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pregnenolone carbonitrile and Cholestasis, Intrahepatic

pregnenolone carbonitrile has been researched along with Cholestasis, Intrahepatic in 2 studies

*Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). [MeSH]

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brown, KK; Goodwin, B; Hawkins-Brown, D; Jones, SA; Klaassen, CD; Kliewer, SA; Koller, BH; LaTour, A; Liu, Y; MacKenzie, KI; Reinhard, J; Staudinger, JL; Willson, TM	1
Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER	1

Other Studies

2 other study(ies) available for pregnenolone carbonitrile and Cholestasis, Intrahepatic

Article	Year
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cholestasis, Intrahepatic; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation, Enzymologic; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid	2001
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1 Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors	2009

Article

Year

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.

Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cholestasis, Intrahepatic; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation, Enzymologic; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid

2001

Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.

Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1

Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors

2009