pregnanolone has been researched along with Aura in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 18 (46.15) | 29.6817 |
| 2010's | 14 (35.90) | 24.3611 |
| 2020's | 5 (12.82) | 2.80 |
| Authors | Studies |
|---|---|
| Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T | 1 |
| Perry, MS | 1 |
| Biagini, G; Costa, AM; Lucchi, C; Rustichelli, C | 1 |
| Pang, Y; Thomas, P | 1 |
| Lattanzi, S; Riva, A; Striano, P | 1 |
| Bertini, ES; Biagini, G; Cusmai, R; Gecz, J; Giannone, G; Lucchi, C; Rustichelli, C; Specchio, N; Terracciano, A; Trivisano, M; Ubertini, GM; Vigevano, F | 1 |
| Joshi, S; Kapur, J | 1 |
| Coppola, G; Greco, M; Iezzi, ML; Operto, F; Varriale, G; Verrotti, A | 1 |
| Carver, CM; Gangisetty, O; Reddy, DS; Wu, X | 1 |
| Lovick, T | 1 |
| Frye, CA; Herzog, AG | 1 |
| Amiri, M; Kamalinejad, M; Narenjkar, J; Rahimi, H; Sardari, S; Sayyah, M | 1 |
| Berkovic, SF; Buchanan, G; Corbett, M; Depienne, C; Douglas, E; Gecz, J; Guerrini, R; Haan, E; Hynes, K; Kumar, R; Leach, D; Marini, C; Mcmahon, J; Moller, RS; Nguyen, LS; Pham, DH; Ranieri, E; Sadleir, L; Scheffer, IE; Shard, C; Shoubridge, C; Specchio, N; Tan, C; Thomas, PQ | 1 |
| Beadles-Bohling, AS; Crabbe, JC; Finn, DA; Ford, MM; Gililland-Kaufman, KR; Mark, GP; Snelling, C; Tanchuck, MA | 1 |
| Reddy, DS; Rogawski, MA | 3 |
| Mares, P; Stehlíková, M | 1 |
| Kapur, J; Lawrence, C; Martin, BS; Sun, C; Williamson, J | 1 |
| Murashima, YL; Yoshii, M | 1 |
| Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F | 1 |
| Harden, CL; Stevens, SJ | 1 |
| Gangisetty, O; Gould, J; Reddy, DS | 1 |
| Bernardi, G; Costamagna, L; Curatolo, P; di Michele, F; Dorofeeva, M; Romeo, E; Verdecchia, M | 1 |
| Beyenburg, S; Bidlingmaier, F; Casarosa, E; Clusmann, H; Elger, CE; Ludwig, M; Luisi, S; Steckelbroeck, S; Stoffel-Wagner, B; Watzka, M | 1 |
| Balestri, P; Cobellis, L; Farnetani, M; Grosso, S; Luisi, S; Morgese, G; Mostardini, R; Petraglia, F | 1 |
| Falcone, T; Foldvary-Schaefer, N | 1 |
| Reddy, DS | 2 |
| Giller, E; Nohria, V | 1 |
| Dulac, O; Giller, E; Pieribone, VA; Rey, E; Shaw, K; Soufflet, C; Tsai, J | 1 |
| Biggio, G; Concas, A; Marotto, MF; Marra, C; Marrosu, F; Melis, GB; Orrù, M; Paoletti, AM; Sogliano, C; Tuveri, A; Zedda, P | 1 |
| Frye, CA | 1 |
| Gee, KW | 1 |
| Devaud, LL; Grobin, AC; Janis, GC; Matthews, DB; Morrow, AL; VanDoren, MJ | 1 |
| Frye, CA; Scalise, TJ | 1 |
| Carlen, PL; Edwards, HE; Epps, T; J MacLusky, N | 1 |
| Kim, HY; Reddy, DS; Rogawski, MA | 1 |
| Frye, CA; Muscatiello, NA | 1 |
10 review(s) available for pregnanolone and Aura
| Article | Year |
|---|---|
New and Emerging Medications for Treatment of Pediatric Epilepsy.
Topics: Anticonvulsants; Cannabidiol; Child; Dioxolanes; Epilepsy; Fenfluramine; Humans; Piperidines; Pregnanolone; Pyridines | 2020 |
Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells.
Topics: Anesthetics; Animals; Apoptosis; Cell Membrane; Epilepsy; Humans; Neurons; Neurosteroids; Pregnanolone; Receptors, Progesterone | 2020 |
Neurosteroid regulation of GABA
Topics: Epilepsy; Estrogens; Female; Humans; Menstrual Cycle; Neurons; Neurosteroids; Pregnanolone; Progesterone; Receptors, GABA; Receptors, GABA-A; Seizures | 2019 |
Investigational small molecules in phase II clinical trials for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Cannabinoids; Clinical Trials, Phase II as Topic; Drug Design; Drug Resistant Epilepsy; Drugs, Investigational; Epilepsy; Humans; Pregnanolone; Quality of Life; Quinazolinones | 2018 |
Neurosteroid replacement therapy for catamenial epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Gonadal Steroid Hormones; Humans; Menstrual Cycle; Pregnanolone; Rats; Receptors, GABA-A | 2009 |
Hormonal therapy for epilepsy.
Topics: Anticonvulsants; Epilepsy; Estrogens; Humans; Menstrual Cycle; Neurons; Pregnanolone; Progesterone; Testosterone | 2011 |
Catamenial epilepsy: pathophysiology, diagnosis, and management.
Topics: Acetazolamide; Adolescent; Adult; Animals; Anticonvulsants; Brain Edema; Bromides; Contraceptives, Oral, Hormonal; Convulsants; Epilepsy; Estradiol; Estrogen Receptor Modulators; Female; Gonadal Steroid Hormones; Humans; Incidence; Menstrual Cycle; Middle Aged; Models, Biological; Periodicity; Potassium Compounds; Pregnanolone; Progesterone; Pyramidal Cells; Rats; Seizures | 2003 |
Pharmacology of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Area Under Curve; Epilepsy; Estrogens; Female; Half-Life; Humans; Incidence; Menstrual Cycle; Mice; Pregnanolone; Progesterone; Receptors, GABA-A | 2004 |
Role of neurosteroids in catamenial epilepsy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Disease Models, Animal; Epilepsy; Female; Humans; Menstruation Disturbances; Models, Molecular; Pregnanolone; Progesterone; Receptors, GABA-A; Steroids | 2004 |
Ganaxolone.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Epilepsy; Humans; Pregnanolone | 2007 |
3 trial(s) available for pregnanolone and Aura
| Article | Year |
|---|---|
Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Menstrual Cycle; Pregnanolone; Progesterone; Radioimmunoassay; Seizures; Treatment Outcome | 2014 |
Inter-ictal and post-ictal circulating levels of allopregnanolone, an anticonvulsant metabolite of progesterone, in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Pregnanolone; Progesterone; Seizures | 2003 |
Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Pilot Projects; Pregnanolone; Treatment Outcome | 2007 |
26 other study(ies) available for pregnanolone and Aura
| Article | Year |
|---|---|
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; Humans; Infant, Newborn; Phenobarbital; Pregnanolone; Seizures; Sheep | 2022 |
Allopregnanolone and Pregnanolone Are Reduced in the Hippocampus of Epileptic Rats, but Only Allopregnanolone Correlates with Seizure Frequency.
Topics: Animals; Disease Models, Animal; Electrocorticography; Epilepsy; Hippocampus; Male; Neocortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2021 |
Ganaxolone treatment for epilepsy patients: from pharmacology to place in therapy.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Pregnanolone; Status Epilepticus | 2021 |
Reduced steroidogenesis in patients with PCDH19-female limited epilepsy.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Cadherins; Case-Control Studies; Child; Child, Preschool; DNA Mutational Analysis; Epilepsy; Estradiol; Female; Genetic Diseases, X-Linked; Gonadal Steroid Hormones; Humans; Hydrocortisone; Intellectual Disability; Pregnanolone; Pregnenolone; Progesterone; Prospective Studies; Protocadherins; Puberty, Precocious; Reference Values | 2017 |
Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
Topics: 5-alpha Reductase Inhibitors; Animals; Behavior, Animal; CA1 Region, Hippocampal; Dentate Gyrus; Disease Susceptibility; Epilepsy; Estrous Cycle; Female; GABAergic Neurons; Gene Expression Regulation; In Vitro Techniques; Kindling, Neurologic; Mice; Mice, Knockout; Nerve Tissue Proteins; Neural Inhibition; Neuronal Plasticity; Pregnanolone; Progesterone; Protein Subunits; Receptors, GABA-A; Receptors, Progesterone | 2013 |
SSRIs and the female brain--potential for utilizing steroid-stimulating properties to treat menstrual cycle-linked dysphorias.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; Female; Fluoxetine; GABAergic Neurons; Humans; Menstrual Cycle; Neurons; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Selective Serotonin Reuptake Inhibitors | 2013 |
Anticonvulsant effect of Cicer arietinum seed in animal models of epilepsy: introduction of an active molecule with novel chemical structure.
Topics: Animals; Anticonvulsants; Cicer; Disease Models, Animal; Electroshock; Epilepsy; Male; Mice; Pentylenetetrazole; Plant Extracts; Pregnanolone; Rats; Rats, Wistar; Seeds; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency.
Topics: 3-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Age of Onset; Aldo-Keto Reductase Family 1 Member C3; Cadherins; Child; Child, Preschool; Cluster Analysis; Epilepsy; Female; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Hydroxyprostaglandin Dehydrogenases; Infant; Infant, Newborn; Intellectual Disability; Middle Aged; Mutation; Phenotype; Pregnanolone; Protocadherins; Reproducibility of Results; Signal Transduction; Young Adult | 2015 |
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Alcohol-Induced Disorders, Nervous System; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epilepsy; Finasteride; Genetic Predisposition to Disease; Hippocampus; Mice; Mice, Transgenic; Neurons; Pentylenetetrazole; Pregnanolone; Substance Withdrawal Syndrome | 2008 |
Anticonvulsant doses of ganaxolone do not compromise motor performance in immature rats.
Topics: Aging; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Male; Motor Activity; Neuropsychological Tests; Pregnanolone; Rats; Rats, Wistar; Seizures; Time Factors | 2010 |
Endogenous neurosteroid synthesis modulates seizure frequency.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Gonadotropins; Lithium; Neurotransmitter Agents; Pilocarpus; Pregnanolone; Rats | 2010 |
New therapeutic approaches for epilepsies, focusing on reorganization of the GABAA receptor subunits by neurosteroids.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Age Factors; Animals; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Epilepsy; Hippocampus; Immunoblotting; Male; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A | 2010 |
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoassay; Leptin; Male; Obesity; Pregnanolone; Valproic Acid; Weight Gain | 2011 |
A mouse kindling model of perimenstrual catamenial epilepsy.
Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteride; Gonadotropins; Hippocampus; Kindling, Neurologic; Menstrual Cycle; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Rats; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2012 |
GABA(A) receptor active steroids are altered in epilepsy patients with tuberous sclerosis.
Topics: Adolescent; Adult; Child; Child, Preschool; Disease Susceptibility; Epilepsy; Female; GABA Antagonists; GABA Modulators; Humans; Infant; Isomerism; Male; Pregnanolone; Receptors, GABA-A; Tuberous Sclerosis | 2003 |
Allopregnanolone serum levels and expression of 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase isoforms in hippocampal and temporal cortex of patients with epilepsy.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Alkaline Phosphatase; Astrocytoma; Brain Neoplasms; Epilepsy; Female; Ganglioglioma; Hippocampus; Hormones; Humans; Hydroxysteroid Dehydrogenases; Isoenzymes; Male; Oligonucleotide Probes; Pregnanolone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temporal Lobe | 2003 |
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroencephalography; Epilepsy; Estradiol; Female; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Premenstrual Syndrome; Progesterone; Receptors, GABA | 2008 |
The neurosteroid 3 alpha, 5 apha-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electric Stimulation; Electrodes, Implanted; Epilepsy; Hippocampus; Male; Maze Learning; Neural Pathways; Neuroprotective Agents; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley | 1995 |
Epalons as anticonvulsants: actions mediated by the GABAA receptor complex.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; GABA-A Receptor Agonists; Humans; Pregnanolone; Receptors, GABA-A; Seizures | 1996 |
Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Cyclooxygenase Inhibitors; Dihydrotestosterone; Electrophysiology; Enzyme Inhibitors; Epilepsy; Ethanol; Finasteride; Indomethacin; Male; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Anti-seizure effects of progesterone and 3alpha,5alpha-THP in kainic acid and perforant pathway models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; Kainic Acid; Ovariectomy; Perforant Pathway; Pregnanolone; Progesterone; Rats; Rats, Long-Evans | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid | 2000 |
Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro.
Topics: Animals; Drug Combinations; Electric Stimulation; Epilepsy; Female; Hippocampus; Hormone Antagonists; In Vitro Techniques; Mifepristone; Pregnanolone; Progesterone; Progesterone Congeners; Promegestone; Rats; Rats, Wistar; Reaction Time; Receptors, Progesterone | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
Topics: 20-alpha-Dihydroprogesterone; Adult; Animals; Behavior, Animal; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Finasteride; Gonadotropins, Equine; Humans; Menstrual Cycle; Pentylenetetrazole; Pregnanolone; Progesterone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome | 2001 |
3alpha,5alpha-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Estrus; Female; GABA Antagonists; Pentylenetetrazole; Pregnanolone; Progesterone; Raphe Nuclei; Rats; Rats, Long-Evans; Rhombencephalon | 2001 |