preproenkephalin and Arterial-Occlusive-Diseases

preproenkephalin has been researched along with Arterial-Occlusive-Diseases* in 1 studies

Other Studies

1 other study(ies) available for preproenkephalin and Arterial-Occlusive-Diseases

Article	Year
Down-regulation of striatal enkephalinergic (PPA) messenger RNA without prior apoptotic features following reversible focal ischemia in rat. Brain research, 1997, Jan-02, Volume: 744, Issue:1 In order to determine whether striatal enkephalinergic neurons were affected by reversible focal ischemia, we have investigated the expression of the preproenkephalin (PPA) messenger by in situ hybridization (ISH) combined with TUNEL staining to display apoptosis in the same rat brain sections. Our data demonstrated a massive reduction of the number of PPA-mRNA containing neurons concomitant with the emergence of apoptotic cells. However, double-labeled neurons (ISH- and TUNEL-positive cells) were not detected, suggesting that either disruption of mRNA precedes DNA fragmentation or ischemia leads to a long lasting reduction of mRNA(s) without damage. Topics: Animals; Apoptosis; Arterial Occlusive Diseases; Biotin; Brain Ischemia; Deoxyuracil Nucleotides; DNA Fragmentation; Enkephalins; In Situ Hybridization; Male; Neostriatum; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staining and Labeling	1997

Article

Year

Down-regulation of striatal enkephalinergic (PPA) messenger RNA without prior apoptotic features following reversible focal ischemia in rat.

Brain research, 1997, Jan-02, Volume: 744, Issue:1

In order to determine whether striatal enkephalinergic neurons were affected by reversible focal ischemia, we have investigated the expression of the preproenkephalin (PPA) messenger by in situ hybridization (ISH) combined with TUNEL staining to display apoptosis in the same rat brain sections. Our data demonstrated a massive reduction of the number of PPA-mRNA containing neurons concomitant with the emergence of apoptotic cells. However, double-labeled neurons (ISH- and TUNEL-positive cells) were not detected, suggesting that either disruption of mRNA precedes DNA fragmentation or ischemia leads to a long lasting reduction of mRNA(s) without damage.

Topics: Animals; Apoptosis; Arterial Occlusive Diseases; Biotin; Brain Ischemia; Deoxyuracil Nucleotides; DNA Fragmentation; Enkephalins; In Situ Hybridization; Male; Neostriatum; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staining and Labeling

1997