pregnanolone has been researched along with Niemann-Pick Disease, Type C in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Antipova, V; Holzmann, C; Rolfs, A; Witt, M; Wree, A | 1 |
| Günther, R; Holzmann, C; Meyer, A; Rolfs, A; Schmitt, O; Witt, M; Wree, A | 1 |
| Bräuer, AU; Burstein, C; Engelmann, R; Frank, M; Gläser, A; Gräler, M; Müller-Hilke, B; Neidhardt, J; Neßlauer, AM; Rolfs, A; Witt, M; Wree, A | 1 |
| Frech, MJ; Holzmann, C; Hovakimyan, M; Hübner, R; Lukas, J; Maass, F; Petersen, J; Rolfs, A; Witt, M; Wree, A | 1 |
| Hawlitschka, A; Hovakimyan, M; Lukas, J; Maass, F; Petersen, J; Rolfs, A; Schmitt, O; Witt, M; Wree, A | 1 |
| Grittner, U; Holzmann, C; Rolfs, A; Schlegel, V; Thieme, M; Witt, M; Wree, A | 1 |
| Erickson, RP; Hicks, CM; Lope-Piedrafita, S; Totenhagen, JW; Trouard, TP | 1 |
| Bembi, B; Butters, TD; Covey, DF; Dardis, A; Mellon, SH; Nevyjel, M; Zampieri, S | 1 |
| Bi, X; Cheung, S; Galeano, J; Ji, AX; Liao, G; Qin, Q | 1 |
| Ali, NF; Davidson, CD; Dobrenis, K; Micsenyi, MC; Ory, DS; Renault, S; Stephney, G; Vanier, MT; Walkley, SU | 1 |
| Guthoff, R; Hovakimyan, M; Lukas, J; Maass, F; Petersen, J; Reichard, M; Rolfs, A; Stachs, O; Witt, M; Wree, A | 1 |
| Gong, W; Mellon, SH; Schonemann, MD | 1 |
1 review(s) available for pregnanolone and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.
Topics: Animals; Disease Models, Animal; Gonadal Steroid Hormones; Humans; Mice; Niemann-Pick Disease, Type C; Pregnanolone; Receptors, GABA-A | 2008 |
11 other study(ies) available for pregnanolone and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
Gender-Specific Effects of Two Treatment Strategies in a Mouse Model of Niemann-Pick Disease Type C1.
Topics: 1-Deoxynojirimycin; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cyclodextrins; Disease Models, Animal; Drug Therapy, Combination; Female; Male; Mice; Mice, Inbred BALB C; Niemann-Pick Disease, Type C; Pregnanolone | 2021 |
Increased Regenerative Capacity of the Olfactory Epithelium in Niemann-Pick Disease Type C1.
Topics: 1-Deoxynojirimycin; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Apoptosis; beta-Cyclodextrins; Cell Proliferation; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Olfactory Mucosa; Pregnanolone; Proteins | 2017 |
A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1.
Topics: 1-Deoxynojirimycin; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cell Separation; Disease Models, Animal; Flow Cytometry; Genotype; Lipid Metabolism; Mice; Niemann-Pick Disease, Type C; Pregnanolone; Spleen | 2019 |
Combined therapy with cyclodextrin/allopregnanolone and miglustat improves motor but not cognitive functions in Niemann-Pick Type C1 mice.
Topics: 1-Deoxynojirimycin; Animals; Cognition; Cyclodextrins; Disease Models, Animal; Drug Therapy, Combination; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Motor Activity; Neuroprotective Agents; Niemann-Pick Disease, Type C; Pregnanolone | 2013 |
Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: a mouse model of Niemann-Pick type C1 disease.
Topics: 1-Deoxynojirimycin; Animals; Cell Count; Cerebellum; Cyclodextrins; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Mice; Nerve Degeneration; Neurons; Niemann-Pick Disease, Type C; Pregnanolone | 2015 |
Pharmacologic Treatment Assigned for Niemann Pick Type C1 Disease Partly Changes Behavioral Traits in Wild-Type Mice.
Topics: 1-Deoxynojirimycin; Animals; Behavior, Animal; Body Weight; Brain; Cognition; Cyclodextrins; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Hypolipidemic Agents; Male; Maze Learning; Mice; Mice, Inbred BALB C; Niemann-Pick Disease, Type C; Organ Size; Pregnanolone | 2016 |
MRI detects therapeutic effects in weanling Niemann-Pick type C mice.
Topics: Animals; Animals, Newborn; Brain; Diffusion Magnetic Resonance Imaging; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Pregnanolone; Proteins; Weaning | 2008 |
Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.
Topics: Apoptosis; Biopsy; Carrier Proteins; Cell Line, Tumor; Child, Preschool; Cholesterol; Female; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Lipid Peroxidation; Lysosomes; Male; Membrane Glycoproteins; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Oxidation-Reduction; Oxidative Stress; Pregnanolone | 2009 |
Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain.
Topics: Anesthetics; Animals; Astrocytes; Autophagy; Cholesterol; Disease Models, Animal; Encephalitis; Intracellular Signaling Peptides and Proteins; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Microglia; Myelin Sheath; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Pregnanolone; Proteins | 2009 |
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
Topics: 1-Deoxynojirimycin; 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Cholesterol; Cyclodextrins; Disease Models, Animal; Disease Progression; Drug Synergism; Enzyme Inhibitors; Glycosphingolipids; Mice; Mice, Transgenic; Neurons; Niemann-Pick Disease, Type C; Pregnanolone; Treatment Outcome | 2009 |
Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease.
Topics: 1-Deoxynojirimycin; Anesthetics; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cornea; Cyclodextrins; Disease Progression; Drug Therapy, Combination; Enzyme Inhibitors; Genotype; Intracellular Signaling Peptides and Proteins; Lysosomes; Mass Spectrometry; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Pregnanolone; Proteins | 2011 |