Page last updated: 2024-08-23

pregnanolone and Niemann-Pick Disease

pregnanolone has been researched along with Niemann-Pick Disease in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gong, W; Griffin, LD; Mellon, SH; Verot, L1
Burns, MP; Duff, K1
Gong, W; Griffin, LD; Mellon, S1
Ahmad, I; Bi, X; Chaitkin, E; Erickson, RP; Hicks, C; Howison, CM; Lope-Piedrafita, S; Trouard, TP; Weberg, L; Yao, Y; Yu, C1
Covey, DF; Frolov, A; Gale, SE; Langmade, SJ; Mellon, SH; Mohri, I; Ory, DS; Schaffer, JE; Suzuki, K; Walkley, SU1
Dietschy, JM; Li, H; Liu, B; Repa, JJ; Turley, SD1

Other Studies

6 other study(ies) available for pregnanolone and Niemann-Pick Disease

ArticleYear
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.
    Nature medicine, 2004, Volume: 10, Issue:7

    Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Animals; Brain; Mice; Niemann-Pick Diseases; Pregnanolone; Pregnenolone; Rats

2004
Brain on steroids resists neurodegeneration.
    Nature medicine, 2004, Volume: 10, Issue:7

    Topics: Animals; Brain; Cell Death; Mice; Neurons; Niemann-Pick Diseases; Pregnanolone

2004
Niemann pick type C disease as a model for defects in neurosteroidogenesis.
    Endocrine research, 2004, Volume: 30, Issue:4

    Topics: Animals; Brain; Embryo, Mammalian; Mice; Mice, Knockout; Mice, Mutant Strains; Nervous System; Neurotransmitter Agents; Niemann-Pick Diseases; Phenotype; Pregnanolone; Steroid 17-alpha-Hydroxylase; Tissue Distribution

2004
Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.
    Journal of neuroscience research, 2005, Dec-15, Volume: 82, Issue:6

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Age Factors; Anesthetics; Animals; Anisotropy; Antigens, Differentiation; Body Weight; Brain; Cell Count; Cell Survival; Demyelinating Diseases; Disease Models, Animal; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Immunohistochemistry; Magnetic Resonance Imaging; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Niemann-Pick Diseases; Pregnanolone; Time Factors

2005
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-12, Volume: 103, Issue:37

    Topics: Animals; Cerebellum; Disease Models, Animal; GABA-A Receptor Agonists; Gene Expression; Hydrocarbons, Fluorinated; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Microglia; Mutation; Neuroprotective Agents; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Pregnane X Receptor; Pregnanolone; Proteins; Purkinje Cells; Receptors, Steroid; Stereoisomerism; Sulfonamides

2006
Genetic variations and treatments that affect the lifespan of the NPC1 mouse.
    Journal of lipid research, 2008, Volume: 49, Issue:3

    Topics: Animals; Cyclodextrins; DNA-Binding Proteins; Gene Deletion; Genetic Variation; Intracellular Signaling Peptides and Proteins; Liver X Receptors; Longevity; Mice; Mice, Knockout; Neurodegenerative Diseases; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Orphan Nuclear Receptors; Pregnanolone; Proteins; Receptors, Cytoplasmic and Nuclear; Sialyltransferases; Treatment Outcome

2008