pregnenolone carbonitrile has been researched along with Disease Models, Animal in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Abe, T; Hosaka, T; Kodama, S; Okamura, M; Sasaki, T; Shizu, R; Yoshinari, K | 1 |
| Horiguchi, N; Kakizaki, S; Sato, K; Takizawa, D; Tojima, H; Uehara, D; Uraoka, T; Yamada, M; Yamazaki, Y | 1 |
| Alston, L; Hansen, A; Hirota, SA; Terc, J | 1 |
| Abe, T; Kodama, S; Kuribayashi, H; Shimura, T; Yoshinari, K | 1 |
| Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER | 1 |
| He, J; Makishima, M; Nishida, S; Xie, W; Xu, M | 1 |
| Beyer, C; Dees, C; Distler, A; Distler, JH; Distler, O; Leipe, J; Munoz, L; Reichert, H; Schett, G; Schulze-Koops, H; Skapenko, A | 1 |
| Gonzalez, FJ; Kim, I; Ma, X; Morimura, K; Shah, YM | 1 |
| Franklin, MR; Kushner, JP; Phillips, JD | 1 |
| Johnson, DR; Klaassen, CD | 1 |
11 other study(ies) available for pregnenolone carbonitrile and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Binding; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2020 |
Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.
Topics: Animals; Antigens, Differentiation; Apoptosis; Colitis; Constitutive Androstane Receptor; Dextran Sulfate; Disease Models, Animal; Inflammation; Interleukin-1beta; Mice; Pregnane X Receptor; Pregnenolone Carbonitrile; Pyridines; Receptors, Cytoplasmic and Nuclear; Tumor Necrosis Factor-alpha | 2019 |
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.
Topics: Animals; Caco-2 Cells; Cell Movement; Colitis; Colon; Dextran Sulfate; Diphosphonates; Disease Models, Animal; Epithelial Cells; Gastrointestinal Agents; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; Rifamycins; Rifaximin; Signal Transduction; Time Factors; Wound Healing | 2014 |
Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.
Topics: Alanine Transaminase; Animals; Biomarkers; CD2 Antigens; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Concanavalin A; Cytoprotection; Disease Models, Animal; Gene Expression Regulation; Immunosuppressive Agents; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Signal Transduction | 2017 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors | 2009 |
PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.
Topics: Animals; Bile; Bile Acids and Salts; Biological Transport; Cholesterol 7-alpha-Hydroxylase; Cholesterol, Dietary; Disease Models, Animal; Fibroblast Growth Factors; Gallstones; Gene Expression Regulation; Hypericum; Intestinal Mucosa; Intestines; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Plant Preparations; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Time Factors | 2011 |
Activation of pregnane X receptor inhibits experimental dermal fibrosis.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; CD4-Positive T-Lymphocytes; Cells, Cultured; Dermis; Disease Models, Animal; Fibroblasts; Fibrosis; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Scleroderma, Systemic; Signal Transduction; Transforming Growth Factor beta | 2013 |
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.
Topics: Animals; ATP-Binding Cassette Transporters; Colitis; Colon; Cytokines; Cytoprotection; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Gene Expression; Glutathione Transferase; HCT116 Cells; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Repressor Proteins; RNA, Messenger; Severity of Illness Index; Time Factors; Transfection | 2007 |
CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda.
Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Female; Oxidoreductases, N-Demethylating; Porphyria Cutanea Tarda; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Troleandomycin; Uroporphyrins | 2000 |
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Topics: Animals; Bile; Disease Models, Animal; Drug Resistance, Multiple; Enzyme Induction; Hyperbilirubinemia; Male; Membrane Transport Proteins; Microsomes, Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Sulfobromophthalein | 2002 |