Page last updated: 2024-11-03

prilocaine and Ache

prilocaine has been researched along with Ache in 423 studies

Prilocaine: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
prilocaine : An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"Children who received lidocaine-prilocaine emulsion reported less pain (mean FPS score = 1."10.17Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. ( Abu-Saad, HH; Arts, SE; Champion, GD; Crawford, MR; Fisher, RJ; Juniper, KH; Ziegler, JB, 1994)
"To compare effectiveness of ice pack to topical lidocaine-prilocaine for pain reduction during axillary laser hair removal."9.69Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial. ( Alam, M; Anvery, N; Brieva, JC; Christensen, RE; Dirr, MA; Geisler, A; Roongpisuthipong, W; Schaeffer, M; Waldman, A, 2023)
"Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia."9.69Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial. ( Gao, J; Li, T; Li, Y; Wang, M; Zhang, E; Zhang, H; Zhang, L; Zhao, X, 2023)
"To compare the effectiveness of suppository diclofenac (100mg), cervical lidocaine 25mg -prilocaine 25mg cream (5% EMLA) and placebo in pain relief for hysterosalpingography."9.41Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo. ( Agboghoroma, OC; Babandi, RM; Durojaiye, KW; Essiet, EA; Jimoh, KO, 2021)
"The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women."9.24Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial. ( Abbas, AM; Abdellah, MS; Abdellah, NH; Abdelmagied, AM; Ali, MK; Bahloul, M; Khalaf, M, 2017)
"This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection."9.20A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection. ( Irkoren, S; Karaca, H; Ozkan, HS, 2015)
"Topical capsaicin 8% was developed for the treatment of peripheral neuropathic pain."9.17Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study. ( Knolle, E; Kovacs, GG; Medwed, S; Scharbert, G; Schemper, M; Zadrazil, M, 2013)
"Topical capsaicin and eutectic mixture of local anesthetics (EMLA) have been found to be equally effective in minimizing the pain of venipuncture."9.17A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain. ( Agarwal, A; Gupta, D; Kishore, K; Rastogi, S; Singh, PK; Singh, U, 2013)
"Lidocaine showed significantly reduced pain compared to placebo at all assessment points."9.16Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. ( Augustin, M; Herberger, K; Krause, K; Maier, K; Radtke, M; Zschocke, I, 2012)
"What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration."9.16Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012)
"To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections."9.15Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011)
"The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers."9.14A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009)
"Our findings suggest that the combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block provides better pain control than the 2 modalities alone during the sampling part of transrectal ultrasound guided prostate biopsy with no increase in the complication rate."9.14Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial. ( Autorino, R; Barbone, F; De Maria, M; Di Lorenzo, G; Giannarini, G; Manassero, F; Mogorovich, A; Morelli, G; Selli, C; Valent, F, 2009)
"Perianal anesthesia with lidocaine-prilocaine cream may solely be sufficient to decrease the pain during prostate biopsy."9.14Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study. ( Kandirali, E; Metin, A; Semercioz, A; Serin, E; Ulukaradag, E; Uysal, B, 2009)
"The purpose of this study was to compare the effectiveness of topically applied lidocaine-prilocaine (EMLA) cream with local anesthetic infiltration in the reduction of pain during perineal suturing after childbirth."9.14Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial. ( Cromi, A; Franchi, M; Gaudino, F; Ghezzi, F; Scarperi, S; Siesto, G, 2009)
"To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy."9.13Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial. ( Briganti, A; Dehò, F; Di Girolamo, V; Gallina, A; Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Salonia, A; Scattoni, V, 2008)
" Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9."9.13EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008)
"Topical application of EMLA and Oraqix before palatal anesthetic infiltration is associated with less pain than with benzocaine gel."9.12Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection. ( Al-Melh, MA; Andersson, L, 2007)
"To compare the efficacy and side effects of transdermal diclofenac patch with eutectic mixture of local anesthetic (EMLA) cream in attenuating venous cannulation pain."9.12Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain. ( Agarwal, A; Gautam, S; Gupta, D; Singh, U, 2007)
" We evaluated the patient's perception of pain/discomfort experienced during the procedure in terms of the type of anesthesia used: periprostatic infiltration with 2% lidocaine, or intrarectal instillation of lidocaine-prilocain cream."9.11Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream. ( Adamakis, I; Alamanis, C; Giannopoulos, A; Haritopoulos, K; Mitropoulos, D; Stravodimos, K, 2004)
") ketamine sedation administered by nonanesthetist physicians for painful procedures."9.11Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005)
"To compare the efficacy of topical eutectic mixture of local anesthetics (EMLA) versus topical lidocaine (LMX) in pain control for Nd:YAG 1,064 nm laser hair removal."9.11Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal. ( Guardiano, RA; Norwood, CW, 2005)
"5% are significantly more effective than 20% benzocaine in reducing pain from needle stick in the maxillary vestibular mucosa."9.11Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. ( Abu Al-Melh, M; Andersson, L; Behbehani, E, 2005)
"Topical lidocaine-prilocaine (EMLA) effectively decreases the pain associated with minor procedures including immunization, although the effect on the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTaP-IPV-Hib) and hepatitis B vaccines has not been assessed."9.10Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in ( Halperin, BA; Halperin, SA; Houston, T; McGrath, P; Smith, B, 2002)
"We conducted a randomized, double blinded, placebo controlled trial to evaluate the effectiveness of EMLA cream together with intraperitoneal lidocaine for pain relief in postpartum tubal ligation."9.10EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization. ( Apidechakul, P; Ariyanon, P; Latthikaviboon, U; Limsakul, A; Parakkamodom, S; Permpolprasert, L; Pethpaisit, N; Santivarangkana, T; Sirilertmakasakul, P; Visalyaputra, S, 2002)
"Prilocaine plain has been described in the literature as causing less pain on injection than bupivacaine with epinephrine, possibly because of the higher pH of the prilocaine anesthetic solution."9.10Injection pain of bupivacaine with epinephrine vs. prilocaine plain. ( Gordon, MK; Overton, DA; Schmitt, MM; Wahl, MJ, 2002)
"Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain."9.10The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003)
"Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0."9.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
"A double-randomized, blinded crossover trial was performed to assess the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics (EMLA) for pain relief during pediatric venipuncture procedures."9.10A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. ( Cunningham, BB; Eichenfield, LF; Fallon-Friedlander, S; Funk, A, 2002)
"This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia."9.09Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. ( Eleazer, PD; Kramp, LF; Scheetz, JP, 1999)
"To compare the relative efficacy of oral sucrose versus EMLA cream for pain relief during venepuncture, 51 full-term newborns (38M, 13F; postnatal age <4 d) in a stable condition were randomly allocated to one of four treatment groups: placebo (2 ml spring water); 2 ml sucrose 24% w/v; 1 g lidocaine-prilocaine 5% cream (EMLA); or EMLA plus sucrose."9.09Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. ( Abad, F; Díaz-Gómez, NM; Domenech, E; Feria, M; González, D; Robayna, M, 2001)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."9.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
" Our aim was to compare EMLA and placebo to assess the efficacy of EMLA in decreasing the pain of venipuncture in children premedicated with oral midazolam 0."9.08[Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam]. ( Cassinello, F; de Stefano, J; Herrero, E; Martín-Celemín, R; Palencia, J; Pérez-Gallardo, A, 1995)
"The efficacy of tetracaine cream versus that of lidocaine-prilocaine cream for the prevention of pain in children undergoing venipuncture was studied."9.08Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. ( Egberts, AC; Lenderink, AW; Rijnvos, WP; ter Pelkwijk, NJ; van Kan, HJ, 1997)
"Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates."9.08Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997)
"A prospective, randomised, double-masked, placebo-controlled study was carried out on 169 patients undergoing cataract extraction to compare the topical anaesthetic cream amethocaine with EMLA (eutetic mixture of local anaesthetic, lignocaine and prilocaine) and placebo in reducing pain during retrobulbar injection."9.07A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Villada, J; Watson, A, 1994)
"A randomized double-blind study was made of 60 children aged 5 to 11 years to assess the efficacy of a eutectic mixture of local anaesthetics (EMLA), lidocaine and prilocaine, and placebo cream in reducing venepuncture pain."9.07Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children. ( Lurngnateetape, A; Tritrakarn, T, 1994)
"To determine whether use of lidocaine-prilocaine 5% cream (EMLA) decreases pain associated with diphtheria-pertussis-tetanus (DPT) vaccination in infants."9.07Use of lidocaine-prilocaine cream for vaccination pain in infants. ( Goldbach, M; Ipp, M; Koren, G; Nulman, I; Taddio, A, 1994)
"A randomised, placebo controlled, double-masked study was undertaken in 115 patients undergoing cataract surgery to assess the efficacy of the anaesthetic cream EMLA (eutetic mixture of local anaesthetic, lignocaine-prilocaine) in alleviating the pain of retrobulbar injection."9.07A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Watson, A, 1991)
"A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch."9.06A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990)
"The aim of the study was to evaluate the effect of a lidocaine-prilocaine cream (EMLA cream, Astra) in relieving pain during arterial cannulation."9.06EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream. ( Danielson, K; Engberg, G; Henneberg, S; Nilsson, A, 1990)
"The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery."9.06Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987)
"The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner."9.06Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation. ( Korpela, R; Maunuksela, EL, 1986)
"A 5% lidocaine-prilocaine local anaesthetic cream, EMLA (Eutectic Mixture of Local Anaesthetics), has proved to be an effective remedy for alleviation of venipuncture pain when applied to intact skin for 60 min."9.05[Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream]. ( Dohlwitz, A; Uppfeldt, A, 1985)
"To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children."8.81Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children. ( Gurguis, MG; Koren, G; Taddio, A, 2002)
"When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection."8.31Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023)
"To compare the onset, anesthesia depth, and duration of topical 10% lidocaine and EMLA cream."8.12Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial. ( Deewongkij, P; Junputipong, N; Kamanamool, N; Rojhirunsakool, S; Udompataikul, M, 2022)
"To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal."7.96Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020)
"The objective of the present study was to investigate the pain on injection of articaine with adrenaline, prilocaine with phenylpressin , and lidocaine with adrenaline."7.74A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline. ( Celebi, N; Misir, F; Muğlali, M; Sumer, M, 2008)
"The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years."7.67Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA). ( Edmar, B; Gisslén, H; Lillieborg, S; Nordin, P; Rosdahl, I, 1988)
" In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low."6.71Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005)
"The pain was rated by each patient on a 100-mm visual analogue scale (VAS)."6.69Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998)
" The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants."6.69Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999)
"Pain was assessed by determination of heart rate, respiratory rate, and behavioral distress scoring."6.69A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision. ( deBlieck, E; Fortune, K; Generelli, P; Howard, CR; Howard, FM; tenHoopen, C; Zolnoun, D, 1999)
"Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale."6.67Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990)
"Pain was evaluated using a three-graded verbal rating scale."6.66A lignocaine-prilocaine cream reduces venipuncture pain. ( Möller, C, 1985)
"Pain was registered on a 10-cm visual analogue scale."6.66Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture. ( Carlsson, P; Hallén, B; Uppfeldt, A, 1985)
"Children who received lidocaine-prilocaine emulsion reported less pain (mean FPS score = 1."6.17Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. ( Abu-Saad, HH; Arts, SE; Champion, GD; Crawford, MR; Fisher, RJ; Juniper, KH; Ziegler, JB, 1994)
"To compare effectiveness of ice pack to topical lidocaine-prilocaine for pain reduction during axillary laser hair removal."5.69Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial. ( Alam, M; Anvery, N; Brieva, JC; Christensen, RE; Dirr, MA; Geisler, A; Roongpisuthipong, W; Schaeffer, M; Waldman, A, 2023)
"Compound lidocaine/prilocaine cream combined with tetracaine may be a more effective approach for preventing coughing and stabilising circulation during extubation following general anaesthesia."5.69Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial. ( Gao, J; Li, T; Li, Y; Wang, M; Zhang, E; Zhang, H; Zhang, L; Zhao, X, 2023)
" We affirm the fact that the combination of EMLA + Sucrose + RB is highly effective for managing pain during circumcision and further reduction of already low scores might not be possible."5.51Music as an adjunct to combination analgesia for neonatal circumcision: A randomized controlled trial. ( Abi-Gerges, C; Charafeddine, L; El-Hout, Y; Fayad, J; Hafez, B; Lakissian, Z; Sharara-Chami, R; Tamim, H; Tazian, V; Zaghal, A, 2022)
"To compare the effectiveness of suppository diclofenac (100mg), cervical lidocaine 25mg -prilocaine 25mg cream (5% EMLA) and placebo in pain relief for hysterosalpingography."5.41Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo. ( Agboghoroma, OC; Babandi, RM; Durojaiye, KW; Essiet, EA; Jimoh, KO, 2021)
"Facial burns are quite common among children."5.36Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients. ( Kargi, E; Tekerekoğlu, B, 2010)
"Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents."5.35Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009)
"Neonatal Infant Pain Scale scores were significantly lower in the intervention groups (EMLA + sucrose, mean [SD]: 3."5.24Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial. ( Charafeddine, L; El-Hout, Y; Lakissian, Z; Milad, N; Sharara-Chami, R, 2017)
"The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women."5.24Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial. ( Abbas, AM; Abdellah, MS; Abdellah, NH; Abdelmagied, AM; Ali, MK; Bahloul, M; Khalaf, M, 2017)
" The network meta-analysis revealed that "bicarbonate-buffered lidocaine with epinephrine" led to a significant decrease in injection pain (preference question) compared to "prilocaine with felypressin" and "lidocaine with epinephrine," whereas no significant differences were detected in the analysis of injection pain measured using the VAS."5.22Patient Comfort with Various Local Infiltration Anesthetics for Minor Oculoplastic Surgery: A Systematic Review and Network Meta-Analysis. ( Chen, C; Chiu, WK; Kang, YN; Liou, CM; Liu, HM; Wu, TJ, 2022)
"This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection."5.20A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection. ( Irkoren, S; Karaca, H; Ozkan, HS, 2015)
"We investigated the efficacy of 5% lidocaine 25 mg-prilocaine 25 mg/g cream (EMLA(®) ) applied to the uterine cervix for reducing pain during diagnostic or operative hysteroscopy, using a visual analogue scale (VAS) for pain in a prospective randomized, non-blinded, controlled study in 92 successive patients."5.17Lidocaine-prilocaine (EMLA(®) ) cream as analgesia in hysteroscopy practice: a prospective, randomized, non-blinded, controlled study. ( Arnau, B; Canals, M; Jiménez, E; Jovell, E; Mir, V; Redón, S, 2013)
"Topical capsaicin 8% was developed for the treatment of peripheral neuropathic pain."5.17Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study. ( Knolle, E; Kovacs, GG; Medwed, S; Scharbert, G; Schemper, M; Zadrazil, M, 2013)
"To compare the clinical efficacy between locally applied diclofenac diethylamine gel, EMLA cream and systemically given diclofenac sodium for the pain relief during extracorporeal shock wave lithotripsy (SWL) using Dornier Delta Compact Lithotripter."5.17Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy. ( Liu, J; Zang, YJ, 2013)
"Lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain."5.17Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2013)
"Topical capsaicin and eutectic mixture of local anesthetics (EMLA) have been found to be equally effective in minimizing the pain of venipuncture."5.17A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain. ( Agarwal, A; Gupta, D; Kishore, K; Rastogi, S; Singh, PK; Singh, U, 2013)
"Lidocaine showed significantly reduced pain compared to placebo at all assessment points."5.16Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. ( Augustin, M; Herberger, K; Krause, K; Maier, K; Radtke, M; Zschocke, I, 2012)
"What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration."5.16Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012)
" access, and blood sampling pain and stress affect hormone values, treatment with N(2)O or midazolam influence the glucose and stress hormone levels differently."5.16Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children. ( Ekbom, K; Jakobsson, J; Kalman, S; Marcus, C, 2012)
"The objective of the study was to compare the efficacy of dimethyl sulfoxide (DMSO) mixed with lignocaine and eutectic mixture of local anesthetics (EMLA) cream as topically applied surface anesthetics in relieving pain during shock wave lithotripsy (SWL) in a prospective randomized study."5.15Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy. ( Ganesamoni, R; Kumar, S; Mandal, AK; Prasad, S; Singh, SK, 2011)
"To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections."5.15Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011)
" The purpose of this study was to evaluate efficacy of lidocaine/prilocaine cream in decreasing the pain of injection for sentinel lymph node biopsy."5.15Do topical anesthetics reduce periareolar injectional pain before sentinel lymph node biopsy? ( Cusick, TE; Helmer, SD; O'Connor, JM; Osland, JS; Tenofsky, PL, 2011)
"The aim of this study was to compare the efficacy of topical piroxicam and EMLA cream on pain control and subsequent inflammation in neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser hair removal in female volunteers."5.14A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal. ( Akinturk, S; Eroglu, A, 2009)
"Breast-feeding in infants under age 6 months and use of sucrose or lidocaine-prilocaine in children age 6 to 48 months significantly reduced crying time and pain scores compared with controls."5.14Interventions to reduce pain during vaccination in infancy. ( Dallar, Y; Dilli, D; Küçük, IG, 2009)
"Our findings suggest that the combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block provides better pain control than the 2 modalities alone during the sampling part of transrectal ultrasound guided prostate biopsy with no increase in the complication rate."5.14Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial. ( Autorino, R; Barbone, F; De Maria, M; Di Lorenzo, G; Giannarini, G; Manassero, F; Mogorovich, A; Morelli, G; Selli, C; Valent, F, 2009)
"Perianal anesthesia with lidocaine-prilocaine cream may solely be sufficient to decrease the pain during prostate biopsy."5.14Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study. ( Kandirali, E; Metin, A; Semercioz, A; Serin, E; Ulukaradag, E; Uysal, B, 2009)
"In this prospective and randomized study, we aimed to compare the efficacy of a eutectic mixture of local anesthetics (EMLA) cream, diclofenac sodium (DS) and EMLA in combination with DS (EMLA+DS) for pain management during extracorporeal shock wave lithotripsy (ESWL)."5.14Comparison of three analgesic treatment protocols for pain management during extracorporeal shock wave lithotripsy. ( Eryildirim, B; Faydaci, G; Kuyumcuoğlu, U; Tarhan, F; Uruç, F, 2009)
"The purpose of this study was to compare the effectiveness of topically applied lidocaine-prilocaine (EMLA) cream with local anesthetic infiltration in the reduction of pain during perineal suturing after childbirth."5.14Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial. ( Cromi, A; Franchi, M; Gaudino, F; Ghezzi, F; Scarperi, S; Siesto, G, 2009)
"To examine the efficacy and safety of a new topical anesthetic containing a disinfection ingredient (LidoDin cream) in reducing the pain associated with venipuncture by comparing it with the proven eutectic mixture of lidocaine 2."5.14Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial. ( Hadash, A; Kassis, I; Knaani-Levinz, H; Shachor-Meyouhas, Y; Shavit, I, 2009)
"No differences in overall pain sensation between the substances were detected during and after liposuction except a more rapid onset with lidocaine (less pain after 15 min, p < 0."5.14Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia. ( Augustin, M; Herberger, K; Maier, K; Sattler, G; Sommer, B, 2010)
"To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy."5.13Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial. ( Briganti, A; Dehò, F; Di Girolamo, V; Gallina, A; Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Salonia, A; Scattoni, V, 2008)
" Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9."5.13EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008)
"Topical application of EMLA and Oraqix before palatal anesthetic infiltration is associated with less pain than with benzocaine gel."5.12Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection. ( Al-Melh, MA; Andersson, L, 2007)
"To compare the efficacy and side effects of transdermal diclofenac patch with eutectic mixture of local anesthetic (EMLA) cream in attenuating venous cannulation pain."5.12Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain. ( Agarwal, A; Gautam, S; Gupta, D; Singh, U, 2007)
"We evaluated the efficacy of topical Myolaxin (capsaican ointment, Geno, Mumbai) ointment over EMLA (eutectic mixture of lignocaine, prilocaine; Neon, Goa) cream for attenuating venous cannulation pain in this prospective, randomised, double blind study."5.12Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study. ( Agarwal, A; Dhiraaj, S; Gupta, D; Singh, PK; Tandon, M; Yadav, G, 2007)
" We evaluated the patient's perception of pain/discomfort experienced during the procedure in terms of the type of anesthesia used: periprostatic infiltration with 2% lidocaine, or intrarectal instillation of lidocaine-prilocain cream."5.11Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream. ( Adamakis, I; Alamanis, C; Giannopoulos, A; Haritopoulos, K; Mitropoulos, D; Stravodimos, K, 2004)
"Intravenous cannulation in children aged 6-12 years is less painful after a 90-min application of a Lidocaine/ Prilocaine cream followed by a 30-min interval without cream, than cannulation immediately after a 60-min application."5.11Improved application of Lidocaine/Prilocaine cream in children. A randomized and prospectively controlled study of two application regimes. ( Culmsee, M; Gad, LN; Lysgaard, AB; Olsen, KS, 2004)
"Although the equimolecular mixture of oxygen and nitrous oxide (EMONO) seems a good choice to relieve procedure-related pain in children, it has not been evaluated for insertion of central venous catheters in children."5.11Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children. ( Abdeladhim, AB; Abdelkefi, A; Abdennebi, YB; Aouf, S; Béjaoui, M; Ladeb, S; Mellouli, F; Othman, TB; Torjman, L, 2004)
") ketamine sedation administered by nonanesthetist physicians for painful procedures."5.11Intravenous ketamine sedation for painful oncology procedures. ( Barbour, K; Evans, D; Kobe, J; Montgomery, CJ; Rogers, P; Turnham, L; Vandebeek, C; Wilson, L, 2005)
"To compare the efficacy of topical eutectic mixture of local anesthetics (EMLA) versus topical lidocaine (LMX) in pain control for Nd:YAG 1,064 nm laser hair removal."5.11Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal. ( Guardiano, RA; Norwood, CW, 2005)
"5% are significantly more effective than 20% benzocaine in reducing pain from needle stick in the maxillary vestibular mucosa."5.11Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. ( Abu Al-Melh, M; Andersson, L; Behbehani, E, 2005)
"The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures."5.11Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments. ( Ekbom, K; Jakobsson, J; Marcus, C, 2005)
"Topical anaesthesia with prilocaine-lidocaine cream significantly reduced pain at transrectal probe insertion and during the biopsy procedure."5.11Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo. ( Montorsi, F; Raber, M; Rigatti, P; Roscigno, M; Scattoni, V, 2005)
"Topical lidocaine-prilocaine (EMLA) effectively decreases the pain associated with minor procedures including immunization, although the effect on the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTaP-IPV-Hib) and hepatitis B vaccines has not been assessed."5.10Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in ( Halperin, BA; Halperin, SA; Houston, T; McGrath, P; Smith, B, 2002)
"A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron has a longer effect on resting pain and pain on movement than the local anesthetic drug."5.10Treatment of tendopathies with tropisetron. ( Müller, W; Stratz, T; Varga, B, 2002)
"We conducted a randomized, double blinded, placebo controlled trial to evaluate the effectiveness of EMLA cream together with intraperitoneal lidocaine for pain relief in postpartum tubal ligation."5.10EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization. ( Apidechakul, P; Ariyanon, P; Latthikaviboon, U; Limsakul, A; Parakkamodom, S; Permpolprasert, L; Pethpaisit, N; Santivarangkana, T; Sirilertmakasakul, P; Visalyaputra, S, 2002)
"Pain scores were significantly lower using the novel lidocaine/tetracaine-based cream peel formulation compared with the EMLA cream."5.10Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study. ( Alster, TS; Lupton, JR, 2002)
"The pain and distress ratings of patients undergoing BMAs (n = 73) and LPs (n = 105) were examined in a comparison of 3 different interventions: (1) a topical eutectic mixture of lidocaine and prilocaine (EMLA cream), (2) oral midazolam and EMLA cream, or (3) propofol/fentanyl general anesthesia."5.10Pain and distress from bone marrow aspirations and lumbar punctures. ( Doran, NH; Frost, JD; Holdsworth, MT; Mathew, P; Moro, MA; Pankey, JM; Phillips, J; Raisch, DW; Winter, SS, 2003)
"Prilocaine plain has been described in the literature as causing less pain on injection than bupivacaine with epinephrine, possibly because of the higher pH of the prilocaine anesthetic solution."5.10Injection pain of bupivacaine with epinephrine vs. prilocaine plain. ( Gordon, MK; Overton, DA; Schmitt, MM; Wahl, MJ, 2002)
"To evaluate the efficacy of eutectic lidocaine/prilocaine cream (EMLA) in reducing the pain associated with steroid joint injection in children with juvenile arthritis."5.10Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial. ( Berkovitch, M; Gazarian, M; Koren, G; Laxer, RM; Schneider, R; Silverman, ED; Uziel, Y, 2003)
"The objective of this study is to determine whether use of lidocaine-prilocaine 5% cream (EMLA) and oral glucose decreases pain associated with diphteria-pertussis-tetanus (DPT) immunization in 3-month-old infants."5.10EMLA cream and oral glucose for immunization pain in 3-month-old infants. ( Blomquist, HK; Håkansson, S; Lindh, V; Wiklund, U, 2003)
"Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain."5.10The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003)
"Pain scores with piroxicam gel were higher on cannulation and on advancement of the cannula (P < 0."5.10Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. ( Dutta, A; Puri, GD; Wig, J, 2003)
"A double-randomized, blinded crossover trial was performed to assess the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics (EMLA) for pain relief during pediatric venipuncture procedures."5.10A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. ( Cunningham, BB; Eichenfield, LF; Fallon-Friedlander, S; Funk, A, 2002)
"To determine whether the application of a eutectic mixture of anesthetic cream (EMLA cream) can decrease the pain of lidocaine injection during vasectomy."5.10Use of EMLA cream with vasectomy. ( Cooper, TP, 2002)
"This multicentre, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of using Emla (lignocaine/prilocaine) anaesthetic cream to achieve pain control during sharp debridement of chronic leg ulcers of arterial, venous or arteriovenous aetiology."5.09Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers. ( Baxter, M; Gottschalk, R; Lycka, B; Murphy, F; Nevin, K; Rosenthal, D, 2001)
"Lidocaine-prilocaine cream (EMLA) is currently standard therapy to alleviate procedural pain in children."5.09Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children. ( Bar-Oz, B; Bishai, R; Freedman, MH; Koren, G; Taddio, A, 1999)
"The efficacy of lignocaine-prilocaine cream (EMLA) and amethocaine gel (Ametop) in reducing the pain and distress of venepuncture was compared in a single-blind randomized study of 34 children aged 1-14 y."5.09Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children. ( Choy, L; Collier, J; Watson, AR, 1999)
" Prilocaine plus lidocaine cream was more effective than lidocaine spray in decreasing pain at placement of the tenaculum and shoulder pain after the procedure."5.09Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities. ( Di Carlo, C; Fabrizio, A; Nappi, C; Pellicano, M; Stigliano, CM; Zullo, F, 1999)
"Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers."5.09Combined analgesia and local anesthesia to minimize pain during circumcision. ( Gilbert-MacLeod, C; Koren, G; Ohlsson, K; Pollock, N; Taddio, A, 2000)
"This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia."5.09Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. ( Eleazer, PD; Kramp, LF; Scheetz, JP, 1999)
"The mean pain score for the prilocaine group was 1."5.09Prilocaine versus lignocaine for minor lid procedures. ( Backhouse, O; Burton, AJ; Metcalfe, TW, 2000)
" Supplemental lidocaine was then infiltrated through the wound edges and the pain of infiltration was recorded by the patient (or guardian) on a 100-mm visual analog scale marked "most pain" at the high end."5.09LET versus EMLA for pretreating lacerations: a randomized trial. ( Singer, AJ; Stark, MJ, 2001)
"To compare the relative efficacy of oral sucrose versus EMLA cream for pain relief during venepuncture, 51 full-term newborns (38M, 13F; postnatal age <4 d) in a stable condition were randomly allocated to one of four treatment groups: placebo (2 ml spring water); 2 ml sucrose 24% w/v; 1 g lidocaine-prilocaine 5% cream (EMLA); or EMLA plus sucrose."5.09Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. ( Abad, F; Díaz-Gómez, NM; Domenech, E; Feria, M; González, D; Robayna, M, 2001)
"The objective of this study was to explore the relation between the application of a mixture of lidocaine/prilocaine cream (eutectic mixture of local anesthetics [EMLA]) before intravenous cannula insertion and perceived pain in the pediatric patient."5.09Eutectic mixture of local anesthetics reduces pain during intravenous catheter insertion in the pediatric patient. ( Cordoni, A; Cordoni, LE, 2001)
"The effectiveness of a eutectic mixture lidocaine-prilocaine topical anaesthetic cream (EMLA) patch compared with a placebo patch in the reduction of pain associated with intramuscular immunization was evaluated."5.09A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children. ( Brown, TL; Cassidy, KL; Finley, GA; McGrath, PJ; Reid, GJ; Smith, DJ, 2001)
"The efficacy of a eutectic mixture of local anesthetics (EMLA) in alleviating the pain associated with subcutaneous needle insertion for infusion of the iron-chelating agent, deferoxamine, was examined in 12 patients with homozygous beta-thalassemia."5.08Use of a eutectic mixture of local anesthetics for prolonged subcutaneous drug administration. ( Berkovitch, M; Davis, S; Donsky, J; Koren, G; Matsui, D; Olivieri, NF, 1995)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."5.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
" Our aim was to compare EMLA and placebo to assess the efficacy of EMLA in decreasing the pain of venipuncture in children premedicated with oral midazolam 0."5.08[Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam]. ( Cassinello, F; de Stefano, J; Herrero, E; Martín-Celemín, R; Palencia, J; Pérez-Gallardo, A, 1995)
"In an observer blind study, the efficacy of lignocaine-prilocaine eutectic mixture was established in alleviating the pain of needle insertion during retrobulbar and periorbital tissues block in cataract surgery."5.08EMLA prevents pain during local anesthesia for cataract surgery. ( Dovinou, K; Nastou, H; Pappa, X; Pouliou, K; Stamatiou, I, 1995)
"5% prilocaine) in reducing distress, anxiety, and pain associated with phlebotomy in pediatric outpatients."5.08EMLA cream as a topical anesthetic before office phlebotomy in children. ( Schwartz, R; Sheridan, MJ; Young, SS, 1996)
"The use of a topical anesthetic cream containing prilocaine and lidocaine (EMLA) has been considered to reduce the pain of diagnostic allergy skin testing, but the effects of the cream on interpretation of skin tests is unclear."5.08EMLA cream for pain reduction in diagnostic allergy skin testing: effects on wheal and flare responses. ( Eggleston, PA; Sicherer, SH, 1997)
"The efficacy of tetracaine cream versus that of lidocaine-prilocaine cream for the prevention of pain in children undergoing venipuncture was studied."5.08Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. ( Egberts, AC; Lenderink, AW; Rijnvos, WP; ter Pelkwijk, NJ; van Kan, HJ, 1997)
"Lidocaine-prilocaine cream is efficacious and safe for the prevention of pain from circumcision in neonates."5.08Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. ( Ben-David, S; Craig, K; Koren, G; Mulligan, P; Rastogi, P; Shennan, A; Stevens, B; Taddio, A, 1997)
"A prospective, randomised, double-masked, placebo-controlled study was carried out on 169 patients undergoing cataract extraction to compare the topical anaesthetic cream amethocaine with EMLA (eutetic mixture of local anaesthetic, lignocaine and prilocaine) and placebo in reducing pain during retrobulbar injection."5.07A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Villada, J; Watson, A, 1994)
"A randomized double-blind study was made of 60 children aged 5 to 11 years to assess the efficacy of a eutectic mixture of local anaesthetics (EMLA), lidocaine and prilocaine, and placebo cream in reducing venepuncture pain."5.07Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children. ( Lurngnateetape, A; Tritrakarn, T, 1994)
"To determine whether use of lidocaine-prilocaine 5% cream (EMLA) decreases pain associated with diphtheria-pertussis-tetanus (DPT) vaccination in infants."5.07Use of lidocaine-prilocaine cream for vaccination pain in infants. ( Goldbach, M; Ipp, M; Koren, G; Nulman, I; Taddio, A, 1994)
"The emulsion of lidocaine and prilocaine (EMLA) is effective in preventing the pain of venipuncture in children."5.07Pain perception and effectiveness of the eutectic mixture of local anesthetics in children undergoing venipuncture. ( Blanchette, V; Eliopoulos, C; Greenberg, M; Hwang, P; Klein, N; Koren, G; Olivieri, N; Robieux, I, 1992)
"EMLA cream (Astra Pharmaceuticals) which contains lignocaine and prilocaine, is widely used in a thick layer to reduce the pain associated with venepuncture."5.07Thickly and thinly applied lignocaine-prilocaine cream prior to venepuncture in children. ( Sims, C, 1991)
"A randomised, placebo controlled, double-masked study was undertaken in 115 patients undergoing cataract surgery to assess the efficacy of the anaesthetic cream EMLA (eutetic mixture of local anaesthetic, lignocaine-prilocaine) in alleviating the pain of retrobulbar injection."5.07A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection. ( Joyce, PW; Kirby, J; Sunderraj, P; Watson, A, 1991)
"A topical anesthetic emulsion consisting of a mixture of lidocaine and prilocaine (EMLA) was used in an attempt to reduce the pain associated with radial artery cannulation."5.06Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration. ( Desmond, MJ; Fox, MA; Russell, GN, 1988)
"A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch."5.06A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. ( Arendt-Nielsen, L; Bjerring, P, 1990)
"The aim of the study was to evaluate the effect of a lidocaine-prilocaine cream (EMLA cream, Astra) in relieving pain during arterial cannulation."5.06EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream. ( Danielson, K; Engberg, G; Henneberg, S; Nilsson, A, 1990)
"The local analgesic efficacy of EMLA Cream (a eutectic mixture of lidocaine and prilocaine; Astra Pharmaceuticals, Sweden) in reducing the pain at Venous cannulation was investigated in a randommized blind study in 75 children scheduled for elective surgery."5.06Our experience with EMLA Cream (for painless venous cannulation in children). ( Johl, KS; Wig, J, 1990)
"A new topical anesthetic ointment (EMLA, "eutectic mixture of prilocaine and lidocaine was studied in a double-blind, placebo-controlled trial to evaluate its efficiency in alleviating pain associated with venous, subcutaneous drug reservoir and lumbar punctures in children."5.06Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children. ( Attias, D; Greenberg, ML; Halperin, DL; Koren, G; Pellegrini, E; Wyss, M, 1989)
"The cold and warmth thresholds to thermode stimulation and the sensory and pain thresholds to argon laser stimulation were determined before and after topical application of EMLA (Eutectic Mixture of Local Anaesthetics) cream."5.06The effect of topically applied anaesthetics (EMLA cream) on thresholds to thermode and argon laser stimulation. ( Arendt-Nielsen, L; Bjerring, P, 1989)
"The local analgesic efficacy of a cream formulation of lidocaine and prilocaine (EMLA) in reducing pain at venous cannulation was investigated in children scheduled for elective surgery."5.06Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. ( Iisalo, E; Kanto, J; Lindberg, R; Manner, T; Scheinin, M; Viinamäki, O, 1987)
"The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner."5.06Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation. ( Korpela, R; Maunuksela, EL, 1986)
"A new topical anaesthetic formulation, EMLA, consisting of a eutectic mixture of the two local anaesthetics, prilocaine and lidocaine, was used in an attempt to reduce the pain associated with venous cannulation in children."5.05EMLA--a eutectic mixture of local anaesthetics for topical anaesthesia. ( Ehrenström Reiz, GM; Reiz, SL, 1982)
"A 5% lidocaine-prilocaine local anaesthetic cream, EMLA (Eutectic Mixture of Local Anaesthetics), has proved to be an effective remedy for alleviation of venipuncture pain when applied to intact skin for 60 min."5.05[Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream]. ( Dohlwitz, A; Uppfeldt, A, 1985)
" Lidocaine 2% gel, misoprostol, and most NSAIDs did not help reduce pain."4.91Interventions for pain with intrauterine device insertion. ( Allen, RH; Bartz, D; Bernholc, A; Hubacher, D; Lopez, LM; O'Brien, PA; Zeng, Y, 2015)
"Two trials (470 participants with venous leg ulcers) evaluated ibuprofen slow-release foam dressings for persistent venous leg ulcer pain."4.88Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Martyn-St James, M; Nelson, EA, 2012)
"There is no evidence that ibuprofen dressings offer pain relief, as measured at the first evening of use, to people with painful venous leg ulcers compared with foam dressings or best practice."4.86Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2010)
" The weighted mean difference in 100-mm visual analogue scale pain scores favored topical tetracaine over EMLA (-8."4.82Topical anesthetics for dermal instrumentation: a systematic review of randomized, controlled trials. ( Carr, DB; Eidelman, A; Lau, J; Weiss, JM, 2005)
"To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children."4.81Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children. ( Gurguis, MG; Koren, G; Taddio, A, 2002)
"When comparing with topical lidocaine/prilocaine (EMLA) cream, a 1:1 mixture of 1% lidocaine and epinephrine significantly alleviated pain during and after the corticosteroid injection."4.31Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study. ( Park, TH, 2023)
"To compare the onset, anesthesia depth, and duration of topical 10% lidocaine and EMLA cream."4.12Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial. ( Deewongkij, P; Junputipong, N; Kamanamool, N; Rojhirunsakool, S; Udompataikul, M, 2022)
"To investigate the effect of local usage of prilocaine and ıts combination with tramadol on the pain and anxiety levels of patients during nasal packing removal."3.96Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. ( Arslan, E; Tulaci, KG; Tulaci, RG; Yazici, H, 2020)
"We investigated the effect of a possible interaction between topical analgesic treatment and treatment expectation on pain at the behavioral and neuronal level by combining topical lidocaine/prilocaine treatment with an expectancy manipulation in a 2 by 2 within-subject design (open treatment, hidden treatment, placebo, control)."3.80Expectation requires treatment to boost pain relief: an fMRI study. ( Büchel, C; Geuter, S; Schenk, LA; Sprenger, C, 2014)
"The objective of the present study was to investigate the pain on injection of articaine with adrenaline, prilocaine with phenylpressin , and lidocaine with adrenaline."3.74A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline. ( Celebi, N; Misir, F; Muğlali, M; Sumer, M, 2008)
"Some children report significant pain with peripheral intravenous catheter (IV) insertion, despite the appropriate use of topical lidocaine anesthetics."3.74Predictors of topical anesthetic effectiveness in children. ( Floria-Santos, M; Hanrahan, K; Kleiber, C; McCarthy, AM; Murray, JC; Schutte, DL, 2007)
"To assess the patient acceptability of outpatient hysteroscopy when Prilocaine is used as analgesia and to determine if our practice of using Prilocaine only if indicated by pain is appropriate."3.72Outpatient hysteroscopy: an observational study of patient acceptability. ( Brown, V; Dass, M; Jivraj, S; Panikkar, J, 2004)
"Significant changes were found for pain assessment, local anesthesia procedures, and nitrous oxide administration."3.69[Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology]. ( Annequin, D; Bouffet, E; Castaing, MC; Douard, MC; Pichard-Léandri, E, 1996)
"The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years."3.67Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA). ( Edmar, B; Gisslén, H; Lillieborg, S; Nordin, P; Rosdahl, I, 1988)
" After the anesthetic effect had subsided, prilocaine 4% caused post-analgesic pain less frequently than did lidocaine 2% with adrenalin 12."3.65Pain and temperature sensations related to local analgesia. ( Evers, H; Oikarinen, VJ; Ylipaavalniemi, P, 1975)
"Forty volunteers with moderate to severe chronic periodontitis were recruited, of which at least three sextants required periodontal therapy."2.94Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT. ( Farago, PV; Moraes, GS; Pilatti, GL; Pinto, SCS; Pochapski, MT; Santos, FA; Santos, IBD, 2020)
"Pain was assessed subjectively using the numeric rating scale (NRS) and objectively using a Galvanic Skin Response (GSR) tester."2.87[The Effect of Pain Relieving Intervention During Infiltration among Gamma Knife Surgery Patients for Stereotactic Frame Fixation]. ( Jang, YJ; Kim, HO, 2018)
"Pain was continuously recorded during stimulation, and measures of subjective stress and blood pressure were obtained before the pretest, after the application of cream, and after the posttests."2.80Opposite effects of the same drug: reversal of topical analgesia by nocebo information. ( Aslaksen, PM; Bjørkedal, E; Eilertsen, HH; Gorecka, MM; Zwarg, ML, 2015)
"Then, pain was induced in each patient's forearm by introducing a 27 G needle into the skin 4 mm deep three times."2.79The use of skin needling for the delivery of a eutectic mixture of local anesthetics. ( De Vita, V; Fabbrocini, G; Izzo, R; Monfrecola, G, 2014)
"Pain was evaluated using 10-point Visual Analog Scale (VAS)."2.78A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience. ( Anup, K; Biswajit, N; Nayan, MK; Niraj, K; Pawan, V, 2013)
"Pain was assessed by visual analogue scale (VAS) and anxiety levels by the State-Trait Anxiety Inventory (STAI-I and STA-II)."2.77No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial. ( Boyacioglu, S; Cengiz, C; Kuzu, MA; Ozdemir, B; Pampal, HK, 2012)
"Pain was assessed at 2 phases: during venipuncture (from needle introduction to its removal) and during the recovery period (30 seconds after needle removal)."2.76Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants. ( Biran, V; Carbajal, R; Cimerman, P; Gourrier, E; Mitanchez, D; Walter-Nicolet, E, 2011)
"The mean pretreatment pain score was 6."2.75The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. ( Burgoyne, CC; Giglio, JA; Laskin, DM; Reese, SE; Sima, AP, 2010)
" Adverse events were recorded."2.75Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment. ( Carruthers, JA; Carruthers, JD; Mordaunt, J; Oliff, HS; Poirier, J; Schreiber, WE, 2010)
"Pain was assessed by Visual Analogue Scale (VAS) on two different days after skin application of EMLA or placebo cream on the forearms."2.74Pregnancy at term does not alter the responses to a mechanical and an electrical stimulus after skin EMLA application. ( Fassoulaki, A; Katafigioti, A; Paraskeva, A; Petropoulos, G; Siafaka, I, 2009)
" Neither anesthetic was systemically absorbed in any cat, and no adverse clinical signs were observed."2.72Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats. ( Gibbon, KJ; Kurian, JR; Strom, TL; Trepanier, LA; Wagner, KA, 2006)
"Scarring was not observed."2.71Full-face laser resurfacing using a supplemented topical anesthesia protocol. ( Calkin, J; Chotzen, V; Kilmer, SL; McClaren, M; No, D; Silva, S; Zelickson, BD, 2003)
"Pain was assessed with the Newborn Acute Pain scale (DAN) and with the Neonatal Facial Coding System (NFCS)."2.71[Analgesic effects of Emla cream and saccharose solution for subcutaneous injections in preterm newborns: a prospective study of 265 injections]. ( Baudon, JJ; Ducrocq, S; Gold, F; Lebas, F; Mochel, F; Mucignat, V, 2004)
"Pain was evaluated using an 11-point visual analog scale questionnaire."2.71Unilateral pudendal nerve blockade for relief of all pain during transrectal ultrasound-guided biopsy of the prostate: a randomized, double-blind, placebo-controlled study. ( Adsan, O; Cetinkaya, M; Inal, G; Kaygisiz, O; Ozdoğan, L; Uğurlu, O, 2004)
" In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low."2.71Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005)
"Pain was evaluated using a visual analog scale (VAS) after each core biopsy."2.71Local anesthesia in transrectal ultrasound-guided prostate biopsy: EMLA cream as a new alternative technique. ( Akpinar, S; Başar, H; Başar, MM; Batislam, E; Ozcan, S, 2005)
"There were no reports of numbness of the tongue, lip, or cheek, neither were there any adverse local reactions in the oral mucosa."2.70The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing. ( Friskopp, J; Isacsson, G; Nilsson, M, 2001)
"The pain was rated by each patient on a 100-mm visual analogue scale (VAS)."2.69Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time. ( Holst, RG; Kristofferson, A, 1998)
"Pain was less severe in the EMLA group than in the lidocaine infiltration group (Score of 2 vs 7; P = 0."2.69Topical lidocaine-prilocaine cream (EMLA) versus local infiltration anesthesia for radial artery cannulation. ( Ali, OS; Benhamou, D; Joly, LM; Monchi, M; Spaulding, C; Weber, S, 1998)
"Pain was evaluated on a visual analog scale (VAS, 0-10)."2.69[Efficacy of EMLA cream, effect of time and place of application]. ( Cano Serrano, ME; Martínez-Tellería, A; Rufino Ruiz, J, 1999)
"Various minimally invasive approaches to reduce pain during extracorporeal shock wave lithotripsy (ESWL) have been described."2.69Petroleum jelly is an ideal contact medium for pain reduction and successful treatment with extracorporeal shock wave lithotripsy. ( Becker, AJ; Jonas, U; Machtens, S; Oelke, M; Stief, CG; Truss, MC, 1999)
" The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants."2.69Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? ( Aranda, J; Jack, A; Johnston, C; Koren, G; Narciso, J; Stevens, B; Stremler, R; Taddio, A, 1999)
"Pain was assessed by determination of heart rate, respiratory rate, and behavioral distress scoring."2.69A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision. ( deBlieck, E; Fortune, K; Generelli, P; Howard, CR; Howard, FM; tenHoopen, C; Zolnoun, D, 1999)
"Pain was assessed on a 10 cm visual analog scale (0, absence of pain; 10, greatest imaginable pain)."2.69[Use of the anesthetic cream EMLA in arterial punction]. ( Belda, J; Casan, P; Giner, J; Litvan, H; Sanchis, J, 2000)
"Lidocaine (1."2.69Comparison of 4 analgesic agents for venipuncture. ( Fedele, KA; Hackman, CM; Hussa, AA; Patterson, P; Vegh, GL, 2000)
"Prilocaine results in a lower incidence of transient neurological symptoms than lidocaine intrathecally and therefore it is more suitable for short surgical procedures."2.69The incidence of transient neurological symptoms after spinal anaesthesia with lidocaine compared to prilocaine. ( de Weert, K; Dirksen, R; Gielen, M; Slappendel, R; Traksel, M; Weber, E, 2000)
"Pain was assessed using a visual analogue scale, a verbal descriptive scale and a direct comparison between paired treatments."2.67Pain after subcutaneous injection of recombinant human erythropoietin: does Emla cream help? ( Coulthard, MG; Hardy, SP; Hughes, C; Matthews, JN; Morris, KP, 1994)
"Procedure-related pain is a significant problem for many children receiving cytotoxic chemotherapy."2.67Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer. ( Arnold, M; Betcher, DL; Dose, AM; Goh, TS; Loprinzi, CL; MacKellar, DJ; Miser, AW; Niedringhaus, RD; O'Fallon, JR; Simmons, P, 1994)
"Pain was measured with a 100 mm visual analog scale (VAS)."2.67A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis. ( Argo, LF; Flores, CA; Wagner, RF, 1994)
"Prilocaine (Citanest) has been shown to be a satisfactory alternative to lignocaine, with certain important advantages, including superior diffusion."2.67Peribulbar and retrobulbar anesthesia with prilocaine: a comparison of two methods of local ocular anesthesia. ( Bourne, A; Morgan, LH; Pemberton, CJ; Saunders, DC; Sturgess, DA, 1993)
"Pain was assessed by means of a modified visual analogue scale ranging from 0 (no pain) to 10 (excruciating pain) in 25 consecutive patients (average age 65 years) undergoing bilateral eyelid surgery."2.67Effect of a topical anesthetic cream (EMLA) in reducing pain caused by infiltration of local anesthetic in eyelid surgery. ( Codère, F; Degnan, N; Sloan, J; Tucker, N, 1993)
"We investigated the per- and postoperative pain-reducing effect of pethidine given intra-articularly (i."2.67Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy? A double-blind study comparing prilocaine with pethidine. ( Ekblom, A; Eriksson, E; Söderlund, A; Valentin, A; Westman, L, 1993)
"Pain was assessed according to a verbal rating scale and on a 100 mm visual analogue scale."2.67Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA. ( Andrén, B; Grafford, K; Holm, J, 1990)
"Reported pain was significantly less after only 5 minutes of the lignocaine-prilocaine cream (p = 0."2.67Relief of injection pain in adults. EMLA cream for 5 minutes before venepuncture. ( Nott, MR; Peacock, JL, 1990)
"Pain was evaluated using a three-graded verbal rating scale."2.66A lignocaine-prilocaine cream reduces venipuncture pain. ( Möller, C, 1985)
"Pain was registered on a 10-cm visual analogue scale."2.66Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture. ( Carlsson, P; Hallén, B; Uppfeldt, A, 1985)
"Currently, approaches to analgesia can be categorised in two broad categories - non-pharmacological and pharmacological agents."2.47Analgesia for amniocentesis or chorionic villus sampling. ( Alfirevic, Z; Mujezinovic, F, 2011)
"Pain was defined as either persistent pain or pain at dressing changes or debridement."2.42Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2003)
"Pain was defined as either persistent pain or pain at dressing changes or debridement."2.41Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2000)
"If untreated, the pain of circumcision causes both short and long term changes in infant behaviours."2.41Pain management for neonatal circumcision. ( Taddio, A, 2001)
" Physicians must adhere to recommendations to avoid mucous membrane contact and ensure appropriate dosing with these agents."2.40Topical anesthesia. ( Keyes, PD; Rizos, J; Tallon, JM, 1998)
"Apart from short-term effects, untreated pain and stressful stimuli may also have long-term effects, which may later affect their neurological development, including the reaction to pain."2.40Pain management in neonates. ( Larsson, BA, 1999)
"Lidocaine has a shorter time lapse (1-3 min) when used on mucus membrane; however, the effect of lidocaine for desensitization of skin has shown variable results in humans."1.72Lidocaine spray 10% prior to intravenous catheterisation in dogs. ( Haga, HA; Heggernes Softeland, M; Hoeberg, E; Lervik, A; Loken Kolstad, T; Moller, LM; Rosvold, SK, 2022)
"FNAC-related pain is frequent and correlates with the number of nodules biopsied, age under 25 years, female sex, and anxiety."1.39Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology. ( Azoulay, S; Baudin, E; Berdelou, A; Bidault, S; Borget, I; Chougnet, CN; Dauchy, S; Deandreis, D; Girard, E; Hartl, D; Labro, S; Laurent, S; Leboulleux, S; Lumbroso, J; Mirghani, H; Schlumberger, M; Vielh, P, 2013)
"Facial burns are quite common among children."1.36Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients. ( Kargi, E; Tekerekoğlu, B, 2010)
"Alleviating pain is of high importance for children undergoing chemotherapy."1.36Pain reduction in children during port-à-cath catheter puncture using local anaesthesia with EMLA™. ( Gerr, H; Grigull, L; Hoy, L; Klein, C; Leonhardt, J; Linderkamp, C; Lüllmann, B; Metzelder, M, 2010)
"Chronic pain is often a symptom after local anaesthetic-induced nerve injury."1.36Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010)
"Self-reporting of pain is considered to be the primary source of information on pain intensity for older children but a validated observational tool will provide augment information to self-reports during painful procedures."1.35The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years. ( Finnström, B; Kokinsky, E; Nilsson, S, 2008)
"Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents."1.35Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009)
"Immunization pain is a global public health issue."1.34Routine immunization practices: use of topical anesthetics and oral analgesics. ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007)
"Instead, referred pain is most likely a consequence of misinterpretation of the origin of input from the stimulated focal pain area, due to excitation of neurones somewhere along the neuroaxis with projected fields in the referred pain area."1.32Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans. ( Hansson, P; Kosek, E, 2003)
"Most subjects reported tooth sensitivity (recall 84."1.31Factors affecting patients' and potential patients' choices among anaesthetics for periodontal recall visits. ( Gafni, A; Matthews, DC; Rocchi, A, 2001)
"The pain was measured by using a visual analog scale (VAS)."1.31Pain experience during transvaginal aspiration of immature oocytes. ( Hildebrandt, NB; Høst, E; Mikkelsen, AL, 2001)
"Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics."1.30Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine. ( Guler, N; Sumer, M; Uckan, S; Ungor, M, 1998)
"In fact, the nurse coached more, and trends suggested that children coped more with typical care than with EMLA."1.30Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations. ( Blount, RL; Cohen, LL; Cohen, RJ; Schaen, ER; Zaff, JF, 1999)

Research

Studies (423)

TimeframeStudies, this research(%)All Research%
pre-199029 (6.86)18.7374
1990's146 (34.52)18.2507
2000's153 (36.17)29.6817
2010's81 (19.15)24.3611
2020's14 (3.31)2.80

Authors

AuthorsStudies
Sharara-Chami, R2
El-Hout, Y2
Lakissian, Z2
Hafez, B1
Abi-Gerges, C1
Fayad, J1
Charafeddine, L2
Tazian, V1
Tamim, H1
Zaghal, A1
Babandi, RM1
Agboghoroma, OC1
Durojaiye, KW1
Jimoh, KO1
Essiet, EA1
Junputipong, N1
Rojhirunsakool, S1
Deewongkij, P1
Kamanamool, N1
Udompataikul, M1
Liu, HM1
Wu, TJ1
Liou, CM1
Chiu, WK1
Kang, YN1
Chen, C1
Hoeberg, E1
Loken Kolstad, T1
Moller, LM1
Rosvold, SK1
Heggernes Softeland, M1
Haga, HA1
Lervik, A1
Ergün, O1
Öztürk, SA1
Aydemir, S1
Roongpisuthipong, W3
Christensen, RE3
Dirr, MA3
Anvery, N3
Geisler, A3
Schaeffer, M3
Waldman, A3
Brieva, JC3
Alam, M3
Zhang, E1
Zhao, X1
Li, T2
Wang, M1
Gao, J1
Zhang, H1
Li, Y1
Zhang, L1
Park, TH1
Stevic, M1
Vlajkovic, A1
Trifunovic, B1
Rakic, I1
Ristic, N1
Budic, I1
Marjanovic, V1
Jovanovski-Srceva, M1
Simic, D1
Moraes, GS1
Santos, IBD1
Pinto, SCS1
Pochapski, MT1
Farago, PV2
Pilatti, GL1
Santos, FA1
Modekwe, VI1
Ugwu, JO1
Ekwunife, OH1
Osuigwe, AN1
Obiechina, SO1
Okpalike, IV1
Orakwe, JC1
Tulaci, KG1
Arslan, E1
Tulaci, RG1
Yazici, H1
Tanaboonyawat, S1
Choontanom, R1
Rossi, S1
Buonocore, G2
Bellieni, CV2
Höbek Akarsu, R1
Kuş, B1
Doğukan Akarsu, G1
Schreiber, S2
Cozzi, G2
Patti, G1
Taddio, A13
Montico, M1
Pierobon, C1
Barbi, E2
Sari, E1
Bakar, B1
Grosse-Steffen, T1
Krämer, M1
Tuschy, B1
Weiss, C1
Sütterlin, M1
Berlit, S1
Luh, JJ1
Huang, WT1
Lin, KH1
Huang, YY1
Kuo, PL1
Chen, WS1
Milad, N1
Yu, W1
Wang, T1
Zhu, J1
Qiu, Y1
Chen, H1
Jin, Y1
Yang, X1
Hu, X1
Chang, L1
Chen, Y1
Ma, G1
Lin, X1
Jang, YJ1
Kim, HO1
Wambier, LM1
de Geus, JL1
Boing, TF1
Brancher, JA1
Chibinski, AC1
Wambier, DS1
Loguercio, AD1
Reis, A1
Anup, K1
Pawan, V1
Niraj, K1
Biswajit, N1
Nayan, MK1
Arnau, B2
Jovell, E2
Redón, S1
Canals, M1
Mir, V1
Jiménez, E1
Lee, SH2
Lee, NY1
Alagna, MG1
Selder, J1
Veenstra, J1
Knolle, E1
Zadrazil, M1
Kovacs, GG1
Medwed, S1
Scharbert, G1
Schemper, M1
Baudin, G1
Occelli, A1
Boyer, C1
Geoffray, A1
Chevallier, P1
Schenk, LA1
Sprenger, C1
Geuter, S1
Büchel, C1
Liu, J1
Zang, YJ1
Akdas, O1
Basaranoglu, G1
Ozdemir, H1
Comlekci, M1
Erkalp, K1
Saidoglu, L1
Abuelkheir, M1
Alsourani, D1
Al-Eyadhy, A1
Temsah, MH1
Meo, SA1
Alzamil, F1
Lander, JA3
Weltman, BJ2
So, SS2
Kurtzman, GM1
Fabbrocini, G1
De Vita, V1
Izzo, R1
Monfrecola, G1
Nydegger, B1
Nusstein, J1
Reader, A1
Drum, M1
Beck, M1
Miller, AL1
Leach, MC2
Romero, M1
Gonzalez, M1
Esteba, L1
Garcia, A1
Irkoren, S1
Ozkan, HS1
Karaca, H1
Aslaksen, PM1
Zwarg, ML1
Eilertsen, HH1
Gorecka, MM1
Bjørkedal, E1
Hizli, F1
Argun, G1
Özkul, F1
Güven, O1
Arik, AI1
Başay, S1
Köşüş, A1
Günaydin, H1
Başar, H4
Tavakolian, S1
Doulabi, MA1
Baghban, AA1
Mortazavi, A1
Ghorbani, M1
Lopez, LM1
Bernholc, A1
Zeng, Y1
Allen, RH1
Bartz, D1
O'Brien, PA1
Hubacher, D1
Lamberton, JA1
Oesterle, LJ1
Shellhart, WC1
Newman, SM1
Harrell, RE1
Tilliss, T1
Singh, N1
Carey, CM1
Gobbato, AA1
Babadópulos, T1
Gobbato, CA1
Moreno, RA1
Gagliano-Jucá, T1
De Nucci, G1
Khodari, SNK1
Noordin, MI1
Chan, L1
Chik, Z1
Duenas, SM1
Pun, J1
Radwan, HA1
Akerman, M1
Schulder, M1
Harrison, D1
Reszel, J1
Bueno, M1
Sampson, M1
Shah, VS1
Larocque, C1
Turner, L1
Abbas, AM1
Abdellah, MS1
Khalaf, M1
Bahloul, M1
Abdellah, NH1
Ali, MK1
Abdelmagied, AM1
Piao, LH1
Fujita, T1
Yu, T1
Kumamoto, E1
Borrometi, F1
Benini, F1
Neri, E1
Rusalen, F1
Celentano, L1
Zanon, D1
Ronfani, L1
Kaweski, S1
Sumer, M2
Misir, F1
Celebi, N1
Muğlali, M1
Nilsson, S1
Finnström, B1
Kokinsky, E1
Nichani, J1
Camilleri, AE1
Broomfield, S1
Saeed, S1
Fetzer, S1
Holmes, S1
Akinturk, S1
Eroglu, A1
Tan, KL1
Kurniawati, C1
Gold, MH1
Demirci, H1
Erdamar, H1
Karakoc, A1
Arslan, M2
Dilli, D1
Küçük, IG1
Dallar, Y1
Needham, R1
Strehle, EM1
Giannarini, G4
Autorino, R1
Valent, F1
Mogorovich, A3
Manassero, F2
De Maria, M3
Morelli, G1
Barbone, F1
Di Lorenzo, G1
Selli, C4
Sawyer, J1
Febbraro, S1
Masud, S1
Ashburn, MA1
Campbell, JC1
Mishra, S1
Kandirali, E1
Ulukaradag, E1
Uysal, B1
Serin, E1
Semercioz, A1
Metin, A1
Eryildirim, B1
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Marqués, MD1
Hildebrandt, NB1
Høst, E1
Mikkelsen, AL1
Cassidy, KL1
Reid, GJ1
McGrath, PJ1
Smith, DJ1
Brown, TL1
Finley, GA1
Gurguis, MG1
Serour, F1
Ben-Yehuda, Y1
Boaz, M1
Galinkin, JL1
Rose, JB1
Harris, K1
Watcha, MF1
Eichenfield, LF1
Funk, A1
Fallon-Friedlander, S1
Cunningham, BB1
Meaume, S1
Barker, D1
Laing, R1
Cooper, TP1
Carley, S1
Hogg, K1
Oikarinen, VJ1
Ylipaavalniemi, P1
Evers, H1
Southwell, GC1
Kankaanpää, U1
Jakob, RP1
Keskitalo, E1
Persson, G1
Lamarche, Y1
Lebel, M1
Martin, R1
Simons, FE1
Gillespie, CA1
Simons, KJ1
Vickers, ER1
Punnia-Moorthy, A1
McPhail, S1
Fowler-Kerry, S1
Robieux, I3
Eliopoulos, C1
Hwang, P1
Greenberg, M1
Blanchette, V1
Olivieri, N1
Klein, N1
Sims, C1
Hjorth, N1
Harring, M1
Hahn, A1
van den Berg, GM1
Teillol-Foo, WL1
Kassab, JY1
Holm, J1
Andrén, B1
Grafford, K1
Arendt-Nielsen, L3
Kumar, R1
Radhakrishnan, S1
Gunawardene, RD1
Davenport, HT1
Armstrong, P1
Watters, J1
Whitfield, A1
Danielson, K1
Engberg, G1
Henneberg, S1
Smith, M1
Gray, BM1
Ingram, S1
Jewkes, DA1
Peacock, JL1
Ashinoff, R1
Geronemus, RG1
Johl, KS1
Jones, SK1
Handfield-Jones, S1
Kennedy, CT1
Kaalund, S1
Høgsaa, B1
Rosdahl, I1
Edmar, B1
Gisslén, H1
Nordin, P1
Lillieborg, S1
Milligan, KA1
Atkinson, RE1
Schofield, PA1
Wehle, B1
Björnström, M1
Cedgård, M1
Danielsson, K1
Ekernäs, A1
Gutierrez, A1
Petterson, U1
Lindholm, T1
Lowrie, A1
Jones, MJ1
Eastley, RJ1
Halperin, DL1
Attias, D1
Pellegrini, E1
Greenberg, ML1
Wyss, M1
Szymkiw, P1
Morgan, AG1
Hopkins, CS1
Buckley, CJ1
Bush, GH1
Björkstén, B1
Jung, B1
Tågsjö, EB1
Groth, O1
Cooper, CM1
Gerrish, SP1
Hardwick, M1
Kay, R1
Manner, T1
Kanto, J1
Iisalo, E1
Lindberg, R1
Viinamäki, O1
Scheinin, M1
Maunuksela, EL1
Korpela, R1
Clarke, S1
Radford, M1
Möller, C1
Carlsson, P1
Sondergaard, B1
Bretday, R1
Lee, JA1

Clinical Trials (73)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Music as an Adjunct to Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial[NCT04252313]206 participants (Anticipated)Interventional2019-08-01Recruiting
"Clinical Study on Pain Control of Cervical Dilation by Lidocaine Solution Injected Into a Single-use Micro-non-invasive Injection Cervical Dilator"[NCT05955768]74 participants (Anticipated)Interventional2023-07-21Enrolling by invitation
Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children[NCT05233683]Phase 3120 participants (Anticipated)Interventional2022-03-31Not yet recruiting
The Influence of Vasopressin on Observational Learning of Placebo Analgesia[NCT03446456]Phase 1/Phase 240 participants (Actual)Interventional2018-09-17Terminated (stopped due to Due to COVID-19,)
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electromyography in Pediatric Population-A Randomized Controlled Trial[NCT04337814]113 participants (Actual)Interventional2019-12-30Completed
Treatment of Acral Vitiligo : Narrowband Ultraviolet-B and Microneedling With and Without Platelet Rich Plasma[NCT03155698]50 participants (Anticipated)Interventional2021-08-31Not yet recruiting
Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice: a Prospective Randomized Double Blind, Placebo-controlled Clinical Trial[NCT01303614]Phase 4100 participants (Anticipated)Interventional2011-04-30Not yet recruiting
Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial[NCT03362905]Phase 4123 participants (Anticipated)Interventional2017-12-03Not yet recruiting
Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device[NCT04963582]72 participants (Actual)Interventional2021-07-05Completed
Effect of Adding Vaginal Isosorbide Mononitrate to Misoprostol Prior to Intrauterine Device Insertion in Women Delivered Only by Elective Cesarean Section: a Randomized Double-blind Controlled Clinical Trial[NCT03587077]113 participants (Anticipated)Interventional2018-09-30Not yet recruiting
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172]Early Phase 1375 participants (Anticipated)Interventional2019-12-10Recruiting
Effectiveness of the Painless Vaccination Protocol Versus Traditional Vaccination Methodology in Reducing Pain in Children Aged 2 Months to 14 Years. A Multicenter, Quasi-experimental (Non-randomized) Controlled Study[NCT06004258]495 participants (Actual)Interventional2022-06-21Completed
The Effectiveness of Two Different Methods Applied During Heel Blood Collection on Pain Level of Healthy Term Newborns[NCT04625010]105 participants (Actual)Interventional2016-03-01Completed
Efficacy and Safety of Different Doses of Vaginal Misoprostol Prior to Intra Uterine Contraceptive Device Insertion[NCT04273984]Phase 4180 participants (Actual)Interventional2020-03-01Completed
A New Method for Pain Relief, Intravenous Cannulation in Pediatric Patients; A Randomized Prospective Clinical Trial.[NCT04246255]Phase 480 participants (Actual)Interventional2020-02-03Completed
A Randomized, Placebo-Controlled Trial to Evaluate Pain and Anxiety During Venipuncture in Pediatric Patients With or Without Pre-treatment by a Topical Anesthetic[NCT00676364]Phase 4114 participants (Actual)Interventional2003-03-31Completed
A Randomized Control Trial of Virtual Reality to Reduce Anxiety During Pediatric Cast Removal[NCT03903510]184 participants (Anticipated)Interventional2019-05-21Recruiting
Topical Morphine for Analgesia in Pediatric Procedures. Clinical Trial Randomized, Double-blind, Placebo.[NCT02300194]Phase 40 participants (Actual)Interventional2014-12-31Withdrawn (stopped due to Withdrawn by investigators)
Randomized Controlled Trial Comparing Ultrasound-guided Pudendal Nerve Block to Ultrasound-guided Penile Nerve Block for Analgesia Following Pediatric Circumcision[NCT03914365]300 participants (Anticipated)Interventional2019-07-01Active, not recruiting
Testing the Efficacy of a Vibrating, Cold Device for Pediatric IV Cannulation Pain Relief in the Emergency Department[NCT01394250]Phase 2240 participants (Actual)Interventional2011-06-30Completed
Does Alkalinization of Technetium-99m Sulfur Colloid Reduce Perceived Pain Levels During Non-breast Sentinel Lymphoscintigraphy?[NCT01660412]60 participants (Actual)Interventional2012-08-01Completed
Evaluating the Efficacy of an Ablative Fractional Carbon Dioxide Laser on Pathologic Symptoms in Pediatric Hypertrophic Scars: a Prospective Split-scar Controlled Trial[NCT04236167]6 participants (Actual)Interventional2020-11-01Terminated (stopped due to Lack of participants to enroll. Early findings not supportive of fractionated c02 laser improving scars in population studied when used alone.)
Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy: Randomized, Prospective Controlled Study[NCT04064047]284 participants (Actual)Interventional2016-12-31Completed
A Randomized Controlled Study of Compound Lidocaine Cream to Prevent Postoperative Agitation in Patients With Endotracheal Intubation for General Anesthesia[NCT02017392]Phase 42,000 participants (Anticipated)Interventional2013-12-31Not yet recruiting
Effect of Synera in Reducing Pain Associated With Venipuncture and Superficial Dermatologic Procedures[NCT01744197]Phase 261 participants (Actual)Interventional2013-01-31Completed
Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547]Phase 20 participants (Actual)Interventional2016-07-14Withdrawn (stopped due to Lack of human ressources)
Doses Tramadol With Bupivacaine in Penial Block Improve Efficiency of Postoperative Analgésia in Children in Circumcision[NCT03260439]106 participants (Actual)Interventional2014-06-30Completed
Evaluation of the Effect of the Presence Of Clowns on Pain and Anxiety Seen During Injections Botulinum Toxin in Child[NCT03149263]80 participants (Actual)Observational2015-11-10Completed
Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial[NCT05891132]60 participants (Anticipated)Interventional2023-09-01Not yet recruiting
The Effect of Sonophoresis on Topical Anesthesia: a Clinical Trial[NCT01283490]Phase 150 participants (Actual)Interventional2011-02-28Completed
Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726]120 participants (Actual)Interventional2017-06-10Completed
Local Anesthetic Activity of Liposomal Formulations in Dentistry[NCT01054547]Phase 180 participants (Actual)Interventional2006-09-30Completed
Efficacy of Liposome Lidocaine Gel for Topical Anesthesia in the Palatal Mucosa[NCT01425840]Phase 140 participants (Actual)Interventional2008-03-31Completed
A Randomized Trial to Determine if Local Anesthesia Decreases Pain Perception in Women Undergoing Chorionic Villus Sampling[NCT03140293]Early Phase 1120 participants (Actual)Interventional2016-09-30Completed
Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection[NCT04794842]Early Phase 180 participants (Actual)Interventional2021-08-01Active, not recruiting
Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556]Phase 346 participants (Anticipated)Interventional2021-06-16Recruiting
Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335]Phase 47 participants (Actual)Interventional2015-07-31Terminated (stopped due to Difficulties with the recruitment)
Tetracaine (Ametop®) Compared to Placebo for Reducing Pain Associated With Intramuscular Injection of Palivizumab (Synagis®) - A Pilot Study[NCT00484393]Phase 47 participants (Actual)Interventional2007-11-30Completed
Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460]21 participants (Actual)Interventional2010-04-30Completed
Comparing Pain Relief in Early Labor: Nitrous Oxide Versus Butorphonol Study[NCT01636999]0 participants (Actual)Interventional2012-09-30Withdrawn
[NCT01157247]88 participants (Actual)Interventional2009-04-30Completed
A Double-Blind, Randomized Controlled Trial of Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children[NCT01628874]66 participants (Actual)Interventional2012-09-30Terminated (stopped due to Due to low recruitment numbers, the study was terminated.)
Comparing The Effectiveness of Tracing Image and Coloring for Kids-Book With Two Active Distractions on Pain and Fear in Children During Venipuncture: A Randomized Controlled Trial[NCT04983303]150 participants (Anticipated)Interventional2021-08-01Not yet recruiting
Comparing The Effectiveness of Tracing Image and Coloring for Kids-Book With Two Passive Distractions on Pain and Fear in Children During Peripheral Intravenous Cannulation: A Randomized Controlled Trial[NCT04977323]150 participants (Anticipated)Interventional2021-07-28Not yet recruiting
Distraction in the Emergency Using Virtual Reality for Intravenous Needs in Children to Improve Comfort (DEVINCI): A Pilot Randomized Controlled Trial[NCT03750578]62 participants (Actual)Interventional2018-12-17Completed
Characterization of the Pudendal Nerve With Transvaginal Ultrasonography[NCT06021782]24 participants (Anticipated)Observational2021-05-13Recruiting
A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958]Phase 130 participants (Actual)Interventional2017-02-01Completed
A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967]Phase 2100 participants (Anticipated)Interventional2022-11-25Recruiting
A Comparison of Amethocaine Creams Versus Liposomal Lidocaine Cream as Pain Reliever Prior to Venipuncture in Children at the Paediatric Emergency Department.[NCT00353002]0 participants (Actual)Interventional2006-07-31Withdrawn
Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department[NCT05934669]Phase 490 participants (Anticipated)Interventional2024-01-31Not yet recruiting
Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4[NCT00402129]22 participants Interventional2006-01-31Completed
Topical Analgesia Before Inhalational Anaesthesia: A Retrospective Observational Study[NCT04959409]500 participants (Actual)Observational2020-08-01Completed
Effect of Buzzy System (Vibrating Device) Compared to Topical Anaesthesia on Pain Reduction During Injection of Infiltration Anaesthesia in Children: A Randomized Clinical Trial Study.[NCT05083975]30 participants (Anticipated)Interventional2022-07-23Not yet recruiting
Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861]230 participants (Actual)Observational2010-06-30Completed
Childhood Immunization: Reducing Immunization Distress (RID) Using Multi-Modal Distraction[NCT01379885]77 participants (Actual)Interventional2011-06-30Terminated (stopped due to Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.)
The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing[NCT04519463]Early Phase 160 participants (Anticipated)Interventional2020-09-30Not yet recruiting
The Efficacy of the Eutectic Mixture of Local Anesthetics (EMLA) Cream Versus the Synera Patch for Pain Reduction During Venipuncture in Children[NCT00530803]Phase 2100 participants (Actual)Interventional2007-06-30Completed
Evaluation of Analgesia With the Use of Eutectic Mixture of Local Anesthetics (Lidocaine and Prilocaine) and Oral Solution of Glucose to 25% in Preterm Neonates During Arterial Puncture and / or the Installation of Percutaneous Catheter[NCT00808054]Phase 460 participants (Actual)Interventional2008-11-30Completed
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
Transdermal Microneedle Patch To Enhance Topical Anaesthesia Before Intravenous Line Insertion for Blood Transfusion In Paediatric Thalassemia Patients[NCT05078463]Phase 220 participants (Actual)Interventional2021-09-15Completed
Intercostobrachial Nerve Block (ICBN) for Tourniquet Pain: Is it Necessary?[NCT03797924]Early Phase 146 participants (Actual)Interventional2019-04-25Completed
The Effect of Shotblocker on Pain and Patient Satisfaction for Spinal Anesthesia[NCT03554122]88 participants (Actual)Interventional2018-01-01Completed
Comparison of Two Analgesic Pretreatment Techniques (2% Lidocaine Infiltration vs. EMLA Cream Application) Before Spinal Needle Insertion for Pain Reduction and Maternal Satisfaction Level Assessment in Women Undergoing LSCS. A Prospective Randomized Cont[NCT04050059]62 participants (Actual)Interventional2019-11-13Completed
Impact of 50% Nitrous Oxide Inhalation on Pain Induced by Lumbar Puncture in Emergency: a Double-blind Randomized Controlled Trial.[NCT03941990]Phase 488 participants (Anticipated)Interventional2019-11-27Recruiting
Pain Control for Intrauterine Device Placement: A Randomized Controlled Trial of Paracervical Block[NCT02219308]67 participants (Actual)Interventional2014-10-31Completed
An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366]Phase 4121 participants (Actual)Interventional2010-04-30Completed
Understanding Pediatric Symptoms and Other Symptoms[NCT00166231]156 participants (Actual)Observational2004-03-31Completed
The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery[NCT01880775]Phase 450 participants (Actual)Interventional2012-04-30Completed
Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients[NCT04409470]250 participants (Actual)Observational2021-10-11Completed
Prospective,Randomized,Blinded, Comparative,Efficacy and Safety Trial of Vapocoolant (Pain Ease Medium Stream) for Intravenous Cannulation in Emergency Department Patients.[NCT01670487]Phase 4300 participants (Actual)Interventional2012-10-31Completed
Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures[NCT05294640]Phase 495 participants (Actual)Interventional2022-05-17Completed
A Randomized Controlled Trial Evaluating Three Non-invasive Analgesic Techniques in Pain Prevention During Injections[NCT03974633]Phase 4100 participants (Actual)Interventional2018-02-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation

"Blood oxygenation level dependent (BOLD) responses will allow the identification of relative activation/deactivation in the brain as a result of events (e.g. painful stimulations) that will be given during the experiment.~Changes in the Percentage of BOLD signal are calculated as the BOLD signal in the right supplementary motor area during the 20-second heat pain divided by the whole-brain average BOLD signal during that 20-second heat pain." (NCT03446456)
Timeframe: Day 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds

Interventionpercentage of BOLD signal change (Mean)
Saline0.485
Arginine Vasopressin0.482

Heating Temperature

On Day 1, the heating temperature was calibrated to the individual level. The heating temperature corresponding to 50 out of 100 visual analog scale pain ratings was selected as the testing temperature for day 2 (test). (NCT03446456)
Timeframe: Day 1 (calibration)

Interventioncelsius degree (Mean)
Saline44.16
Arginine Vasopressin44.44

Implicit Association Test (IAT) Response Latency Difference

"The IAT is a behavioral test that examines racial biases via measuring the strength of associations between concepts (e.g., African-American, Asian, White) and evaluations (good, bad). Participants were asked to press a response key when they saw images (people) or words (good/bad) on the screen. Response latencies (RL) were measured in milliseconds using E-prime as the reaction time to press the response key. An RL difference (D) score was calculated as 1) Compute the standard deviation (SD) of RL from overall trials; 2) M1 is the mean of RL in the condition where White and good share the same response key. M2 is the mean of RL in the condition where African-American/Asian people and good share the same response key; 3) D = (M2-M1)/SD.~The D score ranges from -2 to +2. Positive values indicate a racial preference for White people. Negative values indicate a racial preference for African-American/Black or Asian people. A value close to 0 indicates no racial preference." (NCT03446456)
Timeframe: Day 1

Interventiondifference score (Mean)
Saline0.03
Arginine Vasopressin0.07

Pain Ratings

Participants will provide their pain on a Visual Analogue Scale raging from 0=no pain to 100= maximum unbearable pain. Normal value will be absence of pain. (NCT03446456)
Timeframe: Day 2 (test)

Interventionunits on a scale (Mean)
Saline44.84
Arginine Vasopressin47.19

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Anxiety of Venipuncture

Participant anxiety was measured by the study participant and the objective observer before (anticipatory), during (venipuncture) and after (recovery) venipuncture using a validated visual analog scale (VAS). The VAS is a validated scale that is used to detect small changes in many types of observations. The scale ranges from 0-100 scores on a scale, and here the higher scores indicate higher anxiety levels. Only the participant's mean venipuncture (during venipuncture) anxiety scores are presented in outcome measure results here. (NCT00676364)
Timeframe: During venipuncture

Interventionscores on a scale (Mean)
ControI Group Receiving Placebo Cream43.1
Investigational Group40.5

Pain From Venipuncture

"Pain was measured immediately after venipuncture by the participant using the six-point FACES scale. FACES in not an acronym, but rather a description of a pain scale that uses pictures of faces in various states of pain. The FACES pain scale is a common scale used to measure pain with scores on a scale. The scale we used had six points from zero (0) to five (5) indicating different levels of pain. Lower scores indicate lower levels of pain, and higher scores indicate higher levels of pain." (NCT00676364)
Timeframe: Pain was measured immediately after venipuncture.

Interventionscores on a scale (Mean)
ControI Group Receiving Placebo Cream2.2
Investigational Group Receiving 4% Lidocaine Cream2.1

Change From Baseline in Faces Pain Scale Revised (FPS-R) at 30 Minutes After IV Cannulation

"The Faces Pain Scale Revised (FPS-R) is numerical self-report measure of pain intensity developed for children to score the sensation of pain from 0-10. Pictures of 6 cartoon faces ranging from neutral expression of no pain (0) to very much pain (10)." (NCT01394250)
Timeframe: Baseline and 30 minutes

Interventionunits on a scale (Mean)
Buzzy®-3.544
Topical Lidocaine 4% Cream-3.436

Comparison of the Face, Legs, Activity, Cry, Consolability Scale (FLACC) Score Immediately After IV Cannulation Between Groups

The Face, Legs, Activity, Cry, Consolability scale or FLACC scale is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2. The FLACC score was completed immediately after IV cannulation by a member of the clinical care team who was not part of the study. During initial trial design, the goal was to collect FLACC score pre and post cannulation; however, it was decided prior to enrollment that FLACC score would not be collected pre cannulation, only post. (NCT01394250)
Timeframe: Up to 5 minutes after IV Cannulation

Interventionunits on a scale (Median)
Buzzy®0.667
Topical Lidocaine 4% Cream0.333

Perceived Pain Level

Immediately after receiving an injection, subjects will rate their perceived pain level, using a validated measure. Subject was asked to quantify the pain of every injection using a validated scale from 0 through 10, with 0 being no pain and 10 being severe pain that is disabling. The effect of treatment was estimated by taking the difference of the mean buffered and SOC pain scores and a paired t-test was used to test whether the mean difference was significantly different from 0. Perceived pain levels assessed after each injection were averaged for each participant. (NCT01660412)
Timeframe: immediately after administration (<1 min) of each injection (up to total 5 minutes)

Interventionunits on a scale (Mean)
Standard of Care Injection5.81
PH Altered Injection4.39

Global Assessment of Satisfaction With Venipuncture

Rates of Satisfied and very satisfied are used to be compared between two groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.

Interventionpercentage of participants (Number)
Synera74.0
Placebo53.7

Percentage of Patients With No or Minor Pain (VAS<3)

The primary efficacy endpoint is the subject's report of pain intensity regarding the venipuncture using a 0-10 VAS. The VAS <3 is considered as patients with no or minor pain and would be compared between 2 groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.

Interventionpercentage of participants (Number)
Synera38.0
Placebo21.3

Percentage of Patients With No Pain (VAS=0)

The primary efficacy endpoint is the subject's report of pain intensity regarding the venipuncture using a 0-10 VAS. The VAS =0 is considered as patients with no pain and would also be compared between 2 groups. (NCT01744197)
Timeframe: 30 minutes after the venipuncture.

Interventionpercentage of participants (Number)
Synera19.4
Placebo8.3

To Determine if a Difference in Pain Scale Ratings is Detectable Following Intramuscular Palivizumab Injection That Was Pre-treated With Placebo or Tetracaine.

Parent score 1-10 (1 representing no pain and 10 representing extreme pain) FLACC (Face, Legs, Activity, Cry, Consolability) Score 0-10 (at baseline and post injection) (0 representing no pain and 10 representing extreme pain) Change in FLACC score (NCT00484393)
Timeframe: 2 visits, 1 month apart

,
Interventionunits on a scale (Mean)
Parent scoreFLACC at baselineFLACC post injectionChange in FLACC
Placebo7.31.69.37.7
Tetracaine7.31.78.46.7

Number of Participants With Lumbar Puncture Success

The success of lumbar puncture was defined as obtaining Cerebrospinal fluid (CSF) on the first attempt and <1000 Red Blood Cells/millimeter cubed (NCT01628874)
Timeframe: Immediately following lumbar puncture

InterventionParticipants (Count of Participants)
EMLA Cream, Then Placebo Via J-Tip8
Placebo Cream, Then Lidocaine Via J-Tip16

Pain Score

The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: At Needle Insertion

Interventionscore on a scale (Median)
EMLA Cream, Then Placebo Via J-Tip5
Placebo Cream, Then Lidocaine Via J-Tip5

Pain Score

The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: At time J-TIP is used

Interventionscore on a scale (Median)
EMLA Cream, Then Placebo Via J-Tip5
Placebo Cream, Then Lidocaine Via J-Tip5

Pain Score

The pain score was assessed using the 5-point Neonatal Coding System (NFCS) on a scale of 0-5, with 0 indicating no pain and 5 the highest level of pain. (NCT01628874)
Timeframe: Immediately Post-Procedure

Interventionscore on a scale (Median)
EMLA Cream, Then Placebo Via J-Tip0
Placebo Cream, Then Lidocaine Via J-Tip0

Change in Heart Rate

Heart rate was measured at 5 points in time (pre-procedure, application of J-Tip, at LP needle insertion, while the needle is in place, and post-procedure) and was compared for significant differences (NCT01628874)
Timeframe: At 5 specific points during the procedure

,
InterventionBeats per Minute (Mean)
Pre-procedureJ-Tip applicationNeedle insertionNeedle in placePost-procedure
EMLA Cream, Then Placebo Via J-Tip154160170172157
Placebo Cream, Then Lidocaine Via J-Tip156167169178159

Blinded Observer's Subjective Ratings of Participants' Pain Level at Tourniquet Placement, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at tourniquet placement. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: before venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4162100
Synera Patch3765110

Blinded Observer's Subjective Ratings of the Participant's Pain Level at 5 Minutes Post Venipuncture Procedure, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain participants were experiencing 5 minutes after the venipuncture was completed. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: 5 minutes post venipuncture

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream4531100
Synera Patch4541000

Blinded Observer's Subjective Ratings of the Participant's Pain Level at Needle Insertion, Using a 6-point NRS

The NRS (Numerical Rating Scale) is a 6-point rating scale where 0= no pain and 5 = worst pain. Blinded observers reported their own subjective evaluation of the level of pain experienced by the participants at needle insertion. Total number of participants subjectively evaluated as experiencing each pain level is reported. (NCT00530803)
Timeframe: during needle insertion

,
InterventionParticipants (Count of Participants)
Participants evaluated at NRS = 0 (No pain)Participants evaluated at NRS = 1Participants evaluated at NRS = 2Participants evaluated at NRS = 3Participants evaluated at NRS = 4Participants evaluated at NRS = 5
EMLA Cream32142200
Synera Patch25129220

Parent Rating of Child's Pain Using a 6-point NRS

The Numerical Rating Scale (NRS) is a 6-point rating scale where 0= no pain and 5 = worst pain. Parents reported their own subjective evaluation of participants pain level. Each participant had only one parental assessment. Total number of parental assessment for each pain level on the 6-point NRS is reported as total number of participants experiencing that pain level. (NCT00530803)
Timeframe: immediately after venipuncture is completed

,
InterventionParticipants (Count of Participants)
number of participants with NRS=0 (no pain)number of participants with NRS=1number of participants with NRS=2number of participants with NRS=3number of participants with NRS=4number of participants with NRS=5
EMLA Cream4261100
Synera Patch4151201

Participants Self-rating of Pain Using the Wong-Baker FACES Pain Rating Scale.

"Participants were asked to report their level of pain using a 6-point Wong-Baker FACES Pain Rating Scale ranging from 0, no pain, to 5, the most pain you can have. The Wong-Baker FACES Pain Rating Scale is a validated tool for measuring pain in patients as young as 3 years old. A FACES pain score less than or equal to 2 is considered no pain to mild pain, and is clinically acceptable. Studies have shown average FACES pain scores for children receiving vascular access with placebo to be 2.2 to 3.5." (NCT00530803)
Timeframe: immediately after completion of venipuncture

,
InterventionParticipants (Count of Participants)
Participants with FACES Score = 0 (No pain)Participants with FACES Score = 1Participants with FACES Score = 2Participants with FACES Score = 3Participants with FACES Score = 4Participants with FACES Score = 5
EMLA Cream4262000
Synera Patch3883100

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Pain With Intrauterine Device (IUD) Placement

Distance (mm) from the left of the 100-mm visual analog scale (reflecting magnitude of pain) recorded at time of IUD Placement. Scale range is from 0mm (no pain) to 100mm (worst pain possible). A lower score (less pain) is considered a better outcome. (NCT02219308)
Timeframe: Moment of IUD insertion

Interventionmm (Median)
No Paracervical Block (Sham PCB)54
Paracervical Block (PCB)33

Median Pain Scores for All Time Points

Distance (mm) from the left of the 100-mm visual analog scale of pain at various time points. Scale range is 0mm (no pain) to 100mm (worst pain possible). Lower scores are considered better outcomes. (NCT02219308)
Timeframe: Anticipation of procedure through 5 minutes after IUD placement

,
Interventionmm (Median)
Anticipated PainBaseline PainSpeculum InsertionCapped Needle or PCBTenaculum placementUterine SoundingIUD placement5 mins after IUD placementOverall pain
No Paracervical Block (Sham PCB)510681047542751
Paracervical Block (PCB)58010301530331230

Pain Score on the Numeric Rating Scale (NRS)

Numeric rating scale (NRS) 0-10 : 0 (no pain) - 5 (moderate pain) - 10 (worst pain). Scores to be utilized after stream device applied and after intravenous catheter placement. (NCT01670487)
Timeframe: pain of intravenous catheter placement.

InterventionNRS (Mean)
Vapocoolant (Pain Ease Medium Stream)2.3
Placebo (Nature's Tears)4.3

Reviews

40 reviews available for prilocaine and Ache

ArticleYear
Patient Comfort with Various Local Infiltration Anesthetics for Minor Oculoplastic Surgery: A Systematic Review and Network Meta-Analysis.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2022, Volume: 75, Issue:9

    Topics: Anesthesia, Local; Anesthetics, Local; Bicarbonates; Double-Blind Method; Epinephrine; Felypressin;

2022
Topical anesthetics for pediatric laser treatment.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2019, Volume: 21, Issue:7-8

    Topics: Anesthetics, Local; Drug Combinations; Drug Therapy, Combination; Humans; Lidocaine; Low-Level Light

2019
Management of pain in newborn circumcision: a systematic review.
    European journal of pediatrics, 2021, Volume: 180, Issue:1

    Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Dr

2021
Analgesia for infants' circumcision.
    Italian journal of pediatrics, 2013, Jun-13, Volume: 39

    Topics: Administration, Cutaneous; Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Infant; Lidoca

2013
WITHDRAWN: EMLA and Amethocaine for reduction of children's pain associated with needle insertion.
    The Cochrane database of systematic reviews, 2014, Mar-13, Issue:3

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Humans; Infant; Lidocaine; Lidocaine, Prilo

2014
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Interventions for pain with intrauterine device insertion.
    The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine;

2015
Breastfeeding for procedural pain in infants beyond the neonatal period.
    The Cochrane database of systematic reviews, 2016, Oct-28, Volume: 10

    Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care

2016
Breastfeeding for procedural pain in infants beyond the neonatal period.
    The Cochrane database of systematic reviews, 2016, Oct-28, Volume: 10

    Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care

2016
Breastfeeding for procedural pain in infants beyond the neonatal period.
    The Cochrane database of systematic reviews, 2016, Oct-28, Volume: 10

    Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care

2016
Breastfeeding for procedural pain in infants beyond the neonatal period.
    The Cochrane database of systematic reviews, 2016, Oct-28, Volume: 10

    Topics: Anesthetics, Local; Breast Feeding; Crying; Female; Glucose; Heart Rate; Humans; Infant; Infant Care

2016
Topical anesthetic creams.
    Plastic and reconstructive surgery, 2008, Volume: 121, Issue:6

    Topics: Administration, Topical; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinati

2008
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2010, Apr-14, Issue:4

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bandages; Debridement; Humans

2010
Clinical inquiries. What's the best way to control circumcision pain in newborns?
    The Journal of family practice, 2011, Volume: 60, Issue:4

    Topics: Anesthetics, Local; Circumcision, Male; Equipment and Supplies; Evidence-Based Medicine; Humans; Inf

2011
Analgesia for amniocentesis or chorionic villus sampling.
    The Cochrane database of systematic reviews, 2011, Nov-09, Issue:11

    Topics: Amniocentesis; Analgesia; Anesthesia, Local; Chorionic Villi Sampling; Cryoanesthesia; Female; Human

2011
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L

2012
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L

2012
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L

2012
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L

2012
Vulvar biopsy. Techniques for reducing patient discomfort.
    Advance for nurse practitioners, 2001, Volume: 9, Issue:1

    Topics: Anesthetics, Local; Biopsy; Female; Hemostatic Techniques; Humans; Lidocaine; Lidocaine, Prilocaine

2001
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2003, Issue:1

    Topics: Administration, Topical; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Li

2003
Pain management in nursing procedures on premature babies.
    Journal of advanced nursing, 2003, Volume: 42, Issue:6

    Topics: Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Prilocaine Dru

2003
Topical local anesthetics.
    The American journal of nursing, 2003, Volume: 103, Issue:6

    Topics: Administration, Cutaneous; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Humans; Lidocain

2003
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
The use of EMLA cream to decrease venipuncture pain in children.
    Journal of pediatric nursing, 2004, Volume: 19, Issue:1

    Topics: Anesthetics, Local; Child; Child Welfare; Controlled Clinical Trials as Topic; Humans; Iontophoresis

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Pain relief for neonatal circumcision.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Analgesics; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, P

2004
Local approaches to the pain of pressure ulcers.
    Ostomy/wound management, 2005, Volume: 51, Issue:1

    Topics: Administration, Cutaneous; Amitriptyline; Anesthetics, Local; Bandages; Humans; Lidocaine; Lidocaine

2005
Use of a eutectic mixture of lidocaine 2.5% and prilocaine 2.5% as a local anesthetic in animals.
    Journal of the American Veterinary Medical Association, 2005, Jun-15, Volume: 226, Issue:12

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Animals; Drug Combinations; Drug

2005
Topical anesthetics for dermal instrumentation: a systematic review of randomized, controlled trials.
    Annals of emergency medicine, 2005, Volume: 46, Issue:4

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Biopsy, N

2005
EMLA and amethocaine for reduction of children's pain associated with needle insertion.
    The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Humans; Infant; Lidocaine; Lidocaine, Prilo

2006
Recent advances in acute pain management.
    Current problems in pediatrics, 1995, Volume: 25, Issue:3

    Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics;

1995
Eutectic lidocaine/prilocaine cream. A review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA).
    Drugs, 1993, Volume: 46, Issue:1

    Topics: Anesthetics, Local; Animals; Drug Combinations; Drug Evaluation; Drug Tolerance; Humans; Lidocaine;

1993
Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation.
    Pediatrics, 1994, Volume: 93, Issue:5

    Topics: Adolescent; Age Factors; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D

1994
Topical anesthesia and pain management before venipuncture.
    The Journal of pediatrics, 1993, Volume: 122, Issue:5 Pt 2

    Topics: Administration, Cutaneous; Adolescent; Anesthesia, Local; Anesthetics, Local; Bloodletting; Child; C

1993
Use of the eutectic mixture of local anesthetics in young children for procedure-related pain.
    The Journal of pediatrics, 1993, Volume: 122, Issue:5 Pt 2

    Topics: Anesthetics, Local; Child; Child, Preschool; Clinical Trials as Topic; Drug Combinations; Humans; In

1993
Management of painful procedures in the newborn.
    Current opinion in pediatrics, 1996, Volume: 8, Issue:2

    Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Drug Combinations; Hum

1996
Topical anesthetic agents in dermatologic surgery. A review.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1997, Volume: 23, Issue:8

    Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Child; Dermatologic Surgica

1997
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.
    Pediatrics, 1998, Volume: 101, Issue:2

    Topics: Acute Disease; Analgesia; Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Humans; Infan

1998
Topical anesthesia.
    Canadian family physician Medecin de famille canadien, 1998, Volume: 44

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Child; Cocaine; Drug Combinations; Epinephrine; Hu

1998
[Pharma clinics. How I treat...or preventing pain with "patches"].
    Revue medicale de Liege, 1998, Volume: 53, Issue:10

    Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Fentanyl; Lidocaine; Lidocaine, P

1998
Reducing the pain of venipuncture.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 1999, Volume: 14, Issue:2

    Topics: Anesthetics, Local; Ethyl Chloride; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain;

1999
Pain management in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:12

    Topics: Anesthesia, Conduction; Anesthetics, Local; Humans; Infant, Newborn; Infant, Premature; Lidocaine; L

1999
Getting the 'ouch' out. Topical anesthesia for procedural pain in children.
    Advance for nurse practitioners, 1999, Volume: 7, Issue:8

    Topics: Administration, Topical; Anesthetics, Local; Child; Humans; Lidocaine; Lidocaine, Prilocaine Drug Co

1999
Topical agents or dressings for pain in venous leg ulcers.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Bandages; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pril

2000
[Analgesia for infants. A review of randomized trials].
    Lakartidningen, 2000, Nov-01, Volume: 97, Issue:44

    Topics: Administration, Oral; Analgesia; Anesthetics, Combined; Anesthetics, Local; Databases, Bibliographic

2000
Pain management for neonatal circumcision.
    Paediatric drugs, 2001, Volume: 3, Issue:2

    Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Hum

2001
Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in children.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:4

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Gels; Humans; Infa

2002
[Lidocaine-prilocaine ointment; a welcome addition in local anesthesia].
    Nederlands tijdschrift voor geneeskunde, 1991, Jul-27, Volume: 135, Issue:30

    Topics: Absorption; Anesthesia, Local; Child; Condylomata Acuminata; Drug Combinations; Female; Humans; Lido

1991

Trials

274 trials available for prilocaine and Ache

ArticleYear
Music as an adjunct to combination analgesia for neonatal circumcision: A randomized controlled trial.
    Journal of pediatric urology, 2022, Volume: 18, Issue:2

    Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Lidocaine; Lidoc

2022
Pain Relief for Hysterosalpingography: A Randomized Controlled, Double Blinded Trial Comparing Suppository Diclofenac, Prilocaine/Lignocaine (EMLA) Cream And Placebo.
    West African journal of medicine, 2021, Dec-30, Volume: 38, Issue:12

    Topics: Diclofenac; Female; Humans; Hysterosalpingography; Lidocaine; Pain; Prilocaine; Prospective Studies

2021
A Randomized Controlled Trial Comparing Two Different Local Intraurethral Anesthetics in Optical Internal Urethrotomy at the Outpatient Clinic.
    Urology, 2022, Volume: 170

    Topics: Ambulatory Care Facilities; Anesthetics, Local; Constriction, Pathologic; Humans; Lidocaine; Pain; P

2022
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial.
    Journal of the American Academy of Dermatology, 2023, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Axilla; Hair Removal; Humans; Ice; Lasers, Semiconductor; Lidocaine; Lidocaine,

2023
Compound lidocaine/prilocaine cream combined with tetracaine prevents cough caused by extubation after general anaesthesia: a randomised controlled trial.
    BMC anesthesiology, 2023, 01-03, Volume: 23, Issue:1

    Topics: Airway Extubation; Anesthesia, General; Anesthetics, Local; Cough; COVID-19; Double-Blind Method; Ep

2023
Liposomal anesthetic gel for pain control during periodontal therapy in adults: a placebo-controlled RCT.
    Journal of applied oral science : revista FOB, 2020, Volume: 28

    Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Chronic Periodontitis; Dental Scaling; Double-B

2020
Comparison of the efficacy of eutectic mixture of local anesthetics (EMLA) and dorsal penile nerve block (DPNB) in neonatal circumcision.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:12

    Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Humans; Infant; Infant, Newborn; Lidocain

2019
Cryoanalgesic versus EMLA® cream to reduced pain during analgesic injection in upper eyelid surgery: a randomized trial.
    Orbit (Amsterdam, Netherlands), 2021, Volume: 40, Issue:4

    Topics: Analgesics; Anesthesia, Local; Anesthetics, Local; Eyelids; Humans; Lidocaine; Lidocaine, Prilocaine

2021
Effects of Valsalva Maneuver, EMLA Cream, and Stress Ball for Pregnant Women's Venipuncture Pain.
    Alternative therapies in health and medicine, 2021, Volume: 27, Issue:5

    Topics: Anesthetics, Local; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Phlebot

2021
Does the Application of Heat Gel Pack After Eutectic Mixture of Local Anesthetic Cream Improve Venipuncture or Intravenous Cannulation Success Rate in Children? A Randomized Control Trial.
    Pediatric emergency care, 2018, Volume: 34, Issue:2

    Topics: Anesthetics, Local; Child; Child, Preschool; Female; Hot Temperature; Humans; Lidocaine; Lidocaine,

2018
Which is more effective for pain relief during fractionated carbon dioxide laser treatment: EMLA cream or forced cold air anesthesia?
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2018, Volume: 20, Issue:1

    Topics: Ablation Techniques; Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Cryotherapy; Face; Fe

2018
Topic anaesthesia with a eutectic mixture of lidocaine/prilocaine cream after elective caesarean section: a randomised, placebo-controlled trial.
    Archives of gynecology and obstetrics, 2017, Volume: 296, Issue:4

    Topics: Adult; Analgesics; Anesthesia, Local; Anesthetics, Local; Cesarean Section; Double-Blind Method; Dru

2017
Combination Analgesia for Neonatal Circumcision: A Randomized Controlled Trial.
    Pediatrics, 2017, Volume: 140, Issue:6

    Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Double-Blind Method; Drug Therapy, Combination; F

2017
EMLA cream does not influence efficacy and pain reduction during pulsed-dye laser treatment of port-wine stain: a prospective side-by-side comparison.
    Lasers in medical science, 2018, Volume: 33, Issue:3

    Topics: Female; Humans; Lasers, Dye; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; P

2018
[The Effect of Pain Relieving Intervention During Infiltration among Gamma Knife Surgery Patients for Stereotactic Frame Fixation].
    Journal of Korean Academy of Nursing, 2018, Volume: 48, Issue:2

    Topics: Aged; Anesthetics, Local; Blood Pressure; Female; Heart Rate; Humans; Hypothermia, Induced; Lidocain

2018
A Randomized Clinical Trial Evaluating Rubber Dam Clamp Pain Reduction from a New Topical Liposomal Anesthetic Gel.
    Pediatric dentistry, 2018, May-15, Volume: 40, Issue:3

    Topics: Anesthetics, Local; Child; Dental Anxiety; Dental Caries; Female; Gels; Humans; Lidocaine; Liposomes

2018
A prospective randomized trial comparing three different analgesic techniques for pain control during transrectal ultrasound guided prostate biopsy: a single center experience.
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2013, Volume: 65, Issue:1

    Topics: Administration, Rectal; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle;

2013
Lidocaine-prilocaine (EMLA(®) ) cream as analgesia in hysteroscopy practice: a prospective, randomized, non-blinded, controlled study.
    Acta obstetricia et gynecologica Scandinavica, 2013, Volume: 92, Issue:8

    Topics: Anesthetics, Local; Cervix Uteri; Female; Humans; Hysteroscopy; Lidocaine; Lidocaine, Prilocaine Dru

2013
Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study.
    Pain, 2013, Volume: 154, Issue:12

    Topics: Adult; Capsaicin; Cryotherapy; Double-Blind Method; Female; Follow-Up Studies; Humans; Lidocaine; Li

2013
Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy.
    Urology journal, 2013, Sep-26, Volume: 10, Issue:3

    Topics: Adult; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; H

2013
The effects of Valsalva maneuver on venipuncture pain in children: comparison to EMLA(®) (lidocaine-prilocaine cream).
    Irish journal of medical science, 2014, Volume: 183, Issue:4

    Topics: Anesthetics, Local; Child; Drug Combinations; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug

2014
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
    The Journal of international medical research, 2014, Volume: 42, Issue:2

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double-

2014
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
    The Journal of international medical research, 2014, Volume: 42, Issue:2

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double-

2014
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
    The Journal of international medical research, 2014, Volume: 42, Issue:2

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double-

2014
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
    The Journal of international medical research, 2014, Volume: 42, Issue:2

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Double-

2014
The use of skin needling for the delivery of a eutectic mixture of local anesthetics.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2014, Volume: 149, Issue:5

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Drug Delive

2014
Anesthetic comparisons of 4% concentrations of articaine, lidocaine, and prilocaine as primary buccal infiltrations of the mandibular first molar: a prospective randomized, double-blind study.
    Journal of endodontics, 2014, Volume: 40, Issue:12

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Carticaine; Cross-Over Studies; Dental Pulp; Double-B

2014
Using the mouse grimace scale to assess pain associated with routine ear notching and the effect of analgesia in laboratory mice.
    Laboratory animals, 2015, Volume: 49, Issue:2

    Topics: Analgesics; Animal Identification Systems; Animals; Ear; Facial Expression; Lidocaine; Lidocaine, Pr

2015
Lidocaine-prilocaine cream as analgesia for hysterosalpingography: a randomized, double blinded, controlled study.
    European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 182

    Topics: Adult; Analgesia; Anesthesia, Local; Anesthetics, Local; Contrast Media; Double-Blind Method; Drug C

2014
A Clinical Comparison of EMLA Cream and Ethyl Chloride Spray Application for Pain Relief of Forehead Botulinum Toxin Injection.
    Annals of plastic surgery, 2015, Volume: 75, Issue:3

    Topics: Acetylcholine Release Inhibitors; Adult; Aerosols; Anesthetics, Local; Botulinum Toxins, Type A; Cos

2015
Opposite effects of the same drug: reversal of topical analgesia by nocebo information.
    Pain, 2015, Volume: 156, Issue:1

    Topics: Administration, Topical; Adult; Analgesia; Anesthetics, Local; Emotions; Female; Humans; Lidocaine;

2015
Novel approach for pain control in patients undergoing prostate biopsy: iliohypogastric nerve block with or without topical application of prilocaine-lidocaine: a randomized controlled trial.
    Urology journal, 2015, Feb-22, Volume: 12, Issue:1

    Topics: Administration, Rectal; Administration, Topical; Anesthesia, Local; Anesthetics, Local; Endoscopic U

2015
Lidocaine-Prilocaine Cream as Analgesia for IUD Insertion: A Prospective, Randomized, Controlled, Triple Blinded Study.
    Global journal of health science, 2015, Jan-27, Volume: 7, Issue:4

    Topics: Adult; Analgesia; Anesthetics, Combined; Double-Blind Method; Female; Humans; Intrauterine Devices;

2015
Comparison of pain perception during miniscrew placement in orthodontic patients with a visual analog scale survey between compound topical and needle-injected anesthetics: A crossover, prospective, randomized clinical trial.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2016, Volume: 149, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Anesthesia, Dental; Anesthetics, Combined; Anesthetics,

2016
Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum.
    Pediatric dermatology, 2016, Volume: 33, Issue:3

    Topics: Anesthetics, Local; Child; Child, Preschool; Cryotherapy; Drug Combinations; Drug Tolerance; Female;

2016
In vitro and in vivo Evaluation of New Topical Anaesthetic Cream Formulated with Palm Oil Base.
    Current drug delivery, 2017, Volume: 14, Issue:5

    Topics: Anesthetics, Local; Drug Combinations; Female; Healthy Volunteers; Humans; Lidocaine; Male; Pain; Pa

2017
A Randomized Trial on the Efficacy of Topical Anesthesia for Pain Reduction during Frame Placement for Gamma Knife Radiosurgery.
    Stereotactic and functional neurosurgery, 2016, Volume: 94, Issue:4

    Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Brain Diseases; Forehead; Humans; Lidocain

2016
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
    Contraception, 2017, Volume: 95, Issue:3

    Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method;

2017
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
    Contraception, 2017, Volume: 95, Issue:3

    Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method;

2017
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
    Contraception, 2017, Volume: 95, Issue:3

    Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method;

2017
Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
    Contraception, 2017, Volume: 95, Issue:3

    Topics: Administration, Intravaginal; Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method;

2017
First-time success with needle procedures was higher with a warm lidocaine and tetracaine patch than an eutectic mixture of lidocaine and prilocaine cream.
    Acta paediatrica (Oslo, Norway : 1992), 2017, Volume: 106, Issue:5

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Female; Hot Temperature; H

2017
Optimizing local anesthesia for grommet insertion: eutectic mixture of local anaesthetics versus Ametop: a randomized clinical trial.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2008, Volume: 29, Issue:5

    Topics: Anesthetics, Local; Double-Blind Method; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination;

2008
A clinical comparison of topical piroxicam and EMLA cream for pain relief and inflammation in laser hair removal.
    Lasers in medical science, 2009, Volume: 24, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroi

2009
Thyroid fine needle aspiration biopsy: is topical local anaesthesia beneficial?
    International journal of clinical practice, 2010, Volume: 64, Issue:1

    Topics: Administration, Cutaneous; Adult; Analgesics; Anesthesia, Local; Anesthetics, Local; Biopsy, Fine-Ne

2010
Interventions to reduce pain during vaccination in infancy.
    The Journal of pediatrics, 2009, Volume: 154, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Breast Feeding; Child, Prescho

2009
Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial.
    The Journal of urology, 2009, Volume: 181, Issue:2

    Topics: Administration, Topical; Aged; Analgesia; Analysis of Variance; Biopsy, Needle; Chi-Square Distribut

2009
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
    British journal of anaesthesia, 2009, Volume: 102, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics,

2009
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
    British journal of anaesthesia, 2009, Volume: 102, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics,

2009
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
    British journal of anaesthesia, 2009, Volume: 102, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics,

2009
Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access.
    British journal of anaesthesia, 2009, Volume: 102, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthesia, Local; Anesthetics, Combined; Anesthetics,

2009
Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study.
    Urologia internationalis, 2009, Volume: 82, Issue:3

    Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Humans; Lidocaine;

2009
Comparison of three analgesic treatment protocols for pain management during extracorporeal shock wave lithotripsy.
    Urologia internationalis, 2009, Volume: 82, Issue:3

    Topics: Adult; Analgesia; Anesthetics, Combined; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal

2009
Amethocaine versus EMLA for successful intravenous cannulation in a children's emergency department: a randomised controlled study.
    Emergency medicine journal : EMJ, 2009, Volume: 26, Issue:7

    Topics: Administration, Topical; Adolescent; Anesthetics, Combined; Anesthetics, Local; Catheterization; Chi

2009
Comparison between lidocaine-prilocaine cream (EMLA) and mepivacaine infiltration for pain relief during perineal repair after childbirth: a randomized trial.
    American journal of obstetrics and gynecology, 2009, Volume: 201, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Delivery, Obstetric; Epis

2009
Pregnancy at term does not alter the responses to a mechanical and an electrical stimulus after skin EMLA application.
    Middle East journal of anaesthesiology, 2009, Volume: 20, Issue:2

    Topics: Adult; Anesthetics, Local; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Electric S

2009
Comparison of local anesthetic effects of tramadol with prilocaine during circumcision procedure.
    Urology, 2010, Volume: 75, Issue:3

    Topics: Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Child; Circumcision, Male; Double-Blind M

2010
Lidocaine-based topical anesthetic with disinfectant (LidoDin) versus EMLA for venipuncture: a randomized controlled trial.
    The Clinical journal of pain, 2009, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Child; Disinfectants; Edema; Erythema;

2009
The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2010, Volume: 68, Issue:1

    Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Dry Socket; Eugenol; Fema

2010
[Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch].
    Der Anaesthesist, 2010, Volume: 59, Issue:6

    Topics: Administration, Cutaneous; Adolescent; Anesthesia, Local; Anesthetics, Local; Behavior; Child; Child

2010
Safety of lidocaine 15% and prilocaine 5% topical ointment used as local anesthesia for intense pulsed light treatment.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:7

    Topics: Administration, Cutaneous; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Cosmetic Techniques;

2010
Effect of eutectic mixture of local anesthetics on pain perception during scaling by ultrasonic or hand instruments: a masked randomized controlled trial.
    Journal of periodontology, 2011, Volume: 82, Issue:2

    Topics: Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Local; Dental Instruments; Drug Com

2011
Double-blind, randomized, intraindividual comparison study of the efficacy of prilocaine and lidocaine in tumescent local anesthesia.
    Dermatology (Basel, Switzerland), 2010, Volume: 221, Issue:3

    Topics: Adult; Anesthesia, Local; Double-Blind Method; Female; Hip; Humans; Lidocaine; Lipectomy; Male; Midd

2010
Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy.
    Urological research, 2011, Volume: 39, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthetics, Local; Dimethyl Sulfoxide; Drug The

2011
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
    The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:1

    Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca

2012
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
    The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:1

    Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca

2012
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
    The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:1

    Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca

2012
Liposomal delivery system for topical anaesthesia of the palatal mucosa.
    The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:1

    Topics: Administration, Topical; Adult; Amides; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Loca

2012
Reducing procedural pain and discomfort associated with transcranial direct current stimulation.
    Brain stimulation, 2011, Volume: 4, Issue:1

    Topics: Adult; Electric Stimulation Therapy; Female; Forehead; Humans; Lidocaine; Lidocaine, Prilocaine Drug

2011
Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2011, Volume: 15, Issue:4

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy; C

2011
Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel.
    Urologic oncology, 2013, Volume: 31, Issue:1

    Topics: Administration, Rectal; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, N

2013
EMLA versus glucose for PICC insertion: a randomised triple-masked controlled study.
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:6

    Topics: Analgesia; Anesthetics, Local; Catheterization, Central Venous; Glucose; Humans; Infant, Newborn; In

2011
Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants.
    Pediatrics, 2011, Volume: 128, Issue:1

    Topics: Administration, Oral; Analgesia; Anesthetics, Local; Dosage Forms; Double-Blind Method; Drug Therapy

2011
Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain.
    The Journal of dermatological treatment, 2012, Volume: 23, Issue:6

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; H

2012
No effect of perianal application of topical anaesthetic on patient comfort during nonsedated flexible sigmoidoscopy: a randomized, placebo-controlled clinical trial.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2012, Volume: 14, Issue:7

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anxiety; Female; Humans; Lidoca

2012
Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy.
    BJU international, 2012, Volume: 109, Issue:12

    Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Cyclooxygenase Inhi

2012
Do topical anesthetics reduce periareolar injectional pain before sentinel lymph node biopsy?
    American journal of surgery, 2011, Volume: 202, Issue:6

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Breast Neoplasms; Double-

2011
Vapocoolant spray vs lidocaine/prilocaine cream for reducing the pain of venipuncture in hemodialysis patients: a randomized, placebo-controlled, crossover study.
    International journal of medical sciences, 2011, Volume: 8, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cold Temperature; Cross-Over Studies; Female; Humans; Li

2011
Pain assessment of the intratympanic injections: a prospective comparative study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012, Volume: 269, Issue:12

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Anti-Bacterial Agents; Anti-Inflammatory Agents; Female

2012
The effect of SonoPrep® on EMLA® cream application for pain relief prior to intravenous cannulation.
    European journal of pediatrics, 2012, Volume: 171, Issue:6

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Double-Blind Method; Femal

2012
Topical EMLA for pain control during extracorporeal shock wave lithotripsy: prospective, comparative, randomized, double-blind study.
    Urological research, 2012, Volume: 40, Issue:5

    Topics: Adult; Aged; Anesthetics, Combined; Body Mass Index; Double-Blind Method; Female; Humans; Lidocaine;

2012
Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children.
    Hormone research in paediatrics, 2012, Volume: 77, Issue:5

    Topics: Adolescent; Anesthetics, Local; Blood Glucose; Blood Specimen Collection; Catheterization, Periphera

2012
The effect of EMLA cream on minimizing pain during venipuncture in premature infants.
    Journal of tropical pediatrics, 2013, Volume: 59, Issue:1

    Topics: Administration, Topical; Anesthetics, Local; Female; Humans; Infant, Newborn; Infant, Premature; Lid

2013
Effect of topical anesthesia on pain during infiltration injection and success of anesthesia for maxillary central incisors.
    Journal of endodontics, 2012, Volume: 38, Issue:12

    Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocain

2012
Comparison of the effects of vapocoolant spray and topical anesthetic cream on pain during needle electromyography in the medial gastrocnemius.
    Archives of physical medicine and rehabilitation, 2013, Volume: 94, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Anesthesia, Local; Anesthetics, Local; Confidence Intervals; Cryo

2013
A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Capsaicin; Double-Blind Method; Drug

2013
Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in
    The Pediatric infectious disease journal, 2002, Volume: 21, Issue:5

    Topics: Administration, Topical; Anesthetics, Local; Antibody Formation; Diphtheria-Tetanus-acellular Pertus

2002
Topical anesthetics for intravenous insertion in children: a randomized equivalency study.
    Pediatrics, 2002, Volume: 110, Issue:4

    Topics: Adolescent; Age Factors; Anesthetics, Local; Child; Female; Humans; Infusions, Intravenous; Injectio

2002
Treatment of tendopathies with tropisetron.
    Rheumatology international, 2002, Volume: 22, Issue:6

    Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Indoles; Infusions, Intralesional; Injectio

2002
EMLA cream and intraperitoneal lidocaine decrease intraoperative pain during postpartum tubal sterilization.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 3

    Topics: Adult; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Female; Humans; Injections,

2002
Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream.
    Pediatrics, 2002, Volume: 110, Issue:6

    Topics: Administration, Oral; Anesthesia, Local; Double-Blind Method; Glucose; Humans; Infant, Newborn; Lido

2002
Evaluation of a novel topical anesthetic agent for cutaneous laser resurfacing: a randomized comparison study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2002, Volume: 28, Issue:11

    Topics: Anesthesia, Local; Anesthetics, Local; Dermatologic Surgical Procedures; Double-Blind Method; Drug C

2002
Pain and distress from bone marrow aspirations and lumbar punctures.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:1

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Biopsy, Needle; Bon

2003
Injection pain of bupivacaine with epinephrine vs. prilocaine plain.
    Journal of the American Dental Association (1939), 2002, Volume: 133, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthesia, Dental; Anesthesia, Lo

2002
Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial.
    The Journal of rheumatology, 2003, Volume: 30, Issue:3

    Topics: Adolescent; Anesthetics, Local; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Double-Blind M

2003
Effective reduction of anxiety and pain during venous cannulation in children: a comparison of analgesic efficacy conferred by nitrous oxide, EMLA and combination.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:3

    Topics: Adolescent; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Local

2003
EMLA does not permit pain-free retrobulbar injection.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:6

    Topics: Administration, Topical; Anesthesia, Spinal; Anesthetics, Local; Cataract Extraction; Double-Blind M

2003
Minimum clinically significant VAS differences for simultaneous (paired) interval serial pain assessments.
    The American journal of emergency medicine, 2003, Volume: 21, Issue:3

    Topics: Administration, Topical; Adult; Anesthetics, Local; Bites and Stings; Catheterization, Peripheral; C

2003
Intrapocket anesthesia for scaling and root planing in pain-sensitive patients.
    Journal of periodontology, 2003, Volume: 74, Issue:5

    Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Dental Scaling; Double-Blind Method; Female; Fo

2003
EMLA cream and oral glucose for immunization pain in 3-month-old infants.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Administration, Oral; Administration, Topical; Analysis of Variance; Chi-Square Distribution; Double

2003
The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthetics, Combi

2003
Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers.
    Journal of wound care, 2001, Volume: 10, Issue:1

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Chronic Disease; Debr

2001
Statistical process control methods allow the analysis and improvement of anesthesia care.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:8

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Peripheral

2003
Full-face laser resurfacing using a supplemented topical anesthesia protocol.
    Archives of dermatology, 2003, Volume: 139, Issue:10

    Topics: Acne Vulgaris; Administration, Topical; Anesthetics, Local; Cicatrix; Face; Female; Follow-Up Studie

2003
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
    Archives of pediatrics & adolescent medicine, 2003, Volume: 157, Issue:11

    Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf

2003
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
    Archives of pediatrics & adolescent medicine, 2003, Volume: 157, Issue:11

    Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf

2003
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
    Archives of pediatrics & adolescent medicine, 2003, Volume: 157, Issue:11

    Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf

2003
A randomized trial of eutectic mixture of local anesthetics during lumbar puncture in newborns.
    Archives of pediatrics & adolescent medicine, 2003, Volume: 157, Issue:11

    Topics: Anesthetics, Combined; Anesthetics, Local; Chi-Square Distribution; Double-Blind Method; Humans; Inf

2003
Pain during transrectal ultrasonography guided prostate biopsy: a randomized prospective trial comparing periprostatic infiltration with lidocaine with the intrarectal instillation of lidocaine-prilocain cream.
    World journal of urology, 2004, Volume: 22, Issue:4

    Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Biopsy; Dosag

2004
Improved application of Lidocaine/Prilocaine cream in children. A randomized and prospectively controlled study of two application regimes.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:4

    Topics: Anesthetics, Local; Catheterization; Child; Double-Blind Method; Drug Administration Schedule; Human

2004
Comparison of EMLA and lidocaine iontophoresis for cannulation analgesia.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:3

    Topics: Adult; Aged; Analgesia; Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Doub

2004
Study on the efficacy of ELA-Max (4% liposomal lidocaine) compared with EMLA cream (eutectic mixture of local anesthetics) using thermosensory threshold analysis in adult volunteers.
    The Journal of dermatological treatment, 2004, Volume: 15, Issue:2

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine

2004
[Analgesic effects of Emla cream and saccharose solution for subcutaneous injections in preterm newborns: a prospective study of 265 injections].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2004, Volume: 11, Issue:8

    Topics: Administration, Cutaneous; Administration, Oral; Analysis of Variance; Anesthetics, Combined; Anesth

2004
Use of topical application of lidocaine-prilocaine cream to reduce injection-site pain of depot antipsychotics.
    Psychiatric services (Washington, D.C.), 2004, Volume: 55, Issue:8

    Topics: Administration, Topical; Adult; Anesthetics, Local; Antipsychotic Agents; Brief Psychiatric Rating S

2004
Unilateral pudendal nerve blockade for relief of all pain during transrectal ultrasound-guided biopsy of the prostate: a randomized, double-blind, placebo-controlled study.
    Urology, 2004, Volume: 64, Issue:3

    Topics: Aged; Anesthetics, Local; Autonomic Nerve Block; Biopsy, Needle; Double-Blind Method; Humans; Male;

2004
Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children.
    Pediatric blood & cancer, 2004, Volume: 43, Issue:7

    Topics: Adolescent; Age Distribution; Catheterization, Central Venous; Child; Child, Preschool; Female; Huma

2004
Pudendal nerve block for pain relief in episiotomy repair.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2004, Volume: 87, Issue:2

    Topics: Anesthetics, Local; Autonomic Nerve Block; Episiotomy; Female; Genitalia, Female; Humans; Injections

2004
Quantification and analysis of pain in nonsurgical scaling and/or root planing.
    Journal of the American Dental Association (1939), 2004, Volume: 135, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Double-Bl

2004
Intravenous ketamine sedation for painful oncology procedures.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:2

    Topics: Adolescent; Analgesics; Anesthetics, Local; Biopsy, Needle; Bone Marrow Examination; Child; Child, P

2005
[Optimized use of Emla cream in children--secondary publication. A randomized, prospective, controlled comparison of two application regimes].
    Ugeskrift for laeger, 2005, Jan-24, Volume: 167, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; Catheterization; Child; Double-Blind Method; Female; Huma

2005
[Application of EMLA creme before upper lid blepharoplasty].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2005, Volume: 102, Issue:8

    Topics: Administration, Topical; Anesthetics; Anesthetics, Local; Blepharoplasty; Chemotherapy, Adjuvant; Fe

2005
Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2005, Volume: 31, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Female; Hair Removal; Humans; Laser

2005
Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy.
    Journal of endourology, 2005, Volume: 19, Issue:5

    Topics: Administration, Topical; Aged; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combination; Fe

2005
Local anesthesia in transrectal ultrasound-guided prostate biopsy: EMLA cream as a new alternative technique.
    Scandinavian journal of urology and nephrology, 2005, Volume: 39, Issue:2

    Topics: Administration, Rectal; Aged; Anesthesia, Local; Anesthetics, Local; Biopsy; Endosonography; Humans;

2005
Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine.
    The Journal of clinical dentistry, 2005, Volume: 16, Issue:2

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Cuspid; Humans; Lidocaine; Lidocaine,

2005
Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments.
    Archives of disease in childhood, 2005, Volume: 90, Issue:10

    Topics: Adolescent; Analgesics; Anesthetics, Inhalation; Anxiety; Catheterization; Child; Female; Humans; Li

2005
Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo.
    BJU international, 2005, Volume: 96, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Double-Bl

2005
[Acute pain management in proximal femoral fractures: femoral nerve block (catheter technique) vs. systemic pain therapy using a clinic internal organisation model].
    Der Anaesthesist, 2006, Volume: 55, Issue:4

    Topics: Acute Disease; Aged; Aged, 80 and over; Amides; Analgesics, Opioid; Anesthetics, Local; Catheterizat

2006
Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats.
    Journal of feline medicine and surgery, 2006, Volume: 8, Issue:2

    Topics: Analgesia; Anesthetics, Combined; Anesthetics, Local; Animals; Cat Diseases; Catheterization, Centra

2006
Lidocaine-prilocaine administration during transrectal ultrasound-guided prostatic biopsy: a randomized, single-blind, placebo-controlled trial.
    Journal of endourology, 2006, Volume: 20, Issue:7

    Topics: Administration, Rectal; Aged; Anesthetics, Local; Biopsy, Needle; Endosonography; Humans; Lidocaine;

2006
Does amethocaine gel influence blood results obtained from capillary sampling?
    Paediatric nursing, 2006, Volume: 18, Issue:6

    Topics: Administration, Cutaneous; Adult; Alanine Transaminase; Alkaline Phosphatase; Anesthetics, Local; As

2006
Efficacy of EMLA cream to reduce fear and pain associated with interferon beta-1a injection in patients with multiple sclerosis.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2006, Volume: 38, Issue:4

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Adolescent; Adult; Anesthetics, Local; Attitude t

2006
Use of lidocaine-prilocaine patch for the mantoux test: Influence on pain and reading.
    International journal of pharmaceutics, 2006, Dec-11, Volume: 327, Issue:1-2

    Topics: Adult; Anesthetics, Local; BCG Vaccine; Drug Delivery Systems; Female; Forearm; Humans; Injections,

2006
Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:9

    Topics: Administration, Topical; Anesthetics, Local; Biopsy; Catheterization; Double-Blind Method; Female; H

2006
Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration.
    Journal of cardiothoracic anesthesia, 1988, Volume: 2, Issue:3

    Topics: Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Injections, Subc

1988
Effects of local anaesthesia on subdermal needle insertion pain and subsequent tests of microvascular function in human.
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Administration, Topical; Adult; Anesthetics, Combined; Anesthetics, Local; Blood Flow Velocity; Dose

2007
The effect of a eutectic mixture of local anesthetic cream on wrist pain during transradial coronary procedures.
    The Journal of invasive cardiology, 2007, Volume: 19, Issue:1

    Topics: Aged; Analysis of Variance; Anesthesia, Local; Cardiac Catheterization; Case-Control Studies; Cathet

2007
Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2007, Volume: 103, Issue:5

    Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Benzocaine; Gels; Humans; Injectio

2007
Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2007, Volume: 54, Issue:3

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Diclofenac; Double-Blind

2007
[Evaluation of analgesic protocol with nitrous oxide and EMLA cream during botulinum toxin injections in children].
    Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique, 2007, Volume: 50, Issue:5

    Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy;

2007
Eutectic mixture of local anesthetic (EMLA) decreases pain during humeral block placement in nonsedated patients.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Double-Blind Method; Elective Surgical Pro

2007
Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
    European urology, 2008, Volume: 53, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Follow-Up

2008
Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study.
    Anaesthesia and intensive care, 2007, Volume: 35, Issue:5

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Capsaicin; Catheterization, Periphe

2007
Comparison of sciatic psoas compartment block and sciatic femoral 3-in-1 block for knee arthroscopy.
    Journal of clinical anesthesia, 2007, Volume: 19, Issue:8

    Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Arthroscopy; Bupivacaine; Elective Surgical Pro

2007
The effect of prilocaine and prilocaine plus meperidine infiltration on the pain during nasal packing removal.
    Rhinology, 2007, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Analgesics, Opioid; Device Removal; Drug Combinations; Female; Formaldehyde; Hemo

2007
Galactography without discomfort using lidocaine/prilocaine anesthetic cream.
    Acta radiologica (Stockholm, Sweden : 1987), 2008, Volume: 49, Issue:1

    Topics: Adult; Aged; Anesthetics, Local; Breast Diseases; Catheterization; Contrast Media; Humans; Lidocaine

2008
The effect of 50% glycolic acid on the percutaneous absorption of eutectic mixture of local anesthetics (EMLA): a study of the electrofulguration-induced pain.
    International journal of dermatology, 2008, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Drug Synergism; Drug Therapy, Combinatio

2008
EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children.
    Pediatrics, 2008, Volume: 121, Issue:6

    Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani

2008
Topical anaesthesia with EMLA, a new lidocaine-prilocaine cream and the Cusum technique for detection of minimal application time.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:6

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Catheteriza

1983
Pain-free venepuncture. Effect of timing of application of local anaesthetic cream.
    Anaesthesia, 1984, Volume: 39, Issue:10

    Topics: Adolescent; Anesthetics, Local; Catheterization; Child; Child, Preschool; Double-Blind Method; Drug

1984
EMLA--a eutectic mixture of local anaesthetics for topical anaesthesia.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:6

    Topics: Adolescent; Anesthesia, Local; Catheterization; Child; Double-Blind Method; Drug Combinations; Femal

1982
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

1995
Use of a eutectic mixture of local anesthetics for prolonged subcutaneous drug administration.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:3

    Topics: Anesthetics, Local; beta-Thalassemia; Deferoxamine; Double-Blind Method; Drug Combinations; Female;

1995
Analgesia for venous cannulation: a comparison of EMLA (5 minutes application), lignocaine, ethyl chloride, and nothing.
    Journal of the Royal Society of Medicine, 1995, Volume: 88, Issue:5

    Topics: Adult; Analgesia; Anesthetics, Local; Catheterization, Peripheral; Drug Combinations; Ethyl Chloride

1995
Prilocaine reduces injection pain caused by propofol.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:2

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi

1995
Single medial injection peribulbar anaesthesia using prilocaine.
    Anaesthesia, 1994, Volume: 49, Issue:11

    Topics: Aged; Anesthesia, Conduction; Eye Diseases; Eye Movements; Eyelids; Female; Humans; Intraoperative C

1994
Pain after subcutaneous injection of recombinant human erythropoietin: does Emla cream help?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:9

    Topics: Adult; Aged; Anemia; Anesthetics, Local; Double-Blind Method; Drug Combinations; Erythropoietin; Fem

1994
A comparison of amethocaine cream with lignocaine-prilocaine cream (EMLA) for reducing pain during retrobulbar injection.
    Eye (London, England), 1994, Volume: 8 ( Pt 4)

    Topics: Aged; Aged, 80 and over; Anesthetics, Local; Cataract Extraction; Double-Blind Method; Drug Combinat

1994
An assessment of prilocaine as a topical anaesthetic agent for fibreoptic bronchoscopy in comparison with lidocaine.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:5

    Topics: Adult; Aged; Anesthetics; Anesthetics, Local; Bronchoscopy; Conscious Sedation; Double-Blind Method;

1994
An alternative for needle pain. Report of the Edmonton EMLA Study.
    AARN news letter, 1994, Volume: 50, Issue:8

    Topics: Anesthetics, Local; Child; Drug Combinations; Female; Humans; Injections; Lidocaine; Lidocaine, Pril

1994
Placebo effect of eutectic mixture of lidocaine and prilocaine (EMLA) cream in reducing venepuncture pain in children.
    Annals of the Academy of Medicine, Singapore, 1994, Volume: 23, Issue:4

    Topics: Anesthesiology; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Double-Blind Method; Drug

1994
Comparison of iontophoresis of lidocaine with a eutectic mixture of lidocaine and prilocaine (EMLA) for topically administered local anesthesia.
    The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:9

    Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug C

1994
Trial of a topically administered local anesthetic (EMLA cream) for pain relief during central venous port accesses in children with cancer.
    Journal of pain and symptom management, 1994, Volume: 9, Issue:4

    Topics: Administration, Cutaneous; Adolescent; Adult; Anesthetics, Local; Antineoplastic Agents; Child; Chil

1994
Comparison of percutaneous anaesthesia for venous cannulation after topical application of either amethocaine or EMLA cream.
    British journal of anaesthesia, 1994, Volume: 72, Issue:2

    Topics: Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Double-Blind

1994
A multicentre randomized study of single-unit dose package of EMLA patch vs EMLA 5% cream for venepuncture in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:1

    Topics: Adhesiveness; Administration, Cutaneous; Analgesics; Anesthetics, Local; Bloodletting; Child; Child,

1994
A double-blind placebo controlled study of a 5% lidocaine/prilocaine cream (EMLA) for topical anesthesia during thermolysis.
    The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinatio

1994
Peribulbar and retrobulbar anesthesia with prilocaine: a comparison of two methods of local ocular anesthesia.
    Ophthalmic surgery, 1993, Volume: 24, Issue:12

    Topics: Aged; Anesthesia, Local; Female; Humans; Male; Nerve Block; Ophthalmologic Surgical Procedures; Pain

1993
Use of lidocaine-prilocaine cream for vaccination pain in infants.
    The Journal of pediatrics, 1994, Volume: 124, Issue:4

    Topics: Anesthetics, Local; Diphtheria-Tetanus-Pertussis Vaccine; Double-Blind Method; Drug Combinations; Fe

1994
Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation.
    Pediatrics, 1994, Volume: 93, Issue:5

    Topics: Adolescent; Age Factors; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D

1994
Alleviation of the pain of heel prick in preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 1994, Volume: 70, Issue:3

    Topics: Anesthetics, Local; Blood Gas Monitoring, Transcutaneous; Blood Specimen Collection; Carbon Dioxide;

1994
The EMLA patch--a new type of local anaesthetic application for dermal analgesia in children.
    Anaesthesia, 1994, Volume: 49, Issue:1

    Topics: Adolescent; Analgesia; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Drug Combinations;

1994
Pethidine has a local anaesthetic action on peripheral nerves in vivo. Addition to prilocaine 0.25% for intravenous regional anaesthesia in volunteers.
    Anaesthesia, 1993, Volume: 48, Issue:5

    Topics: Adult; Anesthesia, Conduction; Anesthesia, Local; Arm; Double-Blind Method; Humans; Male; Meperidine

1993
Dermal patch anaesthesia: comparison of 10% lignocaine gel with absorption promoter and EMLA cream.
    Anaesthesia, 1993, Volume: 48, Issue:5

    Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug C

1993
Effect of a topical anesthetic cream (EMLA) in reducing pain caused by infiltration of local anesthetic in eyelid surgery.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1993, Volume: 28, Issue:4

    Topics: Aged; Anesthetics, Local; Double-Blind Method; Drug Combinations; Eyelid Diseases; Female; Humans; L

1993
A eutectic mixture of lidocaine and prilocaine for alleviating vaccination pain in infants.
    Pediatrics, 1993, Volume: 92, Issue:5

    Topics: Anesthesia, Local; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Humans; Infant;

1993
Comparison of the effect of EMLA cream, subcutaneous ring anaesthesia and a double cuff technique in the prevention of tourniquet pain.
    British journal of anaesthesia, 1993, Volume: 70, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthetics, Local; Drug Combinations; Female; Huma

1993
A comparison of EMLA cream versus nitrous oxide for pediatric venous cannulation.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:6

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Anxiety; Catheterization, Per

1995
Is intra-articular pethidine an alternative to local anaesthetics in arthroscopy? A double-blind study comparing prilocaine with pethidine.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 1993, Volume: 1, Issue:3-4

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Arthroscopy; Double-Blind Method; Female; Humans; Inj

1993
The use of lignocaine to reduce pain on i.v. injection of diluted nalbuphine.
    European journal of anaesthesiology, 1995, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Local; Child; Double-Blind Method; Drug Combinat

1995
[Efficacy of the EMLA cream in the reduction of pain caused by venipuncture in children premedicated with oral midazolam].
    Revista espanola de anestesiologia y reanimacion, 1995, Volume: 42, Issue:9

    Topics: Adjuvants, Anesthesia; Administration, Oral; Anesthetics, Local; Child; Child, Preschool; Drug Combi

1995
Does a local anaesthetic cream (EMLA) alleviate pain from heel-lancing in neonates?
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:8

    Topics: Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Heel; Humans; Infant, Newborn; L

1995
Analgesic and anti-inflammatory effects of lignocaine-prilocaine (EMLA) cream in human burn injury.
    British journal of anaesthesia, 1996, Volume: 76, Issue:6

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Burns; Double-Blind Method; Drug

1996
[EMLA cream in hematology].
    Soins. Pediatrie, puericulture, 1995, Issue:164

    Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Anesthetics, Local; Child; Child, Preschool; Dr

1995
Topical ibuprofen for skin analgesia prior to venepuncture.
    Anaesthesia, 1996, Volume: 51, Issue:5

    Topics: Administration, Topical; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cat

1996
EMLA prevents pain during local anesthesia for cataract surgery.
    Acta anaesthesiologica Belgica, 1995, Volume: 46, Issue:2

    Topics: Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Double-Blind Method; Drug Combinations;

1995
The application of EMLA and glyceryl trinitrate ointment prior to venepuncture.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:3

    Topics: Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations;

1996
Topical application of lidocaine-prilocaine (EMLA) cream reduces the pain of intramuscular infiltration of saline solution.
    The Journal of pediatrics, 1996, Volume: 129, Issue:5

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Injection

1996
Analgesia for venepuncture in a paediatric surgery centre.
    Journal of paediatrics and child health, 1995, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Chi

1995
EMLA cream as a topical anesthetic before office phlebotomy in children.
    Southern medical journal, 1996, Volume: 89, Issue:12

    Topics: Adolescent; Ambulatory Care; Anesthetics, Local; Anxiety; Child; Child, Preschool; Double-Blind Meth

1996
A comparison of topical anaesthesia and electronic nerve stimulation for reducing the pain of intra-oral injections.
    British dental journal, 1996, Nov-09, Volume: 181, Issue:9

    Topics: Administration, Buccal; Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Chi-Squ

1996
EMLA cream for pain reduction in diagnostic allergy skin testing: effects on wheal and flare responses.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 78, Issue:1

    Topics: Adult; Allergens; Anesthetics, Local; Drug Combinations; Female; Humans; Lidocaine; Lidocaine, Prilo

1997
Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Feb-15, Volume: 54, Issue:4

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Dosage Forms; Drug

1997
Effect of neonatal circumcision on pain response during subsequent routine vaccination.
    Lancet (London, England), 1997, Mar-01, Volume: 349, Issue:9052

    Topics: Analysis of Variance; Anesthetics, Local; Circumcision, Male; Cohort Studies; Drug Combinations; Hum

1997
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.
    The New England journal of medicine, 1997, Apr-24, Volume: 336, Issue:17

    Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Crying; Double-Blind Method; Drug Combina

1997
Neonatal circumcision.
    Lancet (London, England), 1997, Apr-26, Volume: 349, Issue:9060

    Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Hypnotics and Sedatives; Infant,

1997
Effect of percutaneous local anaesthetics on pain reduction during pulse dye laser treatment of portwine stains.
    British journal of anaesthesia, 1997, Volume: 78, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinations; Hu

1997
Comparative topical anaesthesia of EMLA and liposome-encapsulated tetracaine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:7

    Topics: Administration, Topical; Adult; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Drug Ca

1997
Prilocaine/lidocaine patch as a local premedication for skin biopsy in children.
    Journal of the American Academy of Dermatology, 1997, Volume: 37, Issue:3 Pt 1

    Topics: Administration, Cutaneous; Adolescent; Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Ch

1997
New non-cocaine-containing topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
    Pediatrics, 1997, Volume: 100, Issue:5

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; C

1997
Use of eutectic mixture of local anesthetics: an effective topical anesthetic for slit-smear testing of patients with Hansen's disease.
    Journal of the American Academy of Dermatology, 1997, Volume: 37, Issue:5 Pt 1

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Biopsy; Ear, External; Elbow; Female; Humans; Knee

1997
Two modalities of topical anesthesia for office hysteroscopy.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1997, Volume: 59, Issue:2

    Topics: Anesthesia, Local; Anesthetics, Local; Female; Humans; Hysteroscopy; Lidocaine; Pain; Prilocaine

1997
[Effectiveness of local anesthesia using EMLA cream for laser treatment of cervical and vulvar lesions].
    Contraception, fertilite, sexualite (1992), 1997, Volume: 25, Issue:11

    Topics: Anesthetics, Combined; Anesthetics, Local; Condylomata Acuminata; Female; Humans; Laser Therapy; Lid

1997
Topical anaesthesia in neonatal circumcision: a study of 208 consecutive cases.
    Australian family physician, 1996, Volume: Suppl 1

    Topics: Administration, Topical; Age Factors; Anesthetics, Local; Australia; Child, Preschool; Circumcision,

1996
Clinical comparison of preinjection anesthetics.
    Journal of the American Podiatric Medical Association, 1998, Volume: 88, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Atmosphere; Child

1998
Prilocaine-phenylephrine and bupivacaine-phenylephrine topical anesthetics compared with tetracaine-adrenaline-cocaine during repair of lacerations.
    The American journal of emergency medicine, 1998, Volume: 16, Issue:2

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Child; Child, Preschool; Cocaine; De

1998
Analgesia for neonatal circumcision: a randomized controlled trial of EMLA cream versus dorsal penile nerve block.
    Pediatrics, 1998, Volume: 101, Issue:4

    Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidoc

1998
Subcutaneous erythropoietin alpha (Eprex) is more painful than erythropoietin beta (Recormon)
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998, Volume: 13, Issue:3

    Topics: Adult; Anesthetics, Local; Child; Drug Compounding; Erythropoietin; Female; Humans; Injections, Subc

1998
Comparison of the effect of EMLA and semicircular subcutaneous anaesthesia in the prevention of tourniquet pain during plexus block anaesthesia of the arm.
    Anaesthesia, 1998, Volume: 53, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Local; Brachial Plexus; Bupivacaine; Female; Forearm; H

1998
Emla cream as a local anaesthetic in MMR vaccination.
    International journal of clinical practice, 1998, Volume: 52, Issue:2

    Topics: Anesthetics, Local; Child; Double-Blind Method; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combin

1998
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
    European journal of dermatology : EJD, 1998, Volume: 8, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr

1998
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
    European journal of dermatology : EJD, 1998, Volume: 8, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr

1998
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
    European journal of dermatology : EJD, 1998, Volume: 8, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr

1998
Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers. The effect of length of application time.
    European journal of dermatology : EJD, 1998, Volume: 8, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Combined; Debridement; Drug Administr

1998
Topical lidocaine-prilocaine cream (EMLA) versus local infiltration anesthesia for radial artery cannulation.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:2

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Inj

1998
Alleviation of the pain of venepuncture in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1998, Volume: 87, Issue:7

    Topics: Anesthetics, Local; Double-Blind Method; Female; Humans; Infant, Newborn; Lidocaine; Lidocaine, Pril

1998
Subcutaneous administration of midazolam: a comparison of the Bioject jet injector with the conventional syringe and needle.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1998, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Equipment Design; Humans; Hypnotics and

1998
A blinded, randomized, paired, placebo-controlled trial of 20-minute EMLA cream to reduce the pain of peripheral i.v. cannulation in the ED.
    The American journal of emergency medicine, 1998, Volume: 16, Issue:7

    Topics: Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Emergency Service, Hospital;

1998
Cutaneous tape stripping to accelerate the anesthetic effects of EMLA cream: a randomized, controlled trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:11

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Catheterization, Peripheral; Female; Humans; Lidoc

1998
Randomised double blind trial of EMLA for the control of pain related to cryotherapy in the treatment of genital HPV lesions.
    Sexually transmitted infections, 1998, Volume: 74, Issue:4

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Cryotherapy; Double-Blind Method; Fema

1998
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
    Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:2 Pt 1

    Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human

1999
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
    Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:2 Pt 1

    Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human

1999
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
    Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:2 Pt 1

    Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human

1999
EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
    Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:2 Pt 1

    Topics: Administration, Cutaneous; Aged; Anesthetics, Local; Debridement; Double-Blind Method; Female; Human

1999
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
EMLA patch for spinal puncture. A comparison of EMLA patch with lignocaine infiltration and placebo patch.
    Anaesthesia, 1998, Volume: 53, Issue:12

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Spinal; Anestheti

1998
[Efficacy of EMLA cream, effect of time and place of application].
    Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:3

    Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Double-Blind Method; Elbow; Emulsions; Erythema; F

1999
Effects of single and repeated applications of a eutectic mixture of local anaesthetics (EMLA) cream on spontaneous and evoked pain in post-herpetic neuralgia.
    Pain, 1999, Volume: 81, Issue:1-2

    Topics: Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Female; Herpesviridae Infections

1999
Efficacy of parental application of eutectic mixture of local anesthetics for intravenous insertion.
    Pediatrics, 1999, Volume: 103, Issue:6

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Anxiety; Child; Child, Preschool; Female; Humans;

1999
Petroleum jelly is an ideal contact medium for pain reduction and successful treatment with extracorporeal shock wave lithotripsy.
    The Journal of urology, 1999, Volume: 162, Issue:1

    Topics: Anesthetics, Local; Emollients; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Lit

1999
The effects of EMLA and a topical formulation of 4% amethocaine (Ametop) on pain associated with retrobulbar injection.
    Anaesthesia, 1999, Volume: 54, Issue:6

    Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Female; Humans;

1999
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
    Pediatrics, 1999, Volume: 104, Issue:3

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe

1999
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
    Pediatrics, 1999, Volume: 104, Issue:3

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe

1999
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
    Pediatrics, 1999, Volume: 104, Issue:3

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe

1999
Relative efficacy of amethocaine gel and lidocaine-prilocaine cream for Port-a-Cath puncture in children.
    Pediatrics, 1999, Volume: 104, Issue:3

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwe

1999
Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
    Journal of developmental and behavioral pediatrics : JDBP, 1999, Volume: 20, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; Heel; Humans; Infant, Newborn; Infant, Premature; Lidocai

1999
Analgesia during extracorporeal shock wave lithotripsy using the Medstone STS lithotriptor: a randomized prospective study.
    Urology, 1999, Volume: 54, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory

1999
Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children.
    Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:9

    Topics: Adolescent; Analgesia; Anesthetics, Combined; Anesthetics, Local; Anxiety; Child; Child, Preschool;

1999
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
    The Journal of reproductive medicine, 1999, Volume: 44, Issue:10

    Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi

1999
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
    The Journal of reproductive medicine, 1999, Volume: 44, Issue:10

    Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi

1999
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
    The Journal of reproductive medicine, 1999, Volume: 44, Issue:10

    Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi

1999
Topical anesthesia for office hysteroscopy. A prospective, randomized study comparing two modalities.
    The Journal of reproductive medicine, 1999, Volume: 44, Issue:10

    Topics: Adult; Anesthetics, Local; Female; Humans; Hysteroscopes; Hysteroscopy; Lidocaine; Middle Aged; Offi

1999
A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) versus penile nerve block for pain relief during circumcision.
    American journal of obstetrics and gynecology, 1999, Volume: 181, Issue:6

    Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Double-Bli

1999
The efficacy of EMLA versus ELA-Max for pain relief in medium-depth chemical peeling: a clinical and histopathologic evaluation.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2000, Volume: 26, Issue:1

    Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Chemexfoliation; Female; Glycolates; Huma

2000
Both EMLA and placebo cream reduced pain during extracorporeal piezoelectric shock wave lithotripsy with the Piezolith 2300.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; Human

2000
A randomised study of lidocaine and prilocaine for spinal anaesthesia.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:4

    Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Female; Humans; Lidocaine; Male; Middle Aged; P

2000
The use of EMLA reduces the pain associated with digital ring block for ingrowing toenail correction.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Lidocaine, Pr

2000
[Use of the anesthetic cream EMLA in arterial punction].
    Revista espanola de anestesiologia y reanimacion, 2000, Volume: 47, Issue:2

    Topics: Anesthesia, Local; Anesthetics, Local; Arteries; Blood Specimen Collection; Double-Blind Method; Fem

2000
Lidocaine-prilocaine patch decreases the pain associated with the subcutaneous administration of measles-mumps-rubella vaccine but does not adversely affect the antibody response.
    The Journal of pediatrics, 2000, Volume: 136, Issue:6

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Antibodies; Double-Blind Method;

2000
Combined analgesia and local anesthesia to minimize pain during circumcision.
    Archives of pediatrics & adolescent medicine, 2000, Volume: 154, Issue:6

    Topics: Acetaminophen; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia, Local; Anesthe

2000
Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration.
    Anesthesia progress, 1999,Spring, Volume: 46, Issue:2

    Topics: Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Double-Blind Method; Humans; In

1999
Comparison of 4 analgesic agents for venipuncture.
    AANA journal, 2000, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor

2000
Comparison of 4 analgesic agents for venipuncture.
    AANA journal, 2000, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor

2000
Comparison of 4 analgesic agents for venipuncture.
    AANA journal, 2000, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor

2000
Comparison of 4 analgesic agents for venipuncture.
    AANA journal, 2000, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aerosols; Aged; Aged, 80 and over; Anesthetics, Local; Chlorofluorocarbons; Chlor

2000
The incidence of transient neurological symptoms after spinal anaesthesia with lidocaine compared to prilocaine.
    Anaesthesia, 2000, Volume: 55, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Double-Blind Method; Female; Humans

2000
Prilocaine versus lignocaine for minor lid procedures.
    Eye (London, England), 2000, Volume: 14 ( Pt 4)

    Topics: Anesthetics, Local; Double-Blind Method; Eyelids; Humans; Injections, Intradermal; Lidocaine; Pain;

2000
Reduction in pain associated with open carpal tunnel decompression.
    Journal of hand surgery (Edinburgh, Scotland), 2000, Volume: 25, Issue:2

    Topics: Anesthetics, Local; Carpal Tunnel Syndrome; Decompression, Surgical; Double-Blind Method; Female; Hu

2000
LET versus EMLA for pretreating lacerations: a randomized trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2001, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Double-Blind Method; Female; Humans;

2001
Comparison of EMLA cream versus placebo in children receiving distraction therapy for venepuncture.
    Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:2

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Cognitive Behavioral Therapy; Double-Blind

2001
Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:2

    Topics: Administration, Oral; Anesthetics, Local; Crying; Double-Blind Method; Drug Combinations; Female; He

2001
The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing.
    Journal of clinical periodontology, 2001, Volume: 28, Issue:5

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Combined; Anesthetics, Local; Dental Scalin

2001
A randomised, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation.
    British dental journal, 2001, Apr-28, Volume: 190, Issue:8

    Topics: Administration, Cutaneous; Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Combined; A

2001
Eutectic mixture of local anesthetics reduces pain during intravenous catheter insertion in the pediatric patient.
    The Clinical journal of pain, 2001, Volume: 17, Issue:2

    Topics: Administration, Cutaneous; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool;

2001
EMLA or Ametop, and for how long?
    Anaesthesia, 2001, Volume: 56, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Drug Administ

2001
A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children.
    Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:11

    Topics: Anesthetics, Combined; Child; Child, Preschool; Diphtheria-Tetanus-Pertussis Vaccine; Double-Blind M

2001
EMLA cream prior to digital nerve block for ingrown nail surgery does not reduce pain at injection of anesthetic solution.
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthetics, Combined; Child; Double-Blind Method; Female; Humans; Injectio

2002
Lidocaine iontophoresis versus eutectic mixture of local anesthetics (EMLA) for IV placement in children.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:6

    Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Cross-Over Studies; Female; Humans;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children.
    Pediatrics, 2002, Volume: 109, Issue:6

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Child, Preschool; Cross-Over Studies;

2002
The use of glyceryl trinitrate ointment with EMLA cream for i.v. cannulation in children undergoing routine surgery.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:3

    Topics: Administration, Topical; Adolescent; Anesthesia, Local; Catheterization, Peripheral; Child; Child, P

2002
Use of EMLA cream with vasectomy.
    Urology, 2002, Volume: 60, Issue:1

    Topics: Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Humans; Injections; Lanolin; Lidocaine;

2002
Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties.
    Odontologisk revy, 1975, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Alveolar Process; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Deglu

1975
EMLA partially relieves the pain of EMG needling.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:8

    Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Drug Combinations; Elbow; Electrodes; El

1992
Local anaesthetic creams and intradermal skin tests.
    Lancet (London, England), 1992, May-30, Volume: 339, Issue:8805

    Topics: Anesthetics, Local; Drug Combinations; Histamine; Humans; Injections, Intradermal; Lidocaine; Lidoca

1992
A clinical evaluation of three topical anaesthetic agents.
    Australian dental journal, 1992, Volume: 37, Issue:4

    Topics: Adult; Anesthetics, Local; Benzocaine; Double-Blind Method; Drug Combinations; Female; Humans; Injec

1992
Pain perception and effectiveness of the eutectic mixture of local anesthetics in children undergoing venipuncture.
    Pediatric research, 1992, Volume: 32, Issue:5

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans

1992
Effect of lidocaine-prilocaine cream on pain from subcutaneous injection.
    Clinical pharmacy, 1992, Volume: 11, Issue:4

    Topics: Administration, Topical; Adult; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female;

1992
Thickly and thinly applied lignocaine-prilocaine cream prior to venepuncture in children.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Anesthetics, Local; Bloodletting; Child; Child Behavior; Chil

1991
Epilation of upper lip hirsutism with a eutectic mixture of lidocaine and prilocaine used as a topical anesthetic.
    Journal of the American Academy of Dermatology, 1991, Volume: 25, Issue:5 Pt 1

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Diathermy; Double-Blind Method; Drug Combination

1991
Topical glyceryl trinitrate and eutectic mixture of local anaesthetics in children. A randomised controlled trial on choice of site and ease of venous cannulation.
    Anaesthesia, 1991, Volume: 46, Issue:10

    Topics: Administration, Topical; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D

1991
Pain control in the surgical debridement of leg ulcers by the use of a topical lidocaine--prilocaine cream, EMLA.
    Acta dermato-venereologica, 1990, Volume: 70, Issue:2

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Debridement; Double-Bli

1990
A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch.
    Acta dermato-venereologica, 1990, Volume: 70, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Drug Combinations; Emollients; Female; Histamine

1990
A double-masked evaluation of lignocaine-prilocaine cream (EMLA) used to alleviate the pain of retrobulbar injection.
    The British journal of ophthalmology, 1991, Volume: 75, Issue:3

    Topics: Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Cataract Extraction; Do

1991
Assessing pain and analgesia with a lidocaine-prilocaine emulsion in infants and toddlers during venipuncture.
    The Journal of pediatrics, 1991, Volume: 118, Issue:6

    Topics: Anesthetics, Local; Bloodletting; Child Behavior; Child, Preschool; Double-Blind Method; Drug Combin

1991
Local application of EMLA and glyceryl trinitrate ointment before venepuncture.
    Anaesthesia, 1990, Volume: 45, Issue:1

    Topics: Administration, Cutaneous; Adult; Aged; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Loc

1990
Alkalinisation of prilocaine for intravenous regional anaesthesia. Suitability for clinical use.
    Anaesthesia, 1990, Volume: 45, Issue:11

    Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Conduction; Anesthesia, Intrave

1990
EMLA for pain relief during arterial cannulation. A double-blind, placebo-controlled study of a lidocaine-prilocaine cream.
    Upsala journal of medical sciences, 1990, Volume: 95, Issue:1

    Topics: Anesthetics, Local; Catheterization, Peripheral; Double-Blind Method; Drug Combinations; Humans; Lid

1990
Double-blind comparison of topical lignocaine-prilocaine cream (EMLA) and lignocaine infiltration for arterial cannulation in adults.
    British journal of anaesthesia, 1990, Volume: 65, Issue:2

    Topics: Administration, Topical; Adult; Anesthetics, Local; Catheterization; Double-Blind Method; Drug Combi

1990
Relief of injection pain in adults. EMLA cream for 5 minutes before venepuncture.
    Anaesthesia, 1990, Volume: 45, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Local

1990
Our experience with EMLA Cream (for painless venous cannulation in children).
    Indian journal of physiology and pharmacology, 1990, Volume: 34, Issue:2

    Topics: Anesthetics, Local; Anxiety; Catheterization, Peripheral; Child; Child, Preschool; Drug Combinations

1990
Does EMLA reduce the discomfort associated with local-anaesthetic infiltration?
    Clinical and experimental dermatology, 1990, Volume: 15, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics, Local; Double-Bl

1990
Repeated application of EMLA cream 5% for the alleviation of cannulation pain in haemodialysis.
    Scandinavian journal of urology and nephrology, 1989, Volume: 23, Issue:4

    Topics: Aged; Anesthetics, Local; Catheterization, Central Venous; Dermatitis, Contact; Double-Blind Method;

1989
Effect of a eutectic mixture of local anaesthetic agents (EMLA) on tourniquet pain in volunteers.
    British journal of anaesthesia, 1989, Volume: 63, Issue:6

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinations; Humans; Lidoca

1989
Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children.
    Pediatrics, 1989, Volume: 84, Issue:2

    Topics: Adolescent; Anesthetics, Local; Bloodletting; Child; Child, Preschool; Drug Combinations; Female; Hu

1989
The effect of topically applied anaesthetics (EMLA cream) on thresholds to thermode and argon laser stimulation.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:6

    Topics: Administration, Cutaneous; Anesthetics, Local; Argon; Cold Temperature; Drug Combinations; Hot Tempe

1989
Topical anaesthesia for fistula cannulation in haemodialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1988, Volume: 3, Issue:6

    Topics: Adult; Aged; Anesthetics, Local; Catheters, Indwelling; Clinical Trials as Topic; Double-Blind Metho

1988
Pain-free injection in infants. Use of a lignocaine-prilocaine cream to prevent pain at intravenous induction of general anaesthesia in 1-5-year-old children.
    Anaesthesia, 1988, Volume: 43, Issue:3

    Topics: Anesthesia, General; Anesthetics, Local; Child, Preschool; Clinical Trials as Topic; Double-Blind Me

1988
Delayed hypersensitivity responses in children after local cutaneous anesthesia.
    Acta paediatrica Scandinavica, 1987, Volume: 76, Issue:6

    Topics: Adolescent; Anesthesia, Local; Antigens; Child; Clinical Trials as Topic; Humans; Hypersensitivity,

1987
EMLA cream reduces the pain of venepuncture in children.
    European journal of anaesthesiology, 1987, Volume: 4, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Local; Child; Child, Preschool; Clinical Trials as Topic; Doub

1987
Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication.
    Acta anaesthesiologica Scandinavica, 1987, Volume: 31, Issue:8

    Topics: Administration, Cutaneous; Anesthetics, Local; Anxiety; Catecholamines; Catheterization, Peripheral;

1987
Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.
    British journal of anaesthesia, 1986, Volume: 58, Issue:11

    Topics: Anesthesia, Local; Attitude to Health; Catheterization; Child; Child, Preschool; Clinical Trials as

1986
Topical anaesthesia for venepuncture.
    Archives of disease in childhood, 1986, Volume: 61, Issue:11

    Topics: Administration, Topical; Adolescent; Anesthesia, Local; Child; Child, Preschool; Clinical Trials as

1986
[Pain relief in vein puncture. Application time and effectiveness of lidocaine-prilocaine-cream].
    Der Anaesthesist, 1985, Volume: 34, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans;

1985
A lignocaine-prilocaine cream reduces venipuncture pain.
    Upsala journal of medical sciences, 1985, Volume: 90, Issue:3

    Topics: Anesthetics, Local; Child; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans;

1985
Clinical study of a lignocaine-prilocaine cream to relieve the pain of venepuncture.
    British journal of anaesthesia, 1985, Volume: 57, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Double-Blind Method; Drug Combinatio

1985

Other Studies

110 other studies available for prilocaine and Ache

ArticleYear
Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial.
    The Journal of dermatological treatment, 2022, Volume: 33, Issue:7

    Topics: Anesthesia; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ointments

2022
Lidocaine spray 10% prior to intravenous catheterisation in dogs.
    Acta veterinaria Scandinavica, 2022, Aug-20, Volume: 64, Issue:1

    Topics: Anesthetics, Local; Animals; Catheterization; Dogs; Double-Blind Method; Humans; Lidocaine; Pain; Pr

2022
Topical Anesthetic versus Lidocaine Mixture for Pain Relief During Keloid Treatment: A Prospective, Split Study.
    The Journal of craniofacial surgery, 2023, Oct-01, Volume: 34, Issue:7

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Hum

2023
Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:5

    Topics: Anxiety; Humans; Pain; Prilocaine; Rhinoplasty; Tramadol

2020
Effects of Extracorporeal Shock Wave-Mediated Transdermal Local Anesthetic Drug Delivery on Rat Caudal Nerves.
    Ultrasound in medicine & biology, 2018, Volume: 44, Issue:1

    Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Disease Models, Animal; Extracorporeal Shock

2018
An alternative local anaesthesia technique to reduce pain in paediatric patients during needle insertion.
    European journal of paediatric dentistry, 2013, Volume: 14, Issue:2

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pres

2013
[Methaemoglobinaemia after using EMLA cream].
    Nederlands tijdschrift voor geneeskunde, 2013, Volume: 157, Issue:29

    Topics: Analgesics; Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Female; Humans; Lidocaine

2013
[Evaluation of peripherally inserted central catheters in a pediatric population].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2013, Volume: 20, Issue:10

    Topics: Adolescent; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Catheter-Related Infection

2013
Expectation requires treatment to boost pain relief: an fMRI study.
    Pain, 2014, Volume: 155, Issue:1

    Topics: Adult; Anesthetics, Local; Antipruritics; Brain; Capsaicin; Female; Humans; Image Processing, Comput

2014
Improving the local anesthesia experience for our patients.
    Dentistry today, 2014, Volume: 33, Issue:4

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Carticaine; Equipment Design

2014
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
    Brain research, 2017, 02-15, Volume: 1657

    Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic P

2017
A comparison of injection pain with articaine with adrenaline, prilocaine with phenylpressin and lidocaine with adrenaline.
    Medicina oral, patologia oral y cirugia bucal, 2008, Jul-01, Volume: 13, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Carticaine; Drug Therapy, Combinatio

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
The FLACC behavioral scale for procedural pain assessment in children aged 5-16 years.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:8

    Topics: Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Humans; Lidocaine; Pain; P

2008
Relieving the pain of sentinel lymph node biopsy tracer injection.
    Clinical journal of oncology nursing, 2008, Volume: 12, Issue:4

    Topics: Administration, Cutaneous; Anesthetics, Combined; Anesthetics, Local; Breast Neoplasms; Clinical Nur

2008
Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device.
    Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:8

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Dermatitis, Phototoxic; Female; Humans; Hyperpigmentat

2008
Evaluation of dressings used with local anaesthetic cream and for peripheral venous cannulation.
    Paediatric nursing, 2008, Volume: 20, Issue:8

    Topics: Administration, Cutaneous; Anesthetics, Local; Attitude of Health Personnel; Catheterization, Periph

2008
Safe and less painful injection of triamcenolone acetonide into a keloid--a technique.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2010, Volume: 63, Issue:2

    Topics: Anesthetics, Local; Bupivacaine; Glucocorticoids; Humans; Injections, Intralesional; Keloid; Lidocai

2010
[Radial nerve block for implantation of radial catheter].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:9

    Topics: Anesthetics, Local; Catheterization; Catheters, Indwelling; Humans; Lidocaine; Lidocaine, Prilocaine

2009
Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children.
    Annals of physical and rehabilitation medicine, 2009, Volume: 52, Issue:10

    Topics: Administration, Cutaneous; Administration, Inhalation; Adolescent; Anesthetics; Anti-Dyskinesia Agen

2009
Combined use of infraorbital and external nasal nerve blocks for effective perioperative pain control during and after cleft lip repair.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2009, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Anesthetics, Local; Cleft Lip; Female; Humans; Infant; Lidocaine; Lidocaine, Pril

2009
Editorial comment.
    Urology, 2010, Volume: 75, Issue:3

    Topics: Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Child; Circumcision, Male; Drug Therapy,

2010
Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2010, Volume: 16, Issue:3

    Topics: Administration, Oral; Administration, Topical; Adolescent; Anesthetics, Local; Burns; Child; Female;

2010
Pain reduction in children during port-à-cath catheter puncture using local anaesthesia with EMLA™.
    European journal of pediatrics, 2010, Volume: 169, Issue:12

    Topics: Adolescent; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; Cross-Over Stu

2010
Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections.
    British dental journal, 2010, Volume: 209, Issue:9

    Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Chin; Cranial Nerve Injuries; Female; Gingiva; H

2010
Anesthesia for ritual circumcision in neonates.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:12

    Topics: Anesthesia; Anesthetics, Local; Ceremonial Behavior; Circumcision, Male; Humans; Infant, Newborn; Is

2010
Atraumatic care: EMLA cream and application of heat to facilitate peripheral venous cannulation in children.
    Issues in comprehensive pediatric nursing, 2009, Volume: 32, Issue:2

    Topics: Anesthetics, Local; Child; Female; Humans; Hyperthermia, Induced; Lidocaine; Lidocaine, Prilocaine D

2009
Care to relieve pain-stress in preterm newborns.
    Acta bio-medica : Atenei Parmensis, 2011, Volume: 82, Issue:1

    Topics: Anesthetics, Local; Female; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Priloc

2011
Eutectic mixture of local anaesthetics (EMLA) 5% cream as a primary dressing on a painful lower leg ulcer.
    Journal of wound care, 2012, Volume: 21, Issue:7

    Topics: Analgesics; Bandages; Drug Therapy, Combination; Female; Humans; Lidocaine; Lidocaine, Prilocaine Dr

2012
Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioural and facial expression responses.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Cross-Over Studies; Face; Lidocaine; Lidocaine, Prilo

2012
Frequency and intensity of pain related to thyroid nodule fine-needle aspiration cytology.
    Thyroid : official journal of the American Thyroid Association, 2013, Volume: 23, Issue:9

    Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care Facilities;

2013
[New indication for EMLA creme. Significant reduction of pain in mechanical would debridement].
    Krankenpflege Journal, 2002, Volume: 40, Issue:5-6

    Topics: Anesthesia, Local; Anesthetics, Local; Debridement; Humans; Lidocaine; Lidocaine, Prilocaine Drug Co

2002
Urethral meatal dilatation using topical EMLA cream for anaesthesia.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:4

    Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Child; Child, Preschool; Dilatation; Humans; Lid

2003
RECENT ADVANCES IN LOCAL ANALGESIA. CLINICAL EXPERIENCE WITH PRILOCAINE.
    Proceedings of the Royal Society of Medicine, 1965, Volume: 58

    Topics: Analgesia; Anesthesia; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics; Anesthetics, Lo

1965
Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Adult; Anesthetics, Local; Arm; Conditioning, Psychological; Electric Stimulation; Female; Humans; L

2003
Does lidocaine-prilocaine cream (EMLA) decrease the pain of neonatal circumcision?
    American family physician, 2004, Feb-15, Volume: 69, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Evidence-Based Medicine; Heart Rate;

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Relief of pain and anxiety in pediatric patients in emergency medical systems.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Administration, Oral; Analgesics; Anesthetics, Combined; Anxiety; Child; Conscious Sedation; Emergen

2004
Using EMLA cream before venipuncture.
    Nursing, 2005, Volume: 35, Issue:1

    Topics: Adolescent; Anesthetics, Local; Child; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Oi

2005
Outpatient hysteroscopy: an observational study of patient acceptability.
    Medicina (Kaunas, Lithuania), 2004, Volume: 40, Issue:12

    Topics: Anesthetics, Local; Data Interpretation, Statistical; Female; Humans; Hysteroscopy; Outpatients; Pai

2004
[2/6 EMLA cream application].
    Soins. Pediatrie, puericulture, 2004, Issue:221

    Topics: Administration, Cutaneous; Age Factors; Anesthetics, Combined; Anesthetics, Local; Child; Child, Pre

2004
Vascular access.
    Nephrology news & issues, 2005, Volume: 19, Issue:5

    Topics: Anesthetics, Combined; Anesthetics, Local; Arteriovenous Shunt, Surgical; Hemodialysis, Home; Humans

2005
Bupivacaine versus lidocaine analgesia for neonatal circumcision.
    BMC pediatrics, 2005, May-22, Volume: 5, Issue:1

    Topics: Acetaminophen; Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bupivacaine; C

2005
Pain- and distress-reducing interventions for venepuncture in children.
    Child: care, health and development, 2006, Volume: 32, Issue:3

    Topics: Anesthetics; Anesthetics, Combined; Anesthetics, Local; Child; Child Behavior; Child, Preschool; Fem

2006
Palmar hyperhidrosis. Safety efficacy of two anaesthetic techniques for botulinum toxin therapy.
    Dermatology online journal, 2006, Feb-28, Volume: 12, Issue:2

    Topics: Anesthesia, Local; Anesthetics, Local; Autonomic Nerve Block; Botulinum Toxins, Type A; Hand; Humans

2006
Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo.
    BJU international, 2006, Volume: 97, Issue:5

    Topics: Anesthetics, Combined; Biopsy, Needle; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ma

2006
[Painful defecation and chronic functional constipation in children: Diagnosis and treatment].
    Minerva pediatrica, 2006, Volume: 58, Issue:3

    Topics: Anal Canal; Anesthetics, Local; Child; Child, Preschool; Chronic Disease; Constipation; Defecation;

2006
Predictors of topical anesthetic effectiveness in children.
    The journal of pain, 2007, Volume: 8, Issue:2

    Topics: Administration, Topical; Age Factors; Anesthetics, Local; Anxiety; Catheterization, Peripheral; Chil

2007
The need for pain control during scaling and root planing.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:2 Suppl 1

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Dental Scaling; Humans; Lidocain

2005
Efficacy of an intrapocket anesthetic for scaling and root planing procedures: a review of three multicenter studies.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:2 Suppl 1

    Topics: Administration, Topical; Anesthetics, Combined; Anesthetics, Local; Clinical Trials as Topic; Dental

2005
[Use of ways to prevent pain].
    Soins. Pediatrie, puericulture, 2006, Issue:233

    Topics: Age Factors; Analgesia; Anesthetics, Local; Attitude of Health Personnel; Benchmarking; Blood Specim

2006
Reducing the pain during children's immunizations.
    Child health alert, 2007, Volume: 25

    Topics: Anesthetics, Local; Child; Child, Preschool; Glucose; Humans; Infant; Lidocaine; Lidocaine, Prilocai

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Routine immunization practices: use of topical anesthetics and oral analgesics.
    Pediatrics, 2007, Volume: 120, Issue:3

    Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest

2007
Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
    European urology, 2008, Volume: 53, Issue:5

    Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Humans; Lidocaine; Male; Nerve Block; Oin

2008
Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial.
    European urology, 2008, Volume: 53, Issue:5

    Topics: Anesthetics, Combined; Anesthetics, Local; Biopsy, Needle; Humans; Lidocaine; Male; Nerve Block; Oin

2008
Patient comfort in regional anesthesia.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:1

    Topics: Administration, Topical; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Nerve Block; Oint

2008
Topical anesthesia with EMLA does not decrease pain during vasectomy.
    The Journal of urology, 2008, Volume: 180, Issue:1

    Topics: Adult; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain; Pr

2008
Does lidocaine-prilocaine cream permit painfree insertion of IV catheters in children?
    Anesthesiology, 1982, Volume: 57, Issue:4

    Topics: Adolescent; Catheterization; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Emulsions;

1982
Eutectic mixture of local anesthetic cream--topical anesthesia for extracorporeal shock wave lithotripsy.
    CRNA : the clinical forum for nurse anesthetists, 1994, Volume: 5, Issue:4

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Lidocain

1994
Further applications for EMLA cream.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anesthetics, Local; Drug Combinations; Humans; Injections

1994
EMLA cream in the treatment of causalgic pain.
    Anesthesiology, 1994, Volume: 81, Issue:1

    Topics: Administration, Topical; Adult; Causalgia; Drug Combinations; Humans; Lidocaine; Male; Pain; Priloca

1994
Management of childhood pain: new approaches to procedure-related pain. Proceedings of a roundtable discussion. Palm Beach, Florida, January 9, 1993.
    The Journal of pediatrics, 1993, Volume: 122, Issue:5 Pt 2

    Topics: Anesthetics, Local; Child; Child, Preschool; Drug Combinations; Humans; Infant; Lidocaine; Lidocaine

1993
The use of EMLA cream to reduce and/or eliminate procedural pain in children.
    Journal of pediatric nursing, 1993, Volume: 8, Issue:6

    Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat

1993
A two-year review of pain control during laser therapy using the flashlamp pulsed dye laser.
    British journal of plastic surgery, 1994, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Child; Child, P

1994
Taking the jab out of needles.
    The Canadian nurse, 1993, Volume: 89, Issue:10

    Topics: Bloodletting; Drug Combinations; Humans; Injections; Lidocaine; Pain; Prilocaine

1993
Dermal anaesthesia: comparison of EMLA cream with iontophoretic local anaesthesia.
    British journal of anaesthesia, 1993, Volume: 71, Issue:3

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Drug Combinations; Epinephrine; Female; Humans; Inject

1993
Minimizing the pain of venipuncture.
    RN, 1996, Volume: 59, Issue:5

    Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat

1996
[Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:1

    Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Hypnotics and Sedatives; Lidocaine; Lidocaine,

1996
Effects of local anaesthesia on formalin-induced Fos expression in the rat dorsal horn.
    Neuroreport, 1995, Nov-27, Volume: 6, Issue:17

    Topics: Anesthesia, Local; Anesthetics, Local; Animals; Felypressin; Formaldehyde; Ganglia, Spinal; Hemostat

1995
Which structures are sensitive to painful transcranial electric stimulation?
    Electromyography and clinical neurophysiology, 1995, Volume: 35, Issue:6

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Drug Combinations; Electric Stimulation;

1995
EMLA cream for renal extracorporeal shock wave lithotripsy in ambulatory patients.
    European journal of anaesthesiology, 1996, Volume: 13, Issue:4

    Topics: Ambulatory Care; Analgesia; Analgesics, Opioid; Anesthetics, Local; Drug Combinations; Female; Fenta

1996
Regional variations in skin perfusion and skin thickness may contribute to varying efficacy of topical, local anaesthetics in neonates.
    Paediatric anaesthesia, 1996, Volume: 6, Issue:2

    Topics: Anesthesia, Local; Anesthetics, Local; Blood Specimen Collection; Drug Combinations; Female; Forehea

1996
Circumcision circumspection.
    The New England journal of medicine, 1997, Apr-24, Volume: 336, Issue:17

    Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Humans; Lidocaine; Male; Pain; Prilocaine; Urinar

1997
Neonatal circumcision.
    Lancet (London, England), 1997, Apr-26, Volume: 349, Issue:9060

    Topics: Anesthesia, Local; Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newbor

1997
Neonatal circumcision.
    Lancet (London, England), 1997, Apr-26, Volume: 349, Issue:9060

    Topics: Anesthetics, Local; Circumcision, Male; Drug Combinations; Humans; Infant, Newborn; Lidocaine; Lidoc

1997
Patients can be pain-free while undergoing implanted port assessment.
    Oncology nursing forum, 1997, Volume: 24, Issue:5

    Topics: Anesthetics, Local; Catheterization, Central Venous; Catheters, Indwelling; Drug Combinations; Human

1997
Analgesia during circumcision.
    The Journal of family practice, 1997, Volume: 45, Issue:2

    Topics: Analgesia; Anesthetics, Local; Circumcision, Male; Double-Blind Method; Drug Combinations; Humans; I

1997
Pain during circumcision.
    The American journal of nursing, 1997, Volume: 97, Issue:10

    Topics: Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Circumcision, Male; Humans; Infant, Ne

1997
Utility of EMLA in the relief of pain associated with electroneurography.
    Journal of the American Academy of Audiology, 1998, Volume: 9, Issue:1

    Topics: Administration, Topical; Adult; Anesthetics, Local; Electric Stimulation; Electromyography; Facial N

1998
[Pain-free circumcision].
    Fortschritte der Medizin, 1998, Feb-28, Volume: 116, Issue:6

    Topics: Anesthetics, Combined; Circumcision, Male; Heart Rate; Humans; Infant, Newborn; Lidocaine; Lidocaine

1998
No negative influence of EMLA application prior to BCG vaccination.
    Acta paediatrica (Oslo, Norway : 1992), 1998, Volume: 87, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Local; BCG Vaccine; Child; Child, Preschool; Female; Humans; Inf

1998
Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1998, Volume: 86, Issue:1

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp;

1998
Painful pricks.
    Indian pediatrics, 1998, Volume: 35, Issue:4

    Topics: Anesthetics, Local; Child; Child, Preschool; Female; Humans; India; Infant; Infant, Newborn; Injecti

1998
Alleviation of the pain of venepuncture in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:3

    Topics: Anesthetics, Local; Hand; Heel; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Drug Combi

1999
Analgesia for spinal puncture.
    Anaesthesia, 1999, Volume: 54, Issue:6

    Topics: Analgesia; Anesthetics, Local; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Pril

1999
Relative effectiveness of lignocaine-prilocaine emulsion and nitrous oxide inhalation for routine preoperative laboratory testing.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Adult; Age Factors; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetic

1999
[Use of EMLA Creme in leg ulcers: usefulness and limits].
    Krankenpflege Journal, 1999, Volume: 37, Issue:9

    Topics: Anesthetics, Combined; Anesthetics, Local; Debridement; Humans; Leg Ulcer; Lidocaine; Lidocaine, Pri

1999
Comparative study of distraction versus topical anesthesia for pediatric pain management during immunizations.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1999, Volume: 18, Issue:6

    Topics: Anesthetics, Local; Anxiety; Child; Child Behavior; Female; Humans; Immunization; Lidocaine; Lidocai

1999
Use of a eutectic mixture of local anesthesia in newborns.
    Indian pediatrics, 1999, Volume: 36, Issue:7

    Topics: Anesthetics, Local; Drug Combinations; Emulsions; Humans; Infant; Infant, Newborn; Lidocaine; Pain;

1999
[Emla cream in pediatric emergency cases by using selection criteria. Feasibility study].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2000, Volume: 7, Issue:3

    Topics: Anesthetics, Local; Child; Child Welfare; Emergency Medical Services; Feasibility Studies; Humans; L

2000
EMLA for circumcision?
    The American journal of nursing, 2000, Volume: 100, Issue:8

    Topics: Anesthetics, Local; Child Advocacy; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocain

2000
Lidocaine + prilocaine before 3 months of age: new indication. Correct use is crucial.
    Prescrire international, 2000, Volume: 9, Issue:47

    Topics: Administration, Cutaneous; Age Factors; Blood Specimen Collection; Circumcision, Male; Drug Therapy,

2000
The pediatric forum: pain indication in circumcision.
    Archives of pediatrics & adolescent medicine, 2000, Volume: 154, Issue:12

    Topics: Anesthetics, Local; Circumcision, Male; Humans; Infant, Newborn; Lidocaine; Lidocaine, Prilocaine Dr

2000
Factors affecting patients' and potential patients' choices among anaesthetics for periodontal recall visits.
    Journal of dentistry, 2001, Volume: 29, Issue:3

    Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthetics, Local; Attitude to Health; Choice B

2001
Hot chili, a cook and EMLA.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:6

    Topics: Anesthetics, Local; Capsaicin; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Pril

2001
Re: reduction in pain associated with open carpal tunnel decompression.
    Journal of hand surgery (Edinburgh, Scotland), 2001, Volume: 26, Issue:5

    Topics: Anesthetics, Local; Carpal Tunnel Syndrome; Decompression, Surgical; Humans; Injections; Lidocaine;

2001
[New uses of EMLA: anesthesia for relief of pain caused by hemorrhoid thrombosis].
    Revista espanola de anestesiologia y reanimacion, 2001, Volume: 48, Issue:8

    Topics: Adult; Anesthetics, Combined; Female; Hemorrhoids; Humans; Lidocaine; Lidocaine, Prilocaine Drug Com

2001
Pain experience during transvaginal aspiration of immature oocytes.
    Acta obstetricia et gynecologica Scandinavica, 2001, Volume: 80, Issue:11

    Topics: Acetaminophen; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Anti-An

2001
[Management of leg ulcers in the elderly].
    Revue de l'infirmiere, 2002, Issue:80

    Topics: Age Distribution; Aged; Anesthetics, Local; Bandages; Debridement; Humans; Leg Ulcer; Lidocaine; Lid

2002
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Tape stripping the stratum corneum and the effectiveness of EMLA.
    Emergency medicine journal : EMJ, 2002, Volume: 19, Issue:4

    Topics: Anesthetics, Local; Child, Preschool; Evidence-Based Medicine; Humans; Lidocaine; Lidocaine, Priloca

2002
Pain and temperature sensations related to local analgesia.
    International journal of oral surgery, 1975, Volume: 4, Issue:4

    Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Body Temperature; Female; Humans; Lidocaine; Male; Mep

1975
Physiological responses under dental sedation and anaesthesia.
    Dental anaesthesia and sedation, 1976, Volume: 5, Issue:3

    Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate;

1976
[Intraosseous injections and the osseous pressure in patients with rheumatoid shoulder pain].
    Archiv fur orthopadische und Unfall-Chirurgie, 1975, Volume: 81, Issue:4

    Topics: Bone and Bones; Circadian Rhythm; Female; Humans; Humerus; Injections; Male; Manometry; Middle Aged;

1975
Hemodialysis needles can be pain free: use of a topical anaesthetic cream.
    Le Journal CANNT = CANNT journal : the journal of the Canadian Association of Nephrology Nurses and Technicians, 1992,Fall, Volume: 2, Issue:4

    Topics: Administration, Topical; Anesthetics, Local; Drug Combinations; Humans; Lidocaine; Needles; Ointment

1992
Relieving needle puncture pain.
    The Canadian nurse, 1992, Volume: 88, Issue:11

    Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combinat

1992
Effect of the topical anesthetic EMLA on the efficacy of pulsed dye laser treatment of port-wine stains.
    The Journal of dermatologic surgery and oncology, 1990, Volume: 16, Issue:11

    Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Drug Combin

1990
Insufficient effect of local analgesics in Ehlers Danlos type III patients (connective tissue disorder).
    Acta anaesthesiologica Scandinavica, 1990, Volume: 34, Issue:5

    Topics: Adult; Anesthetics, Local; Drug Combinations; Ehlers-Danlos Syndrome; Female; Humans; Lidocaine; Lid

1990
Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA).
    Acta dermato-venereologica, 1988, Volume: 68, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Analgesia; Child; Child, Preschool; Curettage; Female; Humans

1988
Lignocaine-prilocaine cream in postherpetic neuralgia.
    BMJ (Clinical research ed.), 1989, Jan-28, Volume: 298, Issue:6668

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Drug Combinations; Female; Herpes Zoster; Humans

1989
[Local analgesics in tooth treatment--mode of operation and area of use].
    Tandlaegebladet, 1971, Volume: 75, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dental Pulp Diseases; Drug Synergism; Epinephrine; Felypress

1971
Pain control in dentistry.
    Egyptian dental journal, 1971, Volume: 17, Issue:4

    Topics: Anesthesia, Dental; Diazepam; Pain; Pentazocine; Prilocaine

1971
Regional analgesia.
    International anesthesiology clinics, 1967,Spring, Volume: 5, Issue:1

    Topics: Alcohols; Analgesia; Analgesics; Anesthesia, Conduction; Anesthesia, Local; Anesthesia, Spinal; Auto

1967