pregnenolone has been researched along with Dementia Praecox in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 17 (80.95) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Frau, R; Melis, M | 1 |
| Chodounska, H; Chvojkova, M; Holubova, K; Hrcka Krausova, B; Kudova, E; Vales, K; Vyklicky, L; Vyklicky, V | 1 |
| Chen, CC; Chong, MY; Hsu, ST; Huang, YC; Hung, CF; Lee, Y; Lin, CH; Lin, PY; Wang, LJ; Wu, CC | 1 |
| Akhondzadeh, S; Karkhaneh-Yousefi, MA; Kashani, L; Khodaie-Ardakani, MR; Moazen-Zadeh, E; Rahiminejad, F; Rezaei, F; Sadighi, G; Shams, N | 1 |
| Cai, H; Dougherty, GG; Haas, GL; Keshavan, M; Montrose, DM; Reddy, RD; Yao, JK; Zhou, X | 1 |
| Barbero, JD; Bioque, M; Cobo, J; García-Rizo, C; González-Rodríguez, A; Huerta-Ramos, E; Labad, J; Monreal, JA; Soria, V; Tost, M; Usall, J | 1 |
| Meltzer, HY; Rajagopal, L; Soni, D | 1 |
| Chodounska, H; Kudova, E; Matousova, M; Mertlikova-Kaiserova, H; Slavikova, B; Soucek, R; Tloustova, E | 1 |
| Bawakny, H; Kreinin, A; Ritsner, MS | 1 |
| Bautista, DC; Buchanan, RW; Chan, E; Chong, SA; Hariram, J; Jacob, R; Keefe, RS; Kilts, JD; Lee, J; Marx, CE; Rapisarda, A; Sim, K; Subramaniam, M; Verma, S; Wai, EP | 1 |
| Allen, TB; Bradford, DW; Brancu, M; Brunca, M; Hamer, RM; Kilts, JD; Marx, CE; Naylor, JC; Shampine, LJ; Strauss, JL; Szabo, ST; Youssef, NA | 1 |
| Chang, CC; Lee, J; Sze, Y; Wong, P; Zhang, X | 1 |
| Abbiati, F; Bini, V; Bortolato, M; Caruso, D; Casti, A; Devoto, P; Frau, R | 1 |
| Vallée, M | 1 |
| Bradford, DW; Buchanan, RW; Dunn, L; Hamer, RM; Keefe, RS; Kilts, JD; Leimone, LA; Lieberman, JA; Marx, CE; Morrow, AL; Naylor, JC; Payne, VM; Porcu, P; Savitz, AJ; Shampine, LJ; Strauss, JL | 1 |
| Ritsner, MS | 1 |
| Boguslavsky, I; Gibel, A; Lerner, V; Maayan, R; Ritsner, MS; Shleifer, T; Weizman, A; Zayed, A | 1 |
| Allen, TB; Bradford, DW; Hamer, RM; Kilts, JD; Lieberman, JA; Marx, CE; Naylor, JC; Strauss, JL | 1 |
| Davis, JM; Torrey, EF | 1 |
| Caron, MG; Chang, CC; Marx, CE; Wetsel, WC; Wong, P; Zhang, X | 1 |
| Gibel, A; Maayan, R; Ritsner, M; Weizman, A | 1 |
6 review(s) available for pregnenolone and Dementia Praecox
| Article | Year |
|---|---|
Sex-specific susceptibility to psychotic-like states provoked by prenatal THC exposure: Reversal by pregnenolone.
Topics: Dopamine; Female; Humans; Male; Mental Disorders; Neurosteroids; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Schizophrenia | 2023 |
Targeting hypothalamic-pituitary-adrenal axis hormones and sex steroids for improving cognition in major mood disorders and schizophrenia: a systematic review and narrative synthesis.
Topics: Affective Disorders, Psychotic; Bipolar Disorder; Cognition Disorders; Cognitive Dysfunction; Depressive Disorder, Major; Female; Gonadal Steroid Hormones; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mifepristone; Mood Disorders; Pituitary-Adrenal System; Pregnenolone; Raloxifene Hydrochloride; Schizophrenia | 2018 |
Neurosteroids and potential therapeutics: Focus on pregnenolone.
Topics: Animals; Cognition; Depression; Drug Discovery; Humans; Pregnenolone; Schizophrenia | 2016 |
Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.
Topics: Adjuvants, Immunologic; Animals; Antipsychotic Agents; Central Nervous System; Clinical Trials as Topic; Dehydroepiandrosterone; Humans; Neuroprotective Agents; Pregnenolone; Receptors, Neurotransmitter; Schizophrenia | 2010 |
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Drug Evaluation, Preclinical; Humans; Learning; Neurotransmitter Agents; Pregnenolone; Randomized Controlled Trials as Topic; Rats; Schizophrenia | 2011 |
Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Aspirin; Benzothiazoles; Bipolar Disorder; Celecoxib; Chemotherapy, Adjuvant; Cyclooxygenase 2 Inhibitors; Dopamine Agonists; Estrogens; Fatty Acids, Omega-3; Folic Acid; Humans; Mianserin; Minocycline; Mirtazapine; Pramipexole; Pregnenolone; Pyrazoles; Randomized Controlled Trials as Topic; Schizophrenia; Sulfonamides; Treatment Outcome; Vitamin B Complex | 2012 |
5 trial(s) available for pregnenolone and Dementia Praecox
| Article | Year |
|---|---|
Pregnenolone as an adjunct to risperidone for treatment of women with schizophrenia: A randomized double-blind placebo-controlled clinical trial.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Middle Aged; Outcome Assessment, Health Care; Pregnenolone; Risperidone; Schizophrenia; Young Adult | 2017 |
Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antipsychotic Agents; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Pregnenolone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Young Adult | 2014 |
Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia.
Topics: Adult; Antipsychotic Agents; Cognition; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Female; Humans; Male; Neurotransmitter Agents; Pregnenolone; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Sex Characteristics; Treatment Outcome | 2014 |
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Topics: Adult; Aged; Brain; Brain Chemistry; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Placebos; Pregnanolone; Pregnenolone; Schizophrenia; Treatment Outcome; Up-Regulation | 2009 |
Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial.
Topics: Adolescent; Adult; Antipsychotic Agents; Attention; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Humans; Male; Memory, Short-Term; Middle Aged; Neurotransmitter Agents; Pregnenolone; Psychotic Disorders; Schizophrenia; Severity of Illness Index | 2010 |
10 other study(ies) available for pregnenolone and Dementia Praecox
| Article | Year |
|---|---|
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Elevated Plus Maze Test; HEK293 Cells; Humans; Male; Pregnenolone; Rats, Long-Evans; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Steroids | 2021 |
Gender differences in susceptibility to schizophrenia: Potential implication of neurosteroids.
Topics: Adult; Case-Control Studies; China; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Disease Susceptibility; Female; Humans; Hydrocortisone; Male; Middle Aged; Neurotransmitter Agents; Pregnenolone; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Sex Factors | 2017 |
Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Biomarkers, Pharmacological; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Male; Metabolic Networks and Pathways; Pregnanolone; Pregnenolone; Progesterone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2018 |
Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction.
Topics: Animals; Antipsychotic Agents; Cognition; Drug Therapy, Combination; Interpersonal Relations; Isoindoles; Lurasidone Hydrochloride; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Phencyclidine; Piperazines; Pregnenolone; Pyrimidines; Random Allocation; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2018 |
Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability.
Topics: Androstenols; Animals; Autism Spectrum Disorder; Cell Survival; Cholesterol; Dicarboxylic Acids; Drug Stability; Esters; Hep G2 Cells; Humans; Intellectual Disability; Mitochondria; Molecular Structure; Neurons; Neuroprotective Agents; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tumor Cells, Cultured | 2019 |
Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.
Topics: Adult; Aged; Autopsy; Biomarkers; Bipolar Disorder; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Female; Gas Chromatography-Mass Spectrometry; Gyrus Cinguli; Humans; Male; Middle Aged; Parietal Lobe; Pilot Projects; Pregnanolone; Pregnenolone; Schizophrenia; Suicide; Young Adult | 2015 |
Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Dopamine Plasma Membrane Transport Proteins; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Knockout; Pregnenolone; Proto-Oncogene Proteins c-akt; Schizophrenia | 2015 |
Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Antipsychotic Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Haloperidol; Injections, Intraperitoneal; Male; Nucleus Accumbens; Pregnenolone; Prepulse Inhibition; Random Allocation; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Social Isolation; Stress, Psychological | 2015 |
Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Dopamine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Knockout; Motor Activity; Pregnenolone; Receptors, GABA-A; Schizophrenia | 2012 |
Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects.
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Pregnenolone; Radioimmunoassay; Schizophrenia; Statistics as Topic; Time Factors | 2007 |