pregnanolone has been researched along with Depression, Involutional in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Brunner, LM; Kufner, M; Nothdurfter, C; Pradhan, AK; Puig, X; Rammes, G; Rupprecht, C; Rupprecht, R; Schwarzbach, J; Wein, S | 1 |
| Cusin, C; Dichtel, LE; Dording, C; Fava, M; Fisher, LB; Kimball, AS; Miller, KK; Mischoulon, D; Nyer, M; Pedrelli, P; Rao, EM; Shapero, BG | 1 |
| Amodeo, G; Beccarini Crescenzi, B; Bolognesi, S; Cuomo, A; Fagiolini, A; Goracci, A; Laurenzi, PF; Neal, SM; Rossi, R; Santucci, A | 1 |
| Almeida, FB; Barros, HMT; Pinna, G | 2 |
| Ackley, MA; Althaus, AL; Bai, Z; Belfort, GM; Beresis, RT; Blanco, MJ; Dai, J; Doherty, JJ; Grossman, SJ; Harrison, BL; Hoffmann, E; Loya, CM; Martinez Botella, G; Robichaud, AJ; Salituro, FG | 1 |
| Drakopoulos, P; Genazzani, AR; Luisi, M; Pluchino, N; Sajdak, S; Slopien, R; Warenik-Szymankiewicz, A | 1 |
| Brown, ES; Filbey, F; Marx, CE; Mason, BL; Nakamura, A; Park, J; Sunderajan, P; Van Enkevort, E | 1 |
| Anderson, GM; Gregor, K; Hamouda, M; King, MW; Nillni, YI; Pineles, SL; Pinna, G; Rasmusson, AM; Scioli-Salter, E; Valovski, I | 1 |
| Mody, I | 1 |
| Agis-Balboa, RC; Guidotti, A; Pinna, G | 1 |
| Ben Dor, R; Marx, CE; Rubinow, DR; Schmidt, PJ; Shampine, LJ | 1 |
| Biggio, G; Morgan, ML; Pisu, MG; Rapkin, AJ; Rasgon, N; Serra, M | 1 |
| van Broekhoven, F; Verkes, RJ | 1 |
| Bernardi, G; di Michele, F; Pace, M; Pasinib, A; Pompili, E; Romeo, E; Rupprecht, R | 1 |
| Biggio, G; Carta, MG; Contu, P; Hardoy, MC; Pisu, MG; Serra, M | 1 |
| Costa, E; Davis, JM; Guidotti, A; Rasmusson, A; Sheline, Y; Uzunov, DP; Uzunova, V | 1 |
5 review(s) available for pregnanolone and Depression, Involutional
| Article | Year |
|---|---|
Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.
Topics: Anti-Anxiety Agents; Benzodiazepines; Carrier Proteins; Cognition; Depression; Depression, Postpartum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Ligands; Neuronal Plasticity; Neurosteroids; Neurotransmitter Agents; Pregnanolone; Receptors, GABA; Receptors, GABA-A | 2023 |
Advances in treatment for postpartum major depressive disorder.
Topics: Antidepressive Agents; beta-Cyclodextrins; Depression, Postpartum; Depressive Disorder, Major; Drug Combinations; Drug Monitoring; Estrogens; Female; Humans; Oxytocin; Pregnanolone; Randomized Controlled Trials as Topic; Transcranial Magnetic Stimulation; Treatment Outcome; United States | 2020 |
Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?
Topics: Animals; Biomarkers; Brain; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Humans; Nerve Growth Factors; Neurosteroids; Pregnanolone; Stress Disorders, Post-Traumatic | 2021 |
The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depressive Disorder, Major; Feedback, Physiological; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Male; Models, Biological; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A; Sex Characteristics; Stress Disorders, Post-Traumatic; Stress, Physiological; Stress, Psychological | 2021 |
Neurosteroids in depression: a review.
Topics: Animals; Dehydroepiandrosterone; Depressive Disorder, Major; Humans; Neurotransmitter Agents; Pregnanolone; Selective Serotonin Reuptake Inhibitors | 2003 |
5 trial(s) available for pregnanolone and Depression, Involutional
| Article | Year |
|---|---|
Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women: A Pilot Study.
Topics: Aged; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Female; GABA Modulators; Humans; Middle Aged; Pilot Projects; Postmenopause; Pregnanolone; Treatment Outcome | 2020 |
Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders.
Topics: Adult; Androsterone; Bipolar Disorder; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Marijuana Abuse; Middle Aged; Pregnanolone; Pregnenolone | 2017 |
DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
Topics: Androsterone; Antidepressive Agents; Cross-Over Studies; Dehydroepiandrosterone; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Sex Factors; Treatment Outcome | 2015 |
Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women.
Topics: Brain; Dehydroepiandrosterone; Depressive Disorder, Major; Desoxycorticosterone; Estrogens; Female; Humans; Middle Aged; Postmenopause; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Sertraline | 2010 |
Effects of fluoxetine, indomethacine and placebo on 3 alpha, 5 alpha tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal.
Topics: Adult; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Ethanol; Fluoxetine; gamma-Aminobutyric Acid; Humans; Indomethacin; Male; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome | 2000 |
7 other study(ies) available for pregnanolone and Depression, Involutional
| Article | Year |
|---|---|
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)
Topics: Allosteric Regulation; Animals; Depression, Postpartum; Depressive Disorder, Major; Female; GABA-A Receptor Agonists; Mice; Pregnanolone; Pyrazoles; Rats; Receptors, GABA-A | 2017 |
Correlation between allopregnanolone levels and depressive symptoms during late menopausal transition and early postmenopause.
Topics: Adult; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Incidence; Menopause; Middle Aged; Poland; Postmenopause; Pregnanolone; Psychiatric Status Rating Scales; Severity of Illness Index; Sleep Disorders, Intrinsic | 2018 |
Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD.
Topics: 5-alpha-Dihydroprogesterone; Adult; Cholestenone 5 alpha-Reductase; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depressive Disorder, Major; GABAergic Neurons; Gas Chromatography-Mass Spectrometry; Humans; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Neurosteroids; Pregnanolone; Progesterone; Severity of Illness Index; Stress Disorders, Post-Traumatic | 2019 |
GABA
Topics: Adult; beta-Cyclodextrins; Depression, Postpartum; Depressive Disorder, Major; Drug Combinations; Female; Humans; Mood Disorders; Neurotransmitter Agents; Postpartum Period; Pregnancy; Pregnanolone; Prevalence; Receptors, GABA-A | 2019 |
5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Depressive Disorder, Major; Down-Regulation; Female; Humans; Male; Middle Aged; Pilot Projects; Prefrontal Cortex; Pregnanolone; Pyramidal Cells; RNA, Messenger; Suicide; Tissue Banks; Young Adult | 2014 |
Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder.
Topics: Adult; Anti-Inflammatory Agents; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Hydrocortisone; Pregnanolone; Premenopause; Premenstrual Syndrome; Progesterone; Radioimmunoassay; Steroids | 2006 |
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
Topics: Adult; Depressive Disorder, Major; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Pregnanolone; Psychometrics; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1998 |