pregnanolone has been researched along with Alzheimer Disease in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| El-Kott, AF; El-Maksoud, MMA; Fu, M; Ji, C; Ji, Y; Mao, F; Negm, S; Shati, AA; Yang, T | 1 |
| Bäckström, T; Blackburn, TP; Das, R; Doverskog, M; Turkmen, S | 1 |
| Brinton, RD; Chen, S; Mao, Z; Wang, T; Yao, J | 1 |
| Brinton, RD; Chen, S; Wang, T; Yao, J | 1 |
| Alata, W; Boutin, S; Calon, F; Maltais, R; Poirier, D; Roy, J | 1 |
| Agapouda, A; Eckert, A; Grimm, A; Lejri, I | 1 |
| Brinton, RD | 1 |
| Brinton, RD; Irwin, RW | 1 |
| Chen, SX; Ding, YQ; Gu, QQ; Liao, M; Qi, SS; Sun, CY; Xie, MQ; Zhang, P; Zhou, P | 1 |
| Bauer, G; Brinton, RD; Irwin, RW; Loya, CM; Rodgers, KE; Rogawski, MA; Salituro, FG; Solinsky, CM | 1 |
| Eckert, A; Geoffroy, P; Grimm, A; Lejri, I; Mensah-Nyagan, AG; Miesch, M | 1 |
| Frye, CA | 1 |
| Brinton, RD; Chen, S; Chung, EJ; Irwin, RW; Liu, L; Singh, C; Thompson, RF; Wang, JM | 1 |
| Allen, TB; Blazer, DG; Ervin, JF; Hulette, CM; Kilts, JD; Marx, CE; Massing, MW; Naylor, JC; Payne, VM; Shampine, LJ; Steffens, DC; Strauss, JL; Youssef, NA | 1 |
| Brinton, RD; Chen, S; Henry, S; Irwin, RW; Liu, L; Singh, C; Thompson, RF; Wang, JM; Yao, J | 1 |
| Brinton, RD; Chen, S; Irwin, RW; Liu, L; Wang, JM; Yao, J | 1 |
| Bigler, S; Brinton, RD; Farley, JM; Ou, X; Stockmeier, C; Sun, C; Wang, JM | 1 |
| Bäckström, T; Bengtsson, SK; Johansson, M; Wang, M | 1 |
| Backstrom, T; Bengtsson, SK; Johansson, M; Nitsch, RM; Wang, M | 1 |
| Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S | 1 |
| He, XY; Wegiel, J; Yang, SY | 1 |
| Frye, CA; Markesbery, WR; Smith, CD; Wekstein, DR | 1 |
| Brown, RC; Han, Z; Lecanu, L; Papadopoulos, V; Yao, ZX | 1 |
| Brinton, RD; Wang, JM | 2 |
| Blazer, DG; Butterfield, MI; Ervin, JF; Hulette, CM; Lieberman, JA; Marx, CE; Massing, MW; Shampine, LJ; Steffens, DC; Stevens, RD; Trost, WT | 1 |
| Brinton, RD; Chen, S; Irwin, RW; Liu, L; Wang, JM | 2 |
| Frye, CA; Walf, AA | 1 |
| Bernardi, F; Cento, RM; Genazzani, AD; Genazzani, AR; Lanzone, A; Luisi, M; Luisi, S; Petraglia, F; Pezzani, I; Spada, RS | 1 |
| Bernardi, F; Casarosa, E; Cobellis, L; Genazzani, AR; Luisi, M; Luisi, S; Monteleone, P; Petraglia, F; Stomati, M | 1 |
11 review(s) available for pregnanolone and Alzheimer Disease
| Article | Year |
|---|---|
The GABA system, a new target for medications against cognitive impairment-Associated with neuroactive steroids.
Topics: Aged; Alzheimer Disease; Animals; Cognitive Dysfunction; gamma-Aminobutyric Acid; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2023 |
Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence.
Topics: Alzheimer Disease; Animals; Antioxidants; Clinical Trials as Topic; Cognitive Dysfunction; Drug Evaluation, Preclinical; Energy Metabolism; Evidence-Based Medicine; Ginkgo biloba; Humans; Mitochondria; Oxidative Stress; Phytoestrogens; Plant Extracts; Pregnanolone; Resveratrol | 2019 |
Neurosteroids as regenerative agents in the brain: therapeutic implications.
Topics: Alzheimer Disease; Animals; Brain; Humans; Neurotransmitter Agents; Pregnanolone | 2013 |
Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise.
Topics: Alzheimer Disease; Animals; Brain; Humans; Neuroprotective Agents; Pregnanolone | 2014 |
Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions.
Topics: Affect; Alzheimer Disease; Animals; Brain; Cognition; Disease Models, Animal; Emotions; Female; Humans; Neurotransmitter Agents; Pregnancy; Pregnanolone; Sexual Behavior, Animal; Social Behavior | 2009 |
Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Glioma; Humans; Models, Neurological; Nervous System Diseases; Peripheral Nervous System; Pregnanolone; Receptors, GABA-A; Steroids | 2006 |
Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cell Proliferation; Gonadal Steroid Hormones; Humans; Mice; Mice, Transgenic; Nerve Regeneration; Neurons; Pregnanolone; Receptors, GABA | 2006 |
Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent.
Topics: Aging; Alzheimer Disease; Animals; Brain; Cell Differentiation; Mice; Mice, Transgenic; Nerve Regeneration; Neurons; Pregnanolone; Stem Cell Transplantation; Stem Cells | 2006 |
Regenerative potential of allopregnanolone.
Topics: Aging; Alzheimer Disease; Animals; Brain; Humans; Nerve Regeneration; Pregnanolone | 2008 |
Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Nerve Regeneration; Neuroprotective Agents; Pregnanolone; Rats; tau Proteins | 2007 |
Clinical implications of circulating neurosteroids.
Topics: Aging; Alzheimer Disease; Dehydroepiandrosterone; Female; Humans; Male; Menopause; Menstrual Cycle; Pregnanolone | 2001 |
21 other study(ies) available for pregnanolone and Alzheimer Disease
| Article | Year |
|---|---|
Anti-ovarian cancer potential, in silico studies, and anti-Alzheimer's disease effects of some natural compounds as cholinesterase inhibitors.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Female; Humans; Molecular Docking Simulation; Neoplasms; Pregnanolone | 2023 |
Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Energy Metabolism; Female; Gene Expression; Lipid Peroxidation; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Pregnanolone | 2020 |
Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease.
Topics: Age Factors; Alzheimer Disease; Animals; Cell Differentiation; Cells, Cultured; Mice; Mice, Transgenic; Neural Stem Cells; Neurons; Oligodendroglia; Pregnanolone | 2020 |
Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10.
Topics: 17-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Alzheimer Disease; Enzyme Inhibitors; Estradiol; Estrone; HEK293 Cells; Humans; Pregnanolone; Steroids; Structure-Activity Relationship | 2018 |
Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Doublecortin Protein; Lateral Ventricles; Male; Mesencephalon; Mice, Transgenic; Mutation; Neural Stem Cells; Neurogenesis; Nootropic Agents; Plaque, Amyloid; Pregnanolone; Presenilin-1; Tyrosine 3-Monooxygenase | 2015 |
Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Bromodeoxyuridine; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Cyclodextrins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Evaluation, Preclinical; Female; Humans; Male; Maximum Tolerated Dose; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; No-Observed-Adverse-Effect Level; Phosphorylation; Pregnanolone; Proliferating Cell Nuclear Antigen; Rabbits; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Correction: Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Drug Administration Routes; Female; Male; Mice; Pregnanolone; Rabbits | 2015 |
Allopregnanolone and its analog BR 297 rescue neuronal cells from oxidative stress-induced death through bioenergetic improvement.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Cell Death; Cell Line; Energy Metabolism; Humans; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Pregnanolone; Up-Regulation | 2017 |
Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Proliferation; Disease Models, Animal; Humans; Learning; Male; Memory; Mice; Mice, Transgenic; Neurogenesis; Neurons; Pregnanolone; Stem Cells | 2010 |
Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Case-Control Studies; Cerebral Cortex; Chromatography, High Pressure Liquid; Cognition; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Models, Biological; Postmortem Changes; Pregnanolone; Temporal Lobe | 2010 |
Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.
Topics: Aging; Alzheimer Disease; Animals; Cell Survival; Hippocampus; Learning; Memory; Mice; Mice, Knockout; Neurons; Pregnanolone; Recovery of Function; Stem Cells; Treatment Outcome | 2012 |
Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Flow Cytometry; Humans; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Male; Mice; Microglia; Pregnanolone | 2011 |
Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Anesthetics; Animals; Bromodeoxyuridine; Cell Count; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice; Mice, Transgenic; Mutation; Pregnanolone; Presenilin-1; Substantia Nigra; tau Proteins; Tyrosine 3-Monooxygenase | 2012 |
Chronic allopregnanolone treatment accelerates Alzheimer's disease development in AβPP(Swe)PSEN1(ΔE9) mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antipsychotic Agents; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Pregnanolone; Presenilin-1; Statistics, Nonparametric; Time Factors | 2012 |
Brief but chronic increase in allopregnanolone cause accelerated AD pathology differently in two mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics; Animals; Disease Models, Animal; Drug Administration Schedule; Female; Hippocampus; Humans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Mutation; Pregnanolone; Presenilin-1; Sex Factors; Time Factors | 2013 |
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins | 2002 |
Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cell Line; Female; Humans; Intracellular Fluid; Male; Middle Aged; Oxidation-Reduction; Pregnanolone | 2005 |
3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia.
Topics: Aged; Alzheimer Disease; Biomarkers; Case-Control Studies; Dementia; Estradiol; Female; Humans; Male; Pregnanolone; Progesterone; Testosterone Congeners | 2006 |
The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Disease Progression; Gas Chromatography-Mass Spectrometry; Humans; Male; Prefrontal Cortex; Pregnanolone; Pregnenolone | 2006 |
Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Cognition; Disease Models, Animal; Exploratory Behavior; Female; Heterozygote; Hippocampus; Maze Learning; Mice; Mice, Mutant Strains; Mice, Transgenic; Motor Activity; Pregnanolone; Presenilin-1; Progesterone; Random Allocation; Recognition, Psychology; Statistics, Nonparametric | 2008 |
Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Area Under Curve; Case-Control Studies; Corticotropin-Releasing Hormone; Dehydroepiandrosterone; Dementia, Vascular; Female; GABA Modulators; Humans; Hydrocortisone; Male; Middle Aged; Pregnanolone | 2000 |