| "Topical lidocaine-prilocaine (EMLA) effectively decreases the pain associated with minor procedures including immunization, although the effect on the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTaP-IPV-Hib) and hepatitis B vaccines has not been assessed." | 5.10 | Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in ( Halperin, BA; Halperin, SA; Houston, T; McGrath, P; Smith, B, 2002) |
| "A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron has a longer effect on resting pain and pain on movement than the local anesthetic drug." | 5.10 | Treatment of tendopathies with tropisetron. ( Müller, W; Stratz, T; Varga, B, 2002) |
| "We conducted a randomized, double blinded, placebo controlled trial to evaluate the effectiveness of EMLA cream together with intraperitoneal lidocaine for pain relief in postpartum tubal ligation." | 5.10 | EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization. ( Apidechakul, P; Ariyanon, P; Latthikaviboon, U; Limsakul, A; Parakkamodom, S; Permpolprasert, L; Pethpaisit, N; Santivarangkana, T; Sirilertmakasakul, P; Visalyaputra, S, 2002) |
| "Pain scores were significantly lower using the novel lidocaine/tetracaine-based cream peel formulation compared with the EMLA cream." | 5.10 | Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study. ( Alster, TS; Lupton, JR, 2002) |
| "The pain and distress ratings of patients undergoing BMAs (n = 73) and LPs (n = 105) were examined in a comparison of 3 different interventions: (1) a topical eutectic mixture of lidocaine and prilocaine (EMLA cream), (2) oral midazolam and EMLA cream, or (3) propofol/fentanyl general anesthesia." | 5.10 | Pain and distress from bone marrow aspirations and lumbar punctures. ( Doran, NH; Frost, JD; Holdsworth, MT; Mathew, P; Moro, MA; Pankey, JM; Phillips, J; Raisch, DW; Winter, SS, 2003) |
| "Prilocaine plain has been described in the literature as causing less pain on injection than bupivacaine with epinephrine, possibly because of the higher pH of the prilocaine anesthetic solution." | 5.10 | Injection pain of bupivacaine with epinephrine vs. prilocaine plain. ( Gordon, MK; Overton, DA; Schmitt, MM; Wahl, MJ, 2002) |
| "To evaluate the efficacy of eutectic lidocaine/prilocaine cream (EMLA) in reducing the pain associated with steroid joint injection in children with juvenile arthritis." | 5.10 | Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial. ( Berkovitch, M; Gazarian, M; Koren, G; Laxer, RM; Schneider, R; Silverman, ED; Uziel, Y, 2003) |
| "The objective of this study is to determine whether use of lidocaine-prilocaine 5% cream (EMLA) and oral glucose decreases pain associated with diphteria-pertussis-tetanus (DPT) immunization in 3-month-old infants." | 5.10 | EMLA cream and oral glucose for immunization pain in 3-month-old infants. ( Blomquist, HK; Håkansson, S; Lindh, V; Wiklund, U, 2003) |
| "Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain." | 5.10 | The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003) |
| "Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0." | 5.10 | Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003) |
| "A double-randomized, blinded crossover trial was performed to assess the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics (EMLA) for pain relief during pediatric venipuncture procedures." | 5.10 | A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. ( Cunningham, BB; Eichenfield, LF; Fallon-Friedlander, S; Funk, A, 2002) |
| "To determine whether the application of a eutectic mixture of anesthetic cream (EMLA cream) can decrease the pain of lidocaine injection during vasectomy." | 5.10 | Use of EMLA cream with vasectomy. ( Cooper, TP, 2002) |
| "This multicentre, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of using Emla (lignocaine/prilocaine) anaesthetic cream to achieve pain control during sharp debridement of chronic leg ulcers of arterial, venous or arteriovenous aetiology." | 5.09 | Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers. ( Baxter, M; Gottschalk, R; Lycka, B; Murphy, F; Nevin, K; Rosenthal, D, 2001) |
| "Lidocaine-prilocaine cream (EMLA) is currently standard therapy to alleviate procedural pain in children." | 5.09 | Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children. ( Bar-Oz, B; Bishai, R; Freedman, MH; Koren, G; Taddio, A, 1999) |
| "The efficacy of lignocaine-prilocaine cream (EMLA) and amethocaine gel (Ametop) in reducing the pain and distress of venepuncture was compared in a single-blind randomized study of 34 children aged 1-14 y." | 5.09 | Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children. ( Choy, L; Collier, J; Watson, AR, 1999) |
| " Prilocaine plus lidocaine cream was more effective than lidocaine spray in decreasing pain at placement of the tenaculum and shoulder pain after the procedure." | 5.09 | Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities. ( Di Carlo, C; Fabrizio, A; Nappi, C; Pellicano, M; Stigliano, CM; Zullo, F, 1999) |
| "Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers." | 5.09 | Combined analgesia and local anesthesia to minimize pain during circumcision. ( Gilbert-MacLeod, C; Koren, G; Ohlsson, K; Pollock, N; Taddio, A, 2000) |
| "This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia." | 5.09 | Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. ( Eleazer, PD; Kramp, LF; Scheetz, JP, 1999) |
| "The mean pain score for the prilocaine group was 1." | 5.09 | Prilocaine versus lignocaine for minor lid procedures. ( Backhouse, O; Burton, AJ; Metcalfe, TW, 2000) |
| " Supplemental lidocaine was then infiltrated through the wound edges and the pain of infiltration was recorded by the patient (or guardian) on a 100-mm visual analog scale marked "most pain" at the high end." | 5.09 | LET versus EMLA for pretreating lacerations: a randomized trial. ( Singer, AJ; Stark, MJ, 2001) |
| "To compare the relative efficacy of oral sucrose versus EMLA cream for pain relief during venepuncture, 51 full-term newborns (38M, 13F; postnatal age <4 d) in a stable condition were randomly allocated to one of four treatment groups: placebo (2 ml spring water); 2 ml sucrose 24% w/v; 1 g lidocaine-prilocaine 5% cream (EMLA); or EMLA plus sucrose." | 5.09 | Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. ( Abad, F; Díaz-Gómez, NM; Domenech, E; Feria, M; González, D; Robayna, M, 2001) |
| "The objective of this study was to explore the relation between the application of a mixture of lidocaine/prilocaine cream (eutectic mixture of local anesthetics [EMLA]) before intravenous cannula insertion and perceived pain in the pediatric patient." | 5.09 | Eutectic mixture of local anesthetics reduces pain during intravenous catheter insertion in the pediatric patient. ( Cordoni, A; Cordoni, LE, 2001) |
| "The effectiveness of a eutectic mixture lidocaine-prilocaine topical anaesthetic cream (EMLA) patch compared with a placebo patch in the reduction of pain associated with intramuscular immunization was evaluated." | 5.09 | A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children. ( Brown, TL; Cassidy, KL; Finley, GA; McGrath, PJ; Reid, GJ; Smith, DJ, 2001) |
| "The efficacy of a eutectic mixture of local anesthetics (EMLA) in alleviating the pain associated with subcutaneous needle insertion for infusion of the iron-chelating agent, deferoxamine, was examined in 12 patients with homozygous beta-thalassemia." | 5.08 | Use of a eutectic mixture of local anesthetics for prolonged subcutaneous drug administration. ( Berkovitch, M; Davis, S; Donsky, J; Koren, G; Matsui, D; Olivieri, NF, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 5.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| " Our aim was to compare EMLA and placebo to assess the efficacy of EMLA in decreasing the pain of venipuncture in children premedicated with oral midazolam 0." | 5.08 | [Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam]. ( Cassinello, F; de Stefano, J; Herrero, E; Martín-Celemín, R; Palencia, J; Pérez-Gallardo, A, 1995) |
| "In an observer blind study, the efficacy of lignocaine-prilocaine eutectic mixture was established in alleviating the pain of needle insertion during retrobulbar and periorbital tissues block in cataract surgery." | 5.08 | EMLA prevents pain during local anesthesia for cataract surgery. ( Dovinou, K; Nastou, H; Pappa, X; Pouliou, K; Stamatiou, I, 1995) |
| "5% prilocaine) in reducing distress, anxiety, and pain associated with phlebotomy in pediatric outpatients." | 5.08 | EMLA cream as a topical anesthetic before office phlebotomy in children. ( Schwartz, R; Sheridan, MJ; Young, SS, 1996) |
| "The use of a topical anesthetic cream containing prilocaine and lidocaine (EMLA) has been considered to reduce the pain of diagnostic allergy skin testing, but the effects of the cream on interpretation of skin tests is unclear." | 5.08 | EMLA cream for pain reduction in diagnostic allergy skin testing: effects on wheal and flare responses. ( Eggleston, PA; Sicherer, SH, 1997) |
| "The efficacy of tetracaine cream versus that of lidocaine-prilocaine cream for the prevention of pain in children undergoing venipuncture was studied." | 5.08 | Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. ( Egberts, AC; Lenderink, AW; Rijnvos, WP; ter Pelkwijk, NJ; van Kan, HJ, 1997) |
| "Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates." | 5.08 | Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997) |
| "A prospective, randomised, double-masked, placebo-controlled study was carried out on 169 patients undergoing cataract extraction to compare the topical anaesthetic cream amethocaine with EMLA (eutetic mixture of local anaesthetic, lignocaine and prilocaine) and placebo in reducing pain during retrobulbar injection." | 5.07 | A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Villada, J; Watson, A, 1994) |
| "A randomized double-blind study was made of 60 children aged 5 to 11 years to assess the efficacy of a eutectic mixture of local anaesthetics (EMLA), lidocaine and prilocaine, and placebo cream in reducing venepuncture pain." | 5.07 | Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children. ( Lurngnateetape, A; Tritrakarn, T, 1994) |
| "To determine whether use of lidocaine-prilocaine 5% cream (EMLA) decreases pain associated with diphtheria-pertussis-tetanus (DPT) vaccination in infants." | 5.07 | Use of lidocaine-prilocaine cream for vaccination pain in infants. ( Goldbach, M; Ipp, M; Koren, G; Nulman, I; Taddio, A, 1994) |
| "The emulsion of lidocaine and prilocaine (EMLA) is effective in preventing the pain of venipuncture in children." | 5.07 | Pain perception and effectiveness of the eutectic mixture of local anesthetics in children undergoing venipuncture. ( Blanchette, V; Eliopoulos, C; Greenberg, M; Hwang, P; Klein, N; Koren, G; Olivieri, N; Robieux, I, 1992) |
| "EMLA cream (Astra Pharmaceuticals) which contains lignocaine and prilocaine, is widely used in a thick layer to reduce the pain associated with venepuncture." | 5.07 | Thickly and thinly applied lignocaine-prilocaine cream prior to venepuncture in children. ( Sims, C, 1991) |
| "A randomised, placebo controlled, double-masked study was undertaken in 115 patients undergoing cataract surgery to assess the efficacy of the anaesthetic cream EMLA (eutetic mixture of local anaesthetic, lignocaine-prilocaine) in alleviating the pain of retrobulbar injection." | 5.07 | A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Watson, A, 1991) |
| "A topical anesthetic emulsion consisting of a mixture of lidocaine and prilocaine (EMLA) was used in an attempt to reduce the pain associated with radial artery cannulation." | 5.06 | Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration. ( Desmond, MJ; Fox, MA; Russell, GN, 1988) |
| "A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch." | 5.06 | A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990) |
| "The aim of the study was to evaluate the effect of a lidocaine-prilocaine cream (EMLA cream, Astra) in relieving pain during arterial cannulation." | 5.06 | EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream. ( Danielson, K; Engberg, G; Henneberg, S; Nilsson, A, 1990) |
| "The local analgesic efficacy of EMLA Cream (a eutectic mixture of lidocaine and prilocaine; Astra Pharmaceuticals, Sweden) in reducing the pain at Venous cannulation was investigated in a randommized blind study in 75 children scheduled for elective surgery." | 5.06 | Our experience with EMLA Cream (for painless venous cannulation in children). ( Johl, KS; Wig, J, 1990) |
| "A new topical anesthetic ointment (EMLA, "eutectic mixture of prilocaine and lidocaine was studied in a double-blind, placebo-controlled trial to evaluate its efficiency in alleviating pain associated with venous, subcutaneous drug reservoir and lumbar punctures in children." | 5.06 | Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children. ( Attias, D; Greenberg, ML; Halperin, DL; Koren, G; Pellegrini, E; Wyss, M, 1989) |
| "The cold and warmth thresholds to thermode stimulation and the sensory and pain thresholds to argon laser stimulation were determined before and after topical application of EMLA (Eutectic Mixture of Local Anaesthetics) cream." | 5.06 | The effect of topically applied anaesthetics (EMLA cream) on thresholds to thermode and argon laser stimulation. ( Arendt-Nielsen, L; Bjerring, P, 1989) |
| "The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery." | 5.06 | Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987) |
| "The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner." | 5.06 | Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation. ( Korpela, R; Maunuksela, EL, 1986) |
| "A new topical anaesthetic formulation, EMLA, consisting of a eutectic mixture of the two local anaesthetics, prilocaine and lidocaine, was used in an attempt to reduce the pain associated with venous cannulation in children." | 5.05 | EMLA--a eutectic mixture of local anaesthetics for topical anaesthesia. ( Ehrenström Reiz, GM; Reiz, SL, 1982) |
| "A 5% lidocaine-prilocaine local anaesthetic cream, EMLA (Eutectic Mixture of Local Anaesthetics), has proved to be an effective remedy for alleviation of venipuncture pain when applied to intact skin for 60 min." | 5.05 | [Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream]. ( Dohlwitz, A; Uppfeldt, A, 1985) |
| " Lidocaine 2% gel, misoprostol, and most NSAIDs did not help reduce pain." | 4.91 | Interventions for pain with intrauterine device insertion. ( Allen, RH; Bartz, D; Bernholc, A; Hubacher, D; Lopez, LM; O'Brien, PA; Zeng, Y, 2015) |
| "Two trials (470 participants with venous leg ulcers) evaluated ibuprofen slow-release foam dressings for persistent venous leg ulcer pain." | 4.88 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Martyn-St James, M; Nelson, EA, 2012) |
| "There is no evidence that ibuprofen dressings offer pain relief, as measured at the first evening of use, to people with painful venous leg ulcers compared with foam dressings or best practice." | 4.86 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2010) |
| " The weighted mean difference in 100-mm visual analogue scale pain scores favored topical tetracaine over EMLA (-8." | 4.82 | Topical anesthetics for dermal instrumentation: a systematic review of randomized, controlled trials. ( Carr, DB; Eidelman, A; Lau, J; Weiss, JM, 2005) |
| "To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children." | 4.81 | Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children. ( Gurguis, MG; Koren, G; Taddio, A, 2002) |
| "When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection." | 4.31 | Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023) |
| "To compare the onset, anesthesia depth, and duration of topical 10% lidocaine and EMLA cream." | 4.12 | Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial. ( Deewongkij, P; Junputipong, N; Kamanamool, N; Rojhirunsakool, S; Udompataikul, M, 2022) |
| "To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal." | 3.96 | Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020) |
| "We investigated the effect of a possible interaction between topical analgesic treatment and treatment expectation on pain at the behavioral and neuronal level by combining topical lidocaine/prilocaine treatment with an expectancy manipulation in a 2 by 2 within-subject design (open treatment, hidden treatment, placebo, control)." | 3.80 | Expectation requires treatment to boost pain relief: an fMRI study. ( Büchel, C; Geuter, S; Schenk, LA; Sprenger, C, 2014) |
| "The objective of the present study was to investigate the pain on injection of articaine with adrenaline, prilocaine with phenylpressin , and lidocaine with adrenaline." | 3.74 | A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline. ( Celebi, N; Misir, F; Muğlali, M; Sumer, M, 2008) |
| "Some children report significant pain with peripheral intravenous catheter (IV) insertion, despite the appropriate use of topical lidocaine anesthetics." | 3.74 | Predictors of topical anesthetic effectiveness in children. ( Floria-Santos, M; Hanrahan, K; Kleiber, C; McCarthy, AM; Murray, JC; Schutte, DL, 2007) |
| "To assess the patient acceptability of outpatient hysteroscopy when Prilocaine is used as analgesia and to determine if our practice of using Prilocaine only if indicated by pain is appropriate." | 3.72 | Outpatient hysteroscopy: an observational study of patient acceptability. ( Brown, V; Dass, M; Jivraj, S; Panikkar, J, 2004) |
| "Significant changes were found for pain assessment, local anesthesia procedures, and nitrous oxide administration." | 3.69 | [Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology]. ( Annequin, D; Bouffet, E; Castaing, MC; Douard, MC; Pichard-Léandri, E, 1996) |
| "The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years." | 3.67 | Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA). ( Edmar, B; Gisslén, H; Lillieborg, S; Nordin, P; Rosdahl, I, 1988) |
| " After the anesthetic effect had subsided, prilocaine 4% caused post-analgesic pain less frequently than did lidocaine 2% with adrenalin 12." | 3.65 | Pain and temperature sensations related to local analgesia. ( Evers, H; Oikarinen, VJ; Ylipaavalniemi, P, 1975) |
| "Forty volunteers with moderate to severe chronic periodontitis were recruited, of which at least three sextants required periodontal therapy." | 2.94 | Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT. ( Farago, PV; Moraes, GS; Pilatti, GL; Pinto, SCS; Pochapski, MT; Santos, FA; Santos, IBD, 2020) |
| "Pain was assessed subjectively using the numeric rating scale (NRS) and objectively using a Galvanic Skin Response (GSR) tester." | 2.87 | [The Effect of Pain Relieving Intervention During Infiltration among Gamma Knife Surgery Patients for Stereotactic Frame Fixation]. ( Jang, YJ; Kim, HO, 2018) |
| "Pain was continuously recorded during stimulation, and measures of subjective stress and blood pressure were obtained before the pretest, after the application of cream, and after the posttests." | 2.80 | Opposite effects of the same drug: reversal of topical analgesia by nocebo information. ( Aslaksen, PM; Bjørkedal, E; Eilertsen, HH; Gorecka, MM; Zwarg, ML, 2015) |
| "Then, pain was induced in each patient's forearm by introducing a 27 G needle into the skin 4 mm deep three times." | 2.79 | The use of skin needling for the delivery of a eutectic mixture of local anesthetics. ( De Vita, V; Fabbrocini, G; Izzo, R; Monfrecola, G, 2014) |
| "Pain was evaluated using 10-point Visual Analog Scale (VAS)." | 2.78 | A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience. ( Anup, K; Biswajit, N; Nayan, MK; Niraj, K; Pawan, V, 2013) |
| "Pain was assessed by visual analogue scale (VAS) and anxiety levels by the State-Trait Anxiety Inventory (STAI-I and STA-II)." | 2.77 | No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial. ( Boyacioglu, S; Cengiz, C; Kuzu, MA; Ozdemir, B; Pampal, HK, 2012) |
| "Pain was assessed at 2 phases: during venipuncture (from needle introduction to its removal) and during the recovery period (30 seconds after needle removal)." | 2.76 | Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants. ( Biran, V; Carbajal, R; Cimerman, P; Gourrier, E; Mitanchez, D; Walter-Nicolet, E, 2011) |
| "The mean pretreatment pain score was 6." | 2.75 | The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. ( Burgoyne, CC; Giglio, JA; Laskin, DM; Reese, SE; Sima, AP, 2010) |
| " Adverse events were recorded." | 2.75 | Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment. ( Carruthers, JA; Carruthers, JD; Mordaunt, J; Oliff, HS; Poirier, J; Schreiber, WE, 2010) |
| "Pain was assessed by Visual Analogue Scale (VAS) on two different days after skin application of EMLA or placebo cream on the forearms." | 2.74 | Pregnancy at term does not alter the responses to a mechanical and an electrical stimulus after skin EMLA application. ( Fassoulaki, A; Katafigioti, A; Paraskeva, A; Petropoulos, G; Siafaka, I, 2009) |
| " Neither anesthetic was systemically absorbed in any cat, and no adverse clinical signs were observed." | 2.72 | Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats. ( Gibbon, KJ; Kurian, JR; Strom, TL; Trepanier, LA; Wagner, KA, 2006) |
| "Scarring was not observed." | 2.71 | Full-face laser resurfacing using a supplemented topical anesthesia protocol. ( Calkin, J; Chotzen, V; Kilmer, SL; McClaren, M; No, D; Silva, S; Zelickson, BD, 2003) |
| "Pain was assessed with the Newborn Acute Pain scale (DAN) and with the Neonatal Facial Coding System (NFCS)." | 2.71 | [Analgesic effects of Emla cream and saccharose solution for subcutaneous injections in preterm newborns: a prospective study of 265 injections]. ( Baudon, JJ; Ducrocq, S; Gold, F; Lebas, F; Mochel, F; Mucignat, V, 2004) |
| "Pain was evaluated using an 11-point visual analog scale questionnaire." | 2.71 | Unilateral pudendal nerve blockade for relief of all pain during transrectal ultrasound-guided biopsy of the prostate: a randomized, double-blind, placebo-controlled study. ( Adsan, O; Cetinkaya, M; Inal, G; Kaygisiz, O; Ozdoğan, L; Uğurlu, O, 2004) |
| " In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low." | 2.71 | Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005) |
| "Pain was evaluated using a visual analog scale (VAS) after each core biopsy." | 2.71 | Local anesthesia in transrectal ultrasound-guided prostate biopsy: EMLA cream as a new alternative technique. ( Akpinar, S; Başar, H; Başar, MM; Batislam, E; Ozcan, S, 2005) |
| "There were no reports of numbness of the tongue, lip, or cheek, neither were there any adverse local reactions in the oral mucosa." | 2.70 | The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing. ( Friskopp, J; Isacsson, G; Nilsson, M, 2001) |
| "The pain was rated by each patient on a 100-mm visual analogue scale (VAS)." | 2.69 | Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998) |
| "Pain was less severe in the EMLA group than in the lidocaine infiltration group (Score of 2 vs 7; P = 0." | 2.69 | Topical lidocaine-prilocaine cream (EMLA) versus local infiltration anesthesia for radial artery cannulation. ( Ali, OS; Benhamou, D; Joly, LM; Monchi, M; Spaulding, C; Weber, S, 1998) |
| "Pain was evaluated on a visual analog scale (VAS, 0-10)." | 2.69 | [Efficacy of EMLA cream, effect of time and place of application]. ( Cano Serrano, ME; Martínez-Tellería, A; Rufino Ruiz, J, 1999) |
| "Various minimally invasive approaches to reduce pain during extracorporeal shock wave lithotripsy (ESWL) have been described." | 2.69 | Petroleum jelly is an ideal contact medium for pain reduction and successful treatment with extracorporeal shock wave lithotripsy. ( Becker, AJ; Jonas, U; Machtens, S; Oelke, M; Stief, CG; Truss, MC, 1999) |
| " The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants." | 2.69 | Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999) |
| "Pain was assessed by determination of heart rate, respiratory rate, and behavioral distress scoring." | 2.69 | A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision. ( deBlieck, E; Fortune, K; Generelli, P; Howard, CR; Howard, FM; tenHoopen, C; Zolnoun, D, 1999) |
| "Pain was assessed on a 10 cm visual analog scale (0, absence of pain; 10, greatest imaginable pain)." | 2.69 | [Use of the anesthetic cream EMLA in arterial punction]. ( Belda, J; Casan, P; Giner, J; Litvan, H; Sanchis, J, 2000) |
| "Lidocaine (1." | 2.69 | Comparison of 4 analgesic agents for venipuncture. ( Fedele, KA; Hackman, CM; Hussa, AA; Patterson, P; Vegh, GL, 2000) |
| "Prilocaine results in a lower incidence of transient neurological symptoms than lidocaine intrathecally and therefore it is more suitable for short surgical procedures." | 2.69 | The incidence of transient neurological symptoms after spinal anaesthesia with lidocaine compared to prilocaine. ( de Weert, K; Dirksen, R; Gielen, M; Slappendel, R; Traksel, M; Weber, E, 2000) |
| "Pain was assessed using a visual analogue scale, a verbal descriptive scale and a direct comparison between paired treatments." | 2.67 | Pain after subcutaneous injection of recombinant human erythropoietin: does Emla cream help? ( Coulthard, MG; Hardy, SP; Hughes, C; Matthews, JN; Morris, KP, 1994) |
| "Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy." | 2.67 | Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer. ( Arnold, M; Betcher, DL; Dose, AM; Goh, TS; Loprinzi, CL; MacKellar, DJ; Miser, AW; Niedringhaus, RD; O'Fallon, JR; Simmons, P, 1994) |
| "Pain was measured with a 100 mm visual analog scale (VAS)." | 2.67 | A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis. ( Argo, LF; Flores, CA; Wagner, RF, 1994) |
| "Prilocaine (Citanest) has been shown to be a satisfactory alternative to lignocaine, with certain important advantages, including superior diffusion." | 2.67 | Peribulbar and retrobulbar anesthesia with prilocaine: a comparison of two methods of local ocular anesthesia. ( Bourne, A; Morgan, LH; Pemberton, CJ; Saunders, DC; Sturgess, DA, 1993) |
| "Pain was assessed by means of a modified visual analogue scale ranging from 0 (no pain) to 10 (excruciating pain) in 25 consecutive patients (average age 65 years) undergoing bilateral eyelid surgery." | 2.67 | Effect of a topical anesthetic cream (EMLA) in reducing pain caused by infiltration of local anesthetic in eyelid surgery. ( Codère, F; Degnan, N; Sloan, J; Tucker, N, 1993) |
| "We investigated the per- and postoperative pain-reducing effect of pethidine given intra-articularly (i." | 2.67 | Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy? A double-blind study comparing prilocaine with pethidine. ( Ekblom, A; Eriksson, E; Söderlund, A; Valentin, A; Westman, L, 1993) |
| "Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale." | 2.67 | Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990) |
| "Reported pain was significantly less after only 5 minutes of the lignocaine-prilocaine cream (p = 0." | 2.67 | Relief of injection pain in adults. EMLA cream for 5 minutes before venepuncture. ( Nott, MR; Peacock, JL, 1990) |
| "Pain was evaluated using a three-graded verbal rating scale." | 2.66 | A lignocaine-prilocaine cream reduces venipuncture pain. ( Möller, C, 1985) |
| "Pain was registered on a 10-cm visual analogue scale." | 2.66 | Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture. ( Carlsson, P; Hallén, B; Uppfeldt, A, 1985) |
| "Currently, approaches to analgesia can be categorised in two broad categories - non-pharmacological and pharmacological agents." | 2.47 | Analgesia for amniocentesis or chorionic villus sampling. ( Alfirevic, Z; Mujezinovic, F, 2011) |
| "Pain was defined as either persistent pain or pain at dressing changes or debridement." | 2.42 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2003) |
| "Pain was defined as either persistent pain or pain at dressing changes or debridement." | 2.41 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2000) |
| "If untreated, the pain of circumcision causes both short and long term changes in infant behaviours." | 2.41 | Pain management for neonatal circumcision. ( Taddio, A, 2001) |
| " Physicians must adhere to recommendations to avoid mucous membrane contact and ensure appropriate dosing with these agents." | 2.40 | Topical anesthesia. ( Keyes, PD; Rizos, J; Tallon, JM, 1998) |
| "Apart from short-term effects, untreated pain and stressful stimuli may also have long-term effects, which may later affect their neurological development, including the reaction to pain." | 2.40 | Pain management in neonates. ( Larsson, BA, 1999) |
| "Lidocaine has a shorter time lapse (1-3 min) when used on mucus membrane; however, the effect of lidocaine for desensitization of skin has shown variable results in humans." | 1.72 | Lidocaine spray 10% prior to intravenous catheterisation in dogs. ( Haga, HA; Heggernes Softeland, M; Hoeberg, E; Lervik, A; Loken Kolstad, T; Moller, LM; Rosvold, SK, 2022) |
| "FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety." | 1.39 | Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology. ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013) |
| "Facial burns are quite common among children." | 1.36 | Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients. ( Kargi, E; Tekerekoğlu, B, 2010) |
| "Alleviating pain is of high importance for children undergoing chemotherapy." | 1.36 | Pain reduction in children during port-à-cath catheter puncture using local anaesthesia with EMLA™. ( Gerr, H; Grigull, L; Hoy, L; Klein, C; Leonhardt, J; Linderkamp, C; Lüllmann, B; Metzelder, M, 2010) |
| "Chronic pain is often a symptom after local anaesthetic-induced nerve injury." | 1.36 | Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010) |
| "Self-reporting of pain is considered to be the primary source of information on pain intensity for older children but a validated observational tool will provide augment information to self-reports during painful procedures." | 1.35 | The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years. ( Finnström, B; Kokinsky, E; Nilsson, S, 2008) |
| "Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents." | 1.35 | Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009) |
| "Immunization pain is a global public health issue." | 1.34 | Routine immunization practices: use of topical anesthetics and oral analgesics. ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007) |
| "Instead, referred pain is most likely a consequence of misinterpretation of the origin of input from the stimulated focal pain area, due to excitation of neurones somewhere along the neuroaxis with projected fields in the referred pain area." | 1.32 | Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans. ( Hansson, P; Kosek, E, 2003) |
| "Most subjects reported tooth sensitivity (recall 84." | 1.31 | Factors affecting patients' and potential patients' choices among anaesthetics for periodontal recall visits. ( Gafni, A; Matthews, DC; Rocchi, A, 2001) |
| "The pain was measured by using a visual analog scale (VAS)." | 1.31 | Pain experience during transvaginal aspiration of immature oocytes. ( Hildebrandt, NB; Høst, E; Mikkelsen, AL, 2001) |
| "Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics." | 1.30 | Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine. ( Guler, N; Sumer, M; Uckan, S; Ungor, M, 1998) |
| "In fact, the nurse coached more, and trends suggested that children coped more with typical care than with EMLA." | 1.30 | Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations. ( Blount, RL; Cohen, LL; Cohen, RJ; Schaen, ER; Zaff, JF, 1999) |
Research
Studies (423)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (6.86) | 18.7374 |
| 1990's | 146 (34.52) | 18.2507 |
| 2000's | 153 (36.17) | 29.6817 |
| 2010's | 81 (19.15) | 24.3611 |
| 2020's | 14 (3.31) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sharara-Chami, R | 2 |
| El-Hout, Y | 2 |
| Lakissian, Z | 2 |
| Hafez, B | 1 |
| Abi-Gerges, C | 1 |
| Fayad, J | 1 |
| Charafeddine, L | 2 |
| Tazian, V | 1 |
| Tamim, H | 1 |
| Zaghal, A | 1 |
| Babandi, RM | 1 |
| Agboghoroma, OC | 1 |
| Durojaiye, KW | 1 |
| Jimoh, KO | 1 |
| Essiet, EA | 1 |
| Junputipong, N | 1 |
| Rojhirunsakool, S | 1 |
| Deewongkij, P | 1 |
| Kamanamool, N | 1 |
| Udompataikul, M | 1 |
| Liu, HM | 1 |
| Wu, TJ | 1 |
| Liou, CM | 1 |
| Chiu, WK | 1 |
| Kang, YN | 1 |
| Chen, C | 1 |
| Hoeberg, E | 1 |
| Loken Kolstad, T | 1 |
| Moller, LM | 1 |
| Rosvold, SK | 1 |
| Heggernes Softeland, M | 1 |
| Haga, HA | 1 |
| Lervik, A | 1 |
| Ergün, O | 1 |
| Öztürk, SA | 1 |
| Aydemir, S | 1 |
| Roongpisuthipong, W | 3 |
| Christensen, RE | 3 |
| Dirr, MA | 3 |
| Anvery, N | 3 |
| Geisler, A | 3 |
| Schaeffer, M | 3 |
| Waldman, A | 3 |
| Brieva, JC | 3 |
| Alam, M | 3 |
| Zhang, E | 1 |
| Zhao, X | 1 |
| Li, T | 2 |
| Wang, M | 1 |
| Gao, J | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Zhang, L | 1 |
| Park, TH | 1 |
| Stevic, M | 1 |
| Vlajkovic, A | 1 |
| Trifunovic, B | 1 |
| Rakic, I | 1 |
| Ristic, N | 1 |
| Budic, I | 1 |
| Marjanovic, V | 1 |
| Jovanovski-Srceva, M | 1 |
| Simic, D | 1 |
| Moraes, GS | 1 |
| Santos, IBD | 1 |
| Pinto, SCS | 1 |
| Pochapski, MT | 1 |
| Farago, PV | 2 |
| Pilatti, GL | 1 |
| Santos, FA | 1 |
| Modekwe, VI | 1 |
| Ugwu, JO | 1 |
| Ekwunife, OH | 1 |
| Osuigwe, AN | 1 |
| Obiechina, SO | 1 |
| Okpalike, IV | 1 |
| Orakwe, JC | 1 |
| Tulaci, KG | 1 |
| Arslan, E | 1 |
| Tulaci, RG | 1 |
| Yazici, H | 1 |
| Tanaboonyawat, S | 1 |
| Choontanom, R | 1 |
| Rossi, S | 1 |
| Buonocore, G | 2 |
| Bellieni, CV | 2 |
| Höbek Akarsu, R | 1 |
| Kuş, B | 1 |
| Doğukan Akarsu, G | 1 |
| Schreiber, S | 2 |
| Cozzi, G | 2 |
| Patti, G | 1 |
| Taddio, A | 13 |
| Montico, M | 1 |
| Pierobon, C | 1 |
| Barbi, E | 2 |
| Sari, E | 1 |
| Bakar, B | 1 |
| Grosse-Steffen, T | 1 |
| Krämer, M | 1 |
| Tuschy, B | 1 |
| Weiss, C | 1 |
| Sütterlin, M | 1 |
| Berlit, S | 1 |
| Luh, JJ | 1 |
| Huang, WT | 1 |
| Lin, KH | 1 |
| Huang, YY | 1 |
| Kuo, PL | 1 |
| Chen, WS | 1 |
| Milad, N | 1 |
| Yu, W | 1 |
| Wang, T | 1 |
| Zhu, J | 1 |
| Qiu, Y | 1 |
| Chen, H | 1 |
| Jin, Y | 1 |
| Yang, X | 1 |
| Hu, X | 1 |
| Chang, L | 1 |
| Chen, Y | 1 |
| Ma, G | 1 |
| Lin, X | 1 |
| Jang, YJ | 1 |
| Kim, HO | 1 |
| Wambier, LM | 1 |
| de Geus, JL | 1 |
| Boing, TF | 1 |
| Brancher, JA | 1 |
| Chibinski, AC | 1 |
| Wambier, DS | 1 |
| Loguercio, AD | 1 |
| Reis, A | 1 |
| Anup, K | 1 |
| Pawan, V | 1 |
| Niraj, K | 1 |
| Biswajit, N | 1 |
| Nayan, MK | 1 |
| Arnau, B | 2 |
| Jovell, E | 2 |
| Redón, S | 1 |
| Canals, M | 1 |
| Mir, V | 1 |
| Jiménez, E | 1 |
| Lee, SH | 2 |
| Lee, NY | 1 |
| Alagna, MG | 1 |
| Selder, J | 1 |
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| Hughes, C | 1 |
| Hardy, SP | 1 |
| Matthews, JN | 1 |
| Coulthard, MG | 2 |
| Joyce, PW | 2 |
| Sunderraj, P | 2 |
| Villada, J | 1 |
| Kirby, J | 2 |
| Watson, A | 2 |
| Keller, RJ | 1 |
| Elliott, C | 1 |
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| Morris, S | 1 |
| Wright, EM | 1 |
| Campbell, IA | 1 |
| Mapleson, WW | 1 |
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| Ziegler, JB | 1 |
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| Nilsson, A | 2 |
| Boman, I | 1 |
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| Schwartz, R | 1 |
| Sheridan, MJ | 1 |
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| Sicherer, SH | 1 |
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| van Kan, HJ | 1 |
| Egberts, AC | 1 |
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Clinical Trials (73)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Music as an Adjunct to Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial[NCT04252313] | 206 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | |||
| "Clinical Study on Pain Control of Cervical Dilation by Lidocaine Solution Injected Into a Single-use Micro-non-invasive Injection Cervical Dilator"[NCT05955768] | 74 participants (Anticipated) | Interventional | 2023-07-21 | Enrolling by invitation | |||
| Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children[NCT05233683] | Phase 3 | 120 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | ||
| The Influence of Vasopressin on Observational Learning of Placebo Analgesia[NCT03446456] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2018-09-17 | Terminated (stopped due to Due to COVID-19,) | ||
| "Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623] | 300 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electromyography in Pediatric Population-A Randomized Controlled Trial[NCT04337814] | 113 participants (Actual) | Interventional | 2019-12-30 | Completed | |||
| Treatment of Acral Vitiligo : Narrowband Ultraviolet-B and Microneedling With and Without Platelet Rich Plasma[NCT03155698] | 50 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
| Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice: a Prospective Randomized Double Blind, Placebo-controlled Clinical Trial[NCT01303614] | Phase 4 | 100 participants (Anticipated) | Interventional | 2011-04-30 | Not yet recruiting | ||
| Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial[NCT03362905] | Phase 4 | 123 participants (Anticipated) | Interventional | 2017-12-03 | Not yet recruiting | ||
| Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device[NCT04963582] | 72 participants (Actual) | Interventional | 2021-07-05 | Completed | |||
| Effect of Adding Vaginal Isosorbide Mononitrate to Misoprostol Prior to Intrauterine Device Insertion in Women Delivered Only by Elective Cesarean Section: a Randomized Double-blind Controlled Clinical Trial[NCT03587077] | 113 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | |||
| Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172] | Early Phase 1 | 375 participants (Anticipated) | Interventional | 2019-12-10 | Recruiting | ||
| Effectiveness of the Painless Vaccination Protocol Versus Traditional Vaccination Methodology in Reducing Pain in Children Aged 2 Months to 14 Years. A Multicenter, Quasi-experimental (Non-randomized) Controlled Study[NCT06004258] | 495 participants (Actual) | Interventional | 2022-06-21 | Completed | |||
| The Effectiveness of Two Different Methods Applied During Heel Blood Collection on Pain Level of Healthy Term Newborns[NCT04625010] | 105 participants (Actual) | Interventional | 2016-03-01 | Completed | |||
| Efficacy and Safety of Different Doses of Vaginal Misoprostol Prior to Intra Uterine Contraceptive Device Insertion[NCT04273984] | Phase 4 | 180 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| A New Method for Pain Relief, Intravenous Cannulation in Pediatric Patients; A Randomized Prospective Clinical Trial.[NCT04246255] | Phase 4 | 80 participants (Actual) | Interventional | 2020-02-03 | Completed | ||
| A Randomized, Placebo-Controlled Trial to Evaluate Pain and Anxiety During Venipuncture in Pediatric Patients With or Without Pre-treatment by a Topical Anesthetic[NCT00676364] | Phase 4 | 114 participants (Actual) | Interventional | 2003-03-31 | Completed | ||
| A Randomized Control Trial of Virtual Reality to Reduce Anxiety During Pediatric Cast Removal[NCT03903510] | 184 participants (Anticipated) | Interventional | 2019-05-21 | Recruiting | |||
| Topical Morphine for Analgesia in Pediatric Procedures. Clinical Trial Randomized, Double-blind, Placebo.[NCT02300194] | Phase 4 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Withdrawn by investigators) | ||
| Randomized Controlled Trial Comparing Ultrasound-guided Pudendal Nerve Block to Ultrasound-guided Penile Nerve Block for Analgesia Following Pediatric Circumcision[NCT03914365] | 300 participants (Anticipated) | Interventional | 2019-07-01 | Active, not recruiting | |||
| Testing the Efficacy of a Vibrating, Cold Device for Pediatric IV Cannulation Pain Relief in the Emergency Department[NCT01394250] | Phase 2 | 240 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Does Alkalinization of Technetium-99m Sulfur Colloid Reduce Perceived Pain Levels During Non-breast Sentinel Lymphoscintigraphy?[NCT01660412] | 60 participants (Actual) | Interventional | 2012-08-01 | Completed | |||
| Evaluating the Efficacy of an Ablative Fractional Carbon Dioxide Laser on Pathologic Symptoms in Pediatric Hypertrophic Scars: a Prospective Split-scar Controlled Trial[NCT04236167] | 6 participants (Actual) | Interventional | 2020-11-01 | Terminated (stopped due to Lack of participants to enroll. Early findings not supportive of fractionated c02 laser improving scars in population studied when used alone.) | |||
| Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy: Randomized, Prospective Controlled Study[NCT04064047] | 284 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| A Randomized Controlled Study of Compound Lidocaine Cream to Prevent Postoperative Agitation in Patients With Endotracheal Intubation for General Anesthesia[NCT02017392] | Phase 4 | 2,000 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| Effect of Synera in Reducing Pain Associated With Venipuncture and Superficial Dermatologic Procedures[NCT01744197] | Phase 2 | 61 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547] | Phase 2 | 0 participants (Actual) | Interventional | 2016-07-14 | Withdrawn (stopped due to Lack of human ressources) | ||
| Doses Tramadol With Bupivacaine in Penial Block Improve Efficiency of Postoperative Analgésia in Children in Circumcision[NCT03260439] | 106 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Evaluation of the Effect of the Presence Of Clowns on Pain and Anxiety Seen During Injections Botulinum Toxin in Child[NCT03149263] | 80 participants (Actual) | Observational | 2015-11-10 | Completed | |||
| Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132] | 60 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| The Effect of Sonophoresis on Topical Anesthesia: a Clinical Trial[NCT01283490] | Phase 1 | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726] | 120 participants (Actual) | Interventional | 2017-06-10 | Completed | |||
| Local Anesthetic Activity of Liposomal Formulations in Dentistry[NCT01054547] | Phase 1 | 80 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Efficacy of Liposome Lidocaine Gel for Topical Anesthesia in the Palatal Mucosa[NCT01425840] | Phase 1 | 40 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| A Randomized Trial to Determine if Local Anesthesia Decreases Pain Perception in Women Undergoing Chorionic Villus Sampling[NCT03140293] | Early Phase 1 | 120 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection[NCT04794842] | Early Phase 1 | 80 participants (Actual) | Interventional | 2021-08-01 | Active, not recruiting | ||
| Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556] | Phase 3 | 46 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335] | Phase 4 | 7 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Difficulties with the recruitment) | ||
| Tetracaine (Ametop®) Compared to Placebo for Reducing Pain Associated With Intramuscular Injection of Palivizumab (Synagis®) - A Pilot Study[NCT00484393] | Phase 4 | 7 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460] | 21 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Comparing Pain Relief in Early Labor: Nitrous Oxide Versus Butorphonol Study[NCT01636999] | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn | |||
| [NCT01157247] | 88 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| A Double-Blind, Randomized Controlled Trial of Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children[NCT01628874] | 66 participants (Actual) | Interventional | 2012-09-30 | Terminated (stopped due to Due to low recruitment numbers, the study was terminated.) | |||
| Comparing The Effectiveness of Tracing Image and Coloring for Kids-Book With Two Active Distractions on Pain and Fear in Children During Venipuncture: A Randomized Controlled Trial[NCT04983303] | 150 participants (Anticipated) | Interventional | 2021-08-01 | Not yet recruiting | |||
| Comparing The Effectiveness of Tracing Image and Coloring for Kids-Book With Two Passive Distractions on Pain and Fear in Children During Peripheral Intravenous Cannulation: A Randomized Controlled Trial[NCT04977323] | 150 participants (Anticipated) | Interventional | 2021-07-28 | Not yet recruiting | |||
| Distraction in the Emergency Using Virtual Reality for Intravenous Needs in Children to Improve Comfort (DEVINCI): A Pilot Randomized Controlled Trial[NCT03750578] | 62 participants (Actual) | Interventional | 2018-12-17 | Completed | |||
| Characterization of the Pudendal Nerve With Transvaginal Ultrasonography[NCT06021782] | 24 participants (Anticipated) | Observational | 2021-05-13 | Recruiting | |||
| A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958] | Phase 1 | 30 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-11-25 | Recruiting | ||
| A Comparison of Amethocaine Creams Versus Liposomal Lidocaine Cream as Pain Reliever Prior to Venipuncture in Children at the Paediatric Emergency Department.[NCT00353002] | 0 participants (Actual) | Interventional | 2006-07-31 | Withdrawn | |||
| Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department[NCT05934669] | Phase 4 | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4[NCT00402129] | 22 participants | Interventional | 2006-01-31 | Completed | |||
| Topical Analgesia Before Inhalational Anaesthesia: A Retrospective Observational Study[NCT04959409] | 500 participants (Actual) | Observational | 2020-08-01 | Completed | |||
| Effect of Buzzy System (Vibrating Device) Compared to Topical Anaesthesia on Pain Reduction During Injection of Infiltration Anaesthesia in Children: A Randomized Clinical Trial Study.[NCT05083975] | 30 participants (Anticipated) | Interventional | 2022-07-23 | Not yet recruiting | |||
| Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861] | 230 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Childhood Immunization: Reducing Immunization Distress (RID) Using Multi-Modal Distraction[NCT01379885] | 77 participants (Actual) | Interventional | 2011-06-30 | Terminated (stopped due to Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.) | |||
| The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing[NCT04519463] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2020-09-30 | Not yet recruiting | ||
| The Efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) Cream Versus the Synera Patch for Pain Reduction During Venipuncture in Children[NCT00530803] | Phase 2 | 100 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Evaluation of Analgesia With the Use of Eutectic Mixture of Local Anesthetics (Lidocaine and Prilocaine) and Oral Solution of Glucose to 25% in Preterm Neonates During Arterial Puncture and / or the Installation of Percutaneous Catheter[NCT00808054] | Phase 4 | 60 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients[NCT05078463] | Phase 2 | 20 participants (Actual) | Interventional | 2021-09-15 | Completed | ||
| Intercostobrachial Nerve Block (ICBN) for Tourniquet Pain: Is it Necessary?[NCT03797924] | Early Phase 1 | 46 participants (Actual) | Interventional | 2019-04-25 | Completed | ||
| The Effect of Shotblocker on Pain and Patient Satisfaction for Spinal Anesthesia[NCT03554122] | 88 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Comparison of Two Analgesic Pretreatment Techniques (2% Lidocaine Infiltration vs. EMLA Cream Application) Before Spinal Needle Insertion for Pain Reduction and Maternal Satisfaction Level Assessment in Women Undergoing LSCS. A Prospective Randomized Cont[NCT04050059] | 62 participants (Actual) | Interventional | 2019-11-13 | Completed | |||
| Impact of 50% Nitrous Oxide Inhalation on Pain Induced by Lumbar Puncture in Emergency: a Double-blind Randomized Controlled Trial.[NCT03941990] | Phase 4 | 88 participants (Anticipated) | Interventional | 2019-11-27 | Recruiting | ||
| Pain Control for Intrauterine Device Placement: A Randomized Controlled Trial of Paracervical Block[NCT02219308] | 67 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366] | Phase 4 | 121 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Understanding Pediatric Symptoms and Other Symptoms[NCT00166231] | 156 participants (Actual) | Observational | 2004-03-31 | Completed | |||
| The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery[NCT01880775] | Phase 4 | 50 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients[NCT04409470] | 250 participants (Actual) | Observational | 2021-10-11 | Completed | |||
| Prospective,Randomized,Blinded, Comparative,Efficacy and Safety Trial of Vapocoolant (Pain Ease Medium Stream) for Intravenous Cannulation in Emergency Department Patients.[NCT01670487] | Phase 4 | 300 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures[NCT05294640] | Phase 4 | 95 participants (Actual) | Interventional | 2022-05-17 | Completed | ||
| A Randomized Controlled Trial Evaluating Three Non-invasive Analgesic Techniques in Pain Prevention During Injections[NCT03974633] | Phase 4 | 100 participants (Actual) | Interventional | 2018-02-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation
"Blood oxygenation level dependent (BOLD) responses will allow the identification of relative activation/deactivation in the brain as a result of events (e.g. painful stimulations) that will be given during the experiment.~Changes in the Percentage of BOLD signal are calculated as the BOLD signal in the right supplementary motor area during the 20-second heat pain divided by the whole-brain average BOLD signal during that 20-second heat pain." (NCT03446456)
Timeframe: Day 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds
| Intervention | percentage of BOLD signal change (Mean) |
|---|---|
| Saline | 0.485 |
| Arginine Vasopressin | 0.482 |
Heating Temperature
On Day 1, the heating temperature was calibrated to the individual level. The heating temperature corresponding to 50 out of 100 visual analog scale pain ratings was selected as the testing temperature for day 2 (test). (NCT03446456)
Timeframe: Day 1 (calibration)
| Intervention | celsius degree (Mean) |
|---|---|
| Saline | 44.16 |
| Arginine Vasopressin | 44.44 |
Implicit Association Test (IAT) Response Latency Difference
"The IAT is a behavioral test that examines racial biases via measuring the strength of associations between concepts (e.g., African-American, Asian, White) and evaluations (good, bad). Participants were asked to press a response key when they saw images (people) or words (good/bad) on the screen. Response latencies (RL) were measured in milliseconds using E-prime as the reaction time to press the response key. An RL difference (D) score was calculated as 1) Compute the standard deviation (SD) of RL from overall trials; 2) M1 is the mean of RL in the condition where White and good share the same response key. M2 is the mean of RL in the condition where African-American/Asian people and good share the same response key; 3) D = (M2-M1)/SD.~The D score ranges from -2 to +2. Positive values indicate a racial preference for White people. Negative values indicate a racial preference for African-American/Black or Asian people. A value close to 0 indicates no racial preference." (NCT03446456)
Timeframe: Day 1
| Intervention | difference score (Mean) |
|---|---|
| Saline | 0.03 |
| Arginine Vasopressin | 0.07 |
Pain Ratings
Participants will provide their pain on a Visual Analogue Scale raging from 0=no pain to 100= maximum unbearable pain. Normal value will be absence of pain. (NCT03446456)
Timeframe: Day 2 (test)
| Intervention | units on a scale (Mean) |
|---|---|
| Saline | 44.84 |
| Arginine Vasopressin | 47.19 |
Participants With Edema
Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Participants With Erythema
Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Lactate
A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.
| Intervention | mmol/L (Mean) | |
|---|---|---|
| Lactate before pushups | Lactate after pushups | |
| Compound Exercise of Push-ups | 1.51 | 7.69 |
Level of Pain
Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | |
| Compound Exercise of Push-ups | .14 | .19 | .13 |
| Ibuprofen | .39 | .56 | .28 |
| Placebo | .19 | .22 | .06 |
Serologic Response - A/California/7/2009
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 214.80 | 345.09 |
| Ibuprofen | 171.00 | 239.25 |
| Placebo | 216.75 | 343.03 |
Serologic Response - A/Hong Kong / 4801/2014
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 149.22 | 232.58 |
| Ibuprofen | 177.78 | 243.13 |
| Placebo | 221.09 | 296.66 |
Serologic Response - B/Brisbane/60/2008
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 26.00 | 41.02 |
| Ibuprofen | 17.41 | 25.47 |
| Placebo | 26.09 | 34.09 |
Serologic Response - B/Phuket/3073/2013
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 32.89 | 49.07 |
| Ibuprofen | 40.16 | 47.34 |
| Placebo | 36.69 | 44.78 |
Anxiety of Venipuncture
Participant anxiety was measured by the study participant and the objective observer before (anticipatory), during (venipuncture) and after (recovery) venipuncture using a validated visual analog scale (VAS). The VAS is a validated scale that is used to detect small changes in many types of observations. The scale ranges from 0-100 scores on a scale, and here the higher scores indicate higher anxiety levels. Only the participant's mean venipuncture (during venipuncture) anxiety scores are presented in outcome measure results here. (NCT00676364)
Timeframe: During venipuncture
| Intervention | scores on a scale (Mean) |
|---|---|
| ControI Group Receiving Placebo Cream | 43.1 |
| Investigational Group | 40.5 |
Pain From Venipuncture
"Pain was measured immediately after venipuncture by the participant using the six-point FACES scale. FACES in not an acronym, but rather a description of a pain scale that uses pictures of faces in various states of pain. The FACES pain scale is a common scale used to measure pain with scores on a scale. The scale we used had six points from zero (0) to five (5) indicating different levels of pain. Lower scores indicate lower levels of pain, and higher scores indicate higher levels of pain." (NCT00676364)
Timeframe: Pain was measured immediately after venipuncture.
| Intervention | scores on a scale (Mean) |
|---|---|
| ControI Group Receiving Placebo Cream | 2.2 |
| Investigational Group Receiving 4% Lidocaine Cream | 2.1 |
Change From Baseline in Faces Pain Scale Revised (FPS-R) at 30 Minutes After IV Cannulation
"The Faces Pain Scale Revised (FPS-R) is numerical self-report measure of pain intensity developed for children to score the sensation of pain from 0-10. Pictures of 6 cartoon faces ranging from neutral expression of no pain (0) to very much pain (10)." (NCT01394250)
Timeframe: Baseline and 30 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Buzzy® | -3.544 |
| Topical Lidocaine 4% Cream | -3.436 |
Comparison of the Face, Legs, Activity, Cry, Consolability Scale (FLACC) Score Immediately After IV Cannulation Between Groups
The Face, Legs, Activity, Cry, Consolability scale or FLACC scale is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2. The FLACC score was completed immediately after IV cannulation by a member of the clinical care team who was not part of the study. During initial trial design, the goal was to collect FLACC score pre and post cannulation; however, it was decided prior to enrollment that FLACC score would not be collected pre cannulation, only post. (NCT01394250)
Timeframe: Up to 5 minutes after IV Cannulation
| Intervention | units on a scale (Median) |
|---|---|
| Buzzy® | 0.667 |
| Topical Lidocaine 4% Cream | 0.333 |
Perceived Pain Level
Immediately after receiving an injection, subjects will rate their perceived pain level, using a validated measure. Subject was asked to quantify the pain of every injection using a validated scale from 0 through 10, with 0 being no pain and 10 being severe pain that is disabling. The effect of treatment was estimated by taking the difference of the mean buffered and SOC pain scores and a paired t-test was used to test whether the mean difference was significantly different from 0. Perceived pain levels assessed after each injection were averaged for each participant. (NCT01660412)
Timeframe: immediately after administration (<1 min) of each injection (up to total 5 minutes)
| Intervention | units on a scale (Mean) |
|---|---|
| Standard of Care Injection | 5.81 |
| PH Altered Injection | 4.39 |
Global Assessment of Satisfaction With Venipuncture
Rates of Satisfied and very satisfied are used to be compared between two groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.
| Intervention | percentage of participants (Number) |
|---|---|
| Synera | 74.0 |
| Placebo | 53.7 |
Percentage of Patients With No or Minor Pain (VAS<3)
The primary efficacy endpoint is the subject's report of pain intensity regarding the venipuncture using a 0-10 VAS. The VAS <3 is considered as patients with no or minor pain and would be compared between 2 groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.
| Intervention | percentage of participants (Number) |
|---|---|
| Synera | 38.0 |
| Placebo | 21.3 |
Percentage of Patients With No Pain (VAS=0)
The primary efficacy endpoint is the subject's report of pain intensity regarding the venipuncture using a 0-10 VAS. The VAS =0 is considered as patients with no pain and would also be compared between 2 groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.
| Intervention | percentage of participants (Number) |
|---|---|
| Synera | 19.4 |
| Placebo | 8.3 |
To Determine if a Difference in Pain Scale Ratings is Detectable Following Intramuscular Palivizumab Injection That Was Pre-treated With Placebo or Tetracaine.
Parent score 1-10 (1 representing no pain and 10 representing extreme pain) FLACC (Face, Legs, Activity, Cry, Consolability) Score 0-10 (at baseline and post injection) (0 representing no pain and 10 representing extreme pain) Change in FLACC score (NCT00484393)
Timeframe: 2 visits, 1 month apart
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Parent score | FLACC at baseline | FLACC post injection | Change in FLACC | |
| Placebo | 7.3 | 1.6 | 9.3 | 7.7 |
| Tetracaine | 7.3 | 1.7 | 8.4 | 6.7 |
Number of Participants With Lumbar Puncture Success
The success of lumbar puncture was defined as obtaining Cerebrospinal fluid (CSF) on the first attempt and <1000 Red Blood Cells/millimeter cubed (NCT01628874)
Timeframe: Immediately following lumbar puncture
| Intervention | Participants (Count of Participants) |
|---|---|
| EMLA Cream, Then Placebo Via J-Tip | 8 |
| Placebo Cream, Then Lidocaine Via J-Tip | 16 |
Pain Score
The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: At Needle Insertion
| Intervention | score on a scale (Median) |
|---|---|
| EMLA Cream, Then Placebo Via J-Tip | 5 |
| Placebo Cream, Then Lidocaine Via J-Tip | 5 |
Pain Score
The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: At time J-TIP is used
| Intervention | score on a scale (Median) |
|---|---|
| EMLA Cream, Then Placebo Via J-Tip | 5 |
| Placebo Cream, Then Lidocaine Via J-Tip | 5 |
Pain Score
The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: Immediately Post-Procedure
| Intervention | score on a scale (Median) |
|---|---|
| EMLA Cream, Then Placebo Via J-Tip | 0 |
| Placebo Cream, Then Lidocaine Via J-Tip | 0 |
Change in Heart Rate
Heart rate was measured at 5 points in time (pre-procedure, application of J-Tip, at LP needle insertion, while the needle is in place, and post-procedure) and was compared for significant differences (NCT01628874)
Timeframe: At 5 specific points during the procedure
| Intervention | Beats per Minute (Mean) | ||||
|---|---|---|---|---|---|
| Pre-procedure | J-Tip application | Needle insertion | Needle in place | Post-procedure | |
| EMLA Cream, Then Placebo Via J-Tip | 154 | 160 | 170 | 172 | 157 |
| Placebo Cream, Then Lidocaine Via J-Tip | 156 | 167 | 169 | 178 | 159 |
Blinded Observer's Subjective Ratings of Participants' Pain Level at Tourniquet Placement, Using a 6-point NRS
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at tourniquet placement. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: before venipuncture
| Intervention | Participants (Count of Participants) | |||||
|---|---|---|---|---|---|---|
| Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
| EMLA Cream | 41 | 6 | 2 | 1 | 0 | 0 |
| Synera Patch | 37 | 6 | 5 | 1 | 1 | 0 |
Blinded Observer's Subjective Ratings of the Participant's Pain Level at 5 Minutes Post Venipuncture Procedure, Using a 6-point NRS
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain participants were experiencing 5 minutes after the venipuncture was completed. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: 5 minutes post venipuncture
| Intervention | Participants (Count of Participants) | |||||
|---|---|---|---|---|---|---|
| Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
| EMLA Cream | 45 | 3 | 1 | 1 | 0 | 0 |
| Synera Patch | 45 | 4 | 1 | 0 | 0 | 0 |
Blinded Observer's Subjective Ratings of the Participant's Pain Level at Needle Insertion, Using a 6-point NRS
The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at needle insertion. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: during needle insertion
| Intervention | Participants (Count of Participants) | |||||
|---|---|---|---|---|---|---|
| Participants evaluated at NRS = 0 (No pain) | Participants evaluated at NRS = 1 | Participants evaluated at NRS = 2 | Participants evaluated at NRS = 3 | Participants evaluated at NRS = 4 | Participants evaluated at NRS = 5 | |
| EMLA Cream | 32 | 14 | 2 | 2 | 0 | 0 |
| Synera Patch | 25 | 12 | 9 | 2 | 2 | 0 |
Parent Rating of Child's Pain Using a 6-point NRS
The Numerical Rating Scale (NRS) is a 6-point rating scale where 0= no pain and 5 = worst pain. Parents reported their own subjective evaluation of participants pain level. Each participant had only one parental assessment. Total number of parental assessment for each pain level on the 6-point NRS is reported as total number of participants experiencing that pain level. (NCT00530803)
Timeframe: immediately after venipuncture is completed
| Intervention | Participants (Count of Participants) | |||||
|---|---|---|---|---|---|---|
| number of participants with NRS=0 (no pain) | number of participants with NRS=1 | number of participants with NRS=2 | number of participants with NRS=3 | number of participants with NRS=4 | number of participants with NRS=5 | |
| EMLA Cream | 42 | 6 | 1 | 1 | 0 | 0 |
| Synera Patch | 41 | 5 | 1 | 2 | 0 | 1 |
Participants Self-rating of Pain Using the Wong-Baker FACES Pain Rating Scale.
"Participants were asked to report their level of pain using a 6-point Wong-Baker FACES Pain Rating Scale ranging from 0, no pain, to 5, the most pain you can have. The Wong-Baker FACES Pain Rating Scale is a validated tool for measuring pain in patients as young as 3 years old. A FACES pain score less than or equal to 2 is considered no pain to mild pain, and is clinically acceptable. Studies have shown average FACES pain scores for children receiving vascular access with placebo to be 2.2 to 3.5." (NCT00530803)
Timeframe: immediately after completion of venipuncture
| Intervention | Participants (Count of Participants) | |||||
|---|---|---|---|---|---|---|
| Participants with FACES Score = 0 (No pain) | Participants with FACES Score = 1 | Participants with FACES Score = 2 | Participants with FACES Score = 3 | Participants with FACES Score = 4 | Participants with FACES Score = 5 | |
| EMLA Cream | 42 | 6 | 2 | 0 | 0 | 0 |
| Synera Patch | 38 | 8 | 3 | 1 | 0 | 0 |
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Mechanical Thresholds (Mechanical Detection and Pain).
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Thermal Threshold Detection (Warmth and Heat Pain)
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
Pain With Intrauterine Device (IUD) Placement
Distance (mm) from the left of the 100-mm visual analog scale (reflecting magnitude of pain) recorded at time of IUD Placement. Scale range is from 0mm (no pain) to 100mm (worst pain possible). A lower score (less pain) is considered a better outcome. (NCT02219308)
Timeframe: Moment of IUD insertion
| Intervention | mm (Median) |
|---|---|
| No Paracervical Block (Sham PCB) | 54 |
| Paracervical Block (PCB) | 33 |
Median Pain Scores for All Time Points
Distance (mm) from the left of the 100-mm visual analog scale of pain at various time points. Scale range is 0mm (no pain) to 100mm (worst pain possible). Lower scores are considered better outcomes. (NCT02219308)
Timeframe: Anticipation of procedure through 5 minutes after IUD placement
| Intervention | mm (Median) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Anticipated Pain | Baseline Pain | Speculum Insertion | Capped Needle or PCB | Tenaculum placement | Uterine Sounding | IUD placement | 5 mins after IUD placement | Overall pain | |
| No Paracervical Block (Sham PCB) | 51 | 0 | 6 | 8 | 10 | 47 | 54 | 27 | 51 |
| Paracervical Block (PCB) | 58 | 0 | 10 | 30 | 15 | 30 | 33 | 12 | 30 |
Pain Score on the Numeric Rating Scale (NRS)
Numeric rating scale (NRS) 0-10 : 0 (no pain) - 5 (moderate pain) - 10 (worst pain). Scores to be utilized after stream device applied and after intravenous catheter placement. (NCT01670487)
Timeframe: pain of intravenous catheter placement.
| Intervention | NRS (Mean) |
|---|---|
| Vapocoolant (Pain Ease Medium Stream) | 2.3 |
| Placebo (Nature's Tears) | 4.3 |
Reviews
40 reviews available for prilocaine and Ache
| Article | Year |
|---|---|
Patient Comfort with Various Local Infiltration Anesthetics for Minor Oculoplastic Surgery: A Systematic Review and Network Meta-Analysis.
Topics: Anesthesia, Local; Anesthetics, Local; Bicarbonates; Double-Blind Method; Epinephrine; Felypressin; | 2022 |
Topical anesthetics for pediatric laser treatment.
Topics: Anesthetics, Local; Drug Combinations; Drug Therapy, Combination; Humans; Lidocaine; Low-Level Light | 2019 |
Management of pain in newborn circumcision: a systematic review.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Dr | 2021 |
Analgesia for infants' circumcision.
Topics: Administration, Cutaneous; Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Infant; Lidoca | 2013 |
WITHDRAWN: EMLA and Amethocaine for reduction of children's pain associated with needle insertion.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Humans; Infant; Lidocaine; Lidocaine, Prilo | 2014 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Breastfeeding for procedural pain in infants beyond the neonatal period.
Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care | 2016 |
Breastfeeding for procedural pain in infants beyond the neonatal period.
Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care | 2016 |
Breastfeeding for procedural pain in infants beyond the neonatal period.
Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care | 2016 |
Breastfeeding for procedural pain in infants beyond the neonatal period.
Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care | 2016 |
Topical anesthetic creams.
Topics: Administration, Topical; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinati | 2008 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bandages; Debridement; Humans | 2010 |
Clinical inquiries. What's the best way to control circumcision pain in newborns?
Topics: Anesthetics, Local; Circumcision, Male; Equipment and Supplies; Evidence-Based Medicine; Humans; Inf | 2011 |
Analgesia for amniocentesis or chorionic villus sampling.
Topics: Amniocentesis; Analgesia; Anesthesia, Local; Chorionic Villi Sampling; Cryoanesthesia; Female; Human | 2011 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Vulvar biopsy. Techniques for reducing patient discomfort.
Topics: Anesthetics, Local; Biopsy; Female; Hemostatic Techniques; Humans; Lidocaine; Lidocaine, Prilocaine | 2001 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Li | 2003 |
Pain management in nursing procedures on premature babies.
Topics: Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Prilocaine Dru | 2003 |
Topical local anesthetics.
Topics: Administration, Cutaneous; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Humans; Lidocain | 2003 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
The use of EMLA cream to decrease venipuncture pain in children.
Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Pain relief for neonatal circumcision.
Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P | 2004 |
Local approaches to the pain of pressure ulcers.
Topics: Administration, Cutaneous; Amitriptyline; Anesthetics, Local; Bandages; Humans; Lidocaine; Lidocaine | 2005 |
Use of a eutectic mixture of lidocaine 2.5% and prilocaine 2.5% as a local anesthetic in animals.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Animals; Drug Combinations; Drug | 2005 |
Topical anesthetics for dermal instrumentation: a systematic review of randomized, controlled trials.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Biopsy, N | 2005 |
EMLA and amethocaine for reduction of children's pain associated with needle insertion.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Humans; Infant; Lidocaine; Lidocaine, Prilo | 2006 |
Recent advances in acute pain management.
Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; | 1995 |
Eutectic lidocaine/prilocaine cream. A review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA).
Topics: Anesthetics, Local; Animals; Drug Combinations; Drug Evaluation; Drug Tolerance; Humans; Lidocaine; | 1993 |
Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation.
Topics: Adolescent; Age Factors; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D | 1994 |
Topical anesthesia and pain management before venipuncture.
Topics: Administration, Cutaneous; Adolescent; Anesthesia, Local; Anesthetics, Local; Bloodletting; Child; C | 1993 |
Use of the eutectic mixture of local anesthetics in young children for procedure-related pain.
Topics: Anesthetics, Local; Child; Child, Preschool; Clinical Trials as Topic; Drug Combinations; Humans; In | 1993 |
Management of painful procedures in the newborn.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Drug Combinations; Hum | 1996 |
Topical anesthetic agents in dermatologic surgery. A review.
Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Child; Dermatologic Surgica | 1997 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan | 1998 |
Topical anesthesia.
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Child; Cocaine; Drug Combinations; Epinephrine; Hu | 1998 |
[Pharma clinics. How I treat...or preventing pain with "patches"].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Fentanyl; Lidocaine; Lidocaine, P | 1998 |
Reducing the pain of venipuncture.
Topics: Anesthetics, Local; Ethyl Chloride; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; | 1999 |
Pain management in neonates.
Topics: Anesthesia, Conduction; Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Lidocaine; L | 1999 |
Getting the 'ouch' out. Topical anesthesia for procedural pain in children.
Topics: Administration, Topical; Anesthetics, Local; Child; Humans; Lidocaine; Lidocaine, Prilocaine Drug Co | 1999 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Anesthetics, Local; Bandages; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pril | 2000 |
[Analgesia for infants. A review of randomized trials].
Topics: Administration, Oral; Analgesia; Anesthetics, Combined; Anesthetics, Local; Databases, Bibliographic | 2000 |
Pain management for neonatal circumcision.
Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Hum | 2001 |
Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Gels; Humans; Infa | 2002 |
[Lidocaine-prilocaine ointment; a welcome addition in local anesthesia].
Topics: Absorption; Anesthesia, Local; Child; Condylomata Acuminata; Drug Combinations; Female; Humans; Lido | 1991 |
Trials
274 trials available for prilocaine and Ache
| Article | Year |
|---|---|
Music as an adjunct to combination analgesia for neonatal circumcision: A randomized controlled trial.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Lidocaine; Lidoc | 2022 |
Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo.
Topics: Diclofenac; Female; Humans; Hysterosalpingography; Lidocaine; Pain; Prilocaine; Prospective Studies | 2021 |
A Randomized Controlled Trial Comparing Two Different Local Intraurethral Anesthetics in Optical Internal Urethrotomy at the Outpatient Clinic.
Topics: Ambulatory Care Facilities; Anesthetics, Local; Constriction, Pathologic; Humans; Lidocaine; Pain; P | 2022 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine, | 2023 |
Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial.
Topics: Airway Extubation; Anesthesia, General; Anesthetics, Local; Cough; COVID-19; Double-Blind Method; Ep | 2023 |
Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Chronic Periodontitis; Dental Scaling; Double-B | 2020 |
Comparison of the efficacy of eutectic mixture of local anesthetics (EMLA) and dorsal penile nerve block (DPNB) in neonatal circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Lidocain | 2019 |
Cryoanalgesic versus EMLA® cream to reduced pain during analgesic injection in upper eyelid surgery: a randomized trial.
Topics: Analgesics; Anesthesia, Local; Anesthetics, Local; Eyelids; Humans; Lidocaine; Lidocaine, Prilocaine | 2021 |
Effects of Valsalva Maneuver, EMLA Cream, and Stress Ball for Pregnant Women's Venipuncture Pain.
Topics: Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Phlebot | 2021 |
Does the Application of Heat Gel Pack After Eutectic Mixture of Local Anesthetic Cream Improve Venipuncture or Intravenous Cannulation Success Rate in Children? A Randomized Control Trial.
Topics: Anesthetics, Local; Child; Child, Preschool; Female; Hot Temperature; Humans; Lidocaine; Lidocaine, | 2018 |
Which is more effective for pain relief during fractionated carbon dioxide laser treatment: EMLA cream or forced cold air anesthesia?
Topics: Ablation Techniques; Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Cryotherapy; Face; Fe | 2018 |
Topic anaesthesia with a eutectic mixture of lidocaine/prilocaine cream after elective caesarean section: a randomised, placebo-controlled trial.
Topics: Adult; Analgesics; Anesthesia, Local; Anesthetics, Local; Cesarean Section; Double-Blind Method; Dru | 2017 |
Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Double-Blind Method; Drug Therapy, Combination; F | 2017 |
EMLA cream does not influence efficacy and pain reduction during pulsed-dye laser treatment of port-wine stain: a prospective side-by-side comparison.
Topics: Female; Humans; Lasers, Dye; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; P | 2018 |
[The Effect of Pain Relieving Intervention During Infiltration among Gamma Knife Surgery Patients for Stereotactic Frame Fixation].
Topics: Aged; Anesthetics, Local; Blood Pressure; Female; Heart Rate; Humans; Hypothermia, Induced; Lidocain | 2018 |
A Randomized Clinical Trial Evaluating Rubber Dam Clamp Pain Reduction from a New Topical Liposomal Anesthetic Gel.
Topics: Anesthetics, Local; Child; Dental Anxiety; Dental Caries; Female; Gels; Humans; Lidocaine; Liposomes | 2018 |
A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience.
Topics: Administration, Rectal; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; | 2013 |
Lidocaine-prilocaine (EMLA(®) ) cream as analgesia in hysteroscopy practice: a prospective, randomized, non-blinded, controlled study.
Topics: Anesthetics, Local; Cervix Uteri; Female; Humans; Hysteroscopy; Lidocaine; Lidocaine, Prilocaine Dru | 2013 |
Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Capsaicin; Cryotherapy; Double-Blind Method; Female; Follow-Up Studies; Humans; Lidocaine; Li | 2013 |
Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy.
Topics: Adult; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; H | 2013 |
The effects of Valsalva maneuver on venipuncture pain in children: comparison to EMLA(®) (lidocaine-prilocaine cream).
Topics: Anesthetics, Local; Child; Drug Combinations; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug | 2014 |
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double- | 2014 |
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double- | 2014 |
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double- | 2014 |
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double- | 2014 |
The use of skin needling for the delivery of a eutectic mixture of local anesthetics.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Drug Delive | 2014 |
Anesthetic comparisons of 4% concentrations of articaine, lidocaine, and prilocaine as primary buccal infiltrations of the mandibular first molar: a prospective randomized, double-blind study.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Carticaine; Cross-Over Studies; Dental Pulp; Double-B | 2014 |
Using the mouse grimace scale to assess pain associated with routine ear notching and the effect of analgesia in laboratory mice.
Topics: Analgesics; Animal Identification Systems; Animals; Ear; Facial Expression; Lidocaine; Lidocaine, Pr | 2015 |
Lidocaine-prilocaine cream as analgesia for hysterosalpingography: a randomized, double blinded, controlled study.
Topics: Adult; Analgesia; Anesthesia, Local; Anesthetics, Local; Contrast Media; Double-Blind Method; Drug C | 2014 |
A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection.
Topics: Acetylcholine Release Inhibitors; Adult; Aerosols; Anesthetics, Local; Botulinum Toxins, Type A; Cos | 2015 |
Opposite effects of the same drug: reversal of topical analgesia by nocebo information.
Topics: Administration, Topical; Adult; Analgesia; Anesthetics, Local; Emotions; Female; Humans; Lidocaine; | 2015 |
Novel approach for pain control in patients undergoing prostate biopsy: iliohypogastric nerve block with or without topical application of prilocaine-lidocaine: a randomized controlled trial.
Topics: Administration, Rectal; Administration, Topical; Anesthesia, Local; Anesthetics, Local; Endoscopic U | 2015 |
Lidocaine-Prilocaine Cream as Analgesia for IUD Insertion: A Prospective, Randomized, Controlled, Triple Blinded Study.
Topics: Adult; Analgesia; Anesthetics, Combined; Double-Blind Method; Female; Humans; Intrauterine Devices; | 2015 |
Comparison of pain perception during miniscrew placement in orthodontic patients with a visual analog scale survey between compound topical and needle-injected anesthetics: A crossover, prospective, randomized clinical trial.
Topics: Administration, Topical; Adolescent; Adult; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, | 2016 |
Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum.
Topics: Anesthetics, Local; Child; Child, Preschool; Cryotherapy; Drug Combinations; Drug Tolerance; Female; | 2016 |
In vitro and in vivo Evaluation of New Topical Anaesthetic Cream Formulated with Palm Oil Base.
Topics: Anesthetics, Local; Drug Combinations; Female; Healthy Volunteers; Humans; Lidocaine; Male; Pain; Pa | 2017 |
A Randomized Trial on the Efficacy of Topical Anesthesia for Pain Reduction during Frame Placement for Gamma Knife Radiosurgery.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Brain Diseases; Forehead; Humans; Lidocain | 2016 |
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; | 2017 |
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; | 2017 |
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; | 2017 |
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; | 2017 |
First-time success with needle procedures was higher with a warm lidocaine and tetracaine patch than an eutectic mixture of lidocaine and prilocaine cream.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Female; Hot Temperature; H | 2017 |
Optimizing local anesthesia for grommet insertion: eutectic mixture of local anaesthetics versus Ametop: a randomized clinical trial.
Topics: Anesthetics, Local; Double-Blind Method; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; | 2008 |
A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroi | 2009 |
Thyroid fine needle aspiration biopsy: is topical local anaesthesia beneficial?
Topics: Administration, Cutaneous; Adult; Analgesics; Anesthesia, Local; Anesthetics, Local; Biopsy, Fine-Ne | 2010 |
Interventions to reduce pain during vaccination in infancy.
Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Breast Feeding; Child, Prescho | 2009 |
Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial.
Topics: Administration, Topical; Aged; Analgesia; Analysis of Variance; Biopsy, Needle; Chi-Square Distribut | 2009 |
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, | 2009 |
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, | 2009 |
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, | 2009 |
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics, | 2009 |
Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study.
Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Humans; Lidocaine; | 2009 |
Comparison of three analgesic treatment protocols for pain management during extracorporeal shock wave lithotripsy.
Topics: Adult; Analgesia; Anesthetics, Combined; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal | 2009 |
Amethocaine versus EMLA for successful intravenous cannulation in a children's emergency department: a randomised controlled study.
Topics: Administration, Topical; Adolescent; Anesthetics, Combined; Anesthetics, Local; Catheterization; Chi | 2009 |
Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Delivery, Obstetric; Epis | 2009 |
Pregnancy at term does not alter the responses to a mechanical and an electrical stimulus after skin EMLA application.
Topics: Adult; Anesthetics, Local; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Electric S | 2009 |
Comparison of local anesthetic effects of tramadol with prilocaine during circumcision procedure.
Topics: Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Child; Circumcision, Male; Double-Blind M | 2010 |
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial.
Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Disinfectants; Edema; Erythema; | 2009 |
The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Dry Socket; Eugenol; Fema | 2010 |
[Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch].
Topics: Administration, Cutaneous; Adolescent; Anesthesia, Local; Anesthetics, Local; Behavior; Child; Child | 2010 |
Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment.
Topics: Administration, Cutaneous; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Cosmetic Techniques; | 2010 |
Effect of eutectic mixture of local anesthetics on pain perception during scaling by ultrasonic or hand instruments: a masked randomized controlled trial.
Topics: Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Local; Dental Instruments; Drug Com | 2011 |
Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia.
Topics: Adult; Anesthesia, Local; Double-Blind Method; Female; Hip; Humans; Lidocaine; Lipectomy; Male; Midd | 2010 |
Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthetics, Local; Dimethyl Sulfoxide; Drug The | 2011 |
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca | 2012 |
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca | 2012 |
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca | 2012 |
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca | 2012 |
Reducing procedural pain and discomfort associated with transcranial direct current stimulation.
Topics: Adult; Electric Stimulation Therapy; Female; Forehead; Humans; Lidocaine; Lidocaine, Prilocaine Drug | 2011 |
Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy; C | 2011 |
Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel.
Topics: Administration, Rectal; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, N | 2013 |
EMLA versus glucose for PICC insertion: a randomised triple-masked controlled study.
Topics: Analgesia; Anesthetics, Local; Catheterization, Central Venous; Glucose; Humans; Infant, Newborn; In | 2011 |
Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants.
Topics: Administration, Oral; Analgesia; Anesthetics, Local; Dosage Forms; Double-Blind Method; Drug Therapy | 2011 |
Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain.
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; H | 2012 |
No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anxiety; Female; Humans; Lidoca | 2012 |
Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy.
Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Cyclooxygenase Inhi | 2012 |
Do topical anesthetics reduce periareolar injectional pain before sentinel lymph node biopsy?
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Breast Neoplasms; Double- | 2011 |
Vapocoolant spray vs lidocaine/prilocaine cream for reducing the pain of venipuncture in hemodialysis patients: a randomized, placebo-controlled, crossover study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cold Temperature; Cross-Over Studies; Female; Humans; Li | 2011 |
Pain assessment of the intratympanic injections: a prospective comparative study.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Anti-Bacterial Agents; Anti-Inflammatory Agents; Female | 2012 |
The effect of SonoPrep® on EMLA® cream application for pain relief prior to intravenous cannulation.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Double-Blind Method; Femal | 2012 |
Topical EMLA for pain control during extracorporeal shock wave lithotripsy: prospective, comparative, randomized, double-blind study.
Topics: Adult; Aged; Anesthetics, Combined; Body Mass Index; Double-Blind Method; Female; Humans; Lidocaine; | 2012 |
Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children.
Topics: Adolescent; Anesthetics, Local; Blood Glucose; Blood Specimen Collection; Catheterization, Periphera | 2012 |
The effect of EMLA cream on minimizing pain during venipuncture in premature infants.
Topics: Administration, Topical; Anesthetics, Local; Female; Humans; Infant, Newborn; Infant, Premature; Lid | 2013 |
Effect of topical anesthesia on pain during infiltration injection and success of anesthesia for maxillary central incisors.
Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocain | 2012 |
Comparison of the effects of vapocoolant spray and topical anesthetic cream on pain during needle electromyography in the medial gastrocnemius.
Topics: Adult; Aged; Analysis of Variance; Anesthesia, Local; Anesthetics, Local; Confidence Intervals; Cryo | 2013 |
A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Capsaicin; Double-Blind Method; Drug | 2013 |
Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in
Topics: Administration, Topical; Anesthetics, Local; Antibody Formation; Diphtheria-Tetanus-acellular Pertus | 2002 |
Topical anesthetics for intravenous insertion in children: a randomized equivalency study.
Topics: Adolescent; Age Factors; Anesthetics, Local; Child; Female; Humans; Infusions, Intravenous; Injectio | 2002 |
Treatment of tendopathies with tropisetron.
Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Indoles; Infusions, Intralesional; Injectio | 2002 |
EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization.
Topics: Adult; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Female; Humans; Injections, | 2002 |
Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream.
Topics: Administration, Oral; Anesthesia, Local; Double-Blind Method; Glucose; Humans; Infant, Newborn; Lido | 2002 |
Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study.
Topics: Anesthesia, Local; Anesthetics, Local; Dermatologic Surgical Procedures; Double-Blind Method; Drug C | 2002 |
Pain and distress from bone marrow aspirations and lumbar punctures.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Biopsy, Needle; Bon | 2003 |
Injection pain of bupivacaine with epinephrine vs. prilocaine plain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthesia, Dental; Anesthesia, Lo | 2002 |
Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial.
Topics: Adolescent; Anesthetics, Local; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Double-Blind M | 2003 |
Effective reduction of anxiety and pain during venous cannulation in children: a comparison of analgesic efficacy conferred by nitrous oxide, EMLA and combination.
Topics: Adolescent; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Local | 2003 |
EMLA does not permit pain-free retrobulbar injection.
Topics: Administration, Topical; Anesthesia, Spinal; Anesthetics, Local; Cataract Extraction; Double-Blind M | 2003 |
Minimum clinically significant VAS differences for simultaneous (paired) interval serial pain assessments.
Topics: Administration, Topical; Adult; Anesthetics, Local; Bites and Stings; Catheterization, Peripheral; C | 2003 |
Intrapocket anesthesia for scaling and root planing in pain-sensitive patients.
Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Dental Scaling; Double-Blind Method; Female; Fo | 2003 |
EMLA cream and oral glucose for immunization pain in 3-month-old infants.
Topics: Administration, Oral; Administration, Topical; Analysis of Variance; Chi-Square Distribution; Double | 2003 |
The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol.
Topics: Administration, Topical; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthetics, Combi | 2003 |
Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Disease; Debr | 2001 |
Statistical process control methods allow the analysis and improvement of anesthesia care.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral | 2003 |
Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral | 2003 |
Full-face laser resurfacing using a supplemented topical anesthesia protocol.
Topics: Acne Vulgaris; Administration, Topical; Anesthetics, Local; Cicatrix; Face; Female; Follow-Up Studie | 2003 |
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf | 2003 |
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf | 2003 |
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf | 2003 |
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf | 2003 |
Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Biopsy; Dosag | 2004 |
Improved application of Lidocaine/Prilocaine cream in children. A randomized and prospectively controlled study of two application regimes.
Topics: Anesthetics, Local; Catheterization; Child; Double-Blind Method; Drug Administration Schedule; Human | 2004 |
Comparison of EMLA and lidocaine iontophoresis for cannulation analgesia.
Topics: Adult; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Doub | 2004 |
Study on the efficacy of ELA-Max (4% liposomal lidocaine) compared with EMLA cream (eutectic mixture of local anesthetics) using thermosensory threshold analysis in adult volunteers.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine | 2004 |
[Analgesic effects of Emla cream and saccharose solution for subcutaneous injections in preterm newborns: a prospective study of 265 injections].
Topics: Administration, Cutaneous; Administration, Oral; Analysis of Variance; Anesthetics, Combined; Anesth | 2004 |
Use of topical application of lidocaine-prilocaine cream to reduce injection-site pain of depot antipsychotics.
Topics: Administration, Topical; Adult; Anesthetics, Local; Antipsychotic Agents; Brief Psychiatric Rating S | 2004 |
Unilateral pudendal nerve blockade for relief of all pain during transrectal ultrasound-guided biopsy of the prostate: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Anesthetics, Local; Autonomic Nerve Block; Biopsy, Needle; Double-Blind Method; Humans; Male; | 2004 |
Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children.
Topics: Adolescent; Age Distribution; Catheterization, Central Venous; Child; Child, Preschool; Female; Huma | 2004 |
Pudendal nerve block for pain relief in episiotomy repair.
Topics: Anesthetics, Local; Autonomic Nerve Block; Episiotomy; Female; Genitalia, Female; Humans; Injections | 2004 |
Quantification and analysis of pain in nonsurgical scaling and/or root planing.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Double-Bl | 2004 |
Intravenous ketamine sedation for painful oncology procedures.
Topics: Adolescent; Analgesics; Anesthetics, Local; Biopsy, Needle; Bone Marrow Examination; Child; Child, P | 2005 |
[Optimized use of Emla cream in children--secondary publication. A randomized, prospective, controlled comparison of two application regimes].
Topics: Anesthetics, Combined; Anesthetics, Local; Catheterization; Child; Double-Blind Method; Female; Huma | 2005 |
[Application of EMLA creme before upper lid blepharoplasty].
Topics: Administration, Topical; Anesthetics; Anesthetics, Local; Blepharoplasty; Chemotherapy, Adjuvant; Fe | 2005 |
Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal.
Topics: Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Female; Hair Removal; Humans; Laser | 2005 |
Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy.
Topics: Administration, Topical; Aged; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combination; Fe | 2005 |
Local anesthesia in transrectal ultrasound-guided prostate biopsy: EMLA cream as a new alternative technique.
Topics: Administration, Rectal; Aged; Anesthesia, Local; Anesthetics, Local; Biopsy; Endosonography; Humans; | 2005 |
Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine.
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Cuspid; Humans; Lidocaine; Lidocaine, | 2005 |
Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments.
Topics: Adolescent; Analgesics; Anesthetics, Inhalation; Anxiety; Catheterization; Child; Female; Humans; Li | 2005 |
Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Double-Bl | 2005 |
[Acute pain management in proximal femoral fractures: femoral nerve block (catheter technique) vs. systemic pain therapy using a clinic internal organisation model].
Topics: Acute Disease; Aged; Aged, 80 and over; Amides; Analgesics, Opioid; Anesthetics, Local; Catheterizat | 2006 |
Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats.
Topics: Analgesia; Anesthetics, Combined; Anesthetics, Local; Animals; Cat Diseases; Catheterization, Centra | 2006 |
Lidocaine-prilocaine administration during transrectal ultrasound-guided prostatic biopsy: a randomized, single-blind, placebo-controlled trial.
Topics: Administration, Rectal; Aged; Anesthetics, Local; Biopsy, Needle; Endosonography; Humans; Lidocaine; | 2006 |
Does amethocaine gel influence blood results obtained from capillary sampling?
Topics: Administration, Cutaneous; Adult; Alanine Transaminase; Alkaline Phosphatase; Anesthetics, Local; As | 2006 |
Efficacy of EMLA cream to reduce fear and pain associated with interferon beta-1a injection in patients with multiple sclerosis.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Adolescent; Adult; Anesthetics, Local; Attitude t | 2006 |
Use of lidocaine-prilocaine patch for the mantoux test: Influence on pain and reading.
Topics: Adult; Anesthetics, Local; BCG Vaccine; Drug Delivery Systems; Female; Forearm; Humans; Injections, | 2006 |
Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial.
Topics: Administration, Topical; Anesthetics, Local; Biopsy; Catheterization; Double-Blind Method; Female; H | 2006 |
Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration.
Topics: Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Injections, Subc | 1988 |
Effects of local anaesthesia on subdermal needle insertion pain and subsequent tests of microvascular function in human.
Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Blood Flow Velocity; Dose | 2007 |
The effect of a eutectic mixture of local anesthetic cream on wrist pain during transradial coronary procedures.
Topics: Aged; Analysis of Variance; Anesthesia, Local; Cardiac Catheterization; Case-Control Studies; Cathet | 2007 |
Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocaine; Gels; Humans; Injectio | 2007 |
Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Diclofenac; Double-Blind | 2007 |
[Evaluation of analgesic protocol with nitrous oxide and EMLA cream during botulinum toxin injections in children].
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy; | 2007 |
Eutectic mixture of local anesthetic (EMLA) decreases pain during humeral block placement in nonsedated patients.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Double-Blind Method; Elective Surgical Pro | 2007 |
Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Follow-Up | 2008 |
Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Capsaicin; Catheterization, Periphe | 2007 |
Comparison of sciatic psoas compartment block and sciatic femoral 3-in-1 block for knee arthroscopy.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Arthroscopy; Bupivacaine; Elective Surgical Pro | 2007 |
The effect of prilocaine and prilocaine plus meperidine infiltration on the pain during nasal packing removal.
Topics: Adolescent; Adult; Analgesics, Opioid; Device Removal; Drug Combinations; Female; Formaldehyde; Hemo | 2007 |
Galactography without discomfort using lidocaine/prilocaine anesthetic cream.
Topics: Adult; Aged; Anesthetics, Local; Breast Diseases; Catheterization; Contrast Media; Humans; Lidocaine | 2008 |
The effect of 50% glycolic acid on the percutaneous absorption of eutectic mixture of local anesthetics (EMLA): a study of the electrofulguration-induced pain.
Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Drug Synergism; Drug Therapy, Combinatio | 2008 |
EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani | 2008 |
Topical anaesthesia with EMLA, a new lidocaine-prilocaine cream and the Cusum technique for detection of minimal application time.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Catheteriza | 1983 |
Pain-free venepuncture. Effect of timing of application of local anaesthetic cream.
Topics: Adolescent; Anesthetics, Local; Catheterization; Child; Child, Preschool; Double-Blind Method; Drug | 1984 |
EMLA--a eutectic mixture of local anaesthetics for topical anaesthesia.
Topics: Adolescent; Anesthesia, Local; Catheterization; Child; Double-Blind Method; Drug Combinations; Femal | 1982 |
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; | 1995 |
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; | 1995 |
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; | 1995 |
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; | 1995 |
Use of a eutectic mixture of local anesthetics for prolonged subcutaneous drug administration.
Topics: Anesthetics, Local; beta-Thalassemia; Deferoxamine; Double-Blind Method; Drug Combinations; Female; | 1995 |
Analgesia for venous cannulation: a comparison of EMLA (5 minutes application), lignocaine, ethyl chloride, and nothing.
Topics: Adult; Analgesia; Anesthetics, Local; Catheterization, Peripheral; Drug Combinations; Ethyl Chloride | 1995 |
Prilocaine reduces injection pain caused by propofol.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi | 1995 |
Single medial injection peribulbar anaesthesia using prilocaine.
Topics: Aged; Anesthesia, Conduction; Eye Diseases; Eye Movements; Eyelids; Female; Humans; Intraoperative C | 1994 |
Pain after subcutaneous injection of recombinant human erythropoietin: does Emla cream help?
Topics: Adult; Aged; Anemia; Anesthetics, Local; Double-Blind Method; Drug Combinations; Erythropoietin; Fem | 1994 |
A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Cataract Extraction; Double-Blind Method; Drug Combinat | 1994 |
An assessment of prilocaine as a topical anaesthetic agent for fibreoptic bronchoscopy in comparison with lidocaine.
Topics: Adult; Aged; Anesthetics; Anesthetics, Local; Bronchoscopy; Conscious Sedation; Double-Blind Method; | 1994 |
An alternative for needle pain. Report of the Edmonton EMLA Study.
Topics: Anesthetics, Local; Child; Drug Combinations; Female; Humans; Injections; Lidocaine; Lidocaine, Pril | 1994 |
Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children.
Topics: Anesthesiology; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Double-Blind Method; Drug | 1994 |
Comparison of iontophoresis of lidocaine with a eutectic mixture of lidocaine and prilocaine (EMLA) for topically administered local anesthesia.
Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug C | 1994 |
Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer.
Topics: Administration, Cutaneous; Adolescent; Adult; Anesthetics, Local; Antineoplastic Agents; Child; Chil | 1994 |
Comparison of percutaneous anaesthesia for venous cannulation after topical application of either amethocaine or EMLA cream.
Topics: Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Double-Blind | 1994 |
A multicentre randomized study of single-unit dose package of EMLA patch vs EMLA 5% cream for venepuncture in children.
Topics: Adhesiveness; Administration, Cutaneous; Analgesics; Anesthetics, Local; Bloodletting; Child; Child, | 1994 |
A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis.
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinatio | 1994 |
Peribulbar and retrobulbar anesthesia with prilocaine: a comparison of two methods of local ocular anesthesia.
Topics: Aged; Anesthesia, Local; Female; Humans; Male; Nerve Block; Ophthalmologic Surgical Procedures; Pain | 1993 |
Use of lidocaine-prilocaine cream for vaccination pain in infants.
Topics: Anesthetics, Local; Diphtheria-Tetanus-Pertussis Vaccine; Double-Blind Method; Drug Combinations; Fe | 1994 |
Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation.
Topics: Adolescent; Age Factors; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D | 1994 |
Alleviation of the pain of heel prick in preterm infants.
Topics: Anesthetics, Local; Blood Gas Monitoring, Transcutaneous; Blood Specimen Collection; Carbon Dioxide; | 1994 |
The EMLA patch--a new type of local anaesthetic application for dermal analgesia in children.
Topics: Adolescent; Analgesia; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Drug Combinations; | 1994 |
Pethidine has a local anaesthetic action on peripheral nerves in vivo. Addition to prilocaine 0.25% for intravenous regional anaesthesia in volunteers.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Arm; Double-Blind Method; Humans; Male; Meperidine | 1993 |
Dermal patch anaesthesia: comparison of 10% lignocaine gel with absorption promoter and EMLA cream.
Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug C | 1993 |
Effect of a topical anesthetic cream (EMLA) in reducing pain caused by infiltration of local anesthetic in eyelid surgery.
Topics: Aged; Anesthetics, Local; Double-Blind Method; Drug Combinations; Eyelid Diseases; Female; Humans; L | 1993 |
A eutectic mixture of lidocaine and prilocaine for alleviating vaccination pain in infants.
Topics: Anesthesia, Local; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Humans; Infant; | 1993 |
Comparison of the effect of EMLA cream, subcutaneous ring anaesthesia and a double cuff technique in the prevention of tourniquet pain.
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthetics, Local; Drug Combinations; Female; Huma | 1993 |
A comparison of EMLA cream versus nitrous oxide for pediatric venous cannulation.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Anxiety; Catheterization, Per | 1995 |
Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy? A double-blind study comparing prilocaine with pethidine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Double-Blind Method; Female; Humans; Inj | 1993 |
The use of lignocaine to reduce pain on i.v. injection of diluted nalbuphine.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Local; Child; Double-Blind Method; Drug Combinat | 1995 |
[Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam].
Topics: Adjuvants, Anesthesia; Administration, Oral; Anesthetics, Local; Child; Child, Preschool; Drug Combi | 1995 |
Does a local anaesthetic cream (EMLA) alleviate pain from heel-lancing in neonates?
Topics: Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Heel; Humans; Infant, Newborn; L | 1995 |
Analgesic and anti-inflammatory effects of lignocaine-prilocaine (EMLA) cream in human burn injury.
Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Burns; Double-Blind Method; Drug | 1996 |
[EMLA cream in hematology].
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Anesthetics, Local; Child; Child, Preschool; Dr | 1995 |
Topical ibuprofen for skin analgesia prior to venepuncture.
Topics: Administration, Topical; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cat | 1996 |
EMLA prevents pain during local anesthesia for cataract surgery.
Topics: Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Double-Blind Method; Drug Combinations; | 1995 |
The application of EMLA and glyceryl trinitrate ointment prior to venepuncture.
Topics: Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; | 1996 |
Topical application of lidocaine-prilocaine (EMLA) cream reduces the pain of intramuscular infiltration of saline solution.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Injection | 1996 |
Analgesia for venepuncture in a paediatric surgery centre.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Chi | 1995 |
EMLA cream as a topical anesthetic before office phlebotomy in children.
Topics: Adolescent; Ambulatory Care; Anesthetics, Local; Anxiety; Child; Child, Preschool; Double-Blind Meth | 1996 |
A comparison of topical anaesthesia and electronic nerve stimulation for reducing the pain of intra-oral injections.
Topics: Administration, Buccal; Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Chi-Squ | 1996 |
EMLA cream for pain reduction in diagnostic allergy skin testing: effects on wheal and flare responses.
Topics: Adult; Allergens; Anesthetics, Local; Drug Combinations; Female; Humans; Lidocaine; Lidocaine, Prilo | 1997 |
Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Dosage Forms; Drug | 1997 |
Effect of neonatal circumcision on pain response during subsequent routine vaccination.
Topics: Analysis of Variance; Anesthetics, Local; Circumcision, Male; Cohort Studies; Drug Combinations; Hum | 1997 |
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Crying; Double-Blind Method; Drug Combina | 1997 |
Neonatal circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Hypnotics and Sedatives; Infant, | 1997 |
Effect of percutaneous local anaesthetics on pain reduction during pulse dye laser treatment of portwine stains.
Topics: Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinations; Hu | 1997 |
Comparative topical anaesthesia of EMLA and liposome-encapsulated tetracaine.
Topics: Administration, Topical; Adult; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Drug Ca | 1997 |
Prilocaine/lidocaine patch as a local premedication for skin biopsy in children.
Topics: Administration, Cutaneous; Adolescent; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Ch | 1997 |
New non-cocaine-containing topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; C | 1997 |
Use of eutectic mixture of local anesthetics: an effective topical anesthetic for slit-smear testing of patients with Hansen's disease.
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Biopsy; Ear, External; Elbow; Female; Humans; Knee | 1997 |
Two modalities of topical anesthesia for office hysteroscopy.
Topics: Anesthesia, Local; Anesthetics, Local; Female; Humans; Hysteroscopy; Lidocaine; Pain; Prilocaine | 1997 |
[Effectiveness of local anesthesia using EMLA cream for laser treatment of cervical and vulvar lesions].
Topics: Anesthetics, Combined; Anesthetics, Local; Condylomata Acuminata; Female; Humans; Laser Therapy; Lid | 1997 |
Topical anaesthesia in neonatal circumcision: a study of 208 consecutive cases.
Topics: Administration, Topical; Age Factors; Anesthetics, Local; Australia; Child, Preschool; Circumcision, | 1996 |
Clinical comparison of preinjection anesthetics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Atmosphere; Child | 1998 |
Prilocaine-phenylephrine and bupivacaine-phenylephrine topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Cocaine; De | 1998 |
Analgesia for neonatal circumcision: a randomized controlled trial of EMLA cream versus dorsal penile nerve block.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidoc | 1998 |
Subcutaneous erythropoietin alpha (Eprex) is more painful than erythropoietin beta (Recormon)
Topics: Adult; Anesthetics, Local; Child; Drug Compounding; Erythropoietin; Female; Humans; Injections, Subc | 1998 |
Comparison of the effect of EMLA and semicircular subcutaneous anaesthesia in the prevention of tourniquet pain during plexus block anaesthesia of the arm.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Brachial Plexus; Bupivacaine; Female; Forearm; H | 1998 |
Emla cream as a local anaesthetic in MMR vaccination.
Topics: Anesthetics, Local; Child; Double-Blind Method; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combin | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr | 1998 |
Topical lidocaine-prilocaine cream (EMLA) versus local infiltration anesthesia for radial artery cannulation.
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Inj | 1998 |
Alleviation of the pain of venepuncture in neonates.
Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Infant, Newborn; Lidocaine; Lidocaine, Pril | 1998 |
Subcutaneous administration of midazolam: a comparison of the Bioject jet injector with the conventional syringe and needle.
Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Equipment Design; Humans; Hypnotics and | 1998 |
A blinded, randomized, paired, placebo-controlled trial of 20-minute EMLA cream to reduce the pain of peripheral i.v. cannulation in the ED.
Topics: Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Emergency Service, Hospital; | 1998 |
Cutaneous tape stripping to accelerate the anesthetic effects of EMLA cream: a randomized, controlled trial.
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Lidoc | 1998 |
Randomised double blind trial of EMLA for the control of pain related to cryotherapy in the treatment of genital HPV lesions.
Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Cryotherapy; Double-Blind Method; Fema | 1998 |
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human | 1999 |
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human | 1999 |
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human | 1999 |
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human | 1999 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti | 1998 |
[Efficacy of EMLA cream, effect of time and place of application].
Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Elbow; Emulsions; Erythema; F | 1999 |
Effects of single and repeated applications of a eutectic mixture of local anaesthetics (EMLA) cream on spontaneous and evoked pain in post-herpetic neuralgia.
Topics: Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Female; Herpesviridae Infections | 1999 |
Efficacy of parental application of eutectic mixture of local anesthetics for intravenous insertion.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Anxiety; Child; Child, Preschool; Female; Humans; | 1999 |
Petroleum jelly is an ideal contact medium for pain reduction and successful treatment with extracorporeal shock wave lithotripsy.
Topics: Anesthetics, Local; Emollients; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Lit | 1999 |
The effects of EMLA and a topical formulation of 4% amethocaine (Ametop) on pain associated with retrobulbar injection.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Female; Humans; | 1999 |
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe | 1999 |
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe | 1999 |
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe | 1999 |
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe | 1999 |
Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
Topics: Anesthetics, Combined; Anesthetics, Local; Heel; Humans; Infant, Newborn; Infant, Premature; Lidocai | 1999 |
Analgesia during extracorporeal shock wave lithotripsy using the Medstone STS lithotriptor: a randomized prospective study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory | 1999 |
Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children.
Topics: Adolescent; Analgesia; Anesthetics, Combined; Anesthetics, Local; Anxiety; Child; Child, Preschool; | 1999 |
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi | 1999 |
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi | 1999 |
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi | 1999 |
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi | 1999 |
A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision.
Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Double-Bli | 1999 |
The efficacy of EMLA versus ELA-Max for pain relief in medium-depth chemical peeling: a clinical and histopathologic evaluation.
Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Chemexfoliation; Female; Glycolates; Huma | 2000 |
Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; Human | 2000 |
A randomised study of lidocaine and prilocaine for spinal anaesthesia.
Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Female; Humans; Lidocaine; Male; Middle Aged; P | 2000 |
The use of EMLA reduces the pain associated with digital ring block for ingrowing toenail correction.
Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Lidocaine, Pr | 2000 |
[Use of the anesthetic cream EMLA in arterial punction].
Topics: Anesthesia, Local; Anesthetics, Local; Arteries; Blood Specimen Collection; Double-Blind Method; Fem | 2000 |
Lidocaine-prilocaine patch decreases the pain associated with the subcutaneous administration of measles-mumps-rubella vaccine but does not adversely affect the antibody response.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Antibodies; Double-Blind Method; | 2000 |
Combined analgesia and local anesthesia to minimize pain during circumcision.
Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia, Local; Anesthe | 2000 |
Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration.
Topics: Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Double-Blind Method; Humans; In | 1999 |
Comparison of 4 analgesic agents for venipuncture.
Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor | 2000 |
Comparison of 4 analgesic agents for venipuncture.
Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor | 2000 |
Comparison of 4 analgesic agents for venipuncture.
Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor | 2000 |
Comparison of 4 analgesic agents for venipuncture.
Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor | 2000 |
The incidence of transient neurological symptoms after spinal anaesthesia with lidocaine compared to prilocaine.
Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Double-Blind Method; Female; Humans | 2000 |
Prilocaine versus lignocaine for minor lid procedures.
Topics: Anesthetics, Local; Double-Blind Method; Eyelids; Humans; Injections, Intradermal; Lidocaine; Pain; | 2000 |
Reduction in pain associated with open carpal tunnel decompression.
Topics: Anesthetics, Local; Carpal Tunnel Syndrome; Decompression, Surgical; Double-Blind Method; Female; Hu | 2000 |
LET versus EMLA for pretreating lacerations: a randomized trial.
Topics: Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Double-Blind Method; Female; Humans; | 2001 |
Comparison of EMLA cream versus placebo in children receiving distraction therapy for venepuncture.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Cognitive Behavioral Therapy; Double-Blind | 2001 |
Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates.
Topics: Administration, Oral; Anesthetics, Local; Crying; Double-Blind Method; Drug Combinations; Female; He | 2001 |
The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Dental Scalin | 2001 |
A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Combined; A | 2001 |
Eutectic mixture of local anesthetics reduces pain during intravenous catheter insertion in the pediatric patient.
Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; | 2001 |
EMLA or Ametop, and for how long?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Drug Administ | 2001 |
A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children.
Topics: Anesthetics, Combined; Child; Child, Preschool; Diphtheria-Tetanus-Pertussis Vaccine; Double-Blind M | 2001 |
EMLA cream prior to digital nerve block for ingrown nail surgery does not reduce pain at injection of anesthetic solution.
Topics: Adolescent; Adult; Aged; Anesthetics, Combined; Child; Double-Blind Method; Female; Humans; Injectio | 2002 |
Lidocaine iontophoresis versus eutectic mixture of local anesthetics (EMLA) for IV placement in children.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Cross-Over Studies; Female; Humans; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies; | 2002 |
The use of glyceryl trinitrate ointment with EMLA cream for i.v. cannulation in children undergoing routine surgery.
Topics: Administration, Topical; Adolescent; Anesthesia, Local; Catheterization, Peripheral; Child; Child, P | 2002 |
Use of EMLA cream with vasectomy.
Topics: Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Humans; Injections; Lanolin; Lidocaine; | 2002 |
Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties.
Topics: Adolescent; Adult; Alveolar Process; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Deglu | 1975 |
EMLA partially relieves the pain of EMG needling.
Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Drug Combinations; Elbow; Electrodes; El | 1992 |
Local anaesthetic creams and intradermal skin tests.
Topics: Anesthetics, Local; Drug Combinations; Histamine; Humans; Injections, Intradermal; Lidocaine; Lidoca | 1992 |
A clinical evaluation of three topical anaesthetic agents.
Topics: Adult; Anesthetics, Local; Benzocaine; Double-Blind Method; Drug Combinations; Female; Humans; Injec | 1992 |
Pain perception and effectiveness of the eutectic mixture of local anesthetics in children undergoing venipuncture.
Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans | 1992 |
Effect of lidocaine-prilocaine cream on pain from subcutaneous injection.
Topics: Administration, Topical; Adult; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; | 1992 |
Thickly and thinly applied lignocaine-prilocaine cream prior to venepuncture in children.
Topics: Administration, Cutaneous; Adolescent; Anesthetics, Local; Bloodletting; Child; Child Behavior; Chil | 1991 |
Epilation of upper lip hirsutism with a eutectic mixture of lidocaine and prilocaine used as a topical anesthetic.
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Diathermy; Double-Blind Method; Drug Combination | 1991 |
Topical glyceryl trinitrate and eutectic mixture of local anaesthetics in children. A randomised controlled trial on choice of site and ease of venous cannulation.
Topics: Administration, Topical; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D | 1991 |
Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Double-Bli | 1990 |
A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch.
Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Combinations; Emollients; Female; Histamine | 1990 |
A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cataract Extraction; Do | 1991 |
Assessing pain and analgesia with a lidocaine-prilocaine emulsion in infants and toddlers during venipuncture.
Topics: Anesthetics, Local; Bloodletting; Child Behavior; Child, Preschool; Double-Blind Method; Drug Combin | 1991 |
Local application of EMLA and glyceryl trinitrate ointment before venepuncture.
Topics: Administration, Cutaneous; Adult; Aged; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Loc | 1990 |
Alkalinisation of prilocaine for intravenous regional anaesthesia. Suitability for clinical use.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Conduction; Anesthesia, Intrave | 1990 |
EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream.
Topics: Anesthetics, Local; Catheterization, Peripheral; Double-Blind Method; Drug Combinations; Humans; Lid | 1990 |
Double-blind comparison of topical lignocaine-prilocaine cream (EMLA) and lignocaine infiltration for arterial cannulation in adults.
Topics: Administration, Topical; Adult; Anesthetics, Local; Catheterization; Double-Blind Method; Drug Combi | 1990 |
Relief of injection pain in adults. EMLA cream for 5 minutes before venepuncture.
Topics: Administration, Topical; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Local | 1990 |
Our experience with EMLA Cream (for painless venous cannulation in children).
Topics: Anesthetics, Local; Anxiety; Catheterization, Peripheral; Child; Child, Preschool; Drug Combinations | 1990 |
Does EMLA reduce the discomfort associated with local-anaesthetic infiltration?
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Double-Bl | 1990 |
Repeated application of EMLA cream 5% for the alleviation of cannulation pain in haemodialysis.
Topics: Aged; Anesthetics, Local; Catheterization, Central Venous; Dermatitis, Contact; Double-Blind Method; | 1989 |
Effect of a eutectic mixture of local anaesthetic agents (EMLA) on tourniquet pain in volunteers.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinations; Humans; Lidoca | 1989 |
Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children.
Topics: Adolescent; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Drug Combinations; Female; Hu | 1989 |
The effect of topically applied anaesthetics (EMLA cream) on thresholds to thermode and argon laser stimulation.
Topics: Administration, Cutaneous; Anesthetics, Local; Argon; Cold Temperature; Drug Combinations; Hot Tempe | 1989 |
Topical anaesthesia for fistula cannulation in haemodialysis patients.
Topics: Adult; Aged; Anesthetics, Local; Catheters, Indwelling; Clinical Trials as Topic; Double-Blind Metho | 1988 |
Pain-free injection in infants. Use of a lignocaine-prilocaine cream to prevent pain at intravenous induction of general anaesthesia in 1-5-year-old children.
Topics: Anesthesia, General; Anesthetics, Local; Child, Preschool; Clinical Trials as Topic; Double-Blind Me | 1988 |
Delayed hypersensitivity responses in children after local cutaneous anesthesia.
Topics: Adolescent; Anesthesia, Local; Antigens; Child; Clinical Trials as Topic; Humans; Hypersensitivity, | 1987 |
EMLA cream reduces the pain of venepuncture in children.
Topics: Anesthesia, Intravenous; Anesthetics, Local; Child; Child, Preschool; Clinical Trials as Topic; Doub | 1987 |
Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication.
Topics: Administration, Cutaneous; Anesthetics, Local; Anxiety; Catecholamines; Catheterization, Peripheral; | 1987 |
Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.
Topics: Anesthesia, Local; Attitude to Health; Catheterization; Child; Child, Preschool; Clinical Trials as | 1986 |
Topical anaesthesia for venepuncture.
Topics: Administration, Topical; Adolescent; Anesthesia, Local; Child; Child, Preschool; Clinical Trials as | 1986 |
[Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream].
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1985 |
A lignocaine-prilocaine cream reduces venipuncture pain.
Topics: Anesthetics, Local; Child; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; | 1985 |
Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Drug Combinatio | 1985 |
Other Studies
110 other studies available for prilocaine and Ache
| Article | Year |
|---|---|
Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial.
Topics: Anesthesia; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ointments | 2022 |
Lidocaine spray 10% prior to intravenous catheterisation in dogs.
Topics: Anesthetics, Local; Animals; Catheterization; Dogs; Double-Blind Method; Humans; Lidocaine; Pain; Pr | 2022 |
Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Hum | 2023 |
Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal.
Topics: Anxiety; Humans; Pain; Prilocaine; Rhinoplasty; Tramadol | 2020 |
Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.
Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Disease Models, Animal; Extracorporeal Shock | 2018 |
An alternative local anaesthesia technique to reduce pain in paediatric patients during needle insertion.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pres | 2013 |
[Methaemoglobinaemia after using EMLA cream].
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Female; Humans; Lidocaine | 2013 |
[Evaluation of peripherally inserted central catheters in a pediatric population].
Topics: Adolescent; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Catheter-Related Infection | 2013 |
Expectation requires treatment to boost pain relief: an fMRI study.
Topics: Adult; Anesthetics, Local; Antipruritics; Brain; Capsaicin; Female; Humans; Image Processing, Comput | 2014 |
Improving the local anesthesia experience for our patients.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Carticaine; Equipment Design | 2014 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic P | 2017 |
A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Carticaine; Drug Therapy, Combinatio | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P | 2008 |
Relieving the pain of sentinel lymph node biopsy tracer injection.
Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Breast Neoplasms; Clinical Nur | 2008 |
Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Dermatitis, Phototoxic; Female; Humans; Hyperpigmentat | 2008 |
Evaluation of dressings used with local anaesthetic cream and for peripheral venous cannulation.
Topics: Administration, Cutaneous; Anesthetics, Local; Attitude of Health Personnel; Catheterization, Periph | 2008 |
Safe and less painful injection of triamcenolone acetonide into a keloid--a technique.
Topics: Anesthetics, Local; Bupivacaine; Glucocorticoids; Humans; Injections, Intralesional; Keloid; Lidocai | 2010 |
[Radial nerve block for implantation of radial catheter].
Topics: Anesthetics, Local; Catheterization; Catheters, Indwelling; Humans; Lidocaine; Lidocaine, Prilocaine | 2009 |
Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children.
Topics: Administration, Cutaneous; Administration, Inhalation; Adolescent; Anesthetics; Anti-Dyskinesia Agen | 2009 |
Combined use of infraorbital and external nasal nerve blocks for effective perioperative pain control during and after cleft lip repair.
Topics: Adolescent; Adult; Anesthetics, Local; Cleft Lip; Female; Humans; Infant; Lidocaine; Lidocaine, Pril | 2009 |
Editorial comment.
Topics: Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Child; Circumcision, Male; Drug Therapy, | 2010 |
Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients.
Topics: Administration, Oral; Administration, Topical; Adolescent; Anesthetics, Local; Burns; Child; Female; | 2010 |
Pain reduction in children during port-à-cath catheter puncture using local anaesthesia with EMLA™.
Topics: Adolescent; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Cross-Over Stu | 2010 |
Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections.
Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Chin; Cranial Nerve Injuries; Female; Gingiva; H | 2010 |
Anesthesia for ritual circumcision in neonates.
Topics: Anesthesia; Anesthetics, Local; Ceremonial Behavior; Circumcision, Male; Humans; Infant, Newborn; Is | 2010 |
Atraumatic care: EMLA cream and application of heat to facilitate peripheral venous cannulation in children.
Topics: Anesthetics, Local; Child; Female; Humans; Hyperthermia, Induced; Lidocaine; Lidocaine, Prilocaine D | 2009 |
Care to relieve pain-stress in preterm newborns.
Topics: Anesthetics, Local; Female; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Priloc | 2011 |
Eutectic mixture of local anaesthetics (EMLA) 5% cream as a primary dressing on a painful lower leg ulcer.
Topics: Analgesics; Bandages; Drug Therapy, Combination; Female; Humans; Lidocaine; Lidocaine, Prilocaine Dr | 2012 |
Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioural and facial expression responses.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cross-Over Studies; Face; Lidocaine; Lidocaine, Prilo | 2012 |
Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care Facilities; | 2013 |
[New indication for EMLA creme. Significant reduction of pain in mechanical would debridement].
Topics: Anesthesia, Local; Anesthetics, Local; Debridement; Humans; Lidocaine; Lidocaine, Prilocaine Drug Co | 2002 |
Urethral meatal dilatation using topical EMLA cream for anaesthesia.
Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Child; Child, Preschool; Dilatation; Humans; Lid | 2003 |
RECENT ADVANCES IN LOCAL ANALGESIA. CLINICAL EXPERIENCE WITH PRILOCAINE.
Topics: Analgesia; Anesthesia; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics; Anesthetics, Lo | 1965 |
Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans.
Topics: Adult; Anesthetics, Local; Arm; Conditioning, Psychological; Electric Stimulation; Female; Humans; L | 2003 |
Does lidocaine-prilocaine cream (EMLA) decrease the pain of neonatal circumcision?
Topics: Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Evidence-Based Medicine; Heart Rate; | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Relief of pain and anxiety in pediatric patients in emergency medical systems.
Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen | 2004 |
Using EMLA cream before venipuncture.
Topics: Adolescent; Anesthetics, Local; Child; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Oi | 2005 |
Outpatient hysteroscopy: an observational study of patient acceptability.
Topics: Anesthetics, Local; Data Interpretation, Statistical; Female; Humans; Hysteroscopy; Outpatients; Pai | 2004 |
[2/6 EMLA cream application].
Topics: Administration, Cutaneous; Age Factors; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pre | 2004 |
Vascular access.
Topics: Anesthetics, Combined; Anesthetics, Local; Arteriovenous Shunt, Surgical; Hemodialysis, Home; Humans | 2005 |
Bupivacaine versus lidocaine analgesia for neonatal circumcision.
Topics: Acetaminophen; Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; C | 2005 |
Pain- and distress-reducing interventions for venepuncture in children.
Topics: Anesthetics; Anesthetics, Combined; Anesthetics, Local; Child; Child Behavior; Child, Preschool; Fem | 2006 |
Palmar hyperhidrosis. Safety efficacy of two anaesthetic techniques for botulinum toxin therapy.
Topics: Anesthesia, Local; Anesthetics, Local; Autonomic Nerve Block; Botulinum Toxins, Type A; Hand; Humans | 2006 |
Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo.
Topics: Anesthetics, Combined; Biopsy, Needle; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ma | 2006 |
[Painful defecation and chronic functional constipation in children: Diagnosis and treatment].
Topics: Anal Canal; Anesthetics, Local; Child; Child, Preschool; Chronic Disease; Constipation; Defecation; | 2006 |
Predictors of topical anesthetic effectiveness in children.
Topics: Administration, Topical; Age Factors; Anesthetics, Local; Anxiety; Catheterization, Peripheral; Chil | 2007 |
The need for pain control during scaling and root planing.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Humans; Lidocain | 2005 |
Efficacy of an intrapocket anesthetic for scaling and root planing procedures: a review of three multicenter studies.
Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Clinical Trials as Topic; Dental | 2005 |
[Use of ways to prevent pain].
Topics: Age Factors; Analgesia; Anesthetics, Local; Attitude of Health Personnel; Benchmarking; Blood Specim | 2006 |
Reducing the pain during children's immunizations.
Topics: Anesthetics, Local; Child; Child, Preschool; Glucose; Humans; Infant; Lidocaine; Lidocaine, Prilocai | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Humans; Lidocaine; Male; Nerve Block; Oin | 2008 |
Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Humans; Lidocaine; Male; Nerve Block; Oin | 2008 |
Patient comfort in regional anesthesia.
Topics: Administration, Topical; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Nerve Block; Oint | 2008 |
Topical anesthesia with EMLA does not decrease pain during vasectomy.
Topics: Adult; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain; Pr | 2008 |
Does lidocaine-prilocaine cream permit painfree insertion of IV catheters in children?
Topics: Adolescent; Catheterization; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Emulsions; | 1982 |
Eutectic mixture of local anesthetic cream--topical anesthesia for extracorporeal shock wave lithotripsy.
Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Lidocain | 1994 |
Further applications for EMLA cream.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anesthetics, Local; Drug Combinations; Humans; Injections | 1994 |
EMLA cream in the treatment of causalgic pain.
Topics: Administration, Topical; Adult; Causalgia; Drug Combinations; Humans; Lidocaine; Male; Pain; Priloca | 1994 |
Management of childhood pain: new approaches to procedure-related pain. Proceedings of a roundtable discussion. Palm Beach, Florida, January 9, 1993.
Topics: Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Humans; Infant; Lidocaine; Lidocaine | 1993 |
The use of EMLA cream to reduce and/or eliminate procedural pain in children.
Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat | 1993 |
A two-year review of pain control during laser therapy using the flashlamp pulsed dye laser.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Child; Child, P | 1994 |
Taking the jab out of needles.
Topics: Bloodletting; Drug Combinations; Humans; Injections; Lidocaine; Pain; Prilocaine | 1993 |
Dermal anaesthesia: comparison of EMLA cream with iontophoretic local anaesthesia.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Drug Combinations; Epinephrine; Female; Humans; Inject | 1993 |
Minimizing the pain of venipuncture.
Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat | 1996 |
[Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology].
Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Hypnotics and Sedatives; Lidocaine; Lidocaine, | 1996 |
Effects of local anaesthesia on formalin-induced Fos expression in the rat dorsal horn.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Felypressin; Formaldehyde; Ganglia, Spinal; Hemostat | 1995 |
Which structures are sensitive to painful transcranial electric stimulation?
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Drug Combinations; Electric Stimulation; | 1995 |
EMLA cream for renal extracorporeal shock wave lithotripsy in ambulatory patients.
Topics: Ambulatory Care; Analgesia; Analgesics, Opioid; Anesthetics, Local; Drug Combinations; Female; Fenta | 1996 |
Regional variations in skin perfusion and skin thickness may contribute to varying efficacy of topical, local anaesthetics in neonates.
Topics: Anesthesia, Local; Anesthetics, Local; Blood Specimen Collection; Drug Combinations; Female; Forehea | 1996 |
Circumcision circumspection.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Lidocaine; Male; Pain; Prilocaine; Urinar | 1997 |
Neonatal circumcision.
Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newbor | 1997 |
Neonatal circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc | 1997 |
Patients can be pain-free while undergoing implanted port assessment.
Topics: Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwelling; Drug Combinations; Human | 1997 |
Analgesia during circumcision.
Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Double-Blind Method; Drug Combinations; Humans; I | 1997 |
Pain during circumcision.
Topics: Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Humans; Infant, Ne | 1997 |
Utility of EMLA in the relief of pain associated with electroneurography.
Topics: Administration, Topical; Adult; Anesthetics, Local; Electric Stimulation; Electromyography; Facial N | 1998 |
[Pain-free circumcision].
Topics: Anesthetics, Combined; Circumcision, Male; Heart Rate; Humans; Infant, Newborn; Lidocaine; Lidocaine | 1998 |
No negative influence of EMLA application prior to BCG vaccination.
Topics: Anesthetics, Combined; Anesthetics, Local; BCG Vaccine; Child; Child, Preschool; Female; Humans; Inf | 1998 |
Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp; | 1998 |
Painful pricks.
Topics: Anesthetics, Local; Child; Child, Preschool; Female; Humans; India; Infant; Infant, Newborn; Injecti | 1998 |
Alleviation of the pain of venepuncture in neonates.
Topics: Anesthetics, Local; Hand; Heel; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Drug Combi | 1999 |
Analgesia for spinal puncture.
Topics: Analgesia; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Pril | 1999 |
Relative effectiveness of lignocaine-prilocaine emulsion and nitrous oxide inhalation for routine preoperative laboratory testing.
Topics: Adult; Age Factors; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetic | 1999 |
[Use of EMLA Creme in leg ulcers: usefulness and limits].
Topics: Anesthetics, Combined; Anesthetics, Local; Debridement; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pri | 1999 |
Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations.
Topics: Anesthetics, Local; Anxiety; Child; Child Behavior; Female; Humans; Immunization; Lidocaine; Lidocai | 1999 |
Use of a eutectic mixture of local anesthesia in newborns.
Topics: Anesthetics, Local; Drug Combinations; Emulsions; Humans; Infant; Infant, Newborn; Lidocaine; Pain; | 1999 |
[Emla cream in pediatric emergency cases by using selection criteria. Feasibility study].
Topics: Anesthetics, Local; Child; Child Welfare; Emergency Medical Services; Feasibility Studies; Humans; L | 2000 |
EMLA for circumcision?
Topics: Anesthetics, Local; Child Advocacy; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocain | 2000 |
Lidocaine + prilocaine before 3 months of age: new indication. Correct use is crucial.
Topics: Administration, Cutaneous; Age Factors; Blood Specimen Collection; Circumcision, Male; Drug Therapy, | 2000 |
The pediatric forum: pain indication in circumcision.
Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Dr | 2000 |
Factors affecting patients' and potential patients' choices among anaesthetics for periodontal recall visits.
Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthetics, Local; Attitude to Health; Choice B | 2001 |
Hot chili, a cook and EMLA.
Topics: Anesthetics, Local; Capsaicin; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Pril | 2001 |
Re: reduction in pain associated with open carpal tunnel decompression.
Topics: Anesthetics, Local; Carpal Tunnel Syndrome; Decompression, Surgical; Humans; Injections; Lidocaine; | 2001 |
[New uses of EMLA: anesthesia for relief of pain caused by hemorrhoid thrombosis].
Topics: Adult; Anesthetics, Combined; Female; Hemorrhoids; Humans; Lidocaine; Lidocaine, Prilocaine Drug Com | 2001 |
Pain experience during transvaginal aspiration of immature oocytes.
Topics: Acetaminophen; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-An | 2001 |
[Management of leg ulcers in the elderly].
Topics: Age Distribution; Aged; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Lid | 2002 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Tape stripping the stratum corneum and the effectiveness of EMLA.
Topics: Anesthetics, Local; Child, Preschool; Evidence-Based Medicine; Humans; Lidocaine; Lidocaine, Priloca | 2002 |
Pain and temperature sensations related to local analgesia.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Body Temperature; Female; Humans; Lidocaine; Male; Mep | 1975 |
Physiological responses under dental sedation and anaesthesia.
Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate; | 1976 |
[Intraosseous injections and the osseous pressure in patients with rheumatoid shoulder pain].
Topics: Bone and Bones; Circadian Rhythm; Female; Humans; Humerus; Injections; Male; Manometry; Middle Aged; | 1975 |
Hemodialysis needles can be pain free: use of a topical anaesthetic cream.
Topics: Administration, Topical; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Needles; Ointment | 1992 |
Relieving needle puncture pain.
Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat | 1992 |
Effect of the topical anesthetic EMLA on the efficacy of pulsed dye laser treatment of port-wine stains.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Drug Combin | 1990 |
Insufficient effect of local analgesics in Ehlers Danlos type III patients (connective tissue disorder).
Topics: Adult; Anesthetics, Local; Drug Combinations; Ehlers-Danlos Syndrome; Female; Humans; Lidocaine; Lid | 1990 |
Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA).
Topics: Administration, Cutaneous; Adolescent; Analgesia; Child; Child, Preschool; Curettage; Female; Humans | 1988 |
Lignocaine-prilocaine cream in postherpetic neuralgia.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Drug Combinations; Female; Herpes Zoster; Humans | 1989 |
[Local analgesics in tooth treatment--mode of operation and area of use].
Topics: Anesthesia, Dental; Anesthetics, Local; Dental Pulp Diseases; Drug Synergism; Epinephrine; Felypress | 1971 |
Pain control in dentistry.
Topics: Anesthesia, Dental; Diazepam; Pain; Pentazocine; Prilocaine | 1971 |
Regional analgesia.
Topics: Alcohols; Analgesia; Analgesics; Anesthesia, Conduction; Anesthesia, Local; Anesthesia, Spinal; Auto | 1967 |