pregnanolone has been researched along with Anxiety in 110 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (11.82) | 18.2507 |
| 2000's | 40 (36.36) | 29.6817 |
| 2010's | 51 (46.36) | 24.3611 |
| 2020's | 6 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Betz, JF; Hantsoo, L; Osborne, LM; Payne, JL; Standeven, LR; Voegtline, K; Yenokyan, G | 1 |
| Auta, J; Camussi, D; Gatta, E; Guidotti, A; Pandey, SC | 1 |
| Graham, BM; Kershaw, KA; Pestana, JE | 1 |
| Graham, BM; Pestana, JE | 1 |
| Concas, A; Porcu, P; Serra, M | 1 |
| Bartolomé, I; Darbra, S; Llidó, A; Pallarès, M | 2 |
| Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y | 1 |
| Andréen, L; Bäckström, T; Bixo, M; Ehrenborg, A; Ekberg, K; Hirschberg, AL; Jonasson, AF; Poromaa, IS; Timby, E; Wulff, M | 1 |
| Biggio, F; Boero, G; Concas, A; Congiu, M; Corda, D; Garau, A; Pisu, MG; Porcu, P; Serra, M | 1 |
| Gong, J; Guo, Y; Jiang, XY; Li, L; Li, YF; Sun, LJ; Sun, SZ; Wang, HL; Wang, W; Zhang, LM; Zhang, YZ | 1 |
| Bennett, GA; Hirst, JJ; Palazzi, KL; Palliser, HK; Shaw, JC; Walker, DW | 1 |
| Dichtel, LE; Eddy, KT; Klibanski, A; Lawson, EA; Meenaghan, E; Miller, KK; Nelson, M; Paskal, ML; Pinna, G; Rasmusson, AM; Schorr, M | 1 |
| Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Zhong, DS | 1 |
| Biggio, F; Boero, G; Ciarlo, B; Grayson, DR; Locci, V; Pisu, MG; Serra, M; Talani, G | 1 |
| Carrillo, NR; Giulivi, C; Hagerman, RJ; Napoli, E; Rogawski, M; Schneider, A; Tassone, F; Trivedi, A; Wang, JY | 1 |
| McEvoy, K; Osborne, LM | 1 |
| Locci, A; Pinna, G | 1 |
| Darbra, S; Llidó, A; Mòdol, L; Pallarès, M | 1 |
| Chopde, CT; Thakre, PP; Tundulwar, MR; Ugale, RR | 1 |
| Frye, CA; Koonce, CJ; Rusconi, JC; Walf, AA | 1 |
| Frye, CA; Koonce, CJ | 1 |
| Mohammad, A; Ramroop, J; Shen, H; Smith, SS | 1 |
| Bali, A; Jaggi, AS | 1 |
| Nothdurfter, C; Rupprecht, R; Schüle, C | 1 |
| Berretti, R; Calza, A; Choleris, E; Concas, A; Locci, A; Porcu, P; Santoru, F; Sogliano, C | 1 |
| Alpers, GW; Arolt, V; Binder, EB; Brückl, T; Cichon, S; Deckert, J; Domschke, K; Erhardt, A; Fehm, L; Gerlach, AL; Hamm, A; Kircher, T; Lang, T; Mattheisen, M; Pauli, P; Pfister, H; Quast, C; Reif, A; Rupprecht, R; Ströhle, A; Weber, H; Wittchen, HU | 1 |
| Frye, CA; Koonce, CJ; Walf, AA | 1 |
| Åkerud, H; Bäckström, T; Hellgren, C; Skalkidou, A; Sundström-Poromaa, I | 1 |
| Rakitskaya, VV; Semenova, OG | 1 |
| Becker, HC; Cook, JB; Lopez, MF; Maldonado-Devincci, AM; McKinley, RE; Morrow, AL; Morrow, DH; O'Buckley, TK | 1 |
| Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP | 1 |
| Chen, JS; Chen, Y; He, JL; Lai, S; Li, Y; Liu, X; Luo, M; Ma, JC; Qiu, ZK; Shen, YG; Wu, HW; Zeng, J | 1 |
| Cacioppo, JT; Cacioppo, S | 1 |
| Crawley, JN; Hagerman, RJ; Kazdoba, TM; Rogawski, MA; Zolkowska, D | 1 |
| Hahn, YK; Hauser, KF; Knapp, PE; Paris, JJ; Zou, S | 1 |
| Chen, HX; Chen, XF; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N | 1 |
| André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P | 1 |
| Bäckström, T; Bixo, M; Nyberg, S; Stenlund, H; Timby, E; Wihlbäck, AN | 1 |
| Beckmann, MW; Binder, E; Brown, T; Clive, M; Cox, O; Fasching, PA; Gispen, F; Guintivano, J; Kaminsky, Z; Kimmel, M; Kornhuber, J; Osborne, LM; Payne, JL | 1 |
| Bennett, GA; Hirst, J; Palliser, HK; Walker, D | 1 |
| Gunter, BW; Jones, SA; Paul, IA; Platt, DM; Rowlett, JK | 1 |
| Bičíková, M; Dušková, M; Hill, M; Mohr, P; Řípová, D; Šrámková, M; Stárka, L | 1 |
| Ciarlone, SL; Rogawski, MA; Wang, X; Weeber, EJ | 1 |
| Acca, GM; Jin, J; Maren, S; Mathew, AS; Nagaya, N | 1 |
| Crombie, GK; Cumberland, AL; Hirst, JJ; Palliser, HK; Walker, DW | 1 |
| Darbra, S; Martín-García, E; Pallarés, M | 1 |
| Frye, CA; Paris, JJ; Rhodes, ME | 2 |
| Kumar, A; Singh, A | 1 |
| Aoki, C; Shen, H; Smith, SS | 1 |
| Frye, CA; Kohtz, AS; Paris, JJ | 1 |
| Angioni, MM; Biggio, G; Calza, A; Concas, A; Marra, C; Mostallino, MC; Santoru, F; Sogliano, C | 1 |
| Reddy, DS | 1 |
| Fischer, BD; Rowlett, JK | 1 |
| Darbra, S; Mòdol, L; Pallarès, M | 1 |
| Pinna, G; Rasmusson, AM | 1 |
| Darbra, S; Pallarès, M | 1 |
| Berretti, R; Concas, A; Mostallino, MC; Porcu, P; Santoru, F; Sogliano, C | 1 |
| Bubenikova-Valesova, V; Chodounska, H; Holubova, K; Rambousek, L; Stuchlik, A; Svoboda, J; Vales, K; Vyklicky, L | 1 |
| Connor, B; Evans, J; McGregor, A; Sun, Y | 1 |
| Darbra, S; Mòdol, L; Pallarès, M; Vallèe, M | 1 |
| Delgado, G; Gomez, C; Rodriguez, R; Saldivar-Gonzalez, A | 1 |
| Hodge, CW; McMahon, T; Mehmert, K; Messing, RO; Morrow, AL; Olive, MF; Raber, J; Sanchez-Perez, AM; Walter, H | 1 |
| Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M | 1 |
| Gulinello, M; Smith, SS | 1 |
| Finn, DA; Long, S; Phillips, TJ; Roberts, AJ; Tanchuck, M | 1 |
| Biggio, G; Concas, A; Fratta, S; Lello, S; Melis, GB; Orrù, M; Paoletti, AM; Ranuzzi, F; Sogliano, C | 1 |
| Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A | 1 |
| Kajunski, EW; Zimmerberg, B | 1 |
| Davis, C; Davis, M; Hammond, A; Toufexis, DJ | 1 |
| O'Malley, BW; Reddy, DS; Rogawski, MA | 1 |
| Bitran, D; Smith, SS | 1 |
| Begliuomini, S; Bernardi, F; Genazzani, AR; Lenzi, E; Luisi, M; Palumbo, M; Pluchino, N | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| Alciati, A; Biggio, G; Brambilla, F; Mellado, C; Perini, G; Pisu, MG; Purdy, RH; Serra, M; Zanone, S | 1 |
| Martín-García, E; Pallarès, M | 1 |
| Frye, C; Homanics, G; Ruderman, Y; Smith, SS; Yuan, M | 1 |
| Dudek, BC; Frye, CA; Harney, JP; Lydon, JP; O'Malley, BW; Pfaff, DW; Rhodes, ME; Sumida, K | 1 |
| Brunelli, SA; Frye, CA; Sumida, K; Zimmerberg, B | 1 |
| Davis, M; Myers, KM; Toufexis, DJ | 1 |
| Frye, CA; Rhodes, ME | 2 |
| de Brito Faturi, C; Leite, JR; Teixeira-Silva, F | 1 |
| Aoki, C; Dattilo, M; Gong, QH; Ruderman, Y; Shen, H; Smith, SS; Williams, K; Yuan, M | 1 |
| Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Ugale, RR | 1 |
| Engin, E; Treit, D | 1 |
| Aszalós, Z | 1 |
| Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Subhedar, NK; Ugale, RR | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Almeida, OF; Holsboer, F; Patchev, VK; Shoaib, M | 1 |
| Gallo, MA; Smith, SS | 1 |
| Brunelli, SA; Hofer, MA; Zimmerberg, B | 1 |
| Bitran, D; Kellogg, CK; Purdy, RH | 1 |
| Fernández-Guasti, A; Picazo, O | 1 |
| Chen, SW; Davies, MF; Loew, GH; Rodriguez, L | 1 |
| Carboni, E; Gee, KW; Lan, NC; Wieland, S | 1 |
| Driscoll, P; Schulz, PE; Steimer, T | 1 |
| Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH | 1 |
| Blaskey, LG; Zimmerberg, B | 1 |
| Bitran, D; Frye, CA; Gong, QH; Hsu, FC; Li, X; Moran, MH; Smith, SS | 1 |
| Chatterton, R; Klock, SC; Milad, MP; Moses, S | 1 |
| Faulhaber, J; Harting, J; Koch, M; Lancel, M; Montkowski, A; Rupprecht, R; Spanagel, R | 1 |
| Crabbe, JC; Finn, DA; Gallaher, EJ | 1 |
| Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L | 1 |
| Bitran, D; Klibansky, DA; Martin, GA | 1 |
| Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N | 1 |
| Engel, SR; Grant, KA | 1 |
| Smith, SS | 1 |
| Frye, CA; Walf, AA | 1 |
11 review(s) available for pregnanolone and Anxiety
| Article | Year |
|---|---|
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy.
Topics: Alcoholism; Anxiety; Ethanol; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2022 |
The brain as a target of hormonal contraceptives: Evidence from animal studies.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Contraceptive Agents, Hormonal; Depression; Female; Humans; Learning; Neuropeptides; Neurosteroids; Pregnanolone; Sexual Behavior; Social Behavior; Stress, Psychological; Synaptic Transmission | 2019 |
Allopregnanolone and reproductive psychiatry: an overview.
Topics: Affect; Anxiety; Female; Humans; Menarche; Menstrual Cycle; Perimenopause; Pregnanolone; Psychiatry; Receptors, GABA-A; Reproductive Health | 2019 |
Multifunctional aspects of allopregnanolone in stress and related disorders.
Topics: Anxiety; Brain-Derived Neurotrophic Factor; Calcium Channels; Depression; Dopamine; Glutamic Acid; Humans; Oxytocin; Pregnanolone; Receptors, GABA-A; Stress, Psychological | 2014 |
The role of allopregnanolone in depression and anxiety.
Topics: Animals; Anxiety; Depression; Humans; Pregnanolone | 2014 |
Neurosteroids: endogenous role in the human brain and therapeutic potentials.
Topics: Androstane-3,17-diol; Anesthetics; Anxiety; Brain; Depression; Female; Humans; Male; Neurotransmitter Agents; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A; Seizures; Sex Characteristics; Stress, Physiological | 2010 |
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Mice; Neurotransmitter Agents; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Up-Regulation | 2012 |
Disadaptive disorders in women: allopregnanolone, a sensitive steroid.
Topics: Affect; Amenorrhea; Animals; Anxiety; Behavior; Depression; Female; Humans; Hypothalamus; Menopause; Mental Disorders; Mood Disorders; Pregnanolone; Premenstrual Syndrome; Puerperal Disorders; Stress, Physiological | 2004 |
The effect of gonadal hormones and gender on anxiety and emotional learning.
Topics: Animals; Anxiety; Arginine Vasopressin; Corticotropin-Releasing Hormone; Emotions; Fear; Female; Gonadal Hormones; Humans; Learning; Light; Male; Pregnanolone; Reflex, Startle; Septal Nuclei; Sex Characteristics; Steroids | 2006 |
[Neurological and psychiatric aspects of some endocrine diseases. The role of neurosteroids and neuroactive steroids].
Topics: Addison Disease; Adrenal Cortex Hormones; Androgens; Anxiety; Cognition Disorders; Cushing Syndrome; Depression; Endocrine System Diseases; Estrogens; Fear; Fetal Organ Maturity; Gonadal Steroid Hormones; Humans; Memory Disorders; Mental Disorders; Mood Disorders; Muscle Weakness; Nervous System Diseases; Pain; Pregnanolone; Progesterone | 2007 |
Neurosteroids and behavior.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Dehydroepiandrosterone; Humans; Pregnanolone; Progesterone | 2001 |
3 trial(s) available for pregnanolone and Anxiety
| Article | Year |
|---|---|
Treatment of premenstrual dysphoric disorder with the GABA
Topics: Adult; Affect; Anger; Anxiety; Contraceptives, Oral; Depression; Double-Blind Method; Female; Follicular Phase; GABA-A Receptor Antagonists; Humans; Luteal Phase; Menstrual Cycle; Middle Aged; Pregnanolone; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Progesterone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2017 |
Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
Topics: Aged; Anxiety; Ataxia; Depression; Energy Metabolism; Fragile X Syndrome; gamma-Aminobutyric Acid; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Ornithine; Oxidative Stress; Pilot Projects; Pregnanolone; Tremor | 2019 |
Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol.
Topics: Adult; Androstenes; Anxiety; Contraceptives, Oral, Combined; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Follicular Phase; Humans; Luteal Phase; Phobic Disorders; Pregnanolone; Progesterone; Psychometrics | 2004 |
96 other study(ies) available for pregnanolone and Anxiety
| Article | Year |
|---|---|
Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study.
Topics: Anxiety; Depression; Depression, Postpartum; Female; Humans; Peripartum Period; Pregnancy; Pregnanolone; Psychiatric Status Rating Scales | 2022 |
The impact of the ovarian cycle on anxiety, allopregnanolone, and corticotropin releasing hormone changes after motherhood in female rats and women.
Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Estrous Cycle; Female; Humans; Menstrual Cycle; Pregnancy; Pregnanolone; Rats; Receptors, GABA-A | 2023 |
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychological; Fear; Female; Fluoxetine; Humans; Pregnancy; Pregnanolone; Progesterone; Rats | 2023 |
Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Finasteride; Male; Neurosteroids; Pregnanolone; Rats, Wistar; Recognition, Psychology | 2020 |
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry | 2020 |
Effects of neonatal and adolescent neuroactive steroid manipulation on locomotor activity induced by ethanol in male wistar rats.
Topics: 5-alpha Reductase Inhibitors; Alcohol Drinking; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Ethanol; Exploratory Behavior; Finasteride; Locomotion; Male; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Wistar | 2017 |
Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone.
Topics: Animals; Anxiety; Corticosterone; Disease Models, Animal; Female; Maternal Behavior; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Social Isolation; Weaning | 2017 |
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vectors; Isoquinolines; Lentivirus; Male; Mice, Inbred ICR; Motor Activity; Pregnanolone; Psychotropic Drugs; Receptors, GABA | 2017 |
Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Anxiety; Astrocytes; Behavior, Animal; Cerebellum; Female; Fetus; Guinea Pigs; Male; Neurotransmitter Agents; Oligodendroglia; Pregnancy; Pregnancy Complications; Pregnanolone; Prenatal Exposure Delayed Effects; Receptors, GABA-A; RNA, Messenger; Stress, Psychological | 2017 |
Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.
Topics: Adult; Affective Symptoms; Androstane-3,17-diol; Anorexia Nervosa; Anxiety; Body Mass Index; Cross-Sectional Studies; Depression; Female; Humans; Overweight; Pregnanolone; Progesterone; Psychiatric Status Rating Scales; Severity of Illness Index; Testosterone; Thinness | 2018 |
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Depression; Isoflavones; Male; Maze Learning; Neurotransmitter Agents; Pregnanolone; Rats, Sprague-Dawley; Serotonin | 2018 |
Low doses of prenatal ethanol exposure and maternal separation alter HPA axis function and ethanol consumption in adult male rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Anxiety; Corticosterone; Electroshock; Fetal Alcohol Spectrum Disorders; Male; Maternal Deprivation; Pregnanolone; Random Allocation; Rats, Sprague-Dawley; Stress, Psychological | 2018 |
Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior.
Topics: Amides; Animals; Anxiety; Disease Models, Animal; Emotions; Ethanolamines; Fear; Hippocampus; Male; Mice; Palmitic Acids; PPAR alpha; Pregnanolone; Social Isolation; Stress Disorders, Post-Traumatic | 2019 |
Interaction between neonatal allopregnanolone administration and early maternal separation: effects on adolescent and adult behaviors in male rat.
Topics: Aging; Animals; Animals, Newborn; Anxiety; Anxiety, Separation; Body Weight; Exploratory Behavior; Gonadal Steroid Hormones; Male; Maternal Deprivation; Pregnanolone; Rats; Reflex, Startle | 2013 |
Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice.
Topics: Animals; Anxiety; Finasteride; Indomethacin; Male; Maze Learning; Mice; Motor Activity; Neurotransmitter Agents; Nicotine; Pregnanolone; Progesterone; Substance Withdrawal Syndrome; Time Factors | 2013 |
Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.
Topics: Animals; Anxiety; Estradiol; Female; Gene Knockdown Techniques; Interpersonal Relations; Male; Mesencephalon; Motivation; Pregnane X Receptor; Pregnanolone; Proestrus; Progesterone; Rats; Rats, Long-Evans; Receptors, Steroid; Reproduction; Sexual Behavior, Animal; Ventral Tegmental Area | 2013 |
Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Affect; Animals; Anxiety; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Genotype; Immunohistochemistry; Interpersonal Relations; Medroxyprogesterone; Mice; Mice, Knockout; Motor Activity; Mutation; Ovariectomy; Pregnanolone; Progesterone; Social Behavior; Steroids | 2013 |
A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.
Topics: Amphetamine-Related Disorders; Animals; Anxiety; Gene Expression Regulation; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Sensory Gating; Stress, Psychological; Substance Withdrawal Syndrome | 2013 |
Neonatal exposure to estradiol decreases hypothalamic allopregnanolone concentrations and alters agonistic and sexual but not affective behavior in adult female rats.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Estradiol; Exploratory Behavior; Female; Hypothalamus; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Social Behavior | 2014 |
Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aldo-Keto Reductase Family 1 Member C3; Anxiety; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Hydroxyprostaglandin Dehydrogenases; Hydroxysteroid Dehydrogenases; Male; Membrane Proteins; Middle Aged; Panic Disorder; Polymorphism, Single Nucleotide; Pregnanolone; Progesterone; Receptors, GABA; Sex Factors | 2014 |
Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats.
Topics: 20-alpha-Dihydroprogesterone; Animals; Anxiety; Estradiol; Female; Interpersonal Relations; Motor Activity; Pregnane X Receptor; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, Steroid; Sexual Behavior, Animal; Ventral Tegmental Area | 2014 |
Low serum allopregnanolone is associated with symptoms of depression in late pregnancy.
Topics: Adult; Anxiety; Depression; Depression, Postpartum; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Pregnanolone; Self Report; Young Adult | 2014 |
Selective effect of allopregnanolone on corticoliberin-induced anxiety.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Corticotropin-Releasing Hormone; Male; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Stress, Psychological | 2014 |
Chronic intermittent ethanol exposure and withdrawal alters (3α,5α)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice.
Topics: Alcoholism; Animals; Anxiety; Central Amygdaloid Nucleus; Corpus Striatum; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Stress, Psychological; Time Factors; Withholding Treatment | 2014 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult | 2016 |
The role of allopregnanolone in the anxiolytic-like effect of free and easy wanderer plus (FEWP), a polyherbal preparation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Drugs, Chinese Herbal; Feeding Behavior; Male; Maze Learning; Mice, Inbred ICR; Pregnanolone; Rats, Sprague-Dawley; Reaction Time | 2015 |
Why may allopregnanolone help alleviate loneliness?
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Biological Evolution; Brain-Derived Neurotrophic Factor; Cognition; Fear; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Interpersonal Relations; Limbic System; Loneliness; Models, Theoretical; Pituitary-Adrenal System; Pregnanolone; Social Isolation; Stress, Psychological | 2015 |
Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Diazepam; Female; GABA Modulators; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnanolone; Receptors, GABA-A; Social Behavior | 2016 |
5α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Behavior, Animal; Cholestenone 5 alpha-Reductase; Coculture Techniques; Female; Finasteride; Mice; Microglia; Neurons; Ovariectomy; Pregnanolone; Progesterone; tat Gene Products, Human Immunodeficiency Virus | 2016 |
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Male; Motor Activity; Prefrontal Cortex; Pregnanolone; Purines; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2016 |
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin | 2016 |
Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study.
Topics: Adolescent; Adult; Anxiety; Electrooculography; Female; GABA Modulators; Gonadal Steroid Hormones; Humans; Hypnotics and Sedatives; Menstrual Cycle; Panic; Pilot Projects; Pregnanolone; Premenstrual Dysphoric Disorder; Receptors, GABA-A; Saccades; Young Adult | 2016 |
Oxytocin receptor DNA methylation in postpartum depression.
Topics: Adult; Anxiety; Anxiety Disorders; CpG Islands; Depression, Postpartum; DNA Methylation; Epigenesis, Genetic; Estradiol; Female; Humans; Pregnanolone; Progesterone; Prospective Studies; Receptors, Oxytocin | 2016 |
Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Emotions; Female; Fetal Development; Guinea Pigs; Hippocampus; Neurogenesis; Neuroglia; Neurotransmitter Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Random Allocation; Stress, Physiological; Stress, Psychological | 2016 |
Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clonazepam; Discrimination Learning; Drug Interactions; Hypnotics and Sedatives; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Triazolam | 2016 |
The role of steroids in the prediction of affective disorders in adult men.
Topics: Adult; Anxiety; Dehydroepiandrosterone; Depression; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Mood Disorders; Multivariate Analysis; Pregnanolone; Radioimmunoassay; Steroids; Young Adult | 2017 |
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory, Short-Term; Mice, Knockout; Motor Activity; Pentylenetetrazole; Pregnanolone; Receptors, GABA-A; Seizures; Spatial Memory; Tissue Culture Techniques; Ubiquitin-Protein Ligases | 2017 |
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis.
Topics: Acoustic Stimulation; Amygdala; Animals; Anxiety; Association Learning; Conditioning, Classical; Fear; Male; Pregnanolone; Rats; Septal Nuclei; Stress Disorders, Post-Traumatic | 2017 |
Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero.
Topics: 5-alpha Reductase Inhibitors; Animals; Animals, Newborn; Anxiety; Brain; Disease Models, Animal; Exploratory Behavior; Female; Finasteride; Guinea Pigs; Hydrocortisone; Nerve Tissue Proteins; Neurotransmitter Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Sex Factors; Statistics, Nonparametric | 2017 |
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Enzyme Inhibitors; Finasteride; Gonadal Steroid Hormones; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 2008 |
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; Isoquinolines; Pregnanolone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area | 2009 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation | 2008 |
Puberty, steroids and GABA(A) receptor plasticity.
Topics: Animals; Anxiety; CA1 Region, Hippocampal; Corticosterone; Female; Finasteride; GABA Agents; Humans; Membrane Potentials; Mice; Mice, Transgenic; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Agents; Periaqueductal Gray; Pregnanolone; Premenstrual Syndrome; Progesterone; Puberty; Pyramidal Cells; Rats; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission | 2009 |
Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats.
Topics: Animals; Anxiety; Brain Chemistry; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Estrous Cycle; Female; Male; Motor Activity; Pregnanolone; Progesterone; Progestins; Rats; Sexual Behavior, Animal | 2010 |
Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Diazepam; Estradiol; Female; Immunoblotting; Motor Activity; Neurotransmitter Agents; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2010 |
Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Macaca mulatta; Pregnanolone; Reinforcement, Psychology; Self Administration; Triazolam | 2011 |
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
Effects of early postnatal allopregnanolone administration on elevated plus maze anxiety scores in adult male Wistar rats.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Male; Midazolam; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2012 |
Long-term administration with levonorgestrel decreases allopregnanolone levels and alters GABA(A) receptor subunit expression and anxiety-like behavior.
Topics: Animals; Anxiety; Blotting, Western; Cerebral Cortex; Ethinyl Estradiol; Female; Hippocampus; Levonorgestrel; Maze Learning; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2012 |
3α5β-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia.
Topics: Animals; Anxiety; Avoidance Learning; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Male; Motor Activity; Pregnanolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Vocalization, Animal | 2012 |
Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Survival; Chronic Disease; Depression; Dexamethasone; Feeding Behavior; Hippocampus; Immunohistochemistry; Male; Motor Activity; Neural Stem Cells; Neurogenesis; Pregnanolone; Rats; Rats, Wistar; Social Isolation; Stress, Psychological; Swimming | 2012 |
Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Avoidance Learning; Exploratory Behavior; Finasteride; Hippocampus; Male; Pregnanolone; Rats; Rats, Wistar | 2013 |
Rapid anxiolytic activity of progesterone and pregnanolone in male rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar | 2002 |
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Isoenzymes; Mice; Mice, Inbred C57BL; Pregnanolone; Protein Kinase C; Protein Kinase C-epsilon; Receptors, GABA-A | 2002 |
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids | 2003 |
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Flumazenil; GABA Modulators; Lorazepam; Male; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex, Startle; Sex Characteristics | 2003 |
Neurosteroid consumption has anxiolytic effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Neurotransmitter Agents; Pregnanolone; Radioimmunoassay; Receptors, GABA-A; Species Specificity; Steroids | 2003 |
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values | 2004 |
Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behavior after early deprivation.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Female; Male; Maternal Deprivation; Maze Learning; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Sex Characteristics; Vocalization, Animal | 2004 |
Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone.
Topics: Acoustic Stimulation; Animals; Anxiety; Corticotropin-Releasing Hormone; Estradiol; Fear; Female; Hormone Replacement Therapy; Lactation; Medroxyprogesterone; Ovariectomy; Pregnancy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Reflex, Startle; Septal Nuclei | 2004 |
Anxiolytic activity of progesterone in progesterone receptor knockout mice.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Finasteride; Genotype; Immunohistochemistry; Male; Maze Learning; Mice; Mice, Knockout; Pregnanolone; Progesterone; Receptors, Progesterone; Time Factors | 2005 |
Termination of pseudopregnancy in the rat produces an anxiogenic-like response that is associated with an increase in benzodiazepine receptor binding density and a decrease in GABA-stimulated chloride influx in the hippocampus.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Cerebral Cortex; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropins; Gonadotropins, Equine; Hippocampus; Humans; Isotopes; Maze Learning; Ovariectomy; Pregnanolone; Pseudopregnancy; Radioimmunoassay; Radioligand Assay; Rats; Receptors, GABA-A; Steroids; Time Factors | 2005 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder.
Topics: Adolescent; Adult; Anxiety; Dehydroepiandrosterone; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Humans; Male; Panic Disorder; Pregnanolone; Progesterone; Steroids; Surveys and Questionnaires | 2005 |
Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Self Medication | 2005 |
Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Finasteride; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A | 2006 |
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Knockout; Motor Activity; Motor Skills; Pregnanolone; Progesterone; Receptors, Progesterone | 2006 |
Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Circadian Rhythm; Female; Male; Physiology; Posture; Pregnancy; Pregnanolone; Radioimmunoassay; Rats; Rats, Inbred Strains; Reaction Time; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area | 2006 |
Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats.
Topics: Animals; Anxiety; Brain; Copulation; Diestrus; Estradiol; Estrus; Exploratory Behavior; Female; Mesencephalon; Pregnanolone; Progestins; Rats; Rats, Long-Evans; Reproduction; Social Behavior | 2006 |
Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in th
Topics: Animals; Anxiety; Cerebral Cortex; Diencephalon; Exploratory Behavior; Female; Hippocampus; Microinjections; Neural Pathways; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Signal Transduction; Substantia Nigra; Ventral Tegmental Area | 2006 |
The anxiolytic effect of pregnancy in rats is reversed by finasteride.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Corticosterone; Enzyme Inhibitors; Female; Finasteride; Pregnancy; Pregnancy, Animal; Pregnanolone; Rats; Rats, Wistar | 2006 |
Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty.
Topics: Animals; Anxiety; Arginine; Cell Line; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Ion Channel Gating; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Patch-Clamp Techniques; Pregnanolone; Pyramidal Cells; Radioimmunoassay; Receptors, GABA-A; Stress, Psychological; Transfection | 2007 |
Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex.
Topics: 20-alpha-Dihydroprogesterone; Animals; Anxiety; Brain; Cerebral Cortex; Corpus Striatum; Estradiol; Exploratory Behavior; Female; Hippocampus; Mesencephalon; Pregnanolone; Progestins; Radioimmunoassay; Random Allocation; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Social Behavior | 2007 |
Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats.
Topics: Animals; Anxiety; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Drug Tolerance; Enzyme Inhibitors; Ethanol; Finasteride; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: the amygdala, medial prefrontal cortex, or hippocampus.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Injections, Intraventricular; Maze Learning; Microinjections; Prefrontal Cortex; Pregnanolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2007 |
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.
Topics: Adrenalectomy; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Male; Maze Learning; Muscimol; Oxazines; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticotropin-Releasing Hormone; Gene Expression; Hypothalamus; Male; Paraventricular Hypothalamic Nucleus; Pregnanolone; Rats; Rats, Wistar; RNA, Messenger | 1994 |
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electroshock; Estradiol; Female; Indomethacin; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Substance Withdrawal Syndrome | 1993 |
Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Body Weight; Female; Injections, Intraventricular; Male; Motor Activity; Postural Balance; Pregnanolone; Rats; Rats, Wistar; Sex Characteristics; Social Isolation; Vocalization, Animal | 1994 |
Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function.
Topics: Animals; Anxiety; Cerebral Cortex; Chlorides; Female; Ovariectomy; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Synaptosomes | 1993 |
Flumazenil blocks the anxiolytic action of allopregnanolone.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drug Interactions; Female; Flumazenil; GABA Modulators; Pregnanolone; Rats; Rats, Wistar | 1995 |
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Sprague-Dawley | 1996 |
Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chemical Phenomena; Chemistry; Chlordiazepoxide; Injections, Intraventricular; Male; Maze Learning; Mice; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley | 1996 |
Brain metabolism of progesterone, coping behaviour and emotional reactivity in male rats from two psychogenetically selected lines.
Topics: 20-alpha-Dihydroprogesterone; Adaptation, Psychological; Animals; Anxiety; Brain; Corticosterone; Emotions; Environment; Exploratory Behavior; Frontal Lobe; Male; Pregnanolone; Progesterone; Prolactin; Rats | 1997 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Chloride Channels; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Organophosphorus Compounds; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Prenatal stress effects are partially ameliorated by prenatal administration of the neurosteroid allopregnanolone.
Topics: Animals; Anxiety; Anxiety, Separation; Female; Handling, Psychological; Male; Motor Activity; Neuroprotective Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Vocalization, Animal; Weight Gain | 1998 |
Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety.
Topics: Animals; Anxiety; Female; GABA Agonists; GABA Antagonists; GABA Modulators; Hippocampus; Ion Channel Gating; Kinetics; Maze Learning; Peptide Fragments; Pregnanolone; Progesterone; Pseudopregnancy; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome | 1998 |
Stress and anxiety do not result in pregnancy wastage.
Topics: Adult; Age Factors; Anxiety; Chorionic Gonadotropin; Female; Fertilization in Vitro; Humans; Infertility; Male; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnanolone; Progesterone; Prospective Studies; Stress, Psychological | 1998 |
Assessment of neuroleptic-like properties of progesterone.
Topics: Animals; Antipsychotic Agents; Anxiety; Avoidance Learning; Catalepsy; Dextroamphetamine; Dopamine Uptake Inhibitors; Electroencephalography; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar; Reflex, Startle; Stereotyped Behavior | 1999 |
Differential change in neuroactive steroid sensitivity during ethanol withdrawal.
Topics: Administration, Inhalation; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Anxiety; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Muscle Relaxation; Pentylenetetrazole; Pregnanolone; Radioimmunoassay; Species Specificity; Steroids; Substance Withdrawal Syndrome; Time Factors | 2000 |
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis | 2000 |
The neurosteroid pregnanolone prevents the anxiogenic-like effect of inescapable shock in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Disease Models, Animal; Electric Stimulation; GABA Modulators; Male; Maze Learning; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A | 2000 |
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A | 2000 |
Withdrawal properties of a neuroactive steroid: implications for GABA(A) receptor gene regulation in the brain and anxiety behavior.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Female; Gene Expression Regulation; Pregnanolone; Rats; Receptors, GABA-A; Seizures; Steroids; Substance Withdrawal Syndrome; Synaptic Transmission; Time | 2002 |
Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats.
Topics: Animals; Anxiety; Depression; Enzyme Inhibitors; Exploratory Behavior; Female; Finasteride; Hippocampus; Male; Posture; Pregnanolone; Proestrus; Progesterone; Progestins; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal; Swimming | 2002 |