Compounds > pregnanolone
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pregnanolone and Ataxia

pregnanolone has been researched along with Ataxia in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's4 (40.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adams, P; Brinton, RD; Carrillo, NR; Giulivi, C; Hagerman, RJ; Irwin, RW; Kim, K; Lubarr, N; Olichney, JM; Rivera, SM; Rogawski, MA; Schneider, A; Tassone, F; Trivedi, AM; Wang, JY; Wu, CY; Yang, J1
Budimirovic, DB1
Carrillo, NR; Giulivi, C; Hagerman, RJ; Napoli, E; Rogawski, M; Schneider, A; Tassone, F; Trivedi, A; Wang, JY1
Hagerman, RJ; Martinez-Cerdeno, V; Salcedo-Arellano, MJ1
Khisti, RT; Matthews, DB; Morrow, AL; VanDoren, MJ1
Ahboucha, S; Baker, GB; Butterworth, RF; Chatauret, N; Jiang, W; Mamer, O1
Finn, DA; Gallaher, EJ; Lotrich, F; Roberts, AJ1
Vanover, KE1
Crabbe, JC; Finn, DA; Gallaher, EJ1
Carter, RB; Gee, KW; Hogenkamp, DJ; Lan, NC; Vanover, KE1

Reviews

1 review(s) available for pregnanolone and Ataxia

ArticleYear
[Fragile X associated tremor/ataxia syndrome: its clinical presentation, pathology, and treatment].
    Revista de neurologia, 2019, Mar-01, Volume: 68, Issue:5

    Topics: Antidepressive Agents; Ataxia; Brain; Deep Brain Stimulation; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Male; Memantine; Neurologic Examination; Pregnanolone; Symptom Assessment; Tremor

2019

Trials

2 trial(s) available for pregnanolone and Ataxia

ArticleYear
Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017, Volume: 14, Issue:4

    Topics: Administration, Intravenous; Aged; Ataxia; Brain; Fragile X Syndrome; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Pregnanolone; Treatment Outcome; Tremor

2017
Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
    Molecular neurobiology, 2019, Volume: 56, Issue:5

    Topics: Aged; Anxiety; Ataxia; Depression; Energy Metabolism; Fragile X Syndrome; gamma-Aminobutyric Acid; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Ornithine; Oxidative Stress; Pilot Projects; Pregnanolone; Tremor

2019

Other Studies

7 other study(ies) available for pregnanolone and Ataxia

ArticleYear
Can a Neurosteroid Ameliorate Fragile X-Associated Tremor/Ataxia Syndrome?
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017, Volume: 14, Issue:4

    Topics: Ataxia; Fragile X Syndrome; Humans; Male; Neurotransmitter Agents; Pregnanolone; Tremor

2017
Ethanol-induced elevation of 3 alpha-hydroxy-5 alpha-pregnan-20-one does not modulate motor incoordination in rats.
    Alcoholism, clinical and experimental research, 2004, Volume: 28, Issue:8

    Topics: Animals; Ataxia; Ethanol; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Rotarod Performance Test

2004
Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.
    Neurogastroenterology and motility, 2008, Volume: 20, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Brain Chemistry; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Indomethacin; Male; Molecular Structure; Motor Activity; Portacaval Shunt, Surgical; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids

2008
Genetic differences in behavioral sensitivity to a neuroactive steroid.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Avoidance Learning; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Muscle Relaxation; Pentylenetetrazole; Pregnanolone; Seizures; Species Specificity; Substance Withdrawal Syndrome

1997
Interaction of ethanol with excitatory amino acid receptor antagonists in mice.
    European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3

    Topics: Animals; Ataxia; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Chlordiazepoxide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoquinolines; Male; Mice; Muscle Relaxation; Pentobarbital; Piperazines; Pregnanolone; Psychomotor Performance; Quinoxalines; Receptors, Glutamate; Tetrazoles

1999
Differential change in neuroactive steroid sensitivity during ethanol withdrawal.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1

    Topics: Administration, Inhalation; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Anxiety; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Muscle Relaxation; Pentylenetetrazole; Pregnanolone; Radioimmunoassay; Species Specificity; Steroids; Substance Withdrawal Syndrome; Time Factors

2000
Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid.
    Psychopharmacology, 2001, Volume: 155, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Ataxia; Behavior, Animal; Convulsants; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Electroshock; Female; Hypnotics and Sedatives; Male; Mice; Pentylenetetrazole; Postural Balance; Pregnanolone; Punishment; Rats; Rats, Sprague-Dawley; Seizures

2001