preproenkephalin and Liver-Diseases--Alcoholic

preproenkephalin has been researched along with Liver-Diseases--Alcoholic* in 1 studies

Other Studies

1 other study(ies) available for preproenkephalin and Liver-Diseases--Alcoholic

Article	Year
Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:3 Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)n repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African-Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African-American samples. Topics: Alcoholism; Alleles; Asian People; Black People; China; Chromosome Mapping; Cohort Studies; Cross-Cultural Comparison; Enkephalins; Gene Frequency; Genetics, Population; Humans; Liver; Liver Diseases, Alcoholic; Polymorphism, Restriction Fragment Length; Protein Precursors; Repetitive Sequences, Nucleic Acid; United States; White People	1994

Article

Year

Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics.

Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:3

Evidence from animal models and from recent reports on the efficacy of the opioid antagonist naltrexone in the treatment of alcoholism suggests that the endogenous opioid systems may play a role in alcohol seeking behavior. The gene encoding preproenkephalin A (PENK) is flanked at its 3' end by a polymorphic (CA)n repeat. We determined the allele frequencies for this locus in samples of Chinese and Atayal living in Taiwan, Caucasians living in the United States and Byelorussia, and African-Americans living in the United States. We compared the allele frequencies of nonalcoholics in each population with those of alcoholics with or without alcohol-induced organ pathology. There was no difference in allele frequencies within any racial group when alcoholics with or without organ pathology were compared; there was also no difference in allele frequency between nonalcoholics and alcoholics within the two Asian populations, Caucasians, or African-Americans. There were highly significant differences in the frequency of the various length polymorphisms between the Asian, Caucasian, and African-American samples.

Topics: Alcoholism; Alleles; Asian People; Black People; China; Chromosome Mapping; Cohort Studies; Cross-Cultural Comparison; Enkephalins; Gene Frequency; Genetics, Population; Humans; Liver; Liver Diseases, Alcoholic; Polymorphism, Restriction Fragment Length; Protein Precursors; Repetitive Sequences, Nucleic Acid; United States; White People

1994