preproenkephalin and Epilepsy--Absence

preproenkephalin has been researched along with Epilepsy--Absence* in 2 studies

Other Studies

2 other study(ies) available for preproenkephalin and Epilepsy--Absence

Article	Year
Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy. Neuropeptides, 1994, Volume: 27, Issue:6 An in situ hybridization method was used to estimate the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the brain of epileptic 6-month-old WAG/Rij rats in comparison with non-epileptic: 3-month-old WAG/Rij rats, 3-month-old ACI rats and 6-month-old ACI rats. The epileptic rats had a significantly higher level of PENK mRNA in the striatum as compared to non-epileptic controls. The PDYN mRNA level was significantly elevated only in the hippocampus of epileptic rats, whereas age- or strain-related changes in the striatal and cortical PDYN mRNA levels were found in both epileptic and non-epileptic rats. The changes in the biosynthetic activity of endogenous opioid peptide systems may be important for the occurrence of epileptic discharges in these animals. Topics: Aging; Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalins; Epilepsy, Absence; Hippocampus; In Situ Hybridization; Male; Protein Precursors; Rats; RNA, Messenger	1994
Endogenous opioid peptides in brain and pituitary of rats with absence epilepsy. Neuropeptides, 1992, Volume: 21, Issue:3 The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptide Met-enkephalin-Arg6-Gly7-Leu8 in the mesencephalon and striatum, while the level of the prodynorphin-derived peptide alpha-neoendorphin was increased in the striatum and hippocampus. In addition various age- and/or strain-related changes in these peptide levels were found in the hippocampus, thalamus, striatum, frontal cortex and neurointermediate lobe of the pituitary. No difference in the hypothalamic beta-endorphin level were found between epileptic and non-epileptic rats, though strain- and/or age-related changes in the peptide content were detected in both lobes of the pituitary. The increased level of proenkephalin and prodynorphin opioid peptides in brain structures, essential for the appearance of spike-wave discharges, suggests that these opioid systems, but not proopiomelanocortin one, may play a role in absence epilepsy. Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Epilepsy, Absence; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred ACI; Rats, Inbred Strains	1992

Article

Year

Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy.

Neuropeptides, 1994, Volume: 27, Issue:6

An in situ hybridization method was used to estimate the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the brain of epileptic 6-month-old WAG/Rij rats in comparison with non-epileptic: 3-month-old WAG/Rij rats, 3-month-old ACI rats and 6-month-old ACI rats. The epileptic rats had a significantly higher level of PENK mRNA in the striatum as compared to non-epileptic controls. The PDYN mRNA level was significantly elevated only in the hippocampus of epileptic rats, whereas age- or strain-related changes in the striatal and cortical PDYN mRNA levels were found in both epileptic and non-epileptic rats. The changes in the biosynthetic activity of endogenous opioid peptide systems may be important for the occurrence of epileptic discharges in these animals.

Topics: Aging; Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalins; Epilepsy, Absence; Hippocampus; In Situ Hybridization; Male; Protein Precursors; Rats; RNA, Messenger

1994

Endogenous opioid peptides in brain and pituitary of rats with absence epilepsy.

Neuropeptides, 1992, Volume: 21, Issue:3

The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptide Met-enkephalin-Arg6-Gly7-Leu8 in the mesencephalon and striatum, while the level of the prodynorphin-derived peptide alpha-neoendorphin was increased in the striatum and hippocampus. In addition various age- and/or strain-related changes in these peptide levels were found in the hippocampus, thalamus, striatum, frontal cortex and neurointermediate lobe of the pituitary. No difference in the hypothalamic beta-endorphin level were found between epileptic and non-epileptic rats, though strain- and/or age-related changes in the peptide content were detected in both lobes of the pituitary. The increased level of proenkephalin and prodynorphin opioid peptides in brain structures, essential for the appearance of spike-wave discharges, suggests that these opioid systems, but not proopiomelanocortin one, may play a role in absence epilepsy.

Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Enkephalins; Epilepsy, Absence; Male; Pituitary Gland; Protein Precursors; Rats; Rats, Inbred ACI; Rats, Inbred Strains

1992