pregnenolone has been researched along with Disease Models, Animal in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Caruso, D; Cavaletti, G; Diviccaro, S; Falvo, E; Garcia-Segura, LM; Giatti, S; Melcangi, RC; Rigolio, R | 1 |
| Chodounska, H; Chvojkova, M; Holubova, K; Hrcka Krausova, B; Kudova, E; Vales, K; Vyklicky, L; Vyklicky, V | 1 |
| Fuchigami, T; Imamura, H; Kakizuka, A; Nakano, M; Sasaoka, N; Shudo, T; Takahashi, R; Uemura, N; Yamamoto, M | 1 |
| Agusti, A; Cauli, O; Felipo, V; Gonzalez-Usano, A | 1 |
| Abbiati, F; Bini, V; Bortolato, M; Caruso, D; Casti, A; Devoto, P; Frau, R | 1 |
| Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L | 1 |
| Baulieu, EE; Bianchi, M; Froger, N; Fuchs, E; Hoffmann, K; Parésys, L; Villey, I | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Adrian, M; Angebault, C; Caignard, A; Delettre, C; Grenier, J; Hamel, CP; Lacroux, A; Larsen, M; Lavergne, C; Lenaers, G; Milea, D; Müller, A; Quilès, M; Reynier, P; Rönnbäck, C; Sarzi, E; Seveno, M | 1 |
| Beckmann, H; Krügel, U; Schaefer, M; Straub, I | 1 |
| Belliard, A; Desurmont, T; Fabre, S; Favreau, F; Han, Z; Hauet, T; Liu, J; Manguy, E; Papadopoulos, V; Rossard, L; Thuillier, R; Zhang, K | 1 |
| Besheer, J; Hodge, CW; Lindsay, TG; Morrow, AL; O'Buckley, TK | 1 |
| Darbra, S; Mòdol, L; Pallarès, M | 1 |
| Benoit, M; Chen, X; Gudermann, T; Hofmann, T; Janssens, A; Kerselaers, S; Nilius, B; Oberwinkler, J; Owsianik, G; Philipp, SE; Stab, J; Vennekens, R; Voets, T; Vriens, J; Xue, F | 1 |
| Baulieu, EE; David, S; Duchossoy, Y; Robel, P | 1 |
| Allen, TB; Bradford, DW; Hamer, RM; Kilts, JD; Lieberman, JA; Marx, CE; Naylor, JC; Strauss, JL | 1 |
| Chang, F; Chen, L; Sokabe, M; Xie, G; Xu, B; Yang, R | 1 |
| Cheng, F; Meng, B; Song, W; Sun, X; Yang, B; Yuan, H | 1 |
| Anch, AM; Bloom, CM; Dyche, JS | 1 |
| Billiards, SS; Canny, BJ; Hirst, JJ; Walker, DW | 1 |
| Kamei, H; Nabeshima, T; Noda, Y; Yamada, K | 1 |
| Kamei, H; Manh Tran, H; Maurice, T; Nabeshima, T; Nagai, T; Noda, Y; Roman, FJ; Romieu, P; Urani, A; Yamada, K | 1 |
| Baulieu, EE; David, S; Duchossoy, Y; Fellous, A; Fontaine-Lenoir, V; Robel, P | 1 |
| Citraro, R; De Sarro, G; Di Paola, ED; Gratteri, S; Ibbadu, GF; Marra, R; Russo, E | 1 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Barbosa, AD; Morato, GS | 1 |
| Dombro, RS; Itzhak, Y; Norenberg, MD; Roig-Cantisano, A | 1 |
| Minabe, Y; Muneoka, KT; Shirayama, Y; Takigawa, M | 1 |
| Aso, T; Ban, C; Horie, K; Mori, T; Taii, S | 1 |
| Allison, JE; Bardin, CW; Gumbreck, LG; Schneider, G; Stanley, AJ; Vanha-Perttula, T | 1 |
| Goldman, AS | 1 |
3 review(s) available for pregnenolone and Disease Models, Animal
| Article | Year |
|---|---|
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Drug Evaluation, Preclinical; Humans; Learning; Neurotransmitter Agents; Pregnenolone; Randomized Controlled Trials as Topic; Rats; Schizophrenia | 2011 |
[Effects of sigma receptor ligands on psychiatric disorders].
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Humans; Learning Disabilities; Ligands; Memory Disorders; Mental Disorders; Pregnenolone; Progesterone; Receptors, sigma; Sigma-1 Receptor; Stress, Psychological; Substance-Related Disorders | 2003 |
MAPREG: toward a novel approach of neuroprotection and treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Drug Industry; Humans; Microtubule-Associated Proteins; Microtubules; Neuroprotective Agents; Pregnenolone | 2004 |
29 other study(ies) available for pregnenolone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Sex dimorphism in an animal model of multiple sclerosis: Focus on pregnenolone synthesis.
Topics: Animals; Cholesterol; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Kinetics; Male; Multiple Sclerosis; Neurosteroids; Pregnenolone; Rats; Sex Characteristics; Spinal Cord; Substrate Specificity | 2020 |
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Elevated Plus Maze Test; HEK293 Cells; Humans; Male; Pregnenolone; Rats, Long-Evans; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Steroids | 2021 |
ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.
Topics: Adenosine Triphosphate; Animals; Cell Death; Culture Media; Disease Models, Animal; Estrogens; Glycolysis; Glycosides; HEK293 Cells; Humans; Mice; Mitochondria; Parkinson Disease; PC12 Cells; Pregnenolone; Rats; Small Molecule Libraries | 2017 |
Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Glutamic Acid; Hyperammonemia; Learning; Male; Microdialysis; Nitric Oxide; Pregnenolone; Psychomotor Performance; Rats; Rats, Wistar; Receptors, GABA-A; Treatment Outcome | 2014 |
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Antipsychotic Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Haloperidol; Injections, Intraperitoneal; Male; Nucleus Accumbens; Pregnenolone; Prepulse Inhibition; Random Allocation; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Social Isolation; Stress, Psychological | 2015 |
The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Disease Models, Animal; GABA-A Receptor Antagonists; Liver Cirrhosis, Biliary; Male; Memory; Memory Disorders; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2015 |
Effects of the Synthetic Neurosteroid: 3β-Methoxypregnenolone (MAP4343) on Behavioral and Physiological Alterations Provoked by Chronic Psychosocial Stress in Tree Shrews.
Topics: Administration, Oral; Animals; Antidepressive Agents; Avoidance Learning; Body Temperature; Disease Models, Animal; Drug Evaluation, Preclinical; Hippocampus; Hydrocortisone; Male; Motor Activity; Norepinephrine; Pregnenolone; Sleep; Social Behavior; Stress, Psychological; Tubulin; Tupaiidae | 2016 |
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylenediamines; Hyperalgesia; Male; Pain Measurement; Pregnenolone; Purinergic P2X Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Receptors, sigma; Time Factors | 2016 |
Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.
Topics: Adolescent; Animals; Apoptosis; Disease Models, Animal; Female; GTP Phosphohydrolases; Humans; Male; Mice; Mice, Transgenic; Mitochondria; Mutant Proteins; Optic Atrophy, Autosomal Dominant; Optic Nerve; Pregnenolone; Retina; Retinal Degeneration; Retinal Ganglion Cells; Sex Characteristics | 2016 |
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Maprotiline; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Pain; Pain Threshold; Patch-Clamp Techniques; Pregnenolone; Primidone; Rats; TRPM Cation Channels | 2017 |
Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Line; Cell Survival; Cholesterol Side-Chain Cleavage Enzyme; Disease Models, Animal; Hypoxia; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Oxidative Stress; Phosphoproteins; Pregnenolone; Reperfusion Injury; RNA, Messenger; Swine | 2009 |
Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats.
Topics: Alcoholism; Animals; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethanol; Male; Motor Activity; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Self Administration | 2010 |
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels | 2011 |
Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone.
Topics: Animals; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Microtubules; Neuroprotective Agents; Pregnenolone; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries | 2011 |
Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus of APPswe/PS1dE9 mice.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Dehydroepiandrosterone; Dentate Gyrus; Disease Models, Animal; Humans; Male; Mice; Mice, Transgenic; Neural Stem Cells; Neurites; Neurogenesis; Pregnenolone | 2012 |
Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension.
Topics: Animals; Cell Count; Disease Models, Animal; Gene Expression; Glaucoma; Intraocular Pressure; Neuroprotective Agents; Pregnenolone; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, sigma; Retina; Retinal Ganglion Cells; Sigma-1 Receptor | 2012 |
Behavioral effects of chronic melatonin and pregnenolone injections in a myelin mutant rat (taiep).
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Gait; Gait Disorders, Neurologic; Melatonin; Pregnenolone; Random Allocation; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Statistics, Nonparametric | 2002 |
Endotoxin increases sleep and brain allopregnanolone concentrations in newborn lambs.
Topics: Animals; Animals, Newborn; Bacterial Infections; Brain; Disease Models, Animal; Humans; Hydrocortisone; Infant; Lipopolysaccharides; Pregnanolone; Pregnenolone; Progesterone; Risk Factors; Sheep; Sleep; Sudden Infant Death | 2002 |
Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Brain; Cinnamates; Conditioning, Psychological; Cyclopropanes; Dehydroepiandrosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fear; Injections, Intraventricular; Male; Peptide Fragments; Phenazocine; Pregnenolone; Progesterone; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stress, Psychological | 2004 |
Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy, Absence; Male; Microinjections; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Time Factors | 2006 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain.
Topics: Acetates; Ammonia; Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Liver Failure, Acute; Male; Mice; Neurons; Pregnenolone; Receptors, GABA-A; Thioacetamide | 1995 |
Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Aging; Animals; Animals, Newborn; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Dopamine; Female; Male; Mental Disorders; Phenethylamines; Pregnancy; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sex Characteristics; Synaptic Transmission | 2001 |
Impaired steroidogenic function of corpora lutea from hyperprolactinemic baboons induced by sulpiride.
Topics: Animals; Corpus Luteum; Disease Models, Animal; Estradiol; Female; Follicle Stimulating Hormone; Hyperprolactinemia; Luteinizing Hormone; Papio; Pregnenolone; Prolactin; Steroids; Sulpiride | 1986 |
Testicular tumors in the androgen insensitive pseudohermaphrodite rat: histochemistry and steroid metabolism.
Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Dehydroepiandrosterone; Disease Models, Animal; Disorders of Sex Development; Histocytochemistry; Hydroxysteroid Dehydrogenases; Leydig Cell Tumor; Leydig Cells; Male; Oxidoreductases; Pregnenolone; Rats; Sertoli Cell Tumor; Testicular Neoplasms; Testis; Tritium | 1970 |
Production of congenital lipoid adrenal hyperplasia in rats and inhibition of cholesterol side-chain cleavage.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Cholesterol; Disease Models, Animal; Female; Glutethimide; Hydroxysteroid Dehydrogenases; Lyases; Male; Maternal-Fetal Exchange; Organ Size; Ovary; Pregnancy; Pregnancy, Animal; Pregnenolone; Pyridones; Rats; Testis; Virilism | 1970 |