Page last updated: 2024-08-20

pregnenolone and Depression

pregnenolone has been researched along with Depression in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (9.09)	18.2507
2000's	2 (18.18)	29.6817
2010's	7 (63.64)	24.3611
2020's	1 (9.09)	2.80

Authors

Authors	Studies
Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y	1
Brancato, A; Cannizzaro, C; Cannizzaro, E; Marino, RA; Plescia, F	1
Abbiati, F; Caruso, D; Cavaletti, G; Fusco, L; Giatti, S; Melcangi, RC; Romano, S	1
Vallée, M	1
Chung, BC; Weng, JH	1
Girdler, SS; Johnson, JL; Lindgren, M; Morrow, AL; Porcu, P; Rubinow, DR	1
Baulieu, EE; Bianchi, M	1
Abelli, M; Calugi, S; Cardini, A; Cassano, GB; Chelli, B; Costa, B; Da Pozzo, E; Gabelloni, P; Lari, L; Lucacchini, A; Martini, C; Pini, S	1
Dorfman, P; Maayan, R; Morad, O; Overstreet, DH; Weizman, A; Yadid, G	1
Akhondzadeh, S; Stone, TW	1
Allison, CM; Hu, FY; Pearson Murphy, BE; Steinberg, SI	1

Reviews

2 review(s) available for pregnenolone and Depression

Article	Year
Neurosteroids and potential therapeutics: Focus on pregnenolone. The Journal of steroid biochemistry and molecular biology, 2016, Volume: 160 Topics: Animals; Cognition; Depression; Drug Discovery; Humans; Pregnenolone; Schizophrenia	2016
Nongenomic actions of neurosteroid pregnenolone and its metabolites. Steroids, 2016, Volume: 111 Topics: 17-alpha-Hydroxypregnenolone; Animals; Depression; Humans; Microtubules; Neurodegenerative Diseases; Neurotransmitter Agents; Pregnanolone; Pregnenolone	2016

Trials

1 trial(s) available for pregnenolone and Depression

Article	Year
A history of depression in women is associated with an altered GABAergic neuroactive steroid profile. Psychoneuroendocrinology, 2012, Volume: 37, Issue:4 Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Depression; Double-Blind Method; Female; Humans; Hydrocortisone; Neurotransmitter Agents; Pregnenolone; Progesterone	2012

Other Studies

8 other study(ies) available for pregnenolone and Depression

Article	Year
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology, 2020, Volume: 121 Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry	2020
The role of pregnenolone sulphate in spatial orientation-acquisition and retention: an interplay between cognitive potentiation and mood regulation. Behavioural processes, 2013, Volume: 99 Topics: Affect; Animals; Cognition; Data Interpretation, Statistical; Depression; Learning; Longitudinal Studies; Male; Memory; Motor Activity; Nootropic Agents; Orientation; Pregnenolone; Rats; Rats, Wistar; Space Perception; Swimming	2013
Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma. The Journal of steroid biochemistry and molecular biology, 2015, Volume: 146 Topics: 20-alpha-Dihydroprogesterone; Adult; Alopecia; Anxiety Disorders; Case-Control Studies; Depression; Finasteride; Humans; Male; Pregnenolone; Progesterone; Sexual Dysfunctions, Psychological; Steroids	2015
3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders. Proceedings of the National Academy of Sciences of the United States of America, 2012, Jan-31, Volume: 109, Issue:5 Topics: Adaptation, Psychological; Animals; Behavior, Animal; Brain; Depression; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Tubulin	2012
Role of translocator protein (18 kDa) in adult separation anxiety and attachment style in patients with depression. Current molecular medicine, 2012, Volume: 12, Issue:4 Topics: Amino Acid Substitution; Anxiety Disorders; Case-Control Studies; Depression; Gene Frequency; Genetic Association Studies; Humans; Logistic Models; Molecular Imaging; Object Attachment; Polymorphism, Single Nucleotide; Pregnenolone; Receptors, GABA	2012
The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Brain; Brain Chemistry; Cytosol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression; Electroshock; Hydrocortisone; Liver; Male; Nerve Tissue Proteins; Pregnenolone; Rats; Rats, Inbred Strains; Sulfotransferases	2005
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate. Pharmacological research, 1998, Volume: 38, Issue:6 Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors	1998
Neuroactive ring A-reduced metabolites of progesterone in human plasma during pregnancy: elevated levels of 5 alpha-dihydroprogesterone in depressed patients during the latter half of pregnancy. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:12 Topics: 5-alpha-Dihydroprogesterone; Adult; Blood; Depression; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Pregnanediones; Pregnenolone; Progesterone	2001