Page last updated: 2024-08-23

pregnanolone and Anxiety

pregnanolone has been researched along with Anxiety in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (11.82)18.2507
2000's40 (36.36)29.6817
2010's51 (46.36)24.3611
2020's6 (5.45)2.80

Authors

AuthorsStudies
Betz, JF; Hantsoo, L; Osborne, LM; Payne, JL; Standeven, LR; Voegtline, K; Yenokyan, G1
Auta, J; Camussi, D; Gatta, E; Guidotti, A; Pandey, SC1
Graham, BM; Kershaw, KA; Pestana, JE1
Graham, BM; Pestana, JE1
Concas, A; Porcu, P; Serra, M1
Bartolomé, I; Darbra, S; Llidó, A; Pallarès, M2
Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y1
Andréen, L; Bäckström, T; Bixo, M; Ehrenborg, A; Ekberg, K; Hirschberg, AL; Jonasson, AF; Poromaa, IS; Timby, E; Wulff, M1
Biggio, F; Boero, G; Concas, A; Congiu, M; Corda, D; Garau, A; Pisu, MG; Porcu, P; Serra, M1
Gong, J; Guo, Y; Jiang, XY; Li, L; Li, YF; Sun, LJ; Sun, SZ; Wang, HL; Wang, W; Zhang, LM; Zhang, YZ1
Bennett, GA; Hirst, JJ; Palazzi, KL; Palliser, HK; Shaw, JC; Walker, DW1
Dichtel, LE; Eddy, KT; Klibanski, A; Lawson, EA; Meenaghan, E; Miller, KK; Nelson, M; Paskal, ML; Pinna, G; Rasmusson, AM; Schorr, M1
Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Zhong, DS1
Biggio, F; Boero, G; Ciarlo, B; Grayson, DR; Locci, V; Pisu, MG; Serra, M; Talani, G1
Carrillo, NR; Giulivi, C; Hagerman, RJ; Napoli, E; Rogawski, M; Schneider, A; Tassone, F; Trivedi, A; Wang, JY1
McEvoy, K; Osborne, LM1
Locci, A; Pinna, G1
Darbra, S; Llidó, A; Mòdol, L; Pallarès, M1
Chopde, CT; Thakre, PP; Tundulwar, MR; Ugale, RR1
Frye, CA; Koonce, CJ; Rusconi, JC; Walf, AA1
Frye, CA; Koonce, CJ1
Mohammad, A; Ramroop, J; Shen, H; Smith, SS1
Bali, A; Jaggi, AS1
Nothdurfter, C; Rupprecht, R; Schüle, C1
Berretti, R; Calza, A; Choleris, E; Concas, A; Locci, A; Porcu, P; Santoru, F; Sogliano, C1
Alpers, GW; Arolt, V; Binder, EB; Brückl, T; Cichon, S; Deckert, J; Domschke, K; Erhardt, A; Fehm, L; Gerlach, AL; Hamm, A; Kircher, T; Lang, T; Mattheisen, M; Pauli, P; Pfister, H; Quast, C; Reif, A; Rupprecht, R; Ströhle, A; Weber, H; Wittchen, HU1
Frye, CA; Koonce, CJ; Walf, AA1
Åkerud, H; Bäckström, T; Hellgren, C; Skalkidou, A; Sundström-Poromaa, I1
Rakitskaya, VV; Semenova, OG1
Becker, HC; Cook, JB; Lopez, MF; Maldonado-Devincci, AM; McKinley, RE; Morrow, AL; Morrow, DH; O'Buckley, TK1
Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP1
Chen, JS; Chen, Y; He, JL; Lai, S; Li, Y; Liu, X; Luo, M; Ma, JC; Qiu, ZK; Shen, YG; Wu, HW; Zeng, J1
Cacioppo, JT; Cacioppo, S1
Crawley, JN; Hagerman, RJ; Kazdoba, TM; Rogawski, MA; Zolkowska, D1
Hahn, YK; Hauser, KF; Knapp, PE; Paris, JJ; Zou, S1
Chen, HX; Chen, XF; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N1
André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P1
Bäckström, T; Bixo, M; Nyberg, S; Stenlund, H; Timby, E; Wihlbäck, AN1
Beckmann, MW; Binder, E; Brown, T; Clive, M; Cox, O; Fasching, PA; Gispen, F; Guintivano, J; Kaminsky, Z; Kimmel, M; Kornhuber, J; Osborne, LM; Payne, JL1
Bennett, GA; Hirst, J; Palliser, HK; Walker, D1
Gunter, BW; Jones, SA; Paul, IA; Platt, DM; Rowlett, JK1
Bičíková, M; Dušková, M; Hill, M; Mohr, P; Řípová, D; Šrámková, M; Stárka, L1
Ciarlone, SL; Rogawski, MA; Wang, X; Weeber, EJ1
Acca, GM; Jin, J; Maren, S; Mathew, AS; Nagaya, N1
Crombie, GK; Cumberland, AL; Hirst, JJ; Palliser, HK; Walker, DW1
Darbra, S; Martín-García, E; Pallarés, M1
Frye, CA; Paris, JJ; Rhodes, ME2
Kumar, A; Singh, A1
Aoki, C; Shen, H; Smith, SS1
Frye, CA; Kohtz, AS; Paris, JJ1
Angioni, MM; Biggio, G; Calza, A; Concas, A; Marra, C; Mostallino, MC; Santoru, F; Sogliano, C1
Reddy, DS1
Fischer, BD; Rowlett, JK1
Darbra, S; Mòdol, L; Pallarès, M1
Pinna, G; Rasmusson, AM1
Darbra, S; Pallarès, M1
Berretti, R; Concas, A; Mostallino, MC; Porcu, P; Santoru, F; Sogliano, C1
Bubenikova-Valesova, V; Chodounska, H; Holubova, K; Rambousek, L; Stuchlik, A; Svoboda, J; Vales, K; Vyklicky, L1
Connor, B; Evans, J; McGregor, A; Sun, Y1
Darbra, S; Mòdol, L; Pallarès, M; Vallèe, M1
Delgado, G; Gomez, C; Rodriguez, R; Saldivar-Gonzalez, A1
Hodge, CW; McMahon, T; Mehmert, K; Messing, RO; Morrow, AL; Olive, MF; Raber, J; Sanchez-Perez, AM; Walter, H1
Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M1
Gulinello, M; Smith, SS1
Finn, DA; Long, S; Phillips, TJ; Roberts, AJ; Tanchuck, M1
Biggio, G; Concas, A; Fratta, S; Lello, S; Melis, GB; Orrù, M; Paoletti, AM; Ranuzzi, F; Sogliano, C1
Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A1
Kajunski, EW; Zimmerberg, B1
Davis, C; Davis, M; Hammond, A; Toufexis, DJ1
O'Malley, BW; Reddy, DS; Rogawski, MA1
Bitran, D; Smith, SS1
Begliuomini, S; Bernardi, F; Genazzani, AR; Lenzi, E; Luisi, M; Palumbo, M; Pluchino, N1
Chopde, CT; Hirani, K; Jain, NS1
Alciati, A; Biggio, G; Brambilla, F; Mellado, C; Perini, G; Pisu, MG; Purdy, RH; Serra, M; Zanone, S1
Martín-García, E; Pallarès, M1
Frye, C; Homanics, G; Ruderman, Y; Smith, SS; Yuan, M1
Dudek, BC; Frye, CA; Harney, JP; Lydon, JP; O'Malley, BW; Pfaff, DW; Rhodes, ME; Sumida, K1
Brunelli, SA; Frye, CA; Sumida, K; Zimmerberg, B1
Davis, M; Myers, KM; Toufexis, DJ1
Frye, CA; Rhodes, ME2
de Brito Faturi, C; Leite, JR; Teixeira-Silva, F1
Aoki, C; Dattilo, M; Gong, QH; Ruderman, Y; Shen, H; Smith, SS; Williams, K; Yuan, M1
Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Ugale, RR1
Engin, E; Treit, D1
Aszalós, Z1
Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Subhedar, NK; Ugale, RR1
Gillardin, JM; Heulard, I; Verleye, M1
Almeida, OF; Holsboer, F; Patchev, VK; Shoaib, M1
Gallo, MA; Smith, SS1
Brunelli, SA; Hofer, MA; Zimmerberg, B1
Bitran, D; Kellogg, CK; Purdy, RH1
Fernández-Guasti, A; Picazo, O1
Chen, SW; Davies, MF; Loew, GH; Rodriguez, L1
Carboni, E; Gee, KW; Lan, NC; Wieland, S1
Driscoll, P; Schulz, PE; Steimer, T1
Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH1
Blaskey, LG; Zimmerberg, B1
Bitran, D; Frye, CA; Gong, QH; Hsu, FC; Li, X; Moran, MH; Smith, SS1
Chatterton, R; Klock, SC; Milad, MP; Moses, S1
Faulhaber, J; Harting, J; Koch, M; Lancel, M; Montkowski, A; Rupprecht, R; Spanagel, R1
Crabbe, JC; Finn, DA; Gallaher, EJ1
Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L1
Bitran, D; Klibansky, DA; Martin, GA1
Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N1
Engel, SR; Grant, KA1
Smith, SS1
Frye, CA; Walf, AA1

Reviews

11 review(s) available for pregnanolone and Anxiety

ArticleYear
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy.
    Pharmacology & therapeutics, 2022, Volume: 240

    Topics: Alcoholism; Anxiety; Ethanol; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A

2022
The brain as a target of hormonal contraceptives: Evidence from animal studies.
    Frontiers in neuroendocrinology, 2019, Volume: 55

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Contraceptive Agents, Hormonal; Depression; Female; Humans; Learning; Neuropeptides; Neurosteroids; Pregnanolone; Sexual Behavior; Social Behavior; Stress, Psychological; Synaptic Transmission

2019
Allopregnanolone and reproductive psychiatry: an overview.
    International review of psychiatry (Abingdon, England), 2019, Volume: 31, Issue:3

    Topics: Affect; Anxiety; Female; Humans; Menarche; Menstrual Cycle; Perimenopause; Pregnanolone; Psychiatry; Receptors, GABA-A; Reproductive Health

2019
Multifunctional aspects of allopregnanolone in stress and related disorders.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Jan-03, Volume: 48

    Topics: Anxiety; Brain-Derived Neurotrophic Factor; Calcium Channels; Depression; Dopamine; Glutamic Acid; Humans; Oxytocin; Pregnanolone; Receptors, GABA-A; Stress, Psychological

2014
The role of allopregnanolone in depression and anxiety.
    Progress in neurobiology, 2014, Volume: 113

    Topics: Animals; Anxiety; Depression; Humans; Pregnanolone

2014
Neurosteroids: endogenous role in the human brain and therapeutic potentials.
    Progress in brain research, 2010, Volume: 186

    Topics: Androstane-3,17-diol; Anesthetics; Anxiety; Brain; Depression; Female; Humans; Male; Neurotransmitter Agents; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A; Seizures; Sex Characteristics; Stress, Physiological

2010
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder.
    Journal of neuroendocrinology, 2012, Volume: 24, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Mice; Neurotransmitter Agents; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Up-Regulation

2012
Disadaptive disorders in women: allopregnanolone, a sensitive steroid.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2004, Volume: 19, Issue:6

    Topics: Affect; Amenorrhea; Animals; Anxiety; Behavior; Depression; Female; Humans; Hypothalamus; Menopause; Mental Disorders; Mood Disorders; Pregnanolone; Premenstrual Syndrome; Puerperal Disorders; Stress, Physiological

2004
The effect of gonadal hormones and gender on anxiety and emotional learning.
    Hormones and behavior, 2006, Volume: 50, Issue:4

    Topics: Animals; Anxiety; Arginine Vasopressin; Corticotropin-Releasing Hormone; Emotions; Fear; Female; Gonadal Hormones; Humans; Learning; Light; Male; Pregnanolone; Reflex, Startle; Septal Nuclei; Sex Characteristics; Steroids

2006
[Neurological and psychiatric aspects of some endocrine diseases. The role of neurosteroids and neuroactive steroids].
    Orvosi hetilap, 2007, Oct-14, Volume: 148, Issue:41

    Topics: Addison Disease; Adrenal Cortex Hormones; Androgens; Anxiety; Cognition Disorders; Cushing Syndrome; Depression; Endocrine System Diseases; Estrogens; Fear; Fetal Organ Maturity; Gonadal Steroid Hormones; Humans; Memory Disorders; Mental Disorders; Mood Disorders; Muscle Weakness; Nervous System Diseases; Pain; Pregnanolone; Progesterone

2007
Neurosteroids and behavior.
    International review of neurobiology, 2001, Volume: 46

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Dehydroepiandrosterone; Humans; Pregnanolone; Progesterone

2001

Trials

3 trial(s) available for pregnanolone and Anxiety

ArticleYear
Treatment of premenstrual dysphoric disorder with the GABA
    Psychoneuroendocrinology, 2017, Volume: 80

    Topics: Adult; Affect; Anger; Anxiety; Contraceptives, Oral; Depression; Double-Blind Method; Female; Follicular Phase; GABA-A Receptor Antagonists; Humans; Luteal Phase; Menstrual Cycle; Middle Aged; Pregnanolone; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Progesterone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors

2017
Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
    Molecular neurobiology, 2019, Volume: 56, Issue:5

    Topics: Aged; Anxiety; Ataxia; Depression; Energy Metabolism; Fragile X Syndrome; gamma-Aminobutyric Acid; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Ornithine; Oxidative Stress; Pilot Projects; Pregnanolone; Tremor

2019
Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol.
    Fertility and sterility, 2004, Volume: 81, Issue:3

    Topics: Adult; Androstenes; Anxiety; Contraceptives, Oral, Combined; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Follicular Phase; Humans; Luteal Phase; Phobic Disorders; Pregnanolone; Progesterone; Psychometrics

2004

Other Studies

96 other study(ies) available for pregnanolone and Anxiety

ArticleYear
Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study.
    Archives of women's mental health, 2022, Volume: 25, Issue:2

    Topics: Anxiety; Depression; Depression, Postpartum; Female; Humans; Peripartum Period; Pregnancy; Pregnanolone; Psychiatric Status Rating Scales

2022
The impact of the ovarian cycle on anxiety, allopregnanolone, and corticotropin releasing hormone changes after motherhood in female rats and women.
    Translational psychiatry, 2023, 05-30, Volume: 13, Issue:1

    Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Estrous Cycle; Female; Humans; Menstrual Cycle; Pregnancy; Pregnanolone; Rats; Receptors, GABA-A

2023
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.
    Psychopharmacology, 2023, Volume: 240, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychological; Fear; Female; Fluoxetine; Humans; Pregnancy; Pregnanolone; Progesterone; Rats

2023
Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats.
    Behavioural brain research, 2020, 09-15, Volume: 394

    Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Finasteride; Male; Neurosteroids; Pregnanolone; Rats, Wistar; Recognition, Psychology

2020
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
    Psychoneuroendocrinology, 2020, Volume: 121

    Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry

2020
Effects of neonatal and adolescent neuroactive steroid manipulation on locomotor activity induced by ethanol in male wistar rats.
    Behavioural brain research, 2017, 07-14, Volume: 330

    Topics: 5-alpha Reductase Inhibitors; Alcohol Drinking; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Ethanol; Exploratory Behavior; Finasteride; Locomotion; Male; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Wistar

2017
Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone.
    Psychopharmacology, 2017, Volume: 234, Issue:17

    Topics: Animals; Anxiety; Corticosterone; Disease Models, Animal; Female; Maternal Behavior; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Social Isolation; Weaning

2017
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
    Neuropharmacology, 2017, Volume: 125

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vectors; Isoquinolines; Lentivirus; Male; Mice, Inbred ICR; Motor Activity; Pregnanolone; Psychotropic Drugs; Receptors, GABA

2017
Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum.
    Stress (Amsterdam, Netherlands), 2017, Volume: 20, Issue:6

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Anxiety; Astrocytes; Behavior, Animal; Cerebellum; Female; Fetus; Guinea Pigs; Male; Neurotransmitter Agents; Oligodendroglia; Pregnancy; Pregnancy Complications; Pregnanolone; Prenatal Exposure Delayed Effects; Receptors, GABA-A; RNA, Messenger; Stress, Psychological

2017
Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:6

    Topics: Adult; Affective Symptoms; Androstane-3,17-diol; Anorexia Nervosa; Anxiety; Body Mass Index; Cross-Sectional Studies; Depression; Female; Humans; Overweight; Pregnanolone; Progesterone; Psychiatric Status Rating Scales; Severity of Illness Index; Testosterone; Thinness

2018
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain.
    Metabolic brain disease, 2018, Volume: 33, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Depression; Isoflavones; Male; Maze Learning; Neurotransmitter Agents; Pregnanolone; Rats, Sprague-Dawley; Serotonin

2018
Low doses of prenatal ethanol exposure and maternal separation alter HPA axis function and ethanol consumption in adult male rats.
    Neuropharmacology, 2018, 03-15, Volume: 131

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Anxiety; Corticosterone; Electroshock; Fetal Alcohol Spectrum Disorders; Male; Maternal Deprivation; Pregnanolone; Random Allocation; Rats, Sprague-Dawley; Stress, Psychological

2018
Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior.
    Biological psychiatry, 2019, 06-15, Volume: 85, Issue:12

    Topics: Amides; Animals; Anxiety; Disease Models, Animal; Emotions; Ethanolamines; Fear; Hippocampus; Male; Mice; Palmitic Acids; PPAR alpha; Pregnanolone; Social Isolation; Stress Disorders, Post-Traumatic

2019
Interaction between neonatal allopregnanolone administration and early maternal separation: effects on adolescent and adult behaviors in male rat.
    Hormones and behavior, 2013, Volume: 63, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Anxiety; Anxiety, Separation; Body Weight; Exploratory Behavior; Gonadal Steroid Hormones; Male; Maternal Deprivation; Pregnanolone; Rats; Reflex, Startle

2013
Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice.
    Neuroscience letters, 2013, Apr-29, Volume: 541

    Topics: Animals; Anxiety; Finasteride; Indomethacin; Male; Maze Learning; Mice; Motor Activity; Neurotransmitter Agents; Nicotine; Pregnanolone; Progesterone; Substance Withdrawal Syndrome; Time Factors

2013
Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.
    The journal of sexual medicine, 2013, Volume: 10, Issue:7

    Topics: Animals; Anxiety; Estradiol; Female; Gene Knockdown Techniques; Interpersonal Relations; Male; Mesencephalon; Motivation; Pregnane X Receptor; Pregnanolone; Proestrus; Progesterone; Rats; Rats, Long-Evans; Receptors, Steroid; Reproduction; Sexual Behavior, Animal; Ventral Tegmental Area

2013
Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice.
    Behavioural brain research, 2013, Sep-15, Volume: 253

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Affect; Animals; Anxiety; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Genotype; Immunohistochemistry; Interpersonal Relations; Medroxyprogesterone; Mice; Mice, Knockout; Motor Activity; Mutation; Ovariectomy; Pregnanolone; Progesterone; Social Behavior; Steroids

2013
A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.
    Neuroscience, 2013, Dec-19, Volume: 254

    Topics: Amphetamine-Related Disorders; Animals; Anxiety; Gene Expression Regulation; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Sensory Gating; Stress, Psychological; Substance Withdrawal Syndrome

2013
Neonatal exposure to estradiol decreases hypothalamic allopregnanolone concentrations and alters agonistic and sexual but not affective behavior in adult female rats.
    Hormones and behavior, 2014, Volume: 65, Issue:2

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Estradiol; Exploratory Behavior; Female; Hypothalamus; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Social Behavior

2014
Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?
    Depression and anxiety, 2014, Volume: 31, Issue:10

    Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aldo-Keto Reductase Family 1 Member C3; Anxiety; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Hydroxyprostaglandin Dehydrogenases; Hydroxysteroid Dehydrogenases; Male; Membrane Proteins; Middle Aged; Panic Disorder; Polymorphism, Single Nucleotide; Pregnanolone; Progesterone; Receptors, GABA; Sex Factors

2014
Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats.
    Psychopharmacology, 2014, Volume: 231, Issue:17

    Topics: 20-alpha-Dihydroprogesterone; Animals; Anxiety; Estradiol; Female; Interpersonal Relations; Motor Activity; Pregnane X Receptor; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, Steroid; Sexual Behavior, Animal; Ventral Tegmental Area

2014
Low serum allopregnanolone is associated with symptoms of depression in late pregnancy.
    Neuropsychobiology, 2014, Volume: 69, Issue:3

    Topics: Adult; Anxiety; Depression; Depression, Postpartum; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Pregnanolone; Self Report; Young Adult

2014
Selective effect of allopregnanolone on corticoliberin-induced anxiety.
    Bulletin of experimental biology and medicine, 2014, Volume: 156, Issue:6

    Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Corticotropin-Releasing Hormone; Male; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Stress, Psychological

2014
Chronic intermittent ethanol exposure and withdrawal alters (3α,5α)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice.
    Alcoholism, clinical and experimental research, 2014, Volume: 38, Issue:10

    Topics: Alcoholism; Animals; Anxiety; Central Amygdaloid Nucleus; Corpus Striatum; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Models, Animal; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Stress, Psychological; Time Factors; Withholding Treatment

2014
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
    Psychopharmacology, 2016, Volume: 233, Issue:11

    Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult

2016
The role of allopregnanolone in the anxiolytic-like effect of free and easy wanderer plus (FEWP), a polyherbal preparation.
    Neuroscience letters, 2015, May-19, Volume: 595

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Drugs, Chinese Herbal; Feeding Behavior; Male; Maze Learning; Mice, Inbred ICR; Pregnanolone; Rats, Sprague-Dawley; Reaction Time

2015
Why may allopregnanolone help alleviate loneliness?
    Medical hypotheses, 2015, Volume: 85, Issue:6

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Biological Evolution; Brain-Derived Neurotrophic Factor; Cognition; Fear; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Interpersonal Relations; Limbic System; Loneliness; Models, Theoretical; Pituitary-Adrenal System; Pregnanolone; Social Isolation; Stress, Psychological

2015
Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.
    Psychopharmacology, 2016, Volume: 233, Issue:2

    Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Diazepam; Female; GABA Modulators; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnanolone; Receptors, GABA-A; Social Behavior

2016
5α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat.
    Brain, behavior, and immunity, 2016, Volume: 55

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Behavior, Animal; Cholestenone 5 alpha-Reductase; Coculture Techniques; Female; Finasteride; Mice; Microglia; Neurons; Ovariectomy; Pregnanolone; Progesterone; tat Gene Products, Human Immunodeficiency Virus

2016
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Male; Motor Activity; Prefrontal Cortex; Pregnanolone; Purines; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic

2016
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:10

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin

2016
Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study.
    Psychopharmacology, 2016, Volume: 233, Issue:11

    Topics: Adolescent; Adult; Anxiety; Electrooculography; Female; GABA Modulators; Gonadal Steroid Hormones; Humans; Hypnotics and Sedatives; Menstrual Cycle; Panic; Pilot Projects; Pregnanolone; Premenstrual Dysphoric Disorder; Receptors, GABA-A; Saccades; Young Adult

2016
Oxytocin receptor DNA methylation in postpartum depression.
    Psychoneuroendocrinology, 2016, Volume: 69

    Topics: Adult; Anxiety; Anxiety Disorders; CpG Islands; Depression, Postpartum; DNA Methylation; Epigenesis, Genetic; Estradiol; Female; Humans; Pregnanolone; Progesterone; Prospective Studies; Receptors, Oxytocin

2016
Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring.
    Psychoneuroendocrinology, 2016, Volume: 70

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Emotions; Female; Fetal Development; Guinea Pigs; Hippocampus; Neurogenesis; Neuroglia; Neurotransmitter Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Random Allocation; Stress, Physiological; Stress, Psychological

2016
Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects.
    Psychopharmacology, 2016, Volume: 233, Issue:17

    Topics: Anesthetics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clonazepam; Discrimination Learning; Drug Interactions; Hypnotics and Sedatives; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Triazolam

2016
The role of steroids in the prediction of affective disorders in adult men.
    Steroids, 2017, Volume: 121

    Topics: Adult; Anxiety; Dehydroepiandrosterone; Depression; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Mood Disorders; Multivariate Analysis; Pregnanolone; Radioimmunoassay; Steroids; Young Adult

2017
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.
    Neuropharmacology, 2017, Volume: 116

    Topics: Angelman Syndrome; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Disease Models, Animal; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory, Short-Term; Mice, Knockout; Motor Activity; Pentylenetetrazole; Pregnanolone; Receptors, GABA-A; Seizures; Spatial Memory; Tissue Culture Techniques; Ubiquitin-Protein Ligases

2017
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis.
    Hormones and behavior, 2017, Volume: 89

    Topics: Acoustic Stimulation; Amygdala; Animals; Anxiety; Association Learning; Conditioning, Classical; Fear; Male; Pregnanolone; Rats; Septal Nuclei; Stress Disorders, Post-Traumatic

2017
Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2017, Volume: 58

    Topics: 5-alpha Reductase Inhibitors; Animals; Animals, Newborn; Anxiety; Brain; Disease Models, Animal; Exploratory Behavior; Female; Finasteride; Guinea Pigs; Hydrocortisone; Nerve Tissue Proteins; Neurotransmitter Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Sex Factors; Statistics, Nonparametric

2017
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.
    Neuroscience, 2008, Jul-17, Volume: 154, Issue:4

    Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Enzyme Inhibitors; Finasteride; Gonadal Steroid Hormones; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A

2008
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; Isoquinolines; Pregnanolone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area

2009
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:9

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation

2008
Puberty, steroids and GABA(A) receptor plasticity.
    Psychoneuroendocrinology, 2009, Volume: 34 Suppl 1

    Topics: Animals; Anxiety; CA1 Region, Hippocampal; Corticosterone; Female; Finasteride; GABA Agents; Humans; Membrane Potentials; Mice; Mice, Transgenic; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Agents; Periaqueductal Gray; Pregnanolone; Premenstrual Syndrome; Progesterone; Puberty; Pyramidal Cells; Rats; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission

2009
Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats.
    Hormones and behavior, 2010, Volume: 57, Issue:4-5

    Topics: Animals; Anxiety; Brain Chemistry; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Estrous Cycle; Female; Male; Motor Activity; Pregnanolone; Progesterone; Progestins; Rats; Sexual Behavior, Animal

2010
Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs.
    Journal of neurochemistry, 2010, Volume: 113, Issue:5

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Diazepam; Estradiol; Female; Immunoblotting; Motor Activity; Neurotransmitter Agents; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids

2010
Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Macaca mulatta; Pregnanolone; Reinforcement, Psychology; Self Administration; Triazolam

2011
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
    Behavioural brain research, 2011, Sep-12, Volume: 222, Issue:1

    Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric

2011
Effects of early postnatal allopregnanolone administration on elevated plus maze anxiety scores in adult male Wistar rats.
    Neuropsychobiology, 2012, Volume: 65, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Male; Midazolam; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A

2012
Long-term administration with levonorgestrel decreases allopregnanolone levels and alters GABA(A) receptor subunit expression and anxiety-like behavior.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:2

    Topics: Animals; Anxiety; Blotting, Western; Cerebral Cortex; Ethinyl Estradiol; Female; Hippocampus; Levonorgestrel; Maze Learning; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2012
3α5β-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Animals; Anxiety; Avoidance Learning; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Male; Motor Activity; Pregnanolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Vocalization, Animal

2012
Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Survival; Chronic Disease; Depression; Dexamethasone; Feeding Behavior; Hippocampus; Immunohistochemistry; Male; Motor Activity; Neural Stem Cells; Neurogenesis; Pregnanolone; Rats; Rats, Wistar; Social Isolation; Stress, Psychological; Swimming

2012
Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids.
    Behavioural brain research, 2013, Mar-15, Volume: 241

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Avoidance Learning; Exploratory Behavior; Finasteride; Hippocampus; Male; Pregnanolone; Rats; Rats, Wistar

2013
Rapid anxiolytic activity of progesterone and pregnanolone in male rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar

2002
Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.
    The Journal of clinical investigation, 2002, Volume: 110, Issue:7

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Isoenzymes; Mice; Mice, Inbred C57BL; Pregnanolone; Protein Kinase C; Protein Kinase C-epsilon; Receptors, GABA-A

2002
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2

    Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids

2003
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2

    Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Flumazenil; GABA Modulators; Lorazepam; Male; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex, Startle; Sex Characteristics

2003
Neurosteroid consumption has anxiolytic effects in mice.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Neurotransmitter Agents; Pregnanolone; Radioimmunoassay; Receptors, GABA-A; Species Specificity; Steroids

2003
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
    Neuropsychobiology, 2004, Volume: 50, Issue:1

    Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values

2004
Sexually dimorphic effects of postnatal allopregnanolone on the development of anxiety behavior after early deprivation.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:3

    Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Female; Male; Maternal Deprivation; Maze Learning; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Sex Characteristics; Vocalization, Animal

2004
Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45

    Topics: Acoustic Stimulation; Animals; Anxiety; Corticotropin-Releasing Hormone; Estradiol; Fear; Female; Hormone Replacement Therapy; Lactation; Medroxyprogesterone; Ovariectomy; Pregnancy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Reflex, Startle; Septal Nuclei

2004
Anxiolytic activity of progesterone in progesterone receptor knockout mice.
    Neuropharmacology, 2005, Volume: 48, Issue:1

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Finasteride; Genotype; Immunohistochemistry; Male; Maze Learning; Mice; Mice, Knockout; Pregnanolone; Progesterone; Receptors, Progesterone; Time Factors

2005
Termination of pseudopregnancy in the rat produces an anxiogenic-like response that is associated with an increase in benzodiazepine receptor binding density and a decrease in GABA-stimulated chloride influx in the hippocampus.
    Brain research bulletin, 2005, Jan-30, Volume: 64, Issue:6

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Cerebral Cortex; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropins; Gonadotropins, Equine; Hippocampus; Humans; Isotopes; Maze Learning; Ovariectomy; Pregnanolone; Pseudopregnancy; Radioimmunoassay; Radioligand Assay; Rats; Receptors, GABA-A; Steroids; Time Factors

2005
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time

2005
Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder.
    Psychiatry research, 2005, Jun-30, Volume: 135, Issue:3

    Topics: Adolescent; Adult; Anxiety; Dehydroepiandrosterone; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Humans; Male; Panic Disorder; Pregnanolone; Progesterone; Steroids; Surveys and Questionnaires

2005
Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.
    Behavioural brain research, 2005, Oct-14, Volume: 164, Issue:1

    Topics: Administration, Oral; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Self Medication

2005
Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Finasteride; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone; Premenstrual Syndrome; Receptors, GABA-A

2006
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Knockout; Motor Activity; Motor Skills; Pregnanolone; Progesterone; Receptors, Progesterone

2006
Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults.
    Behavioral neuroscience, 2006, Volume: 120, Issue:2

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Circadian Rhythm; Female; Male; Physiology; Posture; Pregnancy; Pregnanolone; Radioimmunoassay; Rats; Rats, Inbred Strains; Reaction Time; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area

2006
Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats.
    Neuroendocrinology, 2006, Volume: 83, Issue:5-6

    Topics: Animals; Anxiety; Brain; Copulation; Diestrus; Estradiol; Estrus; Exploratory Behavior; Female; Mesencephalon; Pregnanolone; Progestins; Rats; Rats, Long-Evans; Reproduction; Social Behavior

2006
Infusions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3alpha,5alpha-THP concentrations in th
    Journal of neuroendocrinology, 2006, Volume: 18, Issue:12

    Topics: Animals; Anxiety; Cerebral Cortex; Diencephalon; Exploratory Behavior; Female; Hippocampus; Microinjections; Neural Pathways; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Signal Transduction; Substantia Nigra; Ventral Tegmental Area

2006
The anxiolytic effect of pregnancy in rats is reversed by finasteride.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Corticosterone; Enzyme Inhibitors; Female; Finasteride; Pregnancy; Pregnancy, Animal; Pregnanolone; Rats; Rats, Wistar

2006
Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty.
    Nature neuroscience, 2007, Volume: 10, Issue:4

    Topics: Animals; Anxiety; Arginine; Cell Line; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Ion Channel Gating; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Patch-Clamp Techniques; Pregnanolone; Pyramidal Cells; Radioimmunoassay; Receptors, GABA-A; Stress, Psychological; Transfection

2007
Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex.
    Reproduction (Cambridge, England), 2007, Volume: 133, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; Animals; Anxiety; Brain; Cerebral Cortex; Corpus Striatum; Estradiol; Exploratory Behavior; Female; Hippocampus; Mesencephalon; Pregnanolone; Progestins; Radioimmunoassay; Random Allocation; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Social Behavior

2007
Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats.
    European journal of pharmacology, 2007, Jul-19, Volume: 567, Issue:3

    Topics: Animals; Anxiety; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Drug Tolerance; Enzyme Inhibitors; Ethanol; Finasteride; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome

2007
The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: the amygdala, medial prefrontal cortex, or hippocampus.
    Behavioural pharmacology, 2007, Volume: 18, Issue:5-6

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Injections, Intraventricular; Maze Learning; Microinjections; Prefrontal Cortex; Pregnanolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2007
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.
    Brain research, 2007, Dec-12, Volume: 1184

    Topics: Adrenalectomy; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Male; Maze Learning; Muscimol; Oxazines; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time

2007
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological

2008
The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
    Neuroscience, 1994, Volume: 62, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticotropin-Releasing Hormone; Gene Expression; Hypothalamus; Male; Paraventricular Hypothalamic Nucleus; Pregnanolone; Rats; Rats, Wistar; RNA, Messenger

1994
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electroshock; Estradiol; Female; Indomethacin; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Substance Withdrawal Syndrome

1993
Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Body Weight; Female; Injections, Intraventricular; Male; Motor Activity; Postural Balance; Pregnanolone; Rats; Rats, Wistar; Sex Characteristics; Social Isolation; Vocalization, Animal

1994
Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2

    Topics: Animals; Anxiety; Cerebral Cortex; Chlorides; Female; Ovariectomy; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Synaptosomes

1993
Flumazenil blocks the anxiolytic action of allopregnanolone.
    European journal of pharmacology, 1995, Jul-25, Volume: 281, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Drug Interactions; Female; Flumazenil; GABA Modulators; Pregnanolone; Rats; Rats, Wistar

1995
The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4

    Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Picrotoxin; Pregnanes; Pregnanolone; Rats; Rats, Sprague-Dawley

1996
Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.
    Psychopharmacology, 1996, Volume: 126, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Chemical Phenomena; Chemistry; Chlordiazepoxide; Injections, Intraventricular; Male; Maze Learning; Mice; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley

1996
Brain metabolism of progesterone, coping behaviour and emotional reactivity in male rats from two psychogenetically selected lines.
    Journal of neuroendocrinology, 1997, Volume: 9, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; Adaptation, Psychological; Animals; Anxiety; Brain; Corticosterone; Emotions; Environment; Exploratory Behavior; Frontal Lobe; Male; Pregnanolone; Progesterone; Prolactin; Rats

1997
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
    European journal of pharmacology, 1997, Apr-23, Volume: 325, Issue:1

    Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Chloride Channels; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Organophosphorus Compounds; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A

1997
Prenatal stress effects are partially ameliorated by prenatal administration of the neurosteroid allopregnanolone.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: Animals; Anxiety; Anxiety, Separation; Female; Handling, Psychological; Male; Motor Activity; Neuroprotective Agents; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Vocalization, Animal; Weight Gain

1998
Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-15, Volume: 18, Issue:14

    Topics: Animals; Anxiety; Female; GABA Agonists; GABA Antagonists; GABA Modulators; Hippocampus; Ion Channel Gating; Kinetics; Maze Learning; Peptide Fragments; Pregnanolone; Progesterone; Pseudopregnancy; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome

1998
Stress and anxiety do not result in pregnancy wastage.
    Human reproduction (Oxford, England), 1998, Volume: 13, Issue:8

    Topics: Adult; Age Factors; Anxiety; Chorionic Gonadotropin; Female; Fertilization in Vitro; Humans; Infertility; Male; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnanolone; Progesterone; Prospective Studies; Stress, Psychological

1998
Assessment of neuroleptic-like properties of progesterone.
    Psychopharmacology, 1999, Volume: 143, Issue:1

    Topics: Animals; Antipsychotic Agents; Anxiety; Avoidance Learning; Catalepsy; Dextroamphetamine; Dopamine Uptake Inhibitors; Electroencephalography; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar; Reflex, Startle; Stereotyped Behavior

1999
Differential change in neuroactive steroid sensitivity during ethanol withdrawal.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:1

    Topics: Administration, Inhalation; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Anxiety; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Muscle Relaxation; Pentylenetetrazole; Pregnanolone; Radioimmunoassay; Species Specificity; Steroids; Substance Withdrawal Syndrome; Time Factors

2000
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
    Journal of neurochemistry, 2000, Volume: 75, Issue:2

    Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis

2000
The neurosteroid pregnanolone prevents the anxiogenic-like effect of inescapable shock in the rat.
    Psychopharmacology, 2000, Volume: 151, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Disease Models, Animal; Electric Stimulation; GABA Modulators; Male; Maze Learning; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A

2000
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
    Psychopharmacology, 2000, Volume: 151, Issue:1

    Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A

2000
Withdrawal properties of a neuroactive steroid: implications for GABA(A) receptor gene regulation in the brain and anxiety behavior.
    Steroids, 2002, Volume: 67, Issue:6

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Female; Gene Expression Regulation; Pregnanolone; Rats; Receptors, GABA-A; Seizures; Steroids; Substance Withdrawal Syndrome; Synaptic Transmission; Time

2002
Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats.
    Hormones and behavior, 2002, Volume: 41, Issue:3

    Topics: Animals; Anxiety; Depression; Enzyme Inhibitors; Exploratory Behavior; Female; Finasteride; Hippocampus; Male; Posture; Pregnanolone; Proestrus; Progesterone; Progestins; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal; Swimming

2002