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pregnenolone carbonitrile and Chemical and Drug Induced Liver Injury

pregnenolone carbonitrile has been researched along with Chemical and Drug Induced Liver Injury in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's3 (30.00)18.2507
2000's0 (0.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Abe, T; Hosaka, T; Kodama, S; Okamura, M; Sasaki, T; Shizu, R; Yoshinari, K1
Abe, T; Kodama, S; Kuribayashi, H; Shimura, T; Yoshinari, K1
Bjondahl, K1
Salas, M; Tuchweber, B1
Huang, HS; Jurima-Romet, M1
Hadjipetrou-Kourounakis, L; Kourounakis, PN; Rekka, E1
Kourounakis, PN; Rekka, E1
Kourounakis, P; Tuchweber, B; Werringloer, J1

Other Studies

10 other study(ies) available for pregnenolone carbonitrile and Chemical and Drug Induced Liver Injury

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
    Cells, 2020, 10-15, Volume: 9, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Binding; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2020
Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.
    Toxicology letters, 2017, Apr-05, Volume: 271

    Topics: Alanine Transaminase; Animals; Biomarkers; CD2 Antigens; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Concanavalin A; Cytoprotection; Disease Models, Animal; Gene Expression Regulation; Immunosuppressive Agents; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Signal Transduction

2017
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides

1978
Prevention by steroids of cerium hepatotoxicity.
    Archives of toxicology, 1976, Mar-11, Volume: 35, Issue:2

    Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estradiol; Fatty Liver; Female; Golgi Apparatus; Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Triglycerides

1976
Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
    Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enalapril; Enzyme Induction; Glutathione; Inactivation, Metabolic; Liver; Liver Diseases; Male; Necrosis; Pregnenolone Carbonitrile; Protoporphyrins; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiazoles; Thiazolidines

1992
Restoration of impaired drug metabolism of rats with adjuvant induced disease by two steroids with different influence on drug biotransformation.
    Die Pharmazie, 1991, Volume: 46, Issue:10

    Topics: Animals; Arthritis, Experimental; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Freund's Adjuvant; Lipid Peroxidation; Liver; Liver Function Tests; Microsomes, Liver; Pharmaceutical Preparations; Pregnenolone Carbonitrile; Rats; Steroids; Triamcinolone

1991
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
    European journal of drug metabolism and pharmacokinetics, 1991, Volume: Spec No 3

    Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; Liver; Liver Function Tests; Organ Size; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Triamcinolone; Triglycerides

1991
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
    Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Female; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Morphinans; NAD; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; Serum Albumin, Bovine; Time Factors

1974