pri-2205 has been researched along with Pancreatic-Neoplasms* in 1 studies
1 other study(ies) available for pri-2205 and Pancreatic-Neoplasms
| Article | Year |
|---|---|
Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment.
In a pancreatic tumor microenvironment, activated pancreatic stellate cells (PSCs) produce extracellular matrix (ECM) to form a barrier to drug penetration. Moreover, the interaction between cancer cells and activated PSCs promotes the tumor growth. Vitamin D receptor (VDR), as a key regulator to promote the recovery of PSCs to the resting state, is an attractive therapeutic target for pancreatic cancer. Herein, we reported the design and synthesis of 57 nonsecosteroidal VDR modulators based on the skeleton of phenyl-pyrrolyl pentane. Among them, compounds Topics: Antimetabolites, Antineoplastic; Cell Proliferation; Deoxycytidine; Gemcitabine; Humans; Pancreatic Neoplasms; Pancreatic Stellate Cells; Receptors, Calcitriol; Tumor Microenvironment | 2021 |