pregnenolone carbonitrile has been researched along with Acute Liver Injury, Drug-Induced in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Abe, T; Hosaka, T; Kodama, S; Okamura, M; Sasaki, T; Shizu, R; Yoshinari, K | 1 |
| Abe, T; Kodama, S; Kuribayashi, H; Shimura, T; Yoshinari, K | 1 |
| Bjondahl, K | 1 |
| Salas, M; Tuchweber, B | 1 |
| Huang, HS; Jurima-Romet, M | 1 |
| Hadjipetrou-Kourounakis, L; Kourounakis, PN; Rekka, E | 1 |
| Kourounakis, PN; Rekka, E | 1 |
| Kourounakis, P; Tuchweber, B; Werringloer, J | 1 |
10 other study(ies) available for pregnenolone carbonitrile and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Binding; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2020 |
Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.
Topics: Alanine Transaminase; Animals; Biomarkers; CD2 Antigens; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Concanavalin A; Cytoprotection; Disease Models, Animal; Gene Expression Regulation; Immunosuppressive Agents; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Signal Transduction | 2017 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides | 1978 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estradiol; Fatty Liver; Female; Golgi Apparatus; Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Triglycerides | 1976 |
Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enalapril; Enzyme Induction; Glutathione; Inactivation, Metabolic; Liver; Liver Diseases; Male; Necrosis; Pregnenolone Carbonitrile; Protoporphyrins; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1992 |
Restoration of impaired drug metabolism of rats with adjuvant induced disease by two steroids with different influence on drug biotransformation.
Topics: Animals; Arthritis, Experimental; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Freund's Adjuvant; Lipid Peroxidation; Liver; Liver Function Tests; Microsomes, Liver; Pharmaceutical Preparations; Pregnenolone Carbonitrile; Rats; Steroids; Triamcinolone | 1991 |
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; Liver; Liver Function Tests; Organ Size; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Triamcinolone; Triglycerides | 1991 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Female; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Morphinans; NAD; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; Serum Albumin, Bovine; Time Factors | 1974 |