pregnanolone has been researched along with Depression in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.92) | 18.2507 |
| 2000's | 13 (25.49) | 29.6817 |
| 2010's | 26 (50.98) | 24.3611 |
| 2020's | 10 (19.61) | 2.80 |
| Authors | Studies |
|---|---|
| Betz, JF; Hantsoo, L; Osborne, LM; Payne, JL; Standeven, LR; Voegtline, K; Yenokyan, G | 1 |
| Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W | 1 |
| Brunner, LM; Kufner, M; Nothdurfter, C; Pradhan, AK; Puig, X; Rammes, G; Rupprecht, C; Rupprecht, R; Schwarzbach, J; Wein, S | 1 |
| Concas, A; Porcu, P; Serra, M | 1 |
| Froger, N | 1 |
| Daly, EJ; Drevets, WC; Fedgchin, M; Hough, D; Mathews, M; Popova, V; Singh, JB | 1 |
| Andrade-Soto, J; Cueto-Escobedo, J; Hernández-López, F; Lima-Maximino, M; Maximino, C; Rodríguez-Landa, JF | 1 |
| Fujita, Y; Hashimoto, K; Iwata, M; Muneoka, K; Oda, Y; Shirayama, Y | 1 |
| Deng, ZD; Henter, ID; Kadriu, B; Kraus, C; Lisanby, SH; Zarate, CA | 1 |
| Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y | 1 |
| Fidecicchi, T; Fruzzetti, F | 1 |
| Hirose, Y; Iyo, M; Kimura, H; Kimura, M; Nangaku, M; Oda, Y; Shirayama, Y; Yoshino, K | 1 |
| Andréen, L; Bäckström, T; Bixo, M; Ehrenborg, A; Ekberg, K; Hirschberg, AL; Jonasson, AF; Poromaa, IS; Timby, E; Wulff, M | 1 |
| Gong, J; Guo, Y; Jiang, XY; Li, L; Li, YF; Sun, LJ; Sun, SZ; Wang, HL; Wang, W; Zhang, LM; Zhang, YZ | 1 |
| Comasco, E; Hellgren, C; Skalkidou, A; Sundström-Poromaa, I | 1 |
| Drakopoulos, P; Genazzani, AR; Luisi, M; Pluchino, N; Sajdak, S; Slopien, R; Warenik-Szymankiewicz, A | 1 |
| Dichtel, LE; Eddy, KT; Klibanski, A; Lawson, EA; Meenaghan, E; Miller, KK; Nelson, M; Paskal, ML; Pinna, G; Rasmusson, AM; Schorr, M | 1 |
| Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Zhong, DS | 1 |
| Burke, CS; Hermann, AD; Susser, LC | 1 |
| McEvoy, K; Osborne, LM; Payne, JL | 1 |
| Carrillo, NR; Giulivi, C; Hagerman, RJ; Napoli, E; Rogawski, M; Schneider, A; Tassone, F; Trivedi, A; Wang, JY | 1 |
| Almeida, FB; Barros, HMT; Gomez, R; Nin, MS | 1 |
| Lüscher, B; Möhler, H | 1 |
| Bali, A; Jaggi, AS | 1 |
| al'Absi, M; Allen, AM; Allen, SS; Hatsukami, D; Lando, H | 1 |
| Nothdurfter, C; Rupprecht, R; Schüle, C | 1 |
| Berretti, R; Concas, A; Locci, A; Porcu, P; Santoru, F | 1 |
| Åkerud, H; Bäckström, T; Hellgren, C; Skalkidou, A; Sundström-Poromaa, I | 1 |
| Chung, BC; Weng, JH | 1 |
| Bičíková, M; Dušková, M; Hill, M; Mohr, P; Řípová, D; Šrámková, M; Stárka, L | 1 |
| Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Shen, YG; Zeng, J; Zhang, GH | 1 |
| Frye, CA; Koonce, CJ; Walf, AA | 1 |
| Canu, S; D'Aquila, PS; Franconi, F; Sardella, M; Serra, G; Spanu, C | 1 |
| Fukami, G; Fukumoto, M; Hashimoto, K; Iyo, M; Muneoka, K; Shirayama, Y; Tadokoro, S | 1 |
| Reddy, DS | 1 |
| Connor, B; Evans, J; McGregor, A; Sun, Y | 1 |
| Agnes, G; Azeredo, LA; Barros, HM; Couto-Pereira, NS; Ferri, MK; Gomez, R; Nin, MS; Souza, MF | 1 |
| Chopde, CT; Hirani, K; Khisti, RT | 1 |
| Ceci, M; Kohler, C; Uzunov, DP; Uzunova, V; Wrynn, AS | 1 |
| Frye, CA; Walf, AA | 2 |
| Begliuomini, S; Bernardi, F; Genazzani, AR; Lenzi, E; Luisi, M; Palumbo, M; Pluchino, N | 1 |
| Girdler, SS; Klatzkin, RR; Light, KC; Morrow, AL; Pedersen, CA | 1 |
| Sampson, L; Uzunov, DP; Uzunova, V | 1 |
| Baghai, TC; di Michele, F; Eser, D; Pasini, A; Romeo, E; Rupprecht, R; Schüle, C; Schwarz, M | 1 |
| Beckley, EH; Finn, DA | 1 |
| Aszalós, Z | 1 |
| Bäckström, T; Sundström, I | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Chopde, CT; Khisti, RT | 1 |
| Conrad, SC; Griffin, LD; Mellon, SH | 1 |
15 review(s) available for pregnanolone and Depression
| Article | Year |
|---|---|
Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.
Topics: Anti-Anxiety Agents; Benzodiazepines; Carrier Proteins; Cognition; Depression; Depression, Postpartum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Ligands; Neuronal Plasticity; Neurosteroids; Neurotransmitter Agents; Pregnanolone; Receptors, GABA; Receptors, GABA-A | 2023 |
The brain as a target of hormonal contraceptives: Evidence from animal studies.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Contraceptive Agents, Hormonal; Depression; Female; Humans; Learning; Neuropeptides; Neurosteroids; Pregnanolone; Sexual Behavior; Social Behavior; Stress, Psychological; Synaptic Transmission | 2019 |
[New therapeutic avenues for neurosteroids in psychiatric diseases].
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression; Drugs, Investigational; Humans; Mental Disorders; Neuronal Plasticity; Neurosteroids; Pregnanolone; Psychiatry; Signal Transduction; Therapies, Investigational | 2019 |
Hormonal Contraception and Depression: Updated Evidence and Implications in Clinical Practice.
Topics: Adolescent; Animals; Depression; Female; Hormonal Contraception; Humans; Menstrual Cycle; Pregnanolone; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Progesterone; Young Adult | 2020 |
GABA
Topics: Depression; Depression, Postpartum; Female; Humans; Menstruation; Mood Disorders; Postpartum Period; Pregnanolone; Receptors, GABA; Weaning | 2019 |
Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature.
Topics: Depression; Depression, Postpartum; Female; Humans; Pregnancy; Pregnancy Complications; Pregnanolone | 2018 |
Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience.
Topics: Antidepressive Agents; beta-Cyclodextrins; Depression; Depression, Postpartum; Drug Combinations; Female; GABA Modulators; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2019 |
Multifunctional aspects of allopregnanolone in stress and related disorders.
Topics: Anxiety; Brain-Derived Neurotrophic Factor; Calcium Channels; Depression; Dopamine; Glutamic Acid; Humans; Oxytocin; Pregnanolone; Receptors, GABA-A; Stress, Psychological | 2014 |
The role of allopregnanolone in depression and anxiety.
Topics: Animals; Anxiety; Depression; Humans; Pregnanolone | 2014 |
Nongenomic actions of neurosteroid pregnenolone and its metabolites.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Depression; Humans; Microtubules; Neurodegenerative Diseases; Neurotransmitter Agents; Pregnanolone; Pregnenolone | 2016 |
Neurosteroids: endogenous role in the human brain and therapeutic potentials.
Topics: Androstane-3,17-diol; Anesthetics; Anxiety; Brain; Depression; Female; Humans; Male; Neurotransmitter Agents; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A; Seizures; Sex Characteristics; Stress, Physiological | 2010 |
Disadaptive disorders in women: allopregnanolone, a sensitive steroid.
Topics: Affect; Amenorrhea; Animals; Anxiety; Behavior; Depression; Female; Humans; Hypothalamus; Menopause; Mental Disorders; Mood Disorders; Pregnanolone; Premenstrual Syndrome; Puerperal Disorders; Stress, Physiological | 2004 |
Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action.
Topics: Animals; Antidepressive Agents; Depression; Humans; Pregnanolone; Selective Serotonin Reuptake Inhibitors | 2006 |
[Neurological and psychiatric aspects of some endocrine diseases. The role of neurosteroids and neuroactive steroids].
Topics: Addison Disease; Adrenal Cortex Hormones; Androgens; Anxiety; Cognition Disorders; Cushing Syndrome; Depression; Endocrine System Diseases; Estrogens; Fear; Fetal Organ Maturity; Gonadal Steroid Hormones; Humans; Memory Disorders; Mental Disorders; Mood Disorders; Muscle Weakness; Nervous System Diseases; Pain; Pregnanolone; Progesterone | 2007 |
Current perspectives on the role of neurosteroids in PMS and depression.
Topics: Animals; Brain Chemistry; Depression; Female; Humans; Pregnanolone; Premenstrual Syndrome | 2001 |
5 trial(s) available for pregnanolone and Depression
| Article | Year |
|---|---|
Treatment of premenstrual dysphoric disorder with the GABA
Topics: Adult; Affect; Anger; Anxiety; Contraceptives, Oral; Depression; Double-Blind Method; Female; Follicular Phase; GABA-A Receptor Antagonists; Humans; Luteal Phase; Menstrual Cycle; Middle Aged; Pregnanolone; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Progesterone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2017 |
Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
Topics: Aged; Anxiety; Ataxia; Depression; Energy Metabolism; Fragile X Syndrome; gamma-Aminobutyric Acid; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Ornithine; Oxidative Stress; Pilot Projects; Pregnanolone; Tremor | 2019 |
Menstrual phase, depressive symptoms, and allopregnanolone during short-term smoking cessation.
Topics: Adolescent; Adult; Comorbidity; Cross-Over Studies; Depression; Female; Follicular Phase; Humans; Luteal Phase; Pregnanolone; Recurrence; Smoking; Smoking Cessation; Smoking Prevention; Substance Withdrawal Syndrome; Young Adult | 2013 |
Effects of combination treatment with mood stabilizers and mirtazapine on plasma concentrations of neuroactive steroids in depressed patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Female; Humans; Lithium Compounds; Male; Mianserin; Middle Aged; Mirtazapine; Pregnanolone; Progesterone; Steroids; Tranquilizing Agents | 2007 |
Citalopram increases pregnanolone sensitivity in patients with premenstrual syndrome: an open trial.
Topics: Adult; Affect; Citalopram; Depression; Eye Movements; Female; Humans; Libido; Middle Aged; Pregnanolone; Premenstrual Syndrome; Radioimmunoassay; Selective Serotonin Reuptake Inhibitors | 1998 |
31 other study(ies) available for pregnanolone and Depression
| Article | Year |
|---|---|
Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study.
Topics: Anxiety; Depression; Depression, Postpartum; Female; Humans; Peripartum Period; Pregnancy; Pregnanolone; Psychiatric Status Rating Scales | 2022 |
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone; Depression; Depression, Postpartum; Disease Models, Animal; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fluoxetine; Glucosides; Hippocampus; Humans; Monoterpenes; Pregnancy; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Stress, Psychological; Sucrose; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2022 |
Approval of esketamine for treatment-resistant depression.
Topics: beta-Cyclodextrins; Depression; Depressive Disorder, Treatment-Resistant; Drug Combinations; Humans; Ketamine; Pregnanolone; United States; United States Food and Drug Administration | 2020 |
Involvement of GABAergic system in the antidepressant-like effects of chrysin (5,7-dihydroxyflavone) in ovariectomized rats in the forced swim test: comparison with neurosteroids.
Topics: Animals; Antidepressive Agents; Bicuculline; Depression; Female; Flavonoids; GABAergic Neurons; Locomotion; Neurosteroids; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Wistar; Receptors, GABA-A | 2020 |
Allopregnanolone induces antidepressant-like effects through BDNF-TrkB signaling independent from AMPA receptor activation in a rat learned helplessness model of depression.
Topics: Animals; Antidepressive Agents; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Helplessness, Learned; Male; Pregnanolone; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, AMPA; Signal Transduction | 2020 |
Not So Fast: Recent Successes and Failures in Treating Depression.
Topics: beta-Cyclodextrins; Depression; Drug Combinations; Excitatory Amino Acid Antagonists; GABA Modulators; Humans; Ketamine; Pregnanolone | 2020 |
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry | 2020 |
Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; Depression; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Helplessness, Learned; Male; Nucleus Accumbens; Pregnanolone; Rats; Rats, Sprague-Dawley | 2021 |
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vectors; Isoquinolines; Lentivirus; Male; Mice, Inbred ICR; Motor Activity; Pregnanolone; Psychotropic Drugs; Receptors, GABA | 2017 |
Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Depression; Depression, Postpartum; Female; Genetic Association Studies; Humans; Hydroxysteroid Dehydrogenases; Membrane Proteins; Metabolic Networks and Pathways; Oxidoreductases; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Complications; Pregnanolone; Psychiatric Status Rating Scales | 2017 |
Correlation between allopregnanolone levels and depressive symptoms during late menopausal transition and early postmenopause.
Topics: Adult; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Incidence; Menopause; Middle Aged; Poland; Postmenopause; Pregnanolone; Psychiatric Status Rating Scales; Severity of Illness Index; Sleep Disorders, Intrinsic | 2018 |
Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.
Topics: Adult; Affective Symptoms; Androstane-3,17-diol; Anorexia Nervosa; Anxiety; Body Mass Index; Cross-Sectional Studies; Depression; Female; Humans; Overweight; Pregnanolone; Progesterone; Psychiatric Status Rating Scales; Severity of Illness Index; Testosterone; Thinness | 2018 |
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Depression; Isoflavones; Male; Maze Learning; Neurotransmitter Agents; Pregnanolone; Rats, Sprague-Dawley; Serotonin | 2018 |
Hemisphere-dependent Changes in mRNA Expression of GABA
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Functional Laterality; GABA Agents; Gene Expression; Hippocampus; Male; Prefrontal Cortex; Pregnanolone; Psychotropic Drugs; Random Allocation; Rats, Wistar; Receptors, GABA-A; RNA, Messenger | 2019 |
Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats.
Topics: Agonistic Behavior; Anhedonia; Animals; Cerebral Cortex; Contraceptives, Oral, Hormonal; Depression; Drug Combinations; Ethinyl Estradiol; Female; Levonorgestrel; Maze Learning; Motivation; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Social Behavior; Swimming | 2014 |
Low serum allopregnanolone is associated with symptoms of depression in late pregnancy.
Topics: Adult; Anxiety; Depression; Depression, Postpartum; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Pregnanolone; Self Report; Young Adult | 2014 |
The role of steroids in the prediction of affective disorders in adult men.
Topics: Adult; Anxiety; Dehydroepiandrosterone; Depression; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Mood Disorders; Multivariate Analysis; Pregnanolone; Radioimmunoassay; Steroids; Young Adult | 2017 |
The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Depression; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Isoquinolines; Ligands; Male; Molecular Weight; Prefrontal Cortex; Pregnanolone; Purines; Rats, Sprague-Dawley; Receptors, GABA-A | 2016 |
Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Corticosterone; Depression; Dihydrotestosterone; Estrogen Receptor beta; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuropsychological Tests; Pregnanolone; Radioimmunoassay; Swimming; Time Factors | 2009 |
Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats.
Topics: Animals; Antidepressive Agents; Benzazepines; Depression; Diestrus; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Estrus; Female; Pregnanolone; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Swimming | 2010 |
Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats.
Topics: Amygdala; Animals; Antidepressive Agents; Avoidance Learning; CA3 Region, Hippocampal; Depression; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Flumazenil; GABA Antagonists; Helplessness, Learned; Humans; Injections, Intraventricular; Male; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 2011 |
Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Survival; Chronic Disease; Depression; Dexamethasone; Feeding Behavior; Hippocampus; Immunohistochemistry; Male; Motor Activity; Neural Stem Cells; Neurogenesis; Pregnanolone; Rats; Rats, Wistar; Social Isolation; Stress, Psychological; Swimming | 2012 |
The effect of intra-nucleus accumbens administration of allopregnanolone on δ and γ2 GABA(A) receptor subunit mRNA expression in the hippocampus and on depressive-like and grooming behaviors in rats.
Topics: Animals; Base Sequence; Behavior, Animal; Depression; DNA Primers; Hippocampus; Male; Nucleus Accumbens; Pregnanolone; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, GABA-A | 2012 |
Behavioral action of ethanol in Porsolt's forced swim test: modulation by 3 alpha-hydroxy-5 alpha-pregnan-20-one.
Topics: Adrenalectomy; Animals; Depression; Dose-Response Relationship, Drug; Ethanol; Immobilization; Male; Mice; Motor Activity; Pregnanolone; Substance Withdrawal Syndrome; Swimming | 2002 |
Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression.
Topics: Animals; Brain; Depression; Disease Models, Animal; Olfactory Bulb; Organ Specificity; Pregnanolone; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats.
Topics: Animals; Depression; Female; Finasteride; Hippocampus; Lactation; Pregnancy; Pregnancy, Animal; Pregnanolone; Rats; Rats, Long-Evans; Swimming | 2004 |
Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women.
Topics: Adult; Demography; Depression; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Luteinizing Hormone; Pregnanolone; Premenstrual Syndrome; Progesterone; Prospective Studies; Radioimmunoassay; Stress Disorders, Post-Traumatic; Stress, Psychological | 2006 |
Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility.
Topics: 5-alpha Reductase Inhibitors; Animals; Depression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Finasteride; Mice; Mice, Inbred DBA; Motor Activity; Pregnanolone; Progesterone; Substance Withdrawal Syndrome; Swimming | 2007 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Depression; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Pregnanolone; Serotonin Agents | 2000 |
Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats.
Topics: Animals; Anxiety; Depression; Enzyme Inhibitors; Exploratory Behavior; Female; Finasteride; Hippocampus; Male; Posture; Pregnanolone; Proestrus; Progesterone; Progestins; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal; Swimming | 2002 |