Page last updated: 2024-08-23

pregnanolone and Seizures

pregnanolone has been researched along with Seizures in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.47)	18.7374
1990's	19 (23.46)	18.2507
2000's	33 (40.74)	29.6817
2010's	18 (22.22)	24.3611
2020's	9 (11.11)	2.80

Authors

Authors	Studies
Bay, CP; Frye, CA; Peng, L; Pennell, KD; Pennell, PB; Stowe, ZN; Tang, KY; Voinescu, PE	1
Aimetti, AA; Amin, S; Bahi-Buisson, N; Benke, TA; Cross, JH; Demarest, ST; Devinsky, O; Fleming, TR; Gasior, M; Knight, EMP; Olson, HE; Specchio, N	1
Burneo, JG; Espino, PH; Mayor, LC; Moscol, G	1
Lamb, YN	1
Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T	1
Biagini, G; Costa, AM; Gol, M; Lucchi, C	1
Aimetti, AA; Gasior, M; Gecz, J; Guerrini, R; Gunning, B; Kolc, KL; Samanta, D; Sullivan, J; Zafar, M; Zhao, Y	1
Chuang, SH; Reddy, DS	3
Ahn, JH; Ahn, SH; Bae, MA; Cho, SH; Hwang, KS; Kan, H; Kim, SS; Lee, BH; Shin, DS; Son, Y; Yang, JY	1
Ackley, MA; Althaus, AL; Doherty, JJ; Hammond, RS; Maciag, C; Martinez Botella, G; Robichaud, AJ; Salituro, FG	1
Joshi, S; Kapur, J	1
Burnham, WM; Wu, YV	1
Carver, CM; Clossen, B; Reddy, DS; Wu, X	1
Cozzoli, DK; Crabbe, JC; Finn, DA; Ford, MM; Helms, M; Jensen, JP; Ramaker, MJ; Rossi, DJ; Snelling, C; Tanchuck-Nipper, MA	1
Frye, CA; Herzog, AG	2
Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST	1
Chopra, K; Dhir, A	1
Carver, CM; Reddy, DS	1
Ciarlone, SL; Rogawski, MA; Wang, X; Weeber, EJ	1
Klein, P; Sperling, MR; Tsai, J	1
Arora, SK; Chakrabarti, A; Hota, D; Khanduja, KL; Prakash, A; Singh, S	1
Mares, P; Stehlíková, M	1
Reddy, DS; Rogawski, MA	2
Reddy, DS	2
Salazar, P; Tapia, R	1
Grobin, AC; Khisti, RT; Morrow, AL; Penland, SN; VanDoren, MJ	1
Burton, G; Grilli, ML; Jaliffa, CO; Rosenstein, RE; Speroni, F; Veleiro, AS	1
Balestri, P; Cobellis, L; Farnetani, M; Grosso, S; Luisi, S; Morgese, G; Mostardini, R; Petraglia, F	1
Carter, RB; Gasior, M; Kaminski, RM; Witkin, JM	1
Matsumoto, K; Murakami, Y; Nomura, H; Takahata, H; Taki, K; Watanabe, H	1
Falcone, T; Foldvary-Schaefer, N	1
Castaneda, DC; O'Malley, BW; Reddy, DS; Rogawski, MA	1
Kaminski, RM; Livingood, MR; Rogawski, MA	1
Chopde, CT; Hirani, K; Mittal, N; Ugale, RR	1
Gavrilovici, C; McIntyre, DC; Poulter, MO; Schwabe, K	1
Frye, CA; Rhodes, ME	1
Martin-Garcia, E; Pallares, M	1
Mares, P	1
Haugvicová, R; Kasal, A; Mares, P; Mikulecká, A	1
Lonsdale, D; McIntyre Burnham, W; Nylen, K	1
Burnham, WM; Lonsdale, D	1
Pericić, D; Strac, DS; Vlainić, J	1
Beckley, EH; Crabbe, JC; Finn, DA; Fretwell, AM; Gililland, KR; Tanchuck, MA	1
Gillardin, JM; Heulard, I; Verleye, M	1
Belluzzi, JD; Lan, NC; Stein, L; Wieland, S	1
Devaud, LL; Morrow, AL; Purdy, RH	1
Crabbe, JC; Finn, DA; Roberts, AJ	1
Finn, DA; Gee, KW	1
Barbaccia, ML; Biggio, G; Concas, A; Lener, R; Mostallino, MC; Perra, C; Purdy, RH; Roscetti, G	1
Bondoux, D; Chapouthier, G; Clément, Y; Launay, JM; Martin, B; Robel, P; Venault, P; Young, J	1
Gee, KW	1
Deutsch, SI; Koetzner, L; Mastropaolo, J; Morn, C; Riggs, R; Rosse, RB; Steinberg, K	1
Finn, DA; Gallaher, EJ; Lotrich, F; Roberts, AJ	1
Belelli, D; Bolger, MB; Carter, RB; Gee, KW; Hawkinson, JE; Lambert, JJ; Lan, NC; Mirsadeghi, S; Tahir, SH; White, HS; Wieland, S; Wolf, HH; Wood, PL	1
Farb, DH; Marek, P; Park-Chung, M; Tam, SW; Weaver, CE	1
Britton, KT; Koob, GF	1
Bayon, LE; Frye, CA; Scalise, TJ	1
Moran, MH; Smith, SS	1
Bayon, LE; Frye, CA	2
Banks, MK; Kokate, TG; Magee, T; Rogawski, MA; Yamaguchi, S	1
Bargas, J; Brailowsky, S; Calixto, E; Casasola, C; López-Colomé, AM; Montiel, T	1
Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM	1
Liptáková, S; Moshé, SL; Velísek, L; Velísková, J	1
Camacho-Arroyo, I; Frye, CA; Manjarrez, J	1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J	1
Crabbe, JC; Finn, DA; Reilly, MT; Rustay, NR	1
Carter, RB; Gee, KW; Hogenkamp, DJ; Lan, NC; Vanover, KE	1
Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J	1
Lu, YQ; Yu, R	1
Smith, SS	1
Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J	1
Allen, PM; Melchior, CL	1
Collins, AC; Freund, RK; Luntz-Leybman, V	1
Belelli, D; Bolger, MB; Gee, KW	1
Angelo, HR; Anker, N; Carl, P; Høgskilde, S; Sørensen, MB; Wagner, J	1

Reviews

7 review(s) available for pregnanolone and Seizures

Article	Year
[Epilepsy with catamenial pattern]. Revista de neurologia, 2022, 05-01, Volume: 74, Issue:9 Topics: Epilepsy, Reflex; Female; Humans; Menstrual Cycle; Pregnanolone; Progesterone; Seizures	2022
Ganaxolone: First Approval. Drugs, 2022, Volume: 82, Issue:8 Topics: Adolescent; Anticonvulsants; Child; Clinical Trials, Phase III as Topic; Drug Approval; Humans; Multicenter Studies as Topic; Pregnanolone; Seizures	2022
Neurosteroid regulation of GABA Brain research, 2019, 01-15, Volume: 1703 Topics: Epilepsy; Estrogens; Female; Humans; Menstrual Cycle; Neurons; Neurosteroids; Pregnanolone; Progesterone; Receptors, GABA; Receptors, GABA-A; Seizures	2019
Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies. Seizure, 2018, Volume: 63 Topics: 20-alpha-Dihydroprogesterone; Animals; Anticonvulsants; Humans; Pregnanolone; Progesterone; Seizures	2018
Neurosteroids: endogenous role in the human brain and therapeutic potentials. Progress in brain research, 2010, Volume: 186 Topics: Androstane-3,17-diol; Anesthetics; Anxiety; Brain; Depression; Female; Humans; Male; Neurotransmitter Agents; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A; Seizures; Sex Characteristics; Stress, Physiological	2010
The clinical potentials of endogenous neurosteroids. Drugs of today (Barcelona, Spain : 1998), 2002, Volume: 38, Issue:7 Topics: Animals; Brain; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Seizures; Stress, Psychological	2002
Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology, 2003, Sep-01, Volume: 61, Issue:6 Suppl 2 Topics: Acetazolamide; Adolescent; Adult; Animals; Anticonvulsants; Brain Edema; Bromides; Contraceptives, Oral, Hormonal; Convulsants; Epilepsy; Estradiol; Estrogen Receptor Modulators; Female; Gonadal Steroid Hormones; Humans; Incidence; Menstrual Cycle; Middle Aged; Models, Biological; Periodicity; Potassium Compounds; Pregnanolone; Progesterone; Pyramidal Cells; Rats; Seizures	2003

Trials

5 trial(s) available for pregnanolone and Seizures

Article	Year
Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial. The Lancet. Neurology, 2022, Volume: 21, Issue:5 Topics: Child; Child, Preschool; Double-Blind Method; Epileptic Syndromes; Humans; Infant; Pregnanolone; Prospective Studies; Protein Serine-Threonine Kinases; Seizures; Spasms, Infantile; Treatment Outcome	2022
Phase 2, placebo-controlled clinical study of oral ganaxolone in PCDH19-clustering epilepsy. Epilepsy research, 2023, Volume: 191 Topics: Anticonvulsants; Child; Cluster Analysis; Epilepsy, Generalized; Female; Humans; Pregnanolone; Protocadherins; Seizures; Treatment Outcome	2023
Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy. Neurology, 2014, Jul-22, Volume: 83, Issue:4 Topics: Anticonvulsants; Epilepsy; Female; Humans; Menstrual Cycle; Pregnanolone; Progesterone; Radioimmunoassay; Seizures; Treatment Outcome	2014
Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures. Epilepsia, 2017, Volume: 58, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anticonvulsants; Double-Blind Method; Female; Humans; Male; Middle Aged; Pregnanolone; Seizures; Treatment Outcome; Young Adult	2017
Inter-ictal and post-ictal circulating levels of allopregnanolone, an anticonvulsant metabolite of progesterone, in epileptic children. Epilepsy research, 2003, Volume: 54, Issue:1 Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Pregnanolone; Progesterone; Seizures	2003

Other Studies

69 other study(ies) available for pregnanolone and Seizures

Article	Year
Pregnant women with more seizures have lower allopregnanolone concentrations. Epilepsy research, 2021, Volume: 177 Topics: Animals; Female; Humans; Neurons; Pregnancy; Pregnanolone; Pregnant Women; Seizures	2021
Ganaxolone versus Phenobarbital for Neonatal Seizure Management. Annals of neurology, 2022, Volume: 92, Issue:6 Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; Humans; Infant, Newborn; Phenobarbital; Pregnanolone; Seizures; Sheep	2022
Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy. Epilepsia, 2023, Volume: 64, Issue:5 Topics: Animals; Epilepsy, Temporal Lobe; Kainic Acid; Neurosteroids; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus	2023
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam. The Journal of pharmacology and experimental therapeutics, 2020, Volume: 372, Issue:3 Topics: Animals; Anticonvulsants; beta-Cyclodextrins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Midazolam; Neurosteroids; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Seizures; Tiagabine	2020
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model. International journal of molecular sciences, 2021, Jan-28, Volume: 22, Issue:3 Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, Animal; Estradiol; gamma-Aminobutyric Acid; Hydrocortisone; Male; Neuroprotective Agents; Normetanephrine; Oxadiazoles; Oxidative Stress; Pentylenetetrazole; Pregnanolone; Progesterone; Reactive Oxygen Species; Seizures; Serotonin; Zebrafish	2021
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models. Epilepsy research, 2017, Volume: 134 Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Fragile X Mental Retardation Protein; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Piperidines; Potassium Channel Blockers; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures	2017
3 The Journal of pharmacology and experimental therapeutics, 2018, Volume: 365, Issue:3 Topics: Allosteric Regulation; Animals; Dentate Gyrus; GABA-A Receptor Antagonists; Ion Channel Gating; Male; Mice; Mice, Inbred C57BL; Neurons; Pregnanolone; Protein Kinase C; Receptors, GABA-A; Seizures; Synapses	2018
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus. Neuropharmacology, 2019, Volume: 148 Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Male; Mice; Microinjections; Neural Inhibition; Neurosteroids; Pregnanolone; Pyridazines; Receptors, GABA-A; Seizures; Zinc	2019
Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures. Epilepsia, 2019, Volume: 60, Issue:4 Topics: Animals; Brain; Female; Male; Mice; Mice, Inbred C57BL; Neurosteroids; Pregnanolone; Receptors, GABA-A; Seizures; Sex Characteristics; Status Epilepticus	2019
Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal. Psychopharmacology, 2014, Volume: 231, Issue:17 Topics: Animals; Central Nervous System Depressants; Chronic Disease; Ethanol; Male; Mice; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A; Reproducibility of Results; Seizures; Substance Withdrawal Syndrome	2014
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology, 2015, Volume: 95 Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Calcium; Cells, Cultured; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hippocampus; Male; Mice; Neuroimmunomodulation; Neurons; Pregnanolone; Seizures	2015
On the anticonvulsant effect of allopregnanolone (a neurosteroid) in neonatal rats. Life sciences, 2015, Dec-15, Volume: 143 Topics: Animals; Animals, Newborn; Anticonvulsants; Kainic Acid; Male; Pregnanolone; Rats; Rats, Wistar; Seizures; Treatment Outcome	2015
Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1 Topics: Animals; Anticonvulsants; Dentate Gyrus; GABA Agonists; GABA Modulators; In Vitro Techniques; Interneurons; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Neurons; Neurotransmitter Agents; Pregnanes; Pregnanolone; Receptors, GABA-A; Seizures; Structure-Activity Relationship	2016
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model. Neuropharmacology, 2017, Volume: 116 Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory, Short-Term; Mice, Knockout; Motor Activity; Pentylenetetrazole; Pregnanolone; Receptors, GABA-A; Seizures; Spatial Memory; Tissue Culture Techniques; Ubiquitin-Protein Ligases	2017
Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice. Pharmacology, biochemistry, and behavior, 2010, Volume: 94, Issue:3 Topics: Animals; Convulsants; Disease Models, Animal; Electrophoresis, Agar Gel; Enzyme Inhibitors; Finasteride; Indomethacin; Male; Mice; Neurons; Picrotoxin; Pregnanolone; Seizures	2010
Anticonvulsant doses of ganaxolone do not compromise motor performance in immature rats. Neuroscience letters, 2010, Jan-29, Volume: 469, Issue:3 Topics: Aging; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Male; Motor Activity; Neuropsychological Tests; Pregnanolone; Rats; Rats, Wistar; Seizures; Time Factors	2010
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. Epilepsy research, 2010, Volume: 89, Issue:2-3 Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Female; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Pregnanolone; Seizures	2010
Allopregnanolone potentiates the glutamate-mediated seizures induced by 4-aminopyridine in rat hippocampus in vivo. Neurochemical research, 2012, Volume: 37, Issue:3 Topics: 4-Aminopyridine; Animals; Drug Interactions; Electroencephalography; Glutamic Acid; Hippocampus; Male; Pregnanolone; Rats; Rats, Wistar; Seizures	2012
GABAergic neurosteroid modulation of ethanol actions. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2002, Volume: 3, Issue:2 Topics: Animals; Behavior, Animal; Cerebral Cortex; Cognition; Ethanol; Finasteride; Male; Muscle, Skeletal; Pregnanolone; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Seizures; Sleep Wake Disorders; Synaptic Transmission	2002
Synthesis and GABA(A) receptor activity of a 6,19-oxido analogue of pregnanolone. Bioorganic & medicinal chemistry letters, 2003, Feb-10, Volume: 13, Issue:3 Topics: 3-Mercaptopropionic Acid; Animals; Cerebral Cortex; Convulsants; Cricetinae; Indicators and Reagents; Pregnanolone; Receptors, GABA-A; Seizures; Stereoisomerism; Structure-Activity Relationship; Synaptosomes	2003
Seizure exacerbation associated with inhibition of progesterone metabolism. Annals of neurology, 2003, Volume: 53, Issue:3 Topics: Adult; Enzyme Inhibitors; Female; Finasteride; Humans; Menstrual Cycle; Pregnanolone; Progesterone; Seizures; Statistics, Nonparametric	2003
Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. European journal of pharmacology, 2003, Aug-08, Volume: 474, Issue:2-3 Topics: Animals; Cocaine; Kindling, Neurologic; Male; Mice; Neuroprotective Agents; Pregnanolone; Seizures	2003
Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems. Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:4 Topics: Animals; Brain; Dose-Response Relationship, Drug; Male; Mice; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures; Social Isolation; Time; Up-Regulation	2003
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1 Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Finasteride; Kindling, Neurologic; Male; Mice; Mice, Knockout; Mutation; Pregnanolone; Progesterone; Receptors, Progesterone; Seizures; Steroids	2004
Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia, 2004, Volume: 45, Issue:7 Topics: Animals; Anticonvulsants; Clonazepam; Cornea; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsies, Partial; GABA Modulators; Humans; Male; Mice; Pregnanolone; Receptors, GABA; Seizures; Steroids	2004
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. Brain research, 2004, Oct-08, Volume: 1023, Issue:1 Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Pregnanolone; Seizures	2004
Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone rats. Journal of neurophysiology, 2005, Volume: 94, Issue:3 Topics: Analysis of Variance; Animals; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Genetic Predisposition to Disease; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Rats, Wistar; Seizures	2005
Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone. Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Estrogens; Female; Hippocampus; Ovariectomy; Pentylenetetrazole; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Seizures	2005
Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats. Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:9 Topics: Animals; Body Weight; Ethanol; Hippocampus; Male; Motor Activity; Nicotine; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome	2005
Anticonvulsant action of three neurosteroids against cortical epileptic afterdischarges in immature rats. Brain research bulletin, 2005, Dec-30, Volume: 68, Issue:3 Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Pregnanolone; Rats; Seizures	2005
Anticonvulsant action of allopregnanolone in immature rats. Epilepsy research, 2006, Volume: 70, Issue:2-3 Topics: Age Factors; Anesthetics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Motor Activity; Pentylenetetrazole; Pregnanolone; Rats; Rats, Wistar; Seizures	2006
The anticonvulsant effects of progesterone and its metabolites on amygdala-kindled seizures in male rats. Brain research, 2006, Jul-26, Volume: 1101, Issue:1 Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Kindling, Neurologic; Locomotion; Male; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Severity of Illness Index; Time Factors	2006
The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats. Neuroscience letters, 2007, Jan-10, Volume: 411, Issue:2 Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Female; Kindling, Neurologic; Pregnanolone; Rats; Rats, Wistar; Seizures; Severity of Illness Index; Time Factors	2007
Interaction of diazepam and swim stress. Brain research, 2007, Dec-12, Volume: 1184 Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming	2007
Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice. Neuropharmacology, 2008, Volume: 54, Issue:2 Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Corticosterone; Estradiol; Ethanol; Female; Mice; Pregnanolone; Progesterone; Radioimmunoassay; Seizures; Substance Withdrawal Syndrome	2008
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. Psychopharmacology, 2008, Volume: 197, Issue:4 Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological	2008
Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents. Psychopharmacology, 1995, Volume: 118, Issue:1 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Isomerism; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Postural Balance; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures	1995
The neurosteroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:2 Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Bicuculline; Brain; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures	1995
Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice. Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:2 Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Electroencephalography; Male; Mice; Pentylenetetrazole; Pregnanolone; Rats; Rats, Inbred Strains; Seizures	1995
The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1 Topics: Animals; Anticonvulsants; Estrus; Female; Male; Pentylenetetrazole; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors	1994
Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress. British journal of pharmacology, 1996, Volume: 118, Issue:4 Topics: Animals; Antitubercular Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; GABA Modulators; Injections, Intraventricular; Isoniazid; Male; Pentylenetetrazole; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Stress, Physiological; Time Factors	1996
A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures. Experimental brain research, 1996, Volume: 110, Issue:1 Topics: Animals; Brain Chemistry; Carbolines; Convulsants; Drug Resistance; Evaluation Studies as Topic; Female; Male; Mice; Mice, Mutant Strains; Pentylenetetrazole; Pregnanolone; Pregnenolone; Radioligand Assay; Receptors, GABA-A; Seizures	1996
Epalons as anticonvulsants: actions mediated by the GABAA receptor complex. Proceedings of the Western Pharmacology Society, 1996, Volume: 39 Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; GABA-A Receptor Agonists; Humans; Pregnanolone; Receptors, GABA-A; Seizures	1996
Evaluation of in vivo interactions in mice between flurazepam and two neuroactive steroids. Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:3 Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Electric Stimulation; Flurazepam; GABA Modulators; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pregnanediones; Pregnanolone; Receptors, GABA-A; Seizures	1996
Genetic differences in behavioral sensitivity to a neuroactive steroid. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Avoidance Learning; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Muscle Relaxation; Pentylenetetrazole; Pregnanolone; Seizures; Species Specificity; Substance Withdrawal Syndrome	1997
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:3 Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; GABA Modulators; Humans; In Vitro Techniques; Kindling, Neurologic; Mice; Pregnanolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Seizures	1997
Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America, 1997, Sep-16, Volume: 94, Issue:19 Topics: Animals; Anticonvulsants; Chick Embryo; Culture Techniques; Excitatory Amino Acid Antagonists; Hippocampus; Hypnotics and Sedatives; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord; Succinates	1997
Neuropharmacology. Premenstrual steroids? Nature, 1998, Apr-30, Volume: 392, Issue:6679 Topics: Animals; Benzodiazepines; Brain; Female; Humans; Luteal Phase; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Receptors, GABA-A; Seizures	1998
Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. Journal of neuroendocrinology, 1998, Volume: 10, Issue:4 Topics: 5-alpha Reductase Inhibitors; Animals; Cell Count; Diestrus; Enzyme Inhibitors; Estrus; Female; Finasteride; GABA Modulators; Neurons; Perforant Pathway; Pregnanolone; Rats; Seizures	1998
Progesterone withdrawal I: pro-convulsant effects. Brain research, 1998, Oct-05, Volume: 807, Issue:1-2 Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Synergism; Female; GABA Modulators; Pregnanolone; Progesterone; Pseudopregnancy; Rats; Rats, Long-Evans; Seizures; Substance Withdrawal Syndrome	1998
Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3 alpha,5 alpha-THP. Neuroendocrinology, 1998, Volume: 68, Issue:4 Topics: Animals; Brain; Brain Chemistry; Corpus Luteum; Endocrine System; Estrus; Female; Finasteride; Injections, Subcutaneous; Isomerism; Kainic Acid; Postpartum Period; Pregnancy; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Seizures; Time Factors	1998
Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Animals; Anticonvulsants; Cholestenone 5 alpha-Reductase; Convulsants; Drug Interactions; Electroshock; Enzyme Inhibitors; Finasteride; Isoenzymes; Male; Mice; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Progesterone; Seizures	1999
Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures. Developmental psychobiology, 1999, Volume: 34, Issue:3 Topics: Analysis of Variance; Animals; Anticonvulsants; Corticosterone; Female; gamma-Aminobutyric Acid; Hippocampus; Immobilization; Kainic Acid; Male; Maze Learning; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Rats; Rats, Long-Evans; Seizures; Sex Characteristics; Stress, Psychological	1999
Neocortical hyperexcitability after GABA withdrawal in vitro. Epilepsy research, 2000, Volume: 39, Issue:1 Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission	2000
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. Neuropharmacology, 2000, Apr-27, Volume: 39, Issue:7 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid	2000
Effect of ganaxolone on flurothyl seizures in developing rats. Epilepsia, 2000, Volume: 41, Issue:7 Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Flurothyl; Male; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures	2000
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid	2000
Infusion of 3alpha,5alpha-THP to the pontine reticular formation attenuates PTZ-induced seizures. Brain research, 2000, Oct-20, Volume: 881, Issue:1 Topics: Animals; Convulsants; Diestrus; Female; Male; Ovariectomy; Pentylenetetrazole; Pregnanolone; Proestrus; Progesterone; Rats; Rats, Long-Evans; Reticular Formation; Seizures	2000
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2 Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids	2000
Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:4 Topics: Animals; Breeding; Hypothermia; Male; Mice; Pregnanolone; Receptors, GABA-A; Seizures; Steroid Hydroxylases; Substance Withdrawal Syndrome	2000
Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology, 2001, Volume: 155, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Behavior, Animal; Convulsants; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Electroshock; Female; Hypnotics and Sedatives; Male; Mice; Pentylenetetrazole; Postural Balance; Pregnanolone; Punishment; Rats; Rats, Sprague-Dawley; Seizures	2001
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. European journal of pharmacology, 2001, Aug-10, Volume: 425, Issue:2 Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures	2001
Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:4 Topics: Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Flunitrazepam; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Pregnanolone; Seizures	2001
Withdrawal properties of a neuroactive steroid: implications for GABA(A) receptor gene regulation in the brain and anxiety behavior. Steroids, 2002, Volume: 67, Issue:6 Topics: Animals; Anxiety; Behavior, Animal; Brain; Female; Gene Expression Regulation; Pregnanolone; Rats; Receptors, GABA-A; Seizures; Steroids; Substance Withdrawal Syndrome; Synaptic Transmission; Time	2002
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam. Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4 Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Male; Mice; Microinjections; Midazolam; Picrotoxin; Pregnanolone; Seizures; Serotonin	2002
Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital. Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:4 Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentobarbital; Pregnanolone; Pregnenolone; Seizures; Sleep; Time Factors	1992
5 alpha-Pregnan-3 alpha-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition. European journal of pharmacology, 1990, Aug-28, Volume: 185, Issue:2-3 Topics: Animals; Anticonvulsants; Electric Stimulation; Electrophysiology; Hippocampus; Male; Mice; Mice, Inbred C3H; Nicotine; Pregnanolone; Seizures	1990
Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one. European journal of pharmacology, 1989, Jul-18, Volume: 166, Issue:2 Topics: Animals; Anticonvulsants; Hypnotics and Sedatives; Lethal Dose 50; Male; Mice; Pregnanes; Pregnanolone; Seizures	1989
Anticonvulsive properties of pregnanolone emulsion compared with althesin and thiopentone in mice. British journal of anaesthesia, 1988, Volume: 61, Issue:4 Topics: Alfaxalone Alfadolone Mixture; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Emulsions; Male; Mice; Pregnanes; Pregnanolone; Seizures; Thiopental	1988