pregnenolone has been researched along with Aging in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (55.26) | 18.7374 |
| 1990's | 11 (14.47) | 18.2507 |
| 2000's | 17 (22.37) | 29.6817 |
| 2010's | 5 (6.58) | 24.3611 |
| 2020's | 1 (1.32) | 2.80 |
| Authors | Studies |
|---|---|
| De Lafollie, J; Hartmann, MF; Heckmann, M; Hübner, S; Ittermann, T; Ruhnau, J; Sunny, D; Wudy, SA | 1 |
| Baulieu, EE; Boddaert, J; Commeau, L; Farina, F; Fonte, C; Lambert, E; Lejeune, FX; Neri, C; Parker, JA; Roudier, N; Verny, M | 1 |
| Denier, C; Fernandez, N; Fréchou, M; Guennoun, R; Liere, P; Mattern, C; Pianos, A; Schumacher, M; Zhang, S; Zhu, X | 1 |
| Bedin, R; Biagini, G; Giovannini, G; Lucchi, C; Meletti, S; Monti, G; Rustichelli, C; Trenti, T | 1 |
| Bu, J; Zu, H | 1 |
| Hatoya, S; Inaba, T; Ito, M; Kawate, N; Morii, H; Ohta, Y; Takahashi, K; Takahashi, M; Tamada, H; Yoshida, K | 1 |
| Hill, M; Meloun, M; Vceláková-Havlíková, H | 1 |
| Belvedere, P; Colombo, L; Dalla Valle, L; Simontacchi, C | 1 |
| Mahler, P; Partsch, CJ; Riepe, FG; Sippell, WG | 1 |
| Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S | 1 |
| Harrison, MB; Kapur, J; Mtchedlishvili, Z; Sun, CS | 1 |
| LORING, JM; VILLEE, CA | 1 |
| AXELROD, LR | 1 |
| Abrous, N; Bouyer, JJ; Darbra, S; Darnaudéry, M; George, O; Le Moal, M; Lemaire-Mayo, V; Mayo, W; Pallarès, M; Piazza, PV; Vallée, M | 1 |
| Bourguiba, S; Carreau, S; Marie, E | 1 |
| Maurice, T; Miyamoto, Y; Nabeshima, T; Phan, VL | 1 |
| George, O; Le Moal, M; Mayo, W; Vallée, M | 1 |
| Koh, E; Mizokami, A; Namiki, M; Yamamoto, K | 1 |
| Cerny, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Kim, MJ; Morley, JE | 1 |
| Ahlstrand, C; Berg, AA; Hammar, M; Läckgren, G | 1 |
| Brinkman, AO; Rommerts, FF | 1 |
| Chen, GC; Cole, BT; Lin, T; Murono, E; Nankin, H; Osterman, J | 1 |
| Deslypere, JP; Rubens, R; Schelfhout, W; Verdonck, L; Vermeulen, A | 1 |
| Catt, KJ; Dufau, ML; Huhtaniemi, IT; Nozu, K; Warren, DW | 1 |
| de Peretti, E; Mappus, E | 1 |
| Chubb, C; Desjardins, C | 1 |
| Brinkmann, AO; Leemborg, FG; Rommerts, FF; van der Molen, HJ | 1 |
| Hemsell, PG; Mason, JI | 1 |
| Kaler, LW; Neaves, WB | 1 |
| Chavis, TR; Dimino, MJ; Downing, JR | 1 |
| Brinkmann, AO; De Jong, FH; Leemborg, FG; Roodnat, EM; Van der Molen, HJ | 1 |
| Baulieu, EE; Corpéchot, C; Haug, M; Mayo, W; Perché, F; Robel, P; Simon, H; Young, J | 1 |
| Gottardo, G; Markowska, A; Mazzochi, G; Nussdorfer, GG; Rebuffat, P | 1 |
| Ashwell, JD; Papadopoulos, V; Vacchio, MS | 1 |
| Bélanger, A; Candas, B; Cusan, L; Gomez, JL; Labrie, F | 1 |
| Baulieu, EE | 1 |
| Baulieu, EE; Corpéchot, C; Darnaudéry, M; Koehl, M; Le Moal, M; Mayo, W; Robel, P; Simon, H; Vallée, M; Young, J | 1 |
| Kulkarni, SK; Reddy, DS | 1 |
| Alonso, G; Legrand, A | 1 |
| Abrous, DN; Le Moal, M; Mayo, W | 1 |
| Minabe, Y; Muneoka, KT; Shirayama, Y; Takigawa, M | 1 |
| Le Moal, M; Mayo, W; Vallée, M | 1 |
| Dearth, RK; Hiney, JK; Les Dees, W; Srivastava, VK | 1 |
| Hampl, R; Havlíková, H; Hill, M; Stárka, L | 1 |
| Muneoka, KT; Takigawa, M | 1 |
| Kalkman, ML; Van der Molen, HJ; Van der Vusse, GJ; Van Winsen, MP | 1 |
| Iwamori, M; Kishimoto, Y; Moser, HW | 1 |
| Bedrak, E; Chap, Z | 1 |
| Hammond, GL; Kontturi, M; Vihko, P; Vihko, R | 1 |
| Leathem, JH; Murono, EP | 1 |
| Lau, IF; Saksena, SK | 1 |
| Corda, R; Genazzani, AR; Pintor, C | 1 |
| Hirano, H; Nakamura, T; Tanabe, Y | 1 |
| Bedrfak, E; Chap, Z; Sod-Moriah, UA | 1 |
| Ford, VL; Weiss, M | 1 |
| Oesch, F | 1 |
| Akwa, Y; Baulieu, EE; Morfin, RF; Robel, P | 1 |
| Baulieu, EE; Eychenne, B; Jo, DH; Lapous, D; Raulin, J; Robel, P; Vourc'h, C | 1 |
| Hoogerbrugge, JW; Rommerts, FF; Teerds, KJ | 1 |
| Maki, T | 1 |
| Carsia, RV; Weber, H | 1 |
| Bertrand, J; David, M; de Peretti, E; Forest, MG; François, R; Loras, B; Morel, Y | 1 |
| Byrne, GC; Perry, YS; Winter, JS | 1 |
| Hardy, A; Leloup-Hatey, J; Querat, B | 1 |
| Jongkind, JF; Molenaar, R; Rommerts, FF; Themmen, AP; van der Molen, HJ; Visser, WJ | 1 |
| Azhar, S; Butte, J; Popplewell, PY | 1 |
| Green, OC; Kenny, FM; Reynolds, JW | 1 |
| Cardiff, C; Killinger, DW; Uden, V | 1 |
| Baxter, MN; Ferrechio, GB; Romanoff, LP; Thomas, AW | 1 |
| Bryk, E; Kurlit, M; Niweliński, J; Zamorska, L | 1 |
| Kao, KY; McGavack, TH; Trout, EC | 1 |
| Sholl, SA | 1 |
| Bell, JB; Collins, PM; Tsang, WN | 1 |
| Björkhem, I; Eriksson, H; Gustafsson, JA; Karlmar, KE; Stenberg, A | 1 |
| Baxter, MN; Grace, MP; Pincus, G; Romanoff, LP | 1 |
8 review(s) available for pregnenolone and Aging
| Article | Year |
|---|---|
Individual differences in cognitive aging: implication of pregnenolone sulfate.
Topics: Acetylcholine; Aging; Animals; Brain; Cognition; Humans; Neuronal Plasticity; Pregnenolone; Sleep | 2003 |
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders | 2006 |
[Testosterone synthesis].
Topics: Aging; Cholesterol; GTP-Binding Proteins; Humans; Leydig Cells; Luteinizing Hormone; Male; Pregnenolone; Receptors, LH; Signal Transduction; Steroid 17-alpha-Hydroxylase; Testosterone | 2006 |
The hormonal fountains of youth: myth or reality?
Topics: Aging; Animals; Dehydroepiandrosterone; Estrogens; Female; Growth Hormone; Hormone Replacement Therapy; Humans; Male; Melatonin; Mythology; Pregnenolone; Rejuvenation; Testosterone; Vitamin D | 2005 |
Modulation of steroidogenic activities in testis Leydig cells.
Topics: Aging; Animals; Aromatase; Cell Membrane; Cell Separation; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Cycloheximide; Estradiol; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Gonadotropin-Releasing Hormone; Hydroxyprogesterones; Leydig Cells; Luteinizing Hormone; Male; Oxidoreductases; Phosphorylation; Pregnenolone; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, LH; Sertoli Cells; Testosterone | 1981 |
Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.
Topics: Adrenalectomy; Aggression; Aging; Animals; Behavior, Animal; Dehydroepiandrosterone; Dihydrotestosterone; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Lactation; Male; Memory; Mice; Orchiectomy; Pregnenolone; Progesterone; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1995 |
Neurosteroids: a role in aging? New functions in the central and peripheral nervous systems.
Topics: Aging; Animals; Central Nervous System; Dehydroepiandrosterone; Peripheral Nervous System; Pregnenolone | 1997 |
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.
Topics: Aging; Animals; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hippocampus; Humans; Learning; Memory; Pregnenolone; Rats; Reproducibility of Results | 2001 |
68 other study(ies) available for pregnenolone and Aging
| Article | Year |
|---|---|
Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry.
Topics: 17-alpha-Hydroxypregnenolone; Adult; Aging; Amniotic Fluid; Cohort Studies; Dehydroepiandrosterone Sulfate; Female; Fetus; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Infant, Extremely Premature; Infant, Newborn; Infant, Premature; Male; Pregnancy; Pregnenolone; Sex Characteristics; Steroids | 2021 |
The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease.
Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drug Evaluation, Preclinical; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Gene Knock-In Techniques; Humans; Huntingtin Protein; Huntington Disease; Lithium Chloride; Mice; Neurons; Pregnenolone; Quercetin | 2017 |
A Role of Endogenous Progesterone in Stroke Cerebroprotection Revealed by the Neural-Specific Deletion of Its Intracellular Receptors.
Topics: Aging; Animals; Brain Chemistry; Female; Gene Deletion; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pregnenolone; Progesterone; Receptors, Progesterone; Sex Characteristics; Stroke | 2017 |
Low levels of progesterone and derivatives in cerebrospinal fluid of patients affected by status epilepticus.
Topics: 5-alpha-Dihydroprogesterone; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Retrospective Studies; Status Epilepticus; Steroids; Tandem Mass Spectrometry; Young Adult | 2018 |
Effects of pregnenolone intervention on the cholinergic system and synaptic protein 1 in aged rats.
Topics: Acetylcholinesterase; Aging; Animals; Choline O-Acetyltransferase; Cholinergic Neurons; Dose-Response Relationship, Drug; Frontal Lobe; Hippocampus; Male; Pregnenolone; Rats; Synapsins; Temporal Lobe | 2014 |
Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats.
Topics: Aging; Animals; Chorionic Gonadotropin; Hydroxycholesterols; Lepidium; Leydig Cells; Male; Plant Extracts; Pregnenolone; Rats; Testosterone | 2018 |
Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Health; Humans; Linear Models; Male; Middle Aged; Pregnenolone; Sex Characteristics | 2009 |
Extraglandular hormonal steroidogenesis in aged rats.
Topics: 17-Hydroxysteroid Dehydrogenases; 20-alpha-Hydroxysteroid Dehydrogenase; Aging; Animals; Chromatography, Thin Layer; Gastrointestinal Tract; Male; Multienzyme Complexes; Organ Specificity; Pregnenolone; Progesterone Reductase; Rats; Rats, Wistar; Skin; Steroid 17-alpha-Hydroxylase; Steroid Isomerases; Testis | 1992 |
Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period.
Topics: 17-alpha-Hydroxypregnenolone; Aging; Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Longitudinal Studies; Male; Maternal-Fetal Exchange; Pregnancy; Pregnenolone; Reference Values; Time Factors | 2002 |
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins | 2002 |
Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Male; Membrane Potentials; Neural Inhibition; Neurons; Pregnanolone; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Steroids; Up-Regulation | 2003 |
SYNTHESIS OF STEROIDS IN THE NEWBORN HUMAN ADRENAL IN VITRO.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Aging; Carbon Isotopes; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Humans; Hydrocortisone; In Vitro Techniques; Infant, Newborn; Metabolism; NADP; Pregnenolone; Progesterone; Radiometry; Steroids | 1965 |
METABOLIC PATTERNS OF STEROID BIOSYNTHESIS IN YOUNG AND AGED HUMAN TESTES.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Aging; Androgens; Chromatography; Estrone; Humans; Hydroxyprogesterones; Lyases; Male; Metabolism; Mixed Function Oxygenases; Pregnenolone; Testis | 1965 |
Testicular and blood steroid levels in aged men.
Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Pregnenolone; Progesterone; Reference Values; Sex Hormone-Binding Globulin; Steroids; Testis; Testosterone | 2004 |
Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse.
Topics: Age Factors; Aging; Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Blotting, Northern; Brain; Cinnamates; Cyclopropanes; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Gene Expression Regulation; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Phenazocine; Pregnenolone; Progesterone; Radioligand Assay; Receptors, sigma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tritium | 2005 |
Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
Topics: Adult; Aging; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Luteal Phase; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA-A | 2006 |
In vitro conversion of 3H-pregnenolone by human testicular tissue from fetal age to senescence.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Aged; Aging; Child; Child, Preschool; Cryptorchidism; Female; Fetus; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Pregnancy; Pregnenolone; Prostatic Neoplasms; Puberty; Steroid 17-alpha-Hydroxylase; Testis; Testosterone | 1984 |
The aging Leydig cell: 2. Two distinct populations of Leydig cells and the possible site of defective steroidogenesis.
Topics: Aging; Animals; Centrifugation, Density Gradient; Cyclic AMP; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Pregnenolone; Progesterone; Rats; Testosterone | 1981 |
Adrenocortical function in old age: response to acute adrenocorticotropin stimulation.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aged; Aging; Androstenedione; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Male; Middle Aged; Pregnenolone; Progesterone | 1982 |
Acquisition of regulatory mechanisms for gonadotropin receptors and steroidogenesis in the maturing rat testis.
Topics: Aging; Animals; Chorionic Gonadotropin; Cyclic AMP; Estrogens; In Vitro Techniques; Male; Pregnenolone; Rats; Receptors, Cell Surface; Receptors, Estrogen; Receptors, LH; Receptors, Peptide; Testis; Testosterone | 1982 |
Pattern of plasma pregnenolone sulfate levels in humans from birth to adulthood.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aging; Child; Child, Preschool; Chorionic Gonadotropin; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Male; Metyrapone; Middle Aged; Pregnenolone | 1983 |
Testicular function and sexual activity in senescent mice.
Topics: Aging; Androgens; Animals; Luteinizing Hormone; Male; Mice; Perfusion; Pregnenolone; Progesterone; Sexual Behavior, Animal; Testis; Testosterone | 1984 |
Differences between the regulation of cholesterol side-chain cleavage in Leydig cells from mice and rats.
Topics: Aging; Animals; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Mice; Pregnenolone; Rats; Species Specificity; Testosterone | 1984 |
Cholesterol sulfate metabolism in human fetal adrenal mitochondria.
Topics: Adolescent; Adrenal Glands; Adult; Aging; Calcium; Cholesterol; Cholesterol Esters; Female; Fetus; Humans; Hydroxycholesterols; Infant; Male; Mitochondria; Pregnancy; Pregnenolone | 1982 |
The steroidogenic capacity of the aging rat testis.
Topics: Aging; Animals; Cholesterol; Male; Pregnenolone; Rats; Testosterone | 1981 |
A relationship between adenosine 5'-triphosphate and pregnenolone syntheses by ovarian mitochondria as demonstrated with aminoglutethimide.
Topics: Adenosine Triphosphate; Aging; Aminoglutethimide; Animals; Dose-Response Relationship, Drug; Female; Hypophysectomy; Kinetics; Mitochondria; Ovary; Oxidative Phosphorylation; Oxygen Consumption; Pregnenolone | 1980 |
A specific action of estradiol on enzymes involved in testicular steroidogenesis.
Topics: Aging; Animals; Estradiol; Leydig Cells; Luteinizing Hormone; Male; Pregnenolone; Rats; Steroids; Testis; Testosterone | 1980 |
Age-dependent changes in the function and morphology of mitochondria of rat adrenal zona fasciculata.
Topics: Aging; Animals; Cholesterol Side-Chain Cleavage Enzyme; Male; Mitochondria; Pregnenolone; Rats; Rats, Wistar; Zona Fasciculata | 1994 |
Steroid production in the thymus: implications for thymocyte selection.
Topics: Aging; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Epithelial Cells; Epithelium; Fetus; Lymphocyte Depletion; Metyrapone; Mice; Mice, Inbred BALB C; Mifepristone; Organ Culture Techniques; Pregnenolone; Receptors, Antigen, T-Cell; Receptors, Glucocorticoid; Signal Transduction; T-Lymphocytes; Thymus Gland | 1994 |
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Aged; Aged, 80 and over; Aging; Androgens; Androstenediol; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Female; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Pregnenolone; Protein Precursors; Reference Values | 1997 |
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus.
Topics: Aging; Animals; Cognition; Hippocampus; Male; Pregnenolone; Rats; Rats, Sprague-Dawley | 1997 |
Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Enzyme Inhibitors; Learning Disabilities; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nootropic Agents; Pregnenolone | 1998 |
Pregnenolone reverses the age-dependent accumulation of glial fibrillary acidic protein within astrocytes of specific regions of the rat brain.
Topics: Aging; Animals; Astrocytes; Brain; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Immunoenzyme Techniques; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; S100 Proteins; Staining and Labeling | 1998 |
Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations.
Topics: Aging; Alzheimer Disease; Animals; Antimetabolites; Behavior, Animal; Brain; Brain Chemistry; Bromodeoxyuridine; Cell Division; Cognition; Humans; Pregnenolone; Rats; Receptors, GABA-A; Sleep | 2001 |
Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Aging; Animals; Animals, Newborn; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Dopamine; Female; Male; Mental Disorders; Phenethylamines; Pregnancy; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sex Characteristics; Synaptic Transmission | 2001 |
Chronic effects of prepubertal ethanol administration on steroidogenic acute regulatory protein in the rat ovary.
Topics: Aging; Animals; Central Nervous System Depressants; Estradiol; Ethanol; Female; Gene Expression; Gonadotropins, Equine; Ovary; Phosphoproteins; Pregnenolone; Rats; Rats, Sprague-Dawley; Sexual Maturation | 2002 |
Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects.
Topics: Adolescent; Adult; Aged; Aging; Child; Epitestosterone; Female; Humans; Male; Middle Aged; Osmolar Concentration; Pregnenolone; Reference Values; Sex Characteristics; Testosterone | 2002 |
A neuroactive steroid, pregnenolone, alters the striatal dopaminergic tone before and after puberty.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Corpus Striatum; Dopamine; Female; Male; Pregnenolone; Rats; Rats, Sprague-Dawley | 2002 |
Effect of Ca2+, ruthenium red and ageing on pregnenolone production by mitochondrial fractions from normal and luteinizing hormone treated rat testes.
Topics: Aging; Animals; Calcium; Edetic Acid; Kinetics; Luteinizing Hormone; Male; Mitochondria; NADP; Pregnenolone; Rats; Ruthenium; Ruthenium Red; Testis | 1976 |
Steroid sulfatase in brain: comparison of sulfohydrolase activities for various steroid sulfates in normal and pathological brains, including the various forms of metachromatic leukodystrophy.
Topics: Aging; Animals; Arylsulfatases; Brain; Cholesterol; Dehydroepiandrosterone; Detergents; Estrone; Female; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Kinetics; Leukodystrophy, Metachromatic; Male; Mutation; Neurologic Manifestations; Pregnenolone; Rats; Steroids; Sulfatases; Testosterone | 1976 |
In vitro testosterone synthesis by testicular tissue of old mouse: the metabolism of 3beta-hydroxy-5-ene steroids.
Topics: 17-alpha-Hydroxypregnenolone; Aging; Androgens; Androstenediols; Androstenedione; Animals; Dehydroepiandrosterone; Hydroxyprogesterones; Male; Mice; Mice, Inbred C57BL; NADP; Pregnenolone; Progesterone; Testis; Testosterone | 1977 |
Serum steroids in normal males and patients with prostatic diseases.
Topics: Adult; Aged; Aging; Androstenedione; Androsterone; Dihydrotestosterone; Estradiol; Humans; Hydroxyprogesterones; Male; Middle Aged; Pregnenolone; Progesterone; Prostatic Hyperplasia; Prostatic Neoplasms; Reference Values; Steroids; Testosterone | 1978 |
Ovarian delta-5-3-beta-hydroxysteroid dehydrogenase in aging rats.
Topics: 17-alpha-Hydroxypregnenolone; Aging; Animals; Corpus Luteum; Cricetinae; Dehydroepiandrosterone; Female; Granulosa Cells; Humans; Hydroxysteroid Dehydrogenases; Mice; Ovary; Pregnenolone; Rats; Theca Cells | 1975 |
Variations in serum androgens, estrogens, progestins, gonadotropins and prolactin levels in male rats from prepubertal to advanced age.
Topics: Aging; Androstenedione; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Estrone; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Luteinizing Hormone; Male; Pregnenolone; Progesterone; Prolactin; Rats; Testosterone | 1979 |
Plasma levels of gonadotropins, prolactin, thyroxine, and adrenal and gonadal steroids in obese prepubertal girls.
Topics: Adrenal Cortex Hormones; Aging; Child; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Obesity; Pregnenolone; Progesterone; Prolactin; Sexual Maturation; Thyroxine | 1978 |
Evidence of the in vitro formation of cortisol by the adrenal gland of embryonic and young chickens (Gallus domesticus).
Topics: Adrenal Cortex Hormones; Adrenal Glands; Aging; Androgens; Animals; Chick Embryo; Chickens; Cholesterol; Female; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Pregnenolone; Progesterone; Steroid Hydroxylases | 1978 |
Metabolism of 3beta-hydroxy-5-ene steroids by testicular tissue in relation to age and environmental temperature.
Topics: Acclimatization; Aging; Androstenediols; Animals; Hot Temperature; Hydroxysteroids; Male; Mice; Mice, Inbred C57BL; Pregnenolone; Progesterone Reductase; Testis | 1976 |
The effects of age, gonadectomy and testosterone treatment on adrenal 5beta-reductase activity in guinea pigs.
Topics: Adrenal Glands; Aging; Animals; Castration; Female; Fetus; Guinea Pigs; Male; Oxidoreductases; Pregnanediones; Pregnenolone; Progesterone; Testosterone | 1975 |
Differential control of rat microsomal "aryl hydrocarbon" monooxygenase and epoxide hydratase.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Epoxide Hydrolases; Female; Fetus; Hydro-Lyases; Liver; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitriles; Phenobarbital; Pregnancy; Pregnenolone; Rats | 1976 |
Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes.
Topics: 17-alpha-Hydroxypregnenolone; Aging; Animals; Brain; Dehydroepiandrosterone; Estrogens; Hydroxylation; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Pregnenolone; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1992 |
Delta 5-3 beta-hydroxysteroid acyl transferase activity in the rat brain.
Topics: Acyltransferases; Aging; Animals; Brain; Dehydroepiandrosterone; Fatty Acids; Hydrogen-Ion Concentration; Hydrolysis; Male; Microsomes; Pregnenolone; Rats; Rats, Inbred Strains; Substrate Specificity; Testosterone | 1992 |
In vitro effects of ethylene-dimethane sulfonate (EDS) on Leydig cells: inhibition of steroid production and cytotoxic effects are dependent on species and age of rat.
Topics: Adenosine Triphosphate; Aging; Alkylating Agents; Animals; Cells, Cultured; Hydroxycholesterols; Leydig Cell Tumor; Leydig Cells; Liver; Luteinizing Hormone; Male; Mesylates; Mice; Pregnenolone; Proteins; Rats; Sertoli Cells; Sexual Maturation; Species Specificity; Testicular Neoplasms; Testis | 1988 |
[Age-related changes in secretion of adrenocortical steroid hormones in normal healthy men].
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Aging; Cosyntropin; Dehydroepiandrosterone; Dexamethasone; Humans; Injections, Intramuscular; Male; Middle Aged; Pregnenolone; Progesterone; Radioimmunoassay | 1986 |
Genetic-dependent alterations in adrenal stress response and adrenocortical cell function of the domestic fowl (Gallus domesticus).
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Chickens; Corticosterone; Dwarfism; Hot Temperature; Male; Organ Size; Pregnenolone; Stress, Physiological | 1986 |
Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children.
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aging; Child; Child, Preschool; Cortodoxone; Dexamethasone; Female; Humans; Hydrocortisone; Infant; Metyrapone; Pituitary Diseases; Pregnenolone | 1986 |
Kinetic analysis of adrenal 3 beta-hydroxysteroid dehydrogenase activity during human development.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adolescent; Adrenal Glands; Adult; Aging; Child; Dehydroepiandrosterone; Female; Humans; Infant; Kinetics; Male; Microsomes; Middle Aged; NAD; Pregnenolone | 1985 |
Ovarian metabolic pathways of steroid biosynthesis in the European eel (Anguilla anguilla L.) at the silver stage.
Topics: Aging; Androstenedione; Anguilla; Animals; Carbon Radioisotopes; Female; Gonadal Steroid Hormones; In Vitro Techniques; Ovary; Pregnenolone; Progesterone; Radioisotope Dilution Technique; Steroids; Testosterone; Tritium | 1986 |
Comparison of the cellular composition and steroidogenic properties of preparations of interstitial cells isolated from immature and mature rat testis.
Topics: Aging; Animals; Centrifugation, Density Gradient; Hydroxycholesterols; Leydig Cells; Luteinizing Hormone; Male; Pregnenolone; Rats; Rats, Inbred Strains; Testis | 1987 |
The influence of age on steroidogenic enzyme activities of the rat adrenal gland: enhanced expression of cholesterol side-chain cleavage activity.
Topics: Adrenal Glands; Aging; Animals; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Microsomes; Mitochondria; Oxidoreductases; Pregnenolone; Rats; Steroid Hydroxylases | 1987 |
Partial 3 -hydroxysteroid dehydrogenase (3 -HSD) deficiency in a family with congenital adrenal hyperplasia: evidence for increasing 3 -HSD activity with age.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Aging; Aldosterone; Androstanes; Androsterone; Child; Child, Preschool; Chlorides; Chromatography, Gas; Chromatography, Thin Layer; Dehydroepiandrosterone; Disorders of Sex Development; Etiocholanolone; Female; Glucuronates; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Hyperkalemia; Hyperplasia; Hyponatremia; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Potassium; Pregnanetriol; Pregnenolone; Sodium; Sulfates; Testosterone | 1971 |
Steroid biosynthesis in gonadal tissue from patients with testicular feminization.
Topics: Adult; Aging; Androgen-Insensitivity Syndrome; Carbon Isotopes; Chromatography; Dehydroepiandrosterone; Estradiol; Humans; In Vitro Techniques; Male; Middle Aged; Pregnenolone; Sulfates; Testis; Testosterone; Tritium | 1972 |
Effect of ACTH on the metabolism of pregnenolone-7 alpha-3H and cortisol-4-14C in young and elderly men.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Carbon Isotopes; Glucuronidase; Humans; Hydrocortisone; Injections, Intravenous; Pregnanes; Pregnenolone; Sterols; Tritium | 1969 |
Stimulating effect of crystalline cholesterol on spermiogenesis and oxidative activity in the senile rat testicle.
Topics: Aging; Androsterone; Animals; Cholesterol; Crystallization; Dehydroepiandrosterone; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Estradiol; Glucosephosphate Dehydrogenase; Histocytochemistry; Hydrocortisone; Hydroxysteroid Dehydrogenases; Male; Pregnenolone; Rats; Spermatogenesis; Stimulation, Chemical; Succinate Dehydrogenase; Testis; Testosterone | 1973 |
Conversion of 17-alpha-hydroxypregnenolone to dehydroepiandrosterone by adrenal homogenates of immature and adult guinea pigs.
Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adrenal Glands; Aging; Animals; Animals, Newborn; Chromatography, Ion Exchange; Chromatography, Thin Layer; Dehydroepiandrosterone; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; NADP; Pregnenolone; Tritium | 1967 |
Ontogeny of mitochondrial steroidogenesis in the guinea pig gonad.
Topics: Aging; Animals; Animals, Newborn; Carbon Radioisotopes; Cholesterol; Estrus; Female; Fetus; Gestational Age; Gonads; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Mitochondria; Pregnancy; Pregnenolone; Progesterone; Testis; Time Factors; Tritium; Uterus | 1974 |
The effect of vasectomy on steroid metabolism by the seminiferous tubules and interstitial tissue of the rat testis: a comparison with the effects of ageing.
Topics: Aging; Animals; Carbon Isotopes; In Vitro Techniques; Male; Organ Size; Pregnenolone; Progesterone; Rats; Testis; Tritium; Vasectomy | 1972 |
Steroid hormone metabolism in developing rats.
Topics: Adrenal Glands; Aging; Animals; Carbon Isotopes; Feces; Female; Hydroxysteroid Dehydrogenases; Male; Ovary; Oxidation-Reduction; Pregnenolone; Progesterone; Rats; Sex Factors; Sulfuric Acids; Testis | 1972 |
Metabolism of pregnenolone-7 alpha-3 H and progesterone-4-14 C in young and elderly men.
Topics: Adult; Aged; Aging; Carbon Isotopes; Humans; Male; Middle Aged; Pregnenolone; Progesterone; Radiometry; Tritium | 1966 |